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Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies

July 1, 2015

Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies

Shuxiao Zhang and colleagues identify neurological functions associated with one gene identified by a forward genetic screen in mice. They use recently developed genome editing tools both to confirm the mouse studies and to test comparative functions in Drosophila melanogaster.

Image credit: Shuxiao Zhang and colleagues

PLOS Genetics will be celebrating its 10th anniversary later this month! 

Keep a look out for highlights from the last 10 years. 

07/01/2015

research article

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

Meghan Morrison and colleagues assessed the role of mTORC1 and mTORC2 complexes in normal mammary epithelial cell branching, survival, and invasion. While mTORC1 was not required for mammary epithelial cells, mTORC2 was necessary for these processes in both mouse and human models.

Image credit: Meghan Morrison and colleagues

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

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Current Issue June 2015

06/25/2015

research article

Epigenetic Aging Signatures Are Coherently Modified in Cancer

In this study, Qiong Lin and Wolfgang Wagner systematically analyzed age-associated DNAm patterns in many types of cancer. In contrast to non-malignant tissue the epigenetic aging signatures hardly reflect chronological age of cancer patients. 

Epigenetic Aging Signatures Are Coherently Modified in Cancer

Image credit: Qiong Lin and Wolfgang Wagner