In influenza virus infected cells, eight viral genomic RNPs are assembled into progeny virions, which predominantly contain one copy of each. Using sets of fluorescence microscope images of four vRNPs, the likelihood that the subcellular distribution of one vRNP can be predicted from the distribution of another was estimated for all pairs of vRNPs with significant relationships. The thick base of the bands indicates the vRNP whose location can be used to predict the location of the vRNP indicated by the thin base. These pairwise and higher order relationships were used to infer the assembly network for all eight vRNPs.
Image Credit: Timothy D. Majarian, Robert F. Murphy and Seema S. Lakdawala. © 2018, Carnegie Mellon University
Editorials
Ten simple rules on how to create open access and reproducible molecular simulations of biological systems
PLOS Computational Biology: published January 17, 2019 | https://doi.org/10.1371/journal.pcbi.1006649
Ten Simple Rules for avoiding and resolving conflicts with your colleagues
PLOS Computational Biology: published January 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006708
Ten simple rules for writing statistical book reviews
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006562
Education
Designing and running an advanced Bioinformatics and genome analyses course in Tunisia
PLOS Computational Biology: published January 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006373
Research Articles
Context-explorer: Analysis of spatially organized protein expression in high-throughput screens
PLOS Computational Biology: published January 2, 2019 | https://doi.org/10.1371/journal.pcbi.1006384
Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods
PLOS Computational Biology: published January 2, 2019 | https://doi.org/10.1371/journal.pcbi.1006663
Short-term synaptic depression can increase the rate of information transfer at a release site
PLOS Computational Biology: published January 2, 2019 | https://doi.org/10.1371/journal.pcbi.1006666
Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model
PLOS Computational Biology: published January 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006267
A computational model to understand mouse iron physiology and disease
PLOS Computational Biology: published January 4, 2019 | https://doi.org/10.1371/journal.pcbi.1006680
Sour grapes and sweet victories: How actions shape preferences
PLOS Computational Biology: published January 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006499
Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia
PLOS Computational Biology: published January 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006664
Protein—protein binding supersites
PLOS Computational Biology: published January 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006704
Calcium phosphate precipitation inhibits mitochondrial energy metabolism
PLOS Computational Biology: published January 7, 2019 | https://doi.org/10.1371/journal.pcbi.1006719
Using the drug-protein interactome to identify anti-ageing compounds for humans
PLOS Computational Biology: published January 9, 2019 | https://doi.org/10.1371/journal.pcbi.1006639
A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types
PLOS Computational Biology: published January 9, 2019 | https://doi.org/10.1371/journal.pcbi.1006644
Computational translation of genomic responses from experimental model systems to humans
PLOS Computational Biology: published January 10, 2019 | https://doi.org/10.1371/journal.pcbi.1006286
Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer
PLOS Computational Biology: published January 10, 2019 | https://doi.org/10.1371/journal.pcbi.1006596
Deep image reconstruction from human brain activity
PLOS Computational Biology: published January 14, 2019 | https://doi.org/10.1371/journal.pcbi.1006633
PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data
PLOS Computational Biology: published January 14, 2019 | https://doi.org/10.1371/journal.pcbi.1006734
The finite state projection based Fisher information matrix approach to estimate information and optimize single-cell experiments
PLOS Computational Biology: published January 15, 2019 | https://doi.org/10.1371/journal.pcbi.1006365
On identifying collective displacements in apo-proteins that reveal eventual binding pathways
PLOS Computational Biology: published January 15, 2019 | https://doi.org/10.1371/journal.pcbi.1006665
Sequential infection experiments for quantifying innate and adaptive immunity during influenza infection
PLOS Computational Biology: published January 17, 2019 | https://doi.org/10.1371/journal.pcbi.1006568
STRFs in primary auditory cortex emerge from masking-based statistics of natural sounds
PLOS Computational Biology: published January 17, 2019 | https://doi.org/10.1371/journal.pcbi.1006595
Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor
PLOS Computational Biology: published January 17, 2019 | https://doi.org/10.1371/journal.pcbi.1006706
Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila
PLOS Computational Biology: published January 17, 2019 | https://doi.org/10.1371/journal.pcbi.1006709
OpenCASA: A new open-source and scalable tool for sperm quality analysis
PLOS Computational Biology: published January 18, 2019 | https://doi.org/10.1371/journal.pcbi.1006691
Differential mobility and local variation in infection attack rate
PLOS Computational Biology: published January 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006600
Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction
PLOS Computational Biology: published January 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006611
Generalizing clusters of similar species as a signature of coexistence under competition
PLOS Computational Biology: published January 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006688
A Gestalt inference model for auditory scene segregation
PLOS Computational Biology: published January 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006711
Epithelial stratification shapes infection dynamics
PLOS Computational Biology: published January 23, 2019 | https://doi.org/10.1371/journal.pcbi.1006646
Multi-study inference of regulatory networks for more accurate models of gene regulation
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006591
Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006685
Cellular determinants of metabolite concentration ranges
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006687
Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006689
A diurnal flux balance model of Synechocystis sp. PCC 6803 metabolism
PLOS Computational Biology: published January 24, 2019 | https://doi.org/10.1371/journal.pcbi.1006692
Spatial synchronization codes from coupled rate-phase neurons
PLOS Computational Biology: published January 25, 2019 | https://doi.org/10.1371/journal.pcbi.1006741
Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization
PLOS Computational Biology: published January 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006199
A low-threshold potassium current enhances sparseness and reliability in a model of avian auditory cortex
PLOS Computational Biology: published January 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006723
Inherent versus induced protein flexibility: Comparisons within and between apo and holo structures
PLOS Computational Biology: published January 30, 2019 | https://doi.org/10.1371/journal.pcbi.1006705
Social dynamics modeling of chrono-nutrition
PLOS Computational Biology: published January 30, 2019 | https://doi.org/10.1371/journal.pcbi.1006714
Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis
PLOS Computational Biology: published January 30, 2019 | https://doi.org/10.1371/journal.pcbi.1006740
Related Articles
Prediction of ultra-high-order antibiotic combinations based on pairwise interactions
PLOS Computational Biology: published January 30, 2019 | https://doi.org/10.1371/journal.pcbi.1006774
Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator
PLOS Computational Biology: published January 31, 2019 | https://doi.org/10.1371/journal.pcbi.1006674
Predicting change: Approximate inference under explicit representation of temporal structure in changing environments
PLOS Computational Biology: published January 31, 2019 | https://doi.org/10.1371/journal.pcbi.1006707
Corrections
Correction: clusterExperiment and RSEC: A Bioconductor package and framework for clustering of single-cell and other large gene expression datasets
PLOS Computational Biology: published January 11, 2019 | https://doi.org/10.1371/journal.pcbi.1006727
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Notice of Republication: Simulating Cortical Development as a Self Constructing Process: A Novel Multi-Scale Approach Combining Molecular and Physical Aspects
PLOS Computational Biology: published January 23, 2019 | https://doi.org/10.1371/journal.pcbi.1006747