Table of Contents

July 2006

Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of the protein structure (bottom), which results in the formation of a distinct fold family (see Ding and Dokholyan).

Image Credit: Protein structures visualized with PyMOL software. Design by Nikolay V.


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