Table of Contents

March 2006

Cortical thickness varies in the hills (gyri) and valleys (sulci) of the convoluted primate brain. Gyral cortex visible at the surface of the brain (top) is comparatively thicker (shown in red) than cortex hidden in the convolutions. Thinner cortical regions (shown in green) only become apparent once the convolutions are unfolded (bottom) (see Hilgetag and Barbas).

Image Credit: Maps were reconstructed and cortical thickness measured using the Freesurfer software (Fischl and Dale 2000), as described in the text. Additional image manipulation completed in Adobe Photoshop.

Research Articles

Large-Scale Trends in the Evolution of Gene Structures within 11 Animal Genomes

Mark Yandell, Chris J Mungall, Chris Smith, Simon Prochnik, Joshua Kaminker, George Hartzell, Suzanna Lewis, Gerald M Rubin

Circadian Clocks Are Resounding in Peripheral Tissues

Andrey A Ptitsyn, Sanjin Zvonic, Steven A Conrad, L. Keith Scott, Randall L Mynatt, Jeffrey M Gimble

A Third Approach to Gene Prediction Suggests Thousands of Additional Human Transcribed Regions

Gustavo Glusman, Shizhen Qin, M. Raafat El-Gewely, Andrew F Siegel, Jared C Roach, Leroy Hood, Arian F. A Smit

Role of Mechanical Factors in the Morphology of the Primate Cerebral Cortex

Claus C Hilgetag, Helen Barbas

The Emergence of Up and Down States in Cortical Networks

David Holcman, Misha Tsodyks

Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection

Vitaly V Ganusov, Rob J De Boer

Dynamical Principles of Two-Component Genetic Oscillators

Raúl Guantes, Juan F Poyatos


Understanding the Degradation of Hominid Gene Control

Peter D Keightley, Martin J Lercher, Adam Eyre-Walker

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