Table of Contents: September 2007

Natural images occupy a small subset of the high-dimensional manifold of possible images, and are therefore characterized by certain statistical properties. The image shown here is a synthetic "dead-leaves" image, which preserves many of the statistical structures common to natural images. Artificial neural networks were trained to recognize surfaces within these images under illumination that vary in space and time, with the result that the trained networks exhibited responses commensurate with human lightness illusions (see Corney and Lotto, e180).

Image Credit: Image by David Corney and R. Beau Lotto (


Developing Computational Biology

Philip E Bourne, Steven E Brenner


From Pathways Databases to Network Models of Switching Behavior

Baltazar D Aguda, Andrew B Goryachev


Development of Genomic Sciences in Mexico: A Good Start and a Long Way to Go

Rafael Palacios, Julio Collado-Vides

Research Articles

A Balanced Memory Network

Yasser Roudi, Peter E Latham

Systems Analysis of Chaperone Networks in the Malarial Parasite Plasmodium falciparum

Soundara Raghavan Pavithra, Ranjit Kumar, Utpal Tatu

Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

Mookyung Cheon, Iksoo Chang, Sandipan Mohanty, Leila M Luheshi, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin

A Computational Approach to the Functional Screening of Genomes

Davide Chiarugi, Pierpaolo Degano, Roberto Marangoni

Orthologous Transcription Factors in Bacteria Have Different Functions and Regulate Different Genes

Morgan N Price, Paramvir S Dehal, Adam P Arkin

A Macaque's-Eye View of Human Insertions and Deletions: Differences in Mechanisms

Erika M Kvikstad, Svitlana Tyekucheva, Francesca Chiaromonte, Kateryna D Makova

Excitability Constraints on Voltage-Gated Sodium Channels

Elaine Angelino, Michael P Brenner

Characterization of Protein Hubs by Inferring Interacting Motifs from Protein Interactions

Ramon Aragues, Andrej Sali, Jaume Bonet, Marc A Marti-Renom, Baldo Oliva

What Are Lightness Illusions and Why Do We See Them?

David Corney, R. Beau Lotto

Organization and Evolution of Primate Centromeric DNA from Whole-Genome Shotgun Sequence Data

Can Alkan, Mario Ventura, Nicoletta Archidiacono, Mariano Rocchi, S. Cenk Sahinalp, Evan E Eichler

Structure-Templated Predictions of Novel Protein Interactions from Sequence Information

Doron Betel, Kevin E Breitkreuz, Ruth Isserlin, Danielle Dewar-Darch, Mike Tyers, Christopher W. V Hogue

Bistability and Oscillations in the Huang-Ferrell Model of MAPK Signaling

Liang Qiao, Robert B Nachbar, Ioannis G Kevrekidis, Stanislav Y Shvartsman

The Origins of Specificity in Polyketide Synthase Protein Interactions

Mukund Thattai, Yoram Burak, Boris I Shraiman


Reply to “Ten Simple Rules for Getting Published”

Eric Grosch


Correction: Adaptive, Fast Walking in a Biped Robot under Neuronal Control and Learning

Poramate Manoonpong, Tao Geng, Tomas Kulvicius, Bernd Porr, Florentin Wörgötter

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