Plesiosaurs maintained the same basic four-flipper body plan across their 135 million year history, yet there is no modern-day swimmer with a similar flipper arrangement. Numerous proposals have been made about the motions of their flippers during swimming. This computer-generated image shows the 3D model of Meyerasaurus victor that was used to study plesiosaur swimming. Thousands of different periodic motions of the flippers were tried using computer simulation. Numerical optimization determined that the fastest swimming motion uses the front flippers in an underwater flight stroke, and that the back flippers could not substantially contribute to forward motion. Turk et al.
Image Credit: Shiqiu Liu
Review
Locust Collective Motion and Its Modeling
PLOS Computational Biology: published December 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004522
Research Articles
The Effect of Farmers’ Decisions on Pest Control with Bt Crops: A Billion Dollar Game of Strategy
PLOS Computational Biology: published December 31, 2015 | https://doi.org/10.1371/journal.pcbi.1004483
Complete Firing-Rate Response of Neurons with Complex Intrinsic Dynamics
PLOS Computational Biology: published December 31, 2015 | https://doi.org/10.1371/journal.pcbi.1004636
Epidemic Reconstruction in a Phylogenetics Framework: Transmission Trees as Partitions of the Node Set
PLOS Computational Biology: published December 30, 2015 | https://doi.org/10.1371/journal.pcbi.1004613
Where’s the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004640
Combining Evolutionary Information and an Iterative Sampling Strategy for Accurate Protein Structure Prediction
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004661
Clustered Desynchronization from High-Frequency Deep Brain Stimulation
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004673
Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004679
Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004684
A Boolean Function for Neural Induction Reveals a Critical Role of Direct Intercellular Interactions in Patterning the Ectoderm of the Ascidian Embryo
PLOS Computational Biology: published December 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004687
Multistability in Large Scale Models of Brain Activity
PLOS Computational Biology: published December 28, 2015 | https://doi.org/10.1371/journal.pcbi.1004644
Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals
PLOS Computational Biology: published December 28, 2015 | https://doi.org/10.1371/journal.pcbi.1004665
Network-Based Isoform Quantification with RNA-Seq Data for Cancer Transcriptome Analysis
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004465
Elastohydrodynamics and Kinetics of Protein Patterning in the Immunological Synapse
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004481
Mechanism of Iron-Dependent Repressor (IdeR) Activation and DNA Binding: A Molecular Dynamics and Protein Structure Network Study
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004500
Distinctive Behaviors of Druggable Proteins in Cellular Networks
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004597
Tamping Ramping: Algorithmic, Implementational, and Computational Explanations of Phasic Dopamine Signals in the Accumbens
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004622
The Role of Symmetric Stem Cell Divisions in Tissue Homeostasis
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004629
Topological Phenotypes Constitute a New Dimension in the Phenotypic Space of Leaf Venation Networks
PLOS Computational Biology: published December 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004680
How Obstacles Perturb Population Fronts and Alter Their Genetic Structure
PLOS Computational Biology: published December 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004615
Recombination Enhances HIV-1 Envelope Diversity by Facilitating the Survival of Latent Genomic Fragments in the Plasma Virus Population
PLOS Computational Biology: published December 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004625
Sources of Variability in a Synthetic Gene Oscillator
PLOS Computational Biology: published December 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004674
Local Geometry and Evolutionary Conservation of Protein Surfaces Reveal the Multiple Recognition Patches in Protein-Protein Interactions
PLOS Computational Biology: published December 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004580
Cultured Cortical Neurons Can Perform Blind Source Separation According to the Free-Energy Principle
PLOS Computational Biology: published December 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004643
Defectors Can Create Conditions That Rescue Cooperation
PLOS Computational Biology: published December 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004645
Structural and Energetic Characterization of the Ankyrin Repeat Protein Family
PLOS Computational Biology: published December 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004659
Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications
PLOS Computational Biology: published December 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004670
High-Specificity Targeted Functional Profiling in Microbial Communities with ShortBRED
PLOS Computational Biology: published December 18, 2015 | https://doi.org/10.1371/journal.pcbi.1004557
Network-Based Integration of Disparate Omic Data To Identify "Silent Players" in Cancer
PLOS Computational Biology: published December 18, 2015 | https://doi.org/10.1371/journal.pcbi.1004595
Computer Simulations Imply Forelimb-Dominated Underwater Flight in Plesiosaurs
PLOS Computational Biology: published December 18, 2015 | https://doi.org/10.1371/journal.pcbi.1004605
Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson’s Disease
PLOS Computational Biology: published December 18, 2015 | https://doi.org/10.1371/journal.pcbi.1004609
The Essential Complexity of Auditory Receptive Fields
PLOS Computational Biology: published December 18, 2015 | https://doi.org/10.1371/journal.pcbi.1004628
Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy
PLOS Computational Biology: published December 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004608
A Large-Scale Assessment of Nucleic Acids Binding Site Prediction Programs
PLOS Computational Biology: published December 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004639
Modeling Fatty Acid Transfer from Artery to Cardiomyocyte
PLOS Computational Biology: published December 16, 2015 | https://doi.org/10.1371/journal.pcbi.1004666
Operational Principles for the Dynamics of the In Vitro ParA-ParB System
PLOS Computational Biology: published December 15, 2015 | https://doi.org/10.1371/journal.pcbi.1004651
Computing the Local Field Potential (LFP) from Integrate-and-Fire Network Models
PLOS Computational Biology: published December 14, 2015 | https://doi.org/10.1371/journal.pcbi.1004584
MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures
PLOS Computational Biology: published December 11, 2015 | https://doi.org/10.1371/journal.pcbi.1004634
Simple Plans or Sophisticated Habits? State, Transition and Learning Interactions in the Two-Step Task
PLOS Computational Biology: published December 11, 2015 | https://doi.org/10.1371/journal.pcbi.1004648
The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects
PLOS Computational Biology: published December 11, 2015 | https://doi.org/10.1371/journal.pcbi.1004656
Simulations Meet Experiment to Reveal New Insights into DNA Intrinsic Mechanics
PLOS Computational Biology: published December 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004631
Predicting Surgery Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations
PLOS Computational Biology: published December 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004642
Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma
PLOS Computational Biology: published December 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004662
Text Mining for Protein Docking
PLOS Computational Biology: published December 9, 2015 | https://doi.org/10.1371/journal.pcbi.1004630
Anxiety-Like Behavioural Inhibition Is Normative under Environmental Threat-Reward Correlations
PLOS Computational Biology: published December 9, 2015 | https://doi.org/10.1371/journal.pcbi.1004646
Morphological and Stress Vulnerability Indices for Human Coronary Plaques and Their Correlations with Cap Thickness and Lipid Percent: An IVUS-Based Fluid-Structure Interaction Multi-patient Study
PLOS Computational Biology: published December 9, 2015 | https://doi.org/10.1371/journal.pcbi.1004652
Biases in Visual, Auditory, and Audiovisual Perception of Space
PLOS Computational Biology: published December 8, 2015 | https://doi.org/10.1371/journal.pcbi.1004649
Protein Connectivity in Chemotaxis Receptor Complexes
PLOS Computational Biology: published December 8, 2015 | https://doi.org/10.1371/journal.pcbi.1004650
Melanoma Cell Colony Expansion Parameters Revealed by Approximate Bayesian Computation
PLOS Computational Biology: published December 7, 2015 | https://doi.org/10.1371/journal.pcbi.1004635
The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome
PLOS Computational Biology: published December 7, 2015 | https://doi.org/10.1371/journal.pcbi.1004647
MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells
PLOS Computational Biology: published December 7, 2015 | https://doi.org/10.1371/journal.pcbi.1004653
Gene Expression Switching of Receptor Subunits in Human Brain Development
PLOS Computational Biology: published December 4, 2015 | https://doi.org/10.1371/journal.pcbi.1004559
Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response
PLOS Computational Biology: published December 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004460
Mirrored STDP Implements Autoencoder Learning in a Network of Spiking Neurons
PLOS Computational Biology: published December 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004566
A Functional Cartography of Cognitive Systems
PLOS Computational Biology: published December 2, 2015 | https://doi.org/10.1371/journal.pcbi.1004533
AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility
PLOS Computational Biology: published December 2, 2015 | https://doi.org/10.1371/journal.pcbi.1004586
Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
PLOS Computational Biology: published December 2, 2015 | https://doi.org/10.1371/journal.pcbi.1004600
Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses
PLOS Computational Biology: published December 2, 2015 | https://doi.org/10.1371/journal.pcbi.1004641
Wham: Identifying Structural Variants of Biological Consequence
PLOS Computational Biology: published December 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004572
Maximizing Sensory Dynamic Range by Tuning the Cortical State to Criticality
PLOS Computational Biology: published December 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004576
Automated Learning of Subcellular Variation among Punctate Protein Patterns and a Generative Model of Their Relation to Microtubules
PLOS Computational Biology: published December 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004614