Microbiome data exhibit rich temporal and phylogenetic structure especially following perturbations. The leaves of the central phylogenetic tree correspond to individual bacterial species, while the lines that radiate out from it represent their abundances over time. Color gives a sense of phylogenetic relationships, while the heights of bars at the base of these lines corresponds to the coefficients of a tree-aware discriminant analysis (treeDA) applied to a study of a perturbation of the human gut microbiome. Fukuyama et al.
Image Credit: Fukuyama et al.
Editorials
Ten simple rules for getting the most out of a summer laboratory internship
PLOS Computational Biology: published August 17, 2017 | https://doi.org/10.1371/journal.pcbi.1005606
Ten simple rules to initiate and run a postdoctoral association
PLOS Computational Biology: published August 17, 2017 | https://doi.org/10.1371/journal.pcbi.1005664
Education
The application of project-based learning in bioinformatics training
PLOS Computational Biology: published August 17, 2017 | https://doi.org/10.1371/journal.pcbi.1005620
Research Articles
A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions
PLOS Computational Biology: published August 31, 2017 | https://doi.org/10.1371/journal.pcbi.1005714
Mouth-clicks used by blind expert human echolocators – signal description and model based signal synthesis
PLOS Computational Biology: published August 31, 2017 | https://doi.org/10.1371/journal.pcbi.1005670
Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing
PLOS Computational Biology: published August 28, 2017 | https://doi.org/10.1371/journal.pcbi.1005717
HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes
PLOS Computational Biology: published August 28, 2017 | https://doi.org/10.1371/journal.pcbi.1005693
A method of determining where to target surveillance efforts in heterogeneous epidemiological systems
PLOS Computational Biology: published August 28, 2017 | https://doi.org/10.1371/journal.pcbi.1005712
Towards a category theory approach to analogy: Analyzing re-representation and acquisition of numerical knowledge
PLOS Computational Biology: published August 25, 2017 | https://doi.org/10.1371/journal.pcbi.1005683
Noise correlations in the human brain and their impact on pattern classification
PLOS Computational Biology: published August 25, 2017 | https://doi.org/10.1371/journal.pcbi.1005674
Robust averaging protects decisions from noise in neural computations
PLOS Computational Biology: published August 25, 2017 | https://doi.org/10.1371/journal.pcbi.1005723
From homeostasis to behavior: Balanced activity in an exploration of embodied dynamic environmental-neural interaction
PLOS Computational Biology: published August 24, 2017 | https://doi.org/10.1371/journal.pcbi.1005721
Data driven flexible backbone protein design
PLOS Computational Biology: published August 24, 2017 | https://doi.org/10.1371/journal.pcbi.1005722
Spread of hospital-acquired infections: A comparison of healthcare networks
PLOS Computational Biology: published August 24, 2017 | https://doi.org/10.1371/journal.pcbi.1005666
Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation
PLOS Computational Biology: published August 24, 2017 | https://doi.org/10.1371/journal.pcbi.1005570
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity
PLOS Computational Biology: published August 23, 2017 | https://doi.org/10.1371/journal.pcbi.1005725
Temperature manipulation of neuronal dynamics in a forebrain motor control nucleus
PLOS Computational Biology: published August 22, 2017 | https://doi.org/10.1371/journal.pcbi.1005699
Host population structure impedes reversion to drug sensitivity after discontinuation of treatment
PLOS Computational Biology: published August 21, 2017 | https://doi.org/10.1371/journal.pcbi.1005704
Spatial dynamics of synthetic microbial mutualists and their parasites
PLOS Computational Biology: published August 21, 2017 | https://doi.org/10.1371/journal.pcbi.1005689
Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock
PLOS Computational Biology: published August 21, 2017 | https://doi.org/10.1371/journal.pcbi.1005711
Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb
PLOS Computational Biology: published August 21, 2017 | https://doi.org/10.1371/journal.pcbi.1005720
Neuron’s eye view: Inferring features of complex stimuli from neural responses
PLOS Computational Biology: published August 21, 2017 | https://doi.org/10.1371/journal.pcbi.1005645
Extracting replicable associations across multiple studies: Empirical Bayes algorithms for controlling the false discovery rate
PLOS Computational Biology: published August 18, 2017 | https://doi.org/10.1371/journal.pcbi.1005700
Efficient and accurate causal inference with hidden confounders from genome-transcriptome variation data
PLOS Computational Biology: published August 18, 2017 | https://doi.org/10.1371/journal.pcbi.1005703
Multidomain analyses of a longitudinal human microbiome intestinal cleanout perturbation experiment
PLOS Computational Biology: published August 18, 2017 | https://doi.org/10.1371/journal.pcbi.1005706
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
PLOS Computational Biology: published August 17, 2017 | https://doi.org/10.1371/journal.pcbi.1005650
An optimal strategy for epilepsy surgery: Disruption of the rich-club?
PLOS Computational Biology: published August 17, 2017 | https://doi.org/10.1371/journal.pcbi.1005637
A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines
PLOS Computational Biology: published August 14, 2017 | https://doi.org/10.1371/journal.pcbi.1005698
Confirmation bias in human reinforcement learning: Evidence from counterfactual feedback processing
PLOS Computational Biology: published August 11, 2017 | https://doi.org/10.1371/journal.pcbi.1005684
Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection
PLOS Computational Biology: published August 8, 2017 | https://doi.org/10.1371/journal.pcbi.1005702
Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels
PLOS Computational Biology: published August 8, 2017 | https://doi.org/10.1371/journal.pcbi.1005675
Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
PLOS Computational Biology: published August 7, 2017 | https://doi.org/10.1371/journal.pcbi.1005678
A stochastic-field description of finite-size spiking neural networks
PLOS Computational Biology: published August 7, 2017 | https://doi.org/10.1371/journal.pcbi.1005691
Multi-scale approaches for high-speed imaging and analysis of large neural populations
PLOS Computational Biology: published August 3, 2017 | https://doi.org/10.1371/journal.pcbi.1005685
Measuring distance through dense weighted networks: The case of hospital-associated pathogens
PLOS Computational Biology: published August 3, 2017 | https://doi.org/10.1371/journal.pcbi.1005622
Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype
PLOS Computational Biology: published August 3, 2017 | https://doi.org/10.1371/journal.pcbi.1005629
Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network
PLOS Computational Biology: published August 2, 2017 | https://doi.org/10.1371/journal.pcbi.1005677
The Stochastic Early Reaction, Inhibition, and late Action (SERIA) model for antisaccades
PLOS Computational Biology: published August 2, 2017 | https://doi.org/10.1371/journal.pcbi.1005692
A model of human motor sequence learning explains facilitation and interference effects based on spike-timing dependent plasticity
PLOS Computational Biology: published August 2, 2017 | https://doi.org/10.1371/journal.pcbi.1005632
Rearrangement moves on rooted phylogenetic networks
PLOS Computational Biology: published August 1, 2017 | https://doi.org/10.1371/journal.pcbi.1005611