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Table of Contents

July 2018

Movement is fundamental to human and animal life, emerging through interaction of complex neural, muscular, and skeletal systems. OpenSim is open-source software that unites state-of-the-art models and methods from biology, neuroscience, mechanics, robotics, and computer science to create fast and accurate physics-based simulations of movement. OpenSim complements experiments by computing muscle forces and other quantities that are difficult to measure, and enables prediction of movements such as bipedal locomotion in human ancestors and neuromuscular adaptations to exoskeletons or orthopaedic surgeries. Seth et al.

Image Credit: Human model and simulation from Rajagopal et al. [1]; chimpanzee model from O'Neill et al. [2] and unpublished simulation results provided by M.C. O'Neill and B.R. Umberger.

1. Rajagopal A, Dembia CL, DeMers MS, Delp DD, Hicks JL, Delp SL. Full-body musculoskeletal model for muscle-driven simulation of human gait. IEEE Trans Biomed Eng. 2016; 63(10):2068-2079

2. O'Neill MC, Lee LF, Larson SG, Demes B, Stern JT Jr, Umberger BR. A three-dimensional musculoskeletal model of the chimpanzee (Pan troglodytes) pelvis and hind limb. J Exp Biol. 2013; 216(19):3709-3723.

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Inter-trial effects in visual pop-out search: Factorial comparison of Bayesian updating models

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Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion

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Bayesian comparison of explicit and implicit causal inference strategies in multisensory heading perception

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PyPhi: A toolbox for integrated information theory

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A model for hydrophobic protrusions on peripheral membrane proteins

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OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement

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FusionPathway: Prediction of pathways and therapeutic targets associated with gene fusions in cancer

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A marginalized two-part Beta regression model for microbiome compositional data

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Punishment and inspection for governing the commons in a feedback-evolving game

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Stochastic resonance enhances the rate of evidence accumulation during combined brain stimulation and perceptual decision-making

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Information-theoretic analysis of realistic odor plumes: What cues are useful for determining location?

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Phase-lags in large scale brain synchronization: Methodological considerations and in-silico analysis

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Differential roles of sleep spindles and sleep slow oscillations in memory consolidation

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Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition

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Age-dependent Pavlovian biases influence motor decision-making

Xiuli Chen, Robb B. Rutledge, Harriet R. Brown, Raymond J. Dolan, Sven Bestmann, Joseph M. Galea

Unsupervised clustering of temporal patterns in high-dimensional neuronal ensembles using a novel dissimilarity measure

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A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

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Subgraphs of functional brain networks identify dynamical constraints of cognitive control

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