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12/01/2017

research article

Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations

In the present study, Xun Chen and Dion Dickman develop the first tissue-specific ribosome profiling system in Drosophila to reveal genome-wide changes in translation. They demonstrate successful ribosome profiling from muscle cells to exhibit superior resolution compared to other translational profiling methods.

Image credit: Xun Chen and Dion Dickman

Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations

Recently Published Articles

Current Issue

Current Issue November 2017

11/27/2017

research article

Rv0004 is a new essential member of the mycobacterial DNA replication machinery

Most of the initial studies on bacterial DNA replication were performed in Escherichia coli and Bacillus subtilis, and more distantly related bacteria have diverged from these organisms in even the most fundamental processes. Katherine M. Mann and colleagues discover that a previously uncharacterized protein in Mycobacteria, named Rv0004, is essential for bacterial viability and involved in DNA replication. 

Image credit: Katherine M. Mann and colleagues

Rv0004 is a new essential member of the mycobacterial DNA replication machinery

11/27/2017

research article

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

Ci Fu and Joseph Heitman identify and characterize two genes in the Cryptococcus species complex, PRM1 and KAR5, which play conserved roles in plasma membrane fusion and karyogamy in fungi. They show that unisexual reproduction is largely independent from cell-cell fusion and mechanistically different from bisexual reproduction. 

Image credit: Ci Fu and Joseph Heitman

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

11/20/2017

RESEARCH ARTICLE

Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord

Krishna Moorthi Bhat shows that Slit/Slit-N interact with Robo in tracts to maintain the fasciculation and position of axon tracts following axon guidance. In the absence of Slit in mature tracts after their guidance, the tracts de-fasciculate and merge with one another and shift their position towards the midline. 

Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord

Image credit: Krishna Moorthi Bhat

11/22/2017

RESEARCH ARTICLE

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects

Christopher H. Chandler, Sudarshan Chari and colleagues examined how the genomic and environmental context influence the expression of multiple mutations in two related genes affecting the fruit fly wing. They found that context can have a big impact on the interpretation of genetic experiments.

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects

Image credit: Chandler, Chari and colleagues

11/28/2017

review

The evolution and adaptation of A-to-I RNA editing

Yablonovitch and colleagues discuss results related to the evolution of RNA editing, with a focus on comparative genomics approaches and its use as a mechanism to adapt to varying environmental conditions.

The evolution and adaptation of A-to-I RNA editing

Image credit: Arielle L. Yablonovitch and colleagues

10/19/2017

VIEWPOINTS

Guidelines for morpholino use in zebrafish

Didier Y. R. Stainier and colleagues provide an updated set of guidelines regarding the use of MOs in zebrafish that they anticipate will be of value for experimentalists as well as journal and grant reviewers, and decision makers. 

Guidelines for morpholino use in zebrafish

Image credit: NICHD, Flickr, CC BY

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