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TACSTD2 silencing disrupts the cellular localization of two major HCV-entry factors, claudin-1 and occludin

Tumor-associated calcium signal transducer (TACSTD2), one of the most down-regulated genes in hepatocellular carcinoma tissue, regulates the cellular localization of claudin-1 (CLDN1) and occludin (OCLN), two tight-junction proteins that mediate HCV entry into hepatocytes. TACSTD2 gene silencing (right panels) disrupts the typical linear distribution of both CLDN1 (red, upper left) and OCLN (red, lower left) along the cellular membrane of primary human hepatocytes. TACSTD2 gene silencing dramatically inhibits HCV infection with a pan-genotype effect. Farci et al. (2018)

Image Credit: Vandana Sekhar, Juraj Kabat and Patrizia Farci; Laboratory of Infectious Diseases and Biological Imaging Facility, NIAID, NIH