Table of Contents

September 2016

A Drosophila epithelium expressing a GFP-tagged form of the morphogen Hedgehog (GFP:Hh, in green). The circles mark a photo-bleached area of the epithelium in a FRAP experiment aimed at determining the Hh effective diffusion coefficient. This coefficient, along with others, was used to parameterize the computational model of the growing eye disc that we developed. The model is based on regulatory interactions that have been experimentally determined and was used to explore how the signaling patterns during development affect the movement of the signaling wave sweeping across the tissue and impact on tissue growth. Fried et al.

Image Credit: Fried et al.

Research Articles

A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation

Michael Schellenberger Costa, Arne Weigenand, Hong-Viet V. Ngo, Lisa Marshall, Jan Born, Thomas Martinetz, Jens Christian Claussen

Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration

Anu G. Nair, Upinder S. Bhalla, Jeanette Hellgren Kotaleski

Learning Reward Uncertainty in the Basal Ganglia

John G. Mikhael, Rafal Bogacz

Leukocyte Motility Models Assessed through Simulation and Multi-objective Optimization-Based Model Selection

Mark N. Read, Jacqueline Bailey, Jon Timmis, Tatyana Chtanova

Direct Correlation between Motile Behavior and Protein Abundance in Single Cells

Yann S. Dufour, Sébastien Gillet, Nicholas W. Frankel, Douglas B. Weibel, Thierry Emonet

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