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Understanding Images: How dispersal shapes spatial patterns of genetic diversity 

Discover the research that led to August's PLOS Genetics cover image in this Biologue post from Stepfanie                                    Aguillon and Nancy Chen

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Current Issue

Current Issue September 2017

10/13/2017

REsearch article

Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

The dry eye disease caused by lacrimal gland dysgenesis is one of the most common ocular ailments. In this study, Ankur Garg and colleagues show that Shp2 mediates the sequential use of FGF signaling in lacrimal gland development. Their study identifies Alx4 as a novel target of Shp2 signaling and a causal gene for lacrimal gland aplasia in humans. 

Image credit: Ankur Garg and colleagues

Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

10/13/2017

Research article

STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila

Prior studies in the wing primordia of Drosophila melanogaster larvae that have been damaged by high energy radiation show that regeneration occurs to restore the original structure. Shilpi Verghese and Tin Tin Su show that, in the same experimental system, abnormal regeneration can also occur to produce extra wing structures. 

Image credit: Shilpi Verghese and Tin Tin Su

STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila

10/09/2017

research article

Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells

Females are predisposed to develop various autoimmune disorders, and the genetic basis for this susceptibility is the X-chromosome. In the present study, Camille M. Syrett et al show that the chromatin of the inactive X loses epigenetic modifications during B cell lineage development.

Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells

Image credit: Camille M. Syrett and colleagues

10/12/2017

research article

Environmental perturbations lead to extensive directional shifts in RNA processing

Environmental perturbations have large effects on both organismal and cellular traits, including gene expression. In this study, Allison L. Richards and colleagues demonstrate that environmental perturbations also lead to extensive changes in alternative RNA processing across a large number of cellular environments that were investigated. 

Environmental perturbations lead to extensive directional shifts in RNA processing

Image credit: Allison L. Richards and colleagues

10/04/2017

research article

A C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians

Hanxia Su and colleagues identify a C-terminally truncated β-catenin (β-catenin4), generated by gene duplication. The results indicate that the role of β-catenin4 is to modulate the activity of β-catenin1, the planarian β-catenin involved in Wnt signal transduction in the nucleus, mediated by the transcription factor TCF-2.

A C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians

Image credit: Hanxia Su, Miquel Sureda-Gomez and colleagues

10/19/2017

VIEWPOINTS

Guidelines for morpholino use in zebrafish

Didier Y. R. Stainier and colleagues provide an updated set of guidelines regarding the use of MOs in zebrafish that they anticipate will be of value for experimentalists as well as journal and grant reviewers, and decision makers. 

Guidelines for morpholino use in zebrafish

Image credit: NICHD, Flickr, CC BY

09/07/2017

perspective

"T-bet"-ing on autoimmunity variants

This perspective discusses Soderquest et al.'s research on how genetic variants alters the binding landscape of T-bet, a critical transcriptional regulator in immune cells, and highlights the need for mechanistic studies in this area.

"T-bet"-ing on autoimmunity variants

Image credit: Michelle L. T. Nguyen, Dimitre R. Simeonov and colleagues

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