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Current Issue March 2017

04/18/2017

RESEARCH ARTICLE

The SnRK2 kinases modulate miRNA accumulation in Arabidopsis

The family of 10 redundant members of SnRK2 protein kinases are the central components of abscisic acid and osmotic stress signaling pathways. Jun Yan, Pengcheng Wang and colleagues show that the SnRK2 kinases are required for the maintenance of the steady state level of HYL1 protein and the miRNA processing complex components, SE and HYL1, are potential substrates of the SnRK2 kinases.

Image credit: Jun Yan, Pengcheng Wang and colleagues

The SnRK2 kinases modulate miRNA accumulation in Arabidopsis

04/17/2017

RESEARCH ARTICLE 

Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo

Semen liquefaction has been considered to be solely modulated by prostate-derived kallikrein-related peptidases (KLKs), especially KLK3. However, Shuai Li demonstrate that female mice lacking estrogen receptor alpha in the uterine epithelial cells had a drastic decrease in Klk transcripts and semen from fertile males fails to liquefy within the uteri of these females. 

Image credit: Shuai Li and colleagues

Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo

04/10/2017

research article

Tissue-specific enhancer repression through molecular integration of cell signaling inputs

In the present study, Luis Humberto Mojica-Vázquez, Mikhail H. Benetah and colleagues used the bric-a-brac2 (bab2) gene as a model to study the integrated regulation of patterning genes implicated in tarsal segmentation. By genetic and molecular analyses, they show that the cell signaling-responding TFs C15 and Bowl interact directly with the limb-specific bab2 enhancer as a repressive duo.

Tissue-specific enhancer repression through molecular integration of cell signaling inputs

Image credit: Luis Humberto Mojica-Vázquez, Mikhail H. Benetah and colleagues

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