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Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation

April 29, 2015

Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation

Wenyan Ren and colleagues identified windpipe (wdp) as a novel component of the JAK/STAT pathway.

Image credit: Wenyan Ren and colleagues

Recently Published Articles

Current Issue

Current Issue April 2015

04/28/2015

research article

The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits

Protein quality control is key in cells to prevent misfolded proteins from forming toxic aggregates. Lee Peters and colleagues examined the role of the ubiquitin proteasome system (UPS), and found that it can degrade its own misassembled subunits. Along with Hsp42-mediated sorting into cytoprotective compartments, this controls proteasome homeostasis.

Image credit: Lee Peters and colleagues

The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits

04/21/2015

RESEARCH ARTICLE

The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia

Bayazit Yunusbayev and colleagues studied genomic samples from Turkic-speaking peoples across Eurasia and propose a single origin in southern Siberia and Mongolia. The data suggest recent large-scale nomadic migrations of Turkic peoples out of this area to inhabit their current vast geographical range.

The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia

Image credit: Bayazit Yunusbayev and colleagues

04/22/2015

RESEARCH ARTICLE

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Warunee Dansithong and colleagues generated a mouse model of the neurogenerative disorder SCA2, which had a mutant version of the ATXN2 gene. They found that mutant ATXN2 interacted with RGS8 mRNA in these mice, reducing its translation to the signaling regulator protein it encodes.

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Image credit: Warunee Dansithong and colleagues

03/19/2015

Perspective

Morphological Mutations: Lessons from the Cockscomb

Dennis Headon describes the informative collection of morphological mutations published over the past five years by Andersson and colleagues.

Morphological Mutations: Lessons from the Cockscomb

Image credit: Ben Dorshorst and colleagues

03/27/2015

Editorial

PLOS Genetics 2014 Reviewer Thank You

The PLOS Genetics editorial team would like to express our tremendous gratitude to all those individuals who participated in the peer review process this past year.

PLOS Genetics 2014 Reviewer Thank You

Image credit: Center for Scientific Review Wikimedia Commons Public Domain

04/16/2015

PERSPECTIVE

Adventures in Wonderland

Weider and colleagues report that CNS oligodendrocyte-like cells can arise from peripheral glia when a single transcription factor is overexpressed. Since Multiple Sclerosis results from oligodendrocyte loss, this has clinical implications.  

 

Adventures in Wonderland

Image credit: Giulio Callegaro, Flickr