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The Molecular Mechanism of Ethylene-Mediated Root Hair Development Induced by Phosphate Starvation

July 18, 2016

The Molecular Mechanism of Ethylene-Mediated Root Hair Development Induced by Phosphate Starvation

Li Song and colleagues identify a group of genes that affect root hair development by regulating cell wall modifications.

Image credit: Li Song and colleagues

07/21/2016

RESEARCH ARTICLE

dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis

Hedgehog (Hh) is involved in the formation of the retina in Drosophila. Catarina Brás-Pereira and colleagues identify the gene dachshund (dac) as necessary to potentiate Hh signaling. Using genetic analysis they find that dac is required for the stabilization of the nuclear transducer of the Hh signal, the Gli transcription factor Ci. 

Image credit: Catarina Brás-Pereira and colleagues

dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis

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Current Issue June 2016

07/18/2016

RESEARCH ARTICLE

R7 Photoreceptor Specification in the Developing Drosophila Eye: The Role of the Transcription Factor Deadpan

The transcription factor Tramtrack (Ttk) inhibits photoreceptor assignment, and previous studies found that the RTK-induced degradation of Ttk was required for R7 specification. In this study, Yannis Mavromatakis and Andrew Tomlinson find that Deadpan is also required; it is needed to silence ttk transcription. 

Image credit: Yannis Mavromatakis and Andrew Tomlinson

R7 Photoreceptor Specification in the Developing Drosophila Eye: The Role of the Transcription Factor Deadpan

07/20/2016

RESEARCH ARTICLE

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

Studies have shown that aberrant structures that form during transcription under certain circumstances, in particular RNA:DNA hybrids (R loops), can lead to DNA double strand breaks (DSB) formation and genomic instability, especially during DNA synthesis. Julio Morales and colleagues show DSBs that arise with XRN2 loss occur at transcriptional pause sites. 

Image credit: Julio Morales and colleagues

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

07/14/2016

research article

Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2

Masashi Naito and colleagues investigate the role of Dnmt3a in muscle satellite cells by analyzing Dnmt3a-conditional knockout (cKO) mice in which Dnmt3a loci are deleted utilizing Cre-recombinase driven by Pax7 or Pax3 promoters that are specifically activated in the muscle precursor lineage. These findings suggest that DNA methylation plays an essential role in muscle homeostasis.

Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2

Image credit: Masashi Naito and colleagues

07/14/2016

research article 

Dynamics of Chloroplast Translation during Chloroplast Differentiation in Maize

Prakitchai Chotewutmontri and Alice Barkan use RNA sequencing and ribosome profiling to generate a comprehensive description of the dynamics of chloroplast gene expression during the transformation of proplastids into the distinct chloroplast types found in bundle sheath and mesophyll cells in maize. 

Dynamics of Chloroplast Translation during Chloroplast Differentiation in Maize

Image credit: Bayer CropScience UK, Flickr, CC BY

07/21/2016

Review

What Is a Genome?

Aaron Goldman and Laura Landweber explore ways in which emerging research is challenging the concepts of physical permanence attached to the genome as well as its role as the sole information source for an organism.

What Is a Genome?

Image credit: Mehmet Pinarci, Flickr, CC BY

07/07/2016

REview

Telomere Length and the Cancer–Atherosclerosis Trade-Off

Rivka Stone and colleagues discuss how shortened telomere length in humans can induce resistance to cancer, but increase risk of atherosclerosis.

Telomere Length and the Cancer–Atherosclerosis Trade-Off

Image credit: National Institute of General Medical Science, National Institutes of Health, Flickr, CC BY