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Extreme Recombination Frequencies Shape Genome Variation and Evolution in the Honeybee, Apis mellifera

April 22, 2015

Extreme Recombination Frequencies Shape Genome Variation and Evolution in the Honeybee, Apis mellifera

The honeybee's unusually high recombination rate interferes with the efficacy of natural selection

Image credit: Andreas Wallberg and colleagues

04/21/2015

RESEARCH ARTICLE

The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia

Bayazit Yunusbayev and colleagues studied genomic samples from Turkic-speaking peoples across Eurasia, finding that they share varying proportions of Asian ancestry that originate in southern Siberia and Mongolia. The data suggest recent large-scale nomadic migrations of Turkic peoples out of this area to inhabit their current vast geographical range.

Image credit: Bayazit Yunusbayev and colleagues

The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia

Recently Published Articles

Current Issue

Current Issue March 2015

04/16/2015

RESEARCH ARTICLE

Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

Noise-induced hearing loss (NIHL) is the most common work-related disease in the world, and there appears to be a heritable susceptibility to the condition. Joel Lavinsky and colleagues studied NIHL in a mouse model and found that susceptibility was associated with the Nox3 gene and was frequency-specific in the cochlea.

Image credit: Lubomir Panak, Flickr

Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

04/22/2015

RESEARCH ARTICLE

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Warunee Dansithong and colleagues generated a mouse model of the neurogenerative disorder SCA2, which had a mutant version of the ATXN2 gene. They found a drop in levels of RGS8 mRNA and RGS8 protein in these mice, and discovered that mutant ATXN2 interacted with RGS8 mRNA, reducing its translation to the signaling regulator protein it encodes.

Image credit: Warunee Dansithong and colleagues

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

04/13/2015

research article

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

Hereditary spastic paraplegia is a genetically heterogeneous neurological disease characterized by weakness and spasticity of the lower limbs. Chrisovalantis Papadopoulos and colleagues show that spastin-M1 harbors a lipid droplet targeting sequence which targets it to the organelles where cells store neutral lipids.

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

Image credit: Chrisovalantis Papadopoulos and colleagues

03/19/2015

Perspective

Morphological Mutations: Lessons from the Cockscomb

Dennis Headon describes the informative collection of morphological mutations published over the past five years by Andersson and colleagues.

Morphological Mutations: Lessons from the Cockscomb

Image credit: Ben Dorshorst and colleagues

03/27/2015

Editorial

PLOS Genetics 2014 Reviewer Thank You

The PLOS Genetics editorial team would like to express our tremendous gratitude to all those individuals who participated in the peer review process this past year.

PLOS Genetics 2014 Reviewer Thank You

Image credit: Center for Scientific Review Wikimedia Commons Public Domain

04/16/2015

PERSPECTIVE

Adventures in Wonderland

Weider and colleagues report that CNS oligodendrocyte-like cells can arise from peripheral glia when a single transcription factor is overexpressed. Since Multiple Sclerosis results from oligodendrocyte loss, this has clinical implications.  

 

Adventures in Wonderland

Image credit: Giulio Callegaro, Flickr