Table of Contents

May 2007

Cell fate specification in C. elegans visualized with blue and yellow fluorescent proteins expressed in the primary and secondary vulval precursor cells, respectively. The markers were used to observe the temporal order in the activation of EGFR and LIN-12/Notch signaling pathways as predicted by computational modeling (see Fisher et al, e92).

Image Credit: Alex Hajnal


Ten Simple Rules for a Good Poster Presentation

Thomas C Erren, Philip E Bourne

Message from ISCB

ISMB/ECCB 2007: The Premier Conference on Computational Biology

Thomas Lengauer, B. J. Morrison McKay, Burkhard Rost

Research Articles

Cooperative Gating and Spatial Organization of Membrane Proteins through Elastic Interactions

Tristan Ursell, Kerwyn Casey Huang, Eric Peterson, Rob Phillips

Integrated Mechanisms of Anticipation and Rate-of-Change Computations in Cortical Circuits

Gabriel D Puccini, Maria V Sanchez-Vives, Albert Compte

Enhancer Responses to Similarly Distributed Antagonistic Gradients in Development

Robert P Zinzen, Dmitri Papatsenko

Can Influenza Epidemics Be Prevented by Voluntary Vaccination?

Raffaele Vardavas, Romulus Breban, Sally Blower

HIV-1 Subtype B Protease and Reverse Transcriptase Amino Acid Covariation

Soo-Yon Rhee, Tommy F Liu, Susan P Holmes, Robert W Shafer

Binding Site Graphs: A New Graph Theoretical Framework for Prediction of Transcription Factor Binding Sites

Timothy E Reddy, Charles DeLisi, Boris E Shakhnovich

A First Look at ARFome: Dual-Coding Genes in Mammalian Genomes

Wen-Yu Chung, Samir Wadhawan, Radek Szklarczyk, Sergei Kosakovsky Pond, Anton Nekrutenko

Predictive Modeling of Signaling Crosstalk during C. elegans Vulval Development

Jasmin Fisher, Nir Piterman, Alex Hajnal, Thomas A Henzinger

The Human Genomic Melting Map

Fang Liu, Eivind Tøstesen, Jostein K Sundet, Tor-Kristian Jenssen, Christoph Bock, Geir Ivar Jerstad, William G Thilly, Eivind Hovig

Prediction of Functional Sites Based on the Fuzzy Oil Drop Model

Michał Bryliński, Katarzyna Prymula, Wiktor Jurkowski, Marek Kochańczyk, Ewa Stawowczyk, Leszek Konieczny, Irena Roterman

The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons

Eli Koren, Galit Lev-Maor, Gil Ast

Comprehensive DNA Signature Discovery and Validation

Adam M Phillippy, Jacquline A Mason, Kunmi Ayanbule, Daniel D Sommer, Elisa Taviani, Anwar Huq, Rita R Colwell, Ivor T Knight, Steven L Salzberg