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14th June: PLOS Science Wednesday AMA

Wallberg, Webster, and Hasselmann's AMA on genetic adaptation in high altitude honey bees 

Read the AMA here

06/12/2017

Research article

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Cleft palate is a serious congenital condition which affects approximately 1 in every 2500 births. Mutations in the gene encoding the transcription factor p63 result in cleft palate in humans and mice. In this current study, Rose Richardson, Karen Mitchell and colleagues' findings establish the role of p63 in governing the fate of the midline epithelial cells, providing new insights into the mechanisms that regulate development of the palate.

Image credit: Rose Richardson, Karen Mitchell and colleagues

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Recently Published Articles

Current Issue

Current Issue May 2017

06/12/2017

research article

The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses

Dieuwertje Van der Does and colleagues contribute to our understanding of how plants sense internal and external danger. Their data reveals that the Arabidopsis thaliana receptor kinase MIK2 regulates responses to cell wall perturbation, and suggests that MIK2 is involved in sensing cell wall perturbations in plants.

Image credit: Dieuwertje Van Der Does and colleagues

The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses

06/15/2017

research article

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

Recombination defects during meiosis can lead to formation of aneuploid gametes, one of the major causes of miscarriages and chromosome abnormalities. Marina Marcet-Ortega and colleagues find that p53 and TAp63 are the effectors responsible for activating recombination-dependent arrest in mouse spermatocytes.

Image credit: Marina Marcet-Ortega and colleagues

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

05/26/2017

Biologue post

PLOS Genetics Research Prize 2017: The story behind last year’s winning research 

In 2016, the PLOS Genetics Research Prize was awarded to Naranjo, Smith et al., for their work on a complex trait adaptation. Hunter Fraser, the corresponding author of the winning article and Associate Professor at Stanford University, tells us about the challenges he faced bringing the research to fruition and what winning the prize meant to him. 

PLOS Genetics Research Prize 2017: The story behind last year’s winning research 

Image credit: Yuan and colleagues

06/08/2017

research article

Dynamics of DNA methylomes underlie oyster development

In this study, Guillaume Riviere and colleagues investigate the dynamics of genome-wide DNA methylation patterns in a mollusc, the oyster C. gigas, throughout its development. They found that the dynamics of DNA methylation correspond to the expression dynamics of distinct functional gene clusters that control two critical development steps, cleavage and metamorphosis.

Dynamics of DNA methylomes underlie oyster development

Image credit: Guillaume Riviere and colleagues

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