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Table of Contents: March 2018

The shape of platelet changes dramatically when activation occurs. Resting, flattened cell becomes a "spiny sphere", facilitating blood clotting. Quantitative model of the shape change is needed for better understanding of hemostasis and for the development of novel antiplatelet therapy strategies. We propose an accurate biophysical description of platelet shape, based on the solution of variational problem. This problem examines tensioned surface lying on the ring of microtubules, which buckles upon activation. Three-dimensional model of platelet shape during activation is easy to build up using our script published along with Moskalensky et al.

Image Credit: Alexander E. Moskalensky et al.

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