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Drosophila species learn dialects through communal living

July 19, 2018

Drosophila species learn dialects through communal living

Image credit: Balint Z. Kacsoh and colleagues

Explore our new Craniofacial Genetics Collection

A curated selection of research from Guest Editors Seth Weinberg, Robert Cornell and Elizabeth Leslie

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07/19/2018

research article

Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

Here, Raiders et al study the cell biology of apoptosis in the C. elegans gonad. The authors show that some germ cells are binucleate; these cells appear to form during germline morphogenesis, and are removed by apoptosis. The results demonstrate heterogeneity between oogenic germ cells, and show that the apoptosis machinery efficiently recognizes and removes cells with two nuclei.

Image credit: Stephan A. Raiders and colleagues

Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

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07/17/2018

research Article

Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae

It was postulated that the extent of uracil-incorporation into DNA is significantly affected by local transcription activity. Owiti et al show that higher transcription rate correlates with higher uracil-density in yeast, and provide multiple lines of evidence supporting a model of uracil-incorporation into DNA that is dependent on the repair synthesis of transcription-associated DNA damage.

Image credit: Flickr, Conor Lawless, CC BY

Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae

07/18/2018

research article

Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme

Signal transduction is known to involve (i) sensing a signal, (ii) a molecular switch triggering a response, and (iii) altering gene expression. For Bacillus subtilis’ response to lysozyme, we have a detailed understanding of (i) and (iii). In this study, Lincoln T. Lewerke and colleagues provide insights for a molecular switch that triggers the lysozyme response via σV activation. 

Image credit: Lincoln T. Lewerke and colleagues

Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme

07/12/2018

research article

Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Here, Johanna M. Huusko and colleagues investigate the presence of rare, possibly risk associated nucleotide variants in mothers with spontaneous preterm births (SPTB). The authors use whole exome sequencing and identify multiple rare variants, likely damaging HSPA1LI, in several families affected by SPTB, and find that this gene is associated with the glucocorticoid receptor signaling pathway. 

Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Image credit: Johanna M. Huusko and colleagues

07/19/2018

perspective

C. elegans germline cell death, live!

Morales and Greenstein comment on new work showing that physiological apoptosis targets at least two distinct populations of germ cells in C. elegans, and that the apoptosis machinery efficiently recognizes cells with two nuclei, from Raiders et al.

C. elegans germline cell death, live!

Image credit: Morales and Greenstein

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