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Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

May 21, 2015

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

George Dialynas and colleagues provide evidence that LMNA mutations activate an intracellular signaling pathway and alter the redox homeostasis of muscle tissue.

Image credit: George Dialynas and colleagues

Recently Published Articles

Current Issue

Current Issue April 2015

05/15/2015

research article

Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids

Using the nematode C. elegans, Zhiyu Liu and colleagues devised a highly specific and sensitive genetic screen to identify new modulators in the BMP pathway. Through this screen, they identified three conserved tetraspanin molecules as novel factors that function to promote BMP signaling in a living organism.

Image credit: Zhiyu Liu and colleagues

Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids

05/07/2015

research article

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

John Moldovan and John Moran demonstrate that the zinc-finger antiviral protein inhibits the retrotransposition of human Long INterspersed Element-1 and Alu retrotransposons, as well as related retrotransposons from mice and zebrafish.

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

Image credit: John Moldovan and John Moran

05/07/2015

interview

The Philosophical Approach: An Interview with Ford Doolittle

Doolittle has cogitated on a variety of intriguing evolutionary questions, including the origin of introns, lateral gene transfer, and the meaning of “function". He is always worth listening to.

The Philosophical Approach: An Interview with Ford Doolittle

Image credit: Jane Gitschier