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Table of Contents

June 2005

The image shows predicted functional linkage gene networks for large and small cytoplasmic ribosomal subunits in eukaryotes, derived from phylogenetic analysis of whole genomes. Each point represents a gene, and each line a functional link. Colors represent protein functional classes. (See Barker and Pagel)

Image Credit: Drawn by Barker and Pagel using BioLayout software.


PLoS Computational Biology: A New Community Journal

Philip E Bourne, Steven E Brenner, Michael B Eisen

Message from ISCB

An Open Forum for Computational Biology

Michael Gribskov


“Antedisciplinary” Science

Sean R Eddy


The Human Connectome: A Structural Description of the Human Brain

Olaf Sporns, Giulio Tononi, Rolf Kötter

Research Articles

Ab Initio Prediction of Transcription Factor Targets Using Structural Knowledge

Tommy Kaplan, Nir Friedman, Hanah Margalit

Extraction of Transcript Diversity from Scientific Literature

Parantu K Shah, Lars J Jensen, Stéphanie Boué, Peer Bork

The Genomic Pattern of tDNA Operon Expression in E. coli

David H Ardell, Leif A Kirsebom

microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets

Dominic Grün, Yi-Lu Wang, David Langenberger, Kristin C Gunsalus, Nikolaus Rajewsky