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Understanding Images: Shedding light on nuclear size control 

Discover the research that led to May's PLOS Genetics cover image in this Biologue post from Kazunori                                       Kume and Helen Cantwell 

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09/11/2017

research article

Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms

Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated. In this study, Yamamoto, Obbineni and colleagues show that the classical Chlamydomonas motility mutant pf23 is defective in the Chlamydomonas homolog of DYX1C1

Image credit: Ryosuke Yamamoto, Jagan M. Obbineni and colleagues

Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms

Recently Published Articles

Current Issue

Current Issue August 2017

09/14/2017

research article

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. In Thra1PV/+ mice expressing a dominant negative mutant TRα1PV, Sunmi Park and colleagues find abnormal red blood cell indices similar to patients. The present study suggests that therapies aimed at GATA1 could be tested as a potential target in treating erythroid abnormalities in patients.

Image credit: Sunmi Park and colleagues

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

09/14/2017

research article

Genomics-enabled analysis of the emergent disease cotton bacterial blight

Cotton bacterial blight (CBB), an important disease of (Gossypium hirsutum) in the early 20th century, had been controlled by resistant germplasm for over half a century. Recently, CBB re-emerged as an agronomic problem in the United States. Here, Anne Z. Phillips and colleagues reveal important insights into the Xcm-G. hirsutum disease complex and strategies for future development of resistant cultivars.

Image credit: Anne Z. Phillips and colleagues

Genomics-enabled analysis of the emergent disease cotton bacterial blight

09/05/2017

research article

Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish

The genes involved in the early stages of vertebrate gonad development remain largely undefined. Leerberg, Sano, and Draper show that in zebrafish, the early somatic gonad organizes into a bi-layered structure, with an outer epithelial layer surrounding an inner mesenchymal core, and demonstrate that the gene encoding the Fibroblast growth factor 24 ligand, fgf24, is expressed by the epithelial population.

Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish

Image credit: Dena M. Leerberg

09/07/2017

perspective

"T-bet"-ing on autoimmunity variants

This perspective discusses Soderquest et al.'s research on how genetic variants alters the binding landscape of T-bet, a critical transcriptional regulator in immune cells, and highlights the need for mechanistic studies in this area.

"T-bet"-ing on autoimmunity variants

Image credit: Michelle L. T. Nguyen, Dimitre R. Simeonov and colleagues

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