This image is an immunocytochemical confocal tile scan of cardiac cell culture with a high fraction of non-conducting cells (69%), where conducting cardiac cells are labelled with anti-α-actinin antibody and coloured in pink. Kudryashova et al. show in this issue that cardiac cells can form a conductive pathway (pink cells outlined in white), which enables electrical wave propagation despite a paradoxically small number of conducting cells. Such self-organisation into a connected branching network can be explained by alignment of cytoskeletons in the neighbouring cells, as demonstrated in a computer model.
Image Credit: Aygul Nizamieva
Education
Ten principles for machine-actionable data management plans
PLOS Computational Biology: published March 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006750
Reviews
Agent-based modeling of morphogenetic systems: Advantages and challenges
PLOS Computational Biology: published March 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006577
Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
PLOS Computational Biology: published March 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006658
Research Articles
The genetic basis for adaptation of model-designed syntrophic co-cultures
PLOS Computational Biology: published March 1, 2019 | https://doi.org/10.1371/journal.pcbi.1006213
Spatial clustering and common regulatory elements correlate with coordinated gene expression
PLOS Computational Biology: published March 1, 2019 | https://doi.org/10.1371/journal.pcbi.1006786
Soma-axon coupling configurations that enhance neuronal coincidence detection
PLOS Computational Biology: published March 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006476
Computational geometry for modeling neural populations: From visualization to simulation
PLOS Computational Biology: published March 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006729
The gradient of the reinforcement landscape influences sensorimotor learning
PLOS Computational Biology: published March 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006839
Genesis of the αβ T-cell receptor
PLOS Computational Biology: published March 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006874
Goal-related feedback guides motor exploration and redundancy resolution in human motor skill acquisition
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006676
New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006701
Evolutionary model for the unequal segregation of high copy plasmids
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006724
In vitro and in silico multidimensional modeling of oncolytic tumor virotherapy dynamics
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006773
Bacterial surface colonization, preferential attachment and fitness under periodic stress
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006815
Determination of effective synaptic conductances using somatic voltage clamp
PLOS Computational Biology: published March 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006871
Tuft dendrites of pyramidal neurons operate as feedback-modulated functional subunits
PLOS Computational Biology: published March 6, 2019 | https://doi.org/10.1371/journal.pcbi.1006757
Modeling individual time courses of thrombopoiesis during multi-cyclic chemotherapy
PLOS Computational Biology: published March 6, 2019 | https://doi.org/10.1371/journal.pcbi.1006775
Humans use multi-objective control to regulate lateral foot placement when walking
PLOS Computational Biology: published March 6, 2019 | https://doi.org/10.1371/journal.pcbi.1006850
A stochastic simulation of skeletal muscle calcium transients in a structurally realistic sarcomere model using MCell
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006712
A new clustering and nomenclature for beta turns derived from high-resolution protein structures
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006844
Predicting the mechanism and rate of H-NS binding to AT-rich DNA
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006845
Predicting proteome allocation, overflow metabolism, and metal requirements in a model acetogen
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006848
An enriched network motif family regulates multistep cell fate transitions with restricted reversibility
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006855
A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006879
Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations
PLOS Computational Biology: published March 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006881
How adaptive plasticity evolves when selected against
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006260
Quantitative agent-based modeling reveals mechanical stress response of growing tumor spheroids is predictable over various growth conditions and cell lines
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006273
Methods for computing the maximum performance of computational models of fMRI responses
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006397
A dynamic power-law sexual network model of gonorrhoea outbreaks
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006748
Effectiveness of Ultra-Low Volume insecticide spraying to prevent dengue in a non-endemic metropolitan area of Brazil
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006831
A spectrum of routing strategies for brain networks
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006833
OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006835
A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows
PLOS Computational Biology: published March 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006856
A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006794
Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006832
Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006840
Myopic control of neural dynamics
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006854
The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006858
Latent goal models for dynamic strategic interaction
PLOS Computational Biology: published March 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006895
Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation
PLOS Computational Biology: published March 12, 2019 | https://doi.org/10.1371/journal.pcbi.1006298
Optimizing the depth and the direction of prospective planning using information values
PLOS Computational Biology: published March 12, 2019 | https://doi.org/10.1371/journal.pcbi.1006827
Synaptic plasticity onto inhibitory neurons as a mechanism for ocular dominance plasticity
PLOS Computational Biology: published March 12, 2019 | https://doi.org/10.1371/journal.pcbi.1006834
A spatio-temporal individual-based network framework for West Nile virus in the USA: Spreading pattern of West Nile virus
PLOS Computational Biology: published March 13, 2019 | https://doi.org/10.1371/journal.pcbi.1006875
Understanding narwhal diving behaviour using Hidden Markov Models with dependent state distributions and long range dependence
PLOS Computational Biology: published March 14, 2019 | https://doi.org/10.1371/journal.pcbi.1006425
The logic of ionic homeostasis: Cations are for voltage, but not for volume
PLOS Computational Biology: published March 14, 2019 | https://doi.org/10.1371/journal.pcbi.1006894
Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K
PLOS Computational Biology: published March 15, 2019 | https://doi.org/10.1371/journal.pcbi.1006402
Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells
PLOS Computational Biology: published March 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006597
Stochastic neural field model of stimulus-dependent variability in cortical neurons
PLOS Computational Biology: published March 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006755
Modeling second-order boundary perception: A machine learning approach
PLOS Computational Biology: published March 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006829
Endemicity and prevalence of multipartite viruses under heterogeneous between-host transmission
PLOS Computational Biology: published March 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006876
Building a mechanistic mathematical model of hepatitis C virus entry
PLOS Computational Biology: published March 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006905
An agent-based model of dengue virus transmission shows how uncertainty about breakthrough infections influences vaccination impact projections
PLOS Computational Biology: published March 20, 2019 | https://doi.org/10.1371/journal.pcbi.1006710
Identification of pathways associated with chemosensitivity through network embedding
PLOS Computational Biology: published March 20, 2019 | https://doi.org/10.1371/journal.pcbi.1006864
ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion
PLOS Computational Biology: published March 20, 2019 | https://doi.org/10.1371/journal.pcbi.1006882
Contrasting the effects of adaptation and synaptic filtering on the timescales of dynamics in recurrent networks
PLOS Computational Biology: published March 21, 2019 | https://doi.org/10.1371/journal.pcbi.1006893
ChIPulate: A comprehensive ChIP-seq simulation pipeline
PLOS Computational Biology: published March 21, 2019 | https://doi.org/10.1371/journal.pcbi.1006921
Rapid interpretation of small-angle X-ray scattering data
PLOS Computational Biology: published March 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006900
Scalable nonlinear programming framework for parameter estimation in dynamic biological system models
PLOS Computational Biology: published March 25, 2019 | https://doi.org/10.1371/journal.pcbi.1006828
Searching algorithm for Type IV effector proteins (S4TE) 2.0: Improved tools for Type IV effector prediction, analysis and comparison in proteobacteria
PLOS Computational Biology: published March 25, 2019 | https://doi.org/10.1371/journal.pcbi.1006847
Evaluating reproducibility of AI algorithms in digital pathology with DAPPER
PLOS Computational Biology: published March 27, 2019 | https://doi.org/10.1371/journal.pcbi.1006269
Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations
PLOS Computational Biology: published March 27, 2019 | https://doi.org/10.1371/journal.pcbi.1006859
LMTRDA: Using logistic model tree to predict MiRNA-disease associations by fusing multi-source information of sequences and similarities
PLOS Computational Biology: published March 27, 2019 | https://doi.org/10.1371/journal.pcbi.1006865
A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations
PLOS Computational Biology: published March 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006564
Synchrony is more than its top-down and climatic parts: interacting Moran effects on phytoplankton in British seas
PLOS Computational Biology: published March 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006744
Bayes-optimal estimation of overlap between populations of fixed size
PLOS Computational Biology: published March 29, 2019 | https://doi.org/10.1371/journal.pcbi.1006898
Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data
PLOS Computational Biology: published March 29, 2019 | https://doi.org/10.1371/journal.pcbi.1006930
Correction
Correction: In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
PLOS Computational Biology: published March 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006880