Table of Contents

March 2013

The yellow bundle in the foreground represents a coarse-grained, computer-generated conformation of human Chromosome 19. The structure was obtained by using steered molecular dynamics simulations to enforce a comprehensive set of knowledge-based constraints. Specifically, the simulations were used to promote the spatial proximity of hundreds of gene pairs that are known to be significantly co-regulated. Conformations were obtained with LAMMPS and visualized by VMD. See Di Stefano, et al.

Image Credit: Marco Di Stefano, Angelo Rosa, Cristian Micheletti


New Methods Section in PLOS Computational Biology

Thomas Lengauer, Ruth Nussinov

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