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Table of Contents

April 2020

Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex. Saxena et al. developed LocaNMF (Localized semi-Nonnegative Matrix Factorization), allowing the decomposition of the recorded data into interpretable spatial and temporal components in a stable manner. This is done by mapping the inferred components onto well-defined brain regions using a widely-used brain atlas (here, the Allen Brain Atlas shown in black lines). Each color in this figure corresponds to a given region's spatial components in this mouse brain. Data collected by Simon Musall in the Churchland Laboratory at Cold Spring Harbor Laboratory.

Image Credit: Shreya Saxena, Columbia University

Editorials

Ten simple rules for more objective decision-making

Anthony C. Fletcher, Georges A. Wagner, Philip E. Bourne

Ten simple rules for innovative dissemination of research

Tony Ross-Hellauer, Jonathan P. Tennant, Viltė Banelytė, Edit Gorogh, Daniela Luzi, Peter Kraker, Lucio Pisacane, Roberta Ruggieri, Electra Sifacaki, Michela Vignoli

Education Articles

Ten quick tips for homology modeling of high-resolution protein 3D structures

Yazan Haddad, Vojtech Adam, Zbynek Heger

On the choice of metric in gradient-based theories of brain function

Simone Carlo Surace, Jean-Pascal Pfister, Wulfram Gerstner, Johanni Brea

Reviews

Multiview learning for understanding functional multiomics

Nam D. Nguyen, Daifeng Wang

Multiple-target tracking in human and machine vision

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