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Genetic prediction of male pattern baldness

February 14, 2017

Genetic prediction of male pattern baldness

Image credit: Douglas Robertson, University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology

PLOS Research News: stay up-to-date with research published in PLOS

PLOS Research News

02/16/2017

RESEARCH ARTICLE

JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity

Using C. elegans as model system, Pier Giorgio Amendola and colleagues show that loss of jmjd-5, resulting in increased levels of H3K36me2, impairs the resolution of recombination intermediates and the release of RAD-51, with consequences in the DNA repair process after ionizing radiation and in meiotic recombination. 

Image credit: Pier Giorgio Amendola and Demetrio Romeo

JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity

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Current Issue

Current Issue January 2017

02/16/2017

RESEARCH ARTICLE

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways

Caspase 9 in mammals and its Drosophila ortholog Dronc carry a protein-protein interaction domain (CARD) in their prodomain which interacts with scaffolding proteins to form the apoptosome. Hatem Elif Kamber Kaya and colleagues show that Dronc is mono-ubiquitylated at Lysine 78 in its CARD domain. 

Image credit: Hatem Elif Kamber Kaya and colleagues

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways

02/14/2017

RESEARCH ARTICLE

Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis

Lijuan Feng and colleagues investigate how chromatin factors interact with signaling pathways in determining stem cell activity. They find that a chromatin regulator called Enhancer of Polycomb [E(Pc)] acts in somatic cells to promote germ cell differentiation and maintain germ cell fate. 

Image credit: Lijuan Feng and colleagues

Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis

02/06/2017

research article

Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes

In this study, Michael D. Hall and colleagues find that Stat3 loss-of-function mutant mice exhibit features consistent with campomelic dysplasia including dwarfism, bent limbs, cleft palate, laryngotracheomalacia and abnormal growth plate hypertrophic chondrocytes. They also demonstrate that ablation of Stat3 from chondroprogenitors reduces the functional level of Sox9 in vivo.

Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes

Image credit: Michael D. Hall and colleagues

02/06/2017

research article

Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication

Using two different fluorescence microscopy techniques, Schenk, Hervás, Rösch and colleagues show that DnaA binding and unbinding to oriC is very rapid in two bacterial species and occurs in the range of a few seconds. Their data reveal that tight regulation of turnover is important for proper initiation control.

Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication

Image credit: Katrin Schenk, Ana. B Hervás, Thomas C. Rösch and colleagues

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