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The occurrence of the N123I mutation of gp85 coincided with the timeline of the ALV-J epidemic outbreak
Avian leukosis virus subgroup J (ALV-J), a retrovirus, undergoes significant genetic evolution. Our study finds for the first time that the N123I mutation within the RBD region of gp85 enhances the replication ability of ALV-J, making it more easily transmissible and potentially causing large-scale epidemics. The picture shows the phylogenetic tree illustrating the evolutionary relationships between the gp85 gene in various ALV-J strains. Broiler, layer, and local chicken strains are primarily in groups 1, 2, and 3, respectively. The N123I mutation (in red) is an adaptive mutation. Yu et al 2024
Image Credit: Yulong Gao