February 2015

Balla et al. show that a strain of the nematode Caenorhabditis elegans from Hawaii is able to clear intracellular infection by its natural microsporidian pathogen Nematocida parisii. The top image labels N. parisii inside the C. elegans intestine, using fluorescent in situ hybridization staining the pathogen in red and DAPI staining DNA in blue—lower images show alternate color schemes for the intestinal infection.

Image Credit: Keir Balla

Editorial

PLOS Pathogens 2014 Reviewer Thank You

PLOS Pathogens: published February 27, 2015 | https://doi.org/10.1371/journal.ppat.1004748

Opinion

A Working Model of How Noroviruses Infect the Intestine

Stephanie M. Karst, Christiane E. Wobus

PLOS Pathogens: published February 27, 2015 | https://doi.org/10.1371/journal.ppat.1004626

Pearls

A Case for Two-Component Signaling Systems As Antifungal Drug Targets

Erika Shor, Neeraj Chauhan

PLOS Pathogens: published February 27, 2015 | https://doi.org/10.1371/journal.ppat.1004632

Prions—Not Your Immunologist’s Pathogen

Mark D. Zabel, Anne C. Avery

PLOS Pathogens: published February 19, 2015 | https://doi.org/10.1371/journal.ppat.1004624

Dimorphism in Fungal Pathogens of Mammals, Plants, and Insects

Gregory M. Gauthier

PLOS Pathogens: published February 12, 2015 | https://doi.org/10.1371/journal.ppat.1004608

Telomeric ORFS in Candida albicans: Does Mediator Tail Wag the Yeast?

Derek J. Sullivan, Judith Berman, Lawrence C. Myers, Gary P. Moran

PLOS Pathogens: published February 12, 2015 | https://doi.org/10.1371/journal.ppat.1004614

Livestock-Associated Staphylococcus aureus: The United States Experience

Tara C. Smith

PLOS Pathogens: published February 5, 2015 | https://doi.org/10.1371/journal.ppat.1004564

Yeast Prions: Proteins Templating Conformation and an Anti-prion System

Reed B. Wickner, Herman K. Edskes, David A. Bateman, Anton Gorkovskiy, Yaron Dayani, Evgeny E. Bezsonov, Maryam Mukhamedova

PLOS Pathogens: published February 5, 2015 | https://doi.org/10.1371/journal.ppat.1004584

Review

G-Quadruplexes in Pathogens: A Common Route to Virulence Control?

Lynne M. Harris, Catherine J. Merrick

PLOS Pathogens: published February 5, 2015 | https://doi.org/10.1371/journal.ppat.1004562

Research Articles

Identification of Effective Subdominant Anti-HIV-1 CD8+ T Cells Within Entire Post-infection and Post-vaccination Immune Responses

Gemma Hancock, Hongbing Yang, Elisabeth Yorke, Emma Wainwright, Victoria Bourne, Alyse Frisbee, Tamika L. Payne, Mark Berrong, Guido Ferrari, Denis Chopera, Tomas Hanke, Beatriz Mothe, Christian Brander, M. Juliana McElrath, Andrew McMichael, Nilu Goonetilleke, Georgia D. Tomaras, Nicole Frahm, Lucy Dorrell

PLOS Pathogens: published February 27, 2015 | https://doi.org/10.1371/journal.ppat.1004658

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

Greta E. Weiss, Paul R. Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke W. M. de Jong, Katherine L. Harvey, Freya J. I. Fowkes, Paul N. Barlow, Julian C. Rayner, Gavin J. Wright, Alan F. Cowman, Brendan S. Crabb

PLOS Pathogens: published February 27, 2015 | https://doi.org/10.1371/journal.ppat.1004670

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles

Anne-lie Ståhl, Ida Arvidsson, Karl E. Johansson, Milan Chromek, Johan Rebetz, Sebastian Loos, Ann-Charlotte Kristoffersson, Zivile D. Békássy, Matthias Mörgelin, Diana Karpman

PLOS Pathogens: published February 26, 2015 | https://doi.org/10.1371/journal.ppat.1004619

Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

Guan-Feng Wang, Jiabing Ji, Farid EI-Kasmi, Jeffery L. Dangl, Guri Johal, Peter J. Balint-Kurti

PLOS Pathogens: published February 26, 2015 | https://doi.org/10.1371/journal.ppat.1004674

ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes

Karolína Šubrtová, Brian Panicucci, Alena Zíková

PLOS Pathogens: published February 25, 2015 | https://doi.org/10.1371/journal.ppat.1004660

Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling

Joachim Kloehn, Eleanor C. Saunders, Sean O’Callaghan, Michael J. Dagley, Malcolm J. McConville

PLOS Pathogens: published February 25, 2015 | https://doi.org/10.1371/journal.ppat.1004683

HITS-CLIP Analysis Uncovers a Link between the Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein and Host Pre-mRNA Metabolism

Emi Sei, Tao Wang, Olga V. Hunter, Yang Xie, Nicholas K. Conrad

PLOS Pathogens: published February 24, 2015 | https://doi.org/10.1371/journal.ppat.1004652

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

Uli S. Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R. Reimann, Paolo Dametto, Tracy O’Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi

PLOS Pathogens: published February 24, 2015 | https://doi.org/10.1371/journal.ppat.1004662

Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites

Jens Prescher, Viola Baumgärtel, Sergey Ivanchenko, Adriano A. Torrano, Christoph Bräuchle, Barbara Müller, Don C. Lamb

PLOS Pathogens: published February 24, 2015 | https://doi.org/10.1371/journal.ppat.1004677

The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection

Jane E. Dalton, Amy C. Glover, Laura Hoodless, Eng-Kiat Lim, Lynette Beattie, Alun Kirby, Paul M. Kaye

PLOS Pathogens: published February 24, 2015 | https://doi.org/10.1371/journal.ppat.1004681

Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing

Friederike S. Rossmann, Tomas Racek, Dominique Wobser, Jacek Puchalka, Elaine M. Rabener, Matthias Reiger, Antoni P. A. Hendrickx, Ann-Kristin Diederich, Kirsten Jung, Christoph Klein, Johannes Huebner

PLOS Pathogens: published February 23, 2015 | https://doi.org/10.1371/journal.ppat.1004653

Rational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging

Maxime Boutier, Maygane Ronsmans, Ping Ouyang, Guillaume Fournier, Anca Reschner, Krzysztof Rakus, Gavin S. Wilkie, Frédéric Farnir, Calixte Bayrou, François Lieffrig, Hong Li, Daniel Desmecht, Andrew J. Davison, Alain Vanderplasschen

PLOS Pathogens: published February 20, 2015 | https://doi.org/10.1371/journal.ppat.1004690

Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism

Matthias T. Ehebauer, Michael Zimmermann, Arjen J. Jakobi, Elke E. Noens, Daniel Laubitz, Bogdan Cichocki, Hedia Marrakchi, Marie-Antoinette Lanéelle, Mamadou Daffé, Carsten Sachse, Andrzej Dziembowski, Uwe Sauer, Matthias Wilmanns

PLOS Pathogens: published February 19, 2015 | https://doi.org/10.1371/journal.ppat.1004623

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation

Suan-Sin Foo, Weiqiang Chen, Adam Taylor, Kuo-Ching Sheng, Xing Yu, Terk-Shin Teng, Patrick C. Reading, Helen Blanchard, Cecilia Garlanda, Alberto Mantovani, Lisa F. P. Ng, Lara J. Herrero, Suresh Mahalingam

PLOS Pathogens: published February 19, 2015 | https://doi.org/10.1371/journal.ppat.1004649

Coordinated Function of Cellular DEAD-Box Helicases in Suppression of Viral RNA Recombination and Maintenance of Viral Genome Integrity

Chingkai Chuang, K. Reddisiva Prasanth, Peter D. Nagy

PLOS Pathogens: published February 18, 2015 | https://doi.org/10.1371/journal.ppat.1004680

Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection

Andreea Popa, Wei Zhang, Megan S. Harrison, Kylia Goodner, Teymur Kazakov, Edward C. Goodwin, Alex Lipovsky, Christopher G. Burd, Daniel DiMaio

PLOS Pathogens: published February 18, 2015 | https://doi.org/10.1371/journal.ppat.1004699

CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection

Sama Adnan, Arnaud D. Colantonio, Yi Yu, Jacqueline Gillis, Fay E. Wong, Ericka A. Becker, Michael Piatak Jr, R. Keith Reeves, Jeffrey D. Lifson, Shelby L. O’Connor, R. Paul Johnson

PLOS Pathogens: published February 17, 2015 | https://doi.org/10.1371/journal.ppat.1004633

A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite

Keir M. Balla, Erik C. Andersen, Leonid Kruglyak, Emily R. Troemel

PLOS Pathogens: published February 13, 2015 | https://doi.org/10.1371/journal.ppat.1004583

Porphyromonas gingivalis Evasion of Autophagy and Intracellular Killing by Human Myeloid Dendritic Cells Involves DC-SIGN-TLR2 Crosstalk

Ahmed R. El-Awady, Brodie Miles, Elizabeth Scisci, Zoya B. Kurago, Chithra D. Palani, Roger M. Arce, Jennifer L. Waller, Caroline A. Genco, Connie Slocum, Matthew Manning, Patricia V. Schoenlein, Christopher W. Cutler

PLOS Pathogens: published February 13, 2015 | https://doi.org/10.1371/journal.ppat.1004647

Evolution of Genome Size and Complexity in the Rhabdoviridae

Peter J. Walker, Cadhla Firth, Steven G. Widen, Kim R. Blasdell, Hilda Guzman, Thomas G. Wood, Prasad N. Paradkar, Edward C. Holmes, Robert B. Tesh, Nikos Vasilakis

PLOS Pathogens: published February 13, 2015 | https://doi.org/10.1371/journal.ppat.1004664

Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in Acinetobacter baumannii

Edward Geisinger, Ralph R. Isberg

PLOS Pathogens: published February 13, 2015 | https://doi.org/10.1371/journal.ppat.1004691

Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells

Annasara Lenman, A. Manuel Liaci, Yan Liu, Carin Årdahl, Anandi Rajan, Emma Nilsson, Will Bradford, Lisa Kaeshammer, Morris S. Jones, Lars Frängsmyr, Ten Feizi, Thilo Stehle, Niklas Arnberg

PLOS Pathogens: published February 12, 2015 | https://doi.org/10.1371/journal.ppat.1004657

The Intracellular Bacterium Wolbachia Uses Parasitoid Wasps as Phoretic Vectors for Efficient Horizontal Transmission

Muhammad Z. Ahmed, Shao-Jian Li, Xia Xue, Xiang-Jie Yin, Shun-Xiang Ren, Francis M. Jiggins, Jaco M. Greeff, Bao-Li Qiu

PLOS Pathogens: published February 12, 2015 | https://doi.org/10.1371/journal.ppat.1004672

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Brian C. VanderVen, Ruth J. Fahey, Wonsik Lee, Yancheng Liu, Robert B. Abramovitch, Christine Memmott, Adam M. Crowe, Lindsay D. Eltis, Emanuele Perola, David D. Deininger, Tiansheng Wang, Christopher P. Locher, David G. Russell

PLOS Pathogens: published February 12, 2015 | https://doi.org/10.1371/journal.ppat.1004679

Recognition and Activation Domains Contribute to Allele-Specific Responses of an Arabidopsis NLR Receptor to an Oomycete Effector Protein

Adam D. Steinbrenner, Sandra Goritschnig, Brian J. Staskawicz

PLOS Pathogens: published February 11, 2015 | https://doi.org/10.1371/journal.ppat.1004665

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

Susu Duan, Victoria A. Meliopoulos, Jennifer L. McClaren, Xi-Zhi J. Guo, Catherine J. Sanders, Heather S. Smallwood, Richard J. Webby, Stacey L. Schultz-Cherry, Peter C. Doherty, Paul G. Thomas

PLOS Pathogens: published February 10, 2015 | https://doi.org/10.1371/journal.ppat.1004642

Mitigation of Prion Infectivity and Conversion Capacity by a Simulated Natural Process—Repeated Cycles of Drying and Wetting

Qi Yuan, Thomas Eckland, Glenn Telling, Jason Bartz, Shannon Bartelt-Hunt

PLOS Pathogens: published February 9, 2015 | https://doi.org/10.1371/journal.ppat.1004638

Control of Murine Cytomegalovirus Infection by γδ T Cells

Sabrina Sell, Monika Dietz, Andrea Schneider, Rafaela Holtappels, Michael Mach, Thomas H. Winkler

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004481

In Vivo Approaches Reveal a Key Role for DCs in CD4+ T Cell Activation and Parasite Clearance during the Acute Phase of Experimental Blood-Stage Malaria

Henrique Borges da Silva, Raíssa Fonseca, Alexandra dos Anjos Cassado, Érika Machado de Salles, Maria Nogueira de Menezes, Jean Langhorne, Katia Regina Perez, Iolanda Midea Cuccovia, Bernhard Ryffel, Vasco M. Barreto, Cláudio Romero Farias Marinho, Silvia Beatriz Boscardin, José Maria Álvarez, Maria Regina D’Império-Lima, Carlos Eduardo Tadokoro

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004598

IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells

Anne-Gaelle Besnard, Rodrigo Guabiraba, Wanda Niedbala, Jennifer Palomo, Flora Reverchon, Tovah N. Shaw, Kevin N. Couper, Bernhard Ryffel, Foo Y. Liew

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004607

A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis

Sambasivan Venkatasubramanian, Rohan Dhiman, Padmaja Paidipally, Satyanarayana S. Cheekatla, Deepak Tripathi, Elwyn Welch, Amy R. Tvinnereim, Brenda Jones, Dan Theodorescu, Peter F. Barnes, Ramakrishna Vankayalapati

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004617

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi

Leonardo da Silva Augusto, Nilmar Silvio Moretti, Thiago Cesar Prata Ramos, Teresa Cristina Leandro de Jesus, Min Zhang, Beatriz A. Castilho, Sergio Schenkman

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004618

Within-host Competition Does Not Select for Virulence in Malaria Parasites; Studies with Plasmodium yoelii

Hussein M. Abkallo, Julie-Anne Tangena, Jianxia Tang, Nobuyuki Kobayashi, Megumi Inoue, Augustin Zoungrana, Nick Colegrave, Richard Culleton

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004628

The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice

Jinling Liu, Chan Ho Park, Feng He, Minoru Nagano, Mo Wang, Maria Bellizzi, Kai Zhang, Xiaoshan Zeng, Wende Liu, Yuese Ning, Yoji Kawano, Guo-Liang Wang

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004629

Cytoplasmic Actin Is an Extracellular Insect Immune Factor which Is Secreted upon Immune Challenge and Mediates Phagocytosis and Direct Killing of Bacteria, and Is a Plasmodium Antagonist

Simone L. Sandiford, Yuemei Dong, Andrew Pike, Benjamin J. Blumberg, Ana C. Bahia, George Dimopoulos

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004631

High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers

Sebastian Bonhoeffer, Christophe Fraser, Gabriel E. Leventhal

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004634

IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells

Hyang-Mi Lee, Anne Fleige, Ruth Forman, Sunglim Cho, Aly Azeem Khan, Ling-Li Lin, Duc T. Nguyen, Aisling O'Hara-Hall, Zhinan Yin, Christopher A. Hunter, Werner Muller, Li-Fan Lu

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004635

Lymph-Node Resident CD8α⁺ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8⁺ T Cell Responses

Andrea J. Radtke, Wolfgang Kastenmüller, Diego A. Espinosa, Michael Y. Gerner, Sze-Wah Tse, Photini Sinnis, Ronald N. Germain, Fidel P. Zavala, Ian A. Cockburn

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004637

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread

Niels A. W. Lemmermann, Astrid Krmpotic, Jürgen Podlech, Ilija Brizic, Adrian Prager, Heiko Adler, Astrid Karbach, Yiquan Wu, Stipan Jonjic, Matthias J. Reddehase, Barbara Adler

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004640

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

Flávio V. Loures, Marc Röhm, Chrono K. Lee, Evelyn Santos, Jennifer P. Wang, Charles A. Specht, Vera L. G. Calich, Constantin F. Urban, Stuart M. Levitz

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004643

Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice

Nichole Goodsmith, Xinzheng V. Guo, Omar H. Vandal, Julien Vaubourgeix, Ruojun Wang, Hélène Botella, Shuang Song, Kamlesh Bhatt, Amir Liba, Padmini Salgame, Dirk Schnappinger, Sabine Ehrt

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004645

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

Roxane Simeone, Fadel Sayes, Okryul Song, Matthias I. Gröschel, Priscille Brodin, Roland Brosch, Laleh Majlessi

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004650

Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation

Marc D. Panas, Tim Schulte, Bastian Thaa, Tatiana Sandalova, Nancy Kedersha, Adnane Achour, Gerald M. McInerney

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004659

CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation

Nina Bertaux-Skeirik, Rui Feng, Michael A. Schumacher, Jing Li, Maxime M. Mahe, Amy C. Engevik, Jose E. Javier, Richard M. Peek Jr, Karen Ottemann, Veronique Orian-Rousseau, Gregory P. Boivin, Michael A. Helmrath, Yana Zavros

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004663

Essential Domains of Anaplasma phagocytophilum Invasins Utilized to Infect Mammalian Host Cells

David Seidman, Kathryn S. Hebert, Hilary K. Truchan, Daniel P. Miller, Brittney K. Tegels, Richard T. Marconi, Jason A. Carlyon

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004669

Manipulating Adenovirus Hexon Hypervariable Loops Dictates Immune Neutralisation and Coagulation Factor X-dependent Cell Interaction In Vitro and In Vivo

Jiangtao Ma, Margaret R. Duffy, Lin Deng, Rachel S. Dakin, Taco Uil, Jerome Custers, Sharon M. Kelly, John H. McVey, Stuart A. Nicklin, Andrew H. Baker

PLOS Pathogens: published February 6, 2015 | https://doi.org/10.1371/journal.ppat.1004673

CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue

Gabrielle Stack, Emma Jones, Morgan Marsden, Maria A. Stacey, Robert J. Snelgrove, Paul Lacaze, Laura C. Jacques, Simone M. Cuff, Richard J. Stanton, Awen M. Gallimore, Tracy Hussell, Gavin W. G. Wilkinson, Peter Ghazal, Philip R. Taylor, Ian R. Humphreys

PLOS Pathogens: published February 5, 2015 | https://doi.org/10.1371/journal.ppat.1004641

A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions

Xue-Song Zhang, Nicole Tegtmeyer, Leah Traube, Shawn Jindal, Guillermo Perez-Perez, Heinrich Sticht, Steffen Backert, Martin J. Blaser

PLOS Pathogens: published February 3, 2015 | https://doi.org/10.1371/journal.ppat.1004621

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress

Jeong Joo Kim, Christian Flueck, Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David A. Baker, Friedrich W. Herberg, Choel Kim

PLOS Pathogens: published February 3, 2015 | https://doi.org/10.1371/journal.ppat.1004639

CXCL9 Contributes to Antimicrobial Protection of the Gut during Citrobacter rodentium Infection Independent of Chemokine-Receptor Signaling

Sarah A. Reid-Yu, Brian R. Tuinema, Cherrie N. Small, Lydia Xing, Brian K. Coombes

PLOS Pathogens: published February 2, 2015 | https://doi.org/10.1371/journal.ppat.1004648

Cover

Intracellular infection of the C. elegans intestine by microsporidia

Editorial

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**Intracellular infection of the C. elegans intestine by microsporidia**