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An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster

April 27, 2016

An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster

Ana Catalán and colleagues show that a deletion mutation in a noncoding region of the Drosophila melanogaster Metallothionein A gene leads to a significant increase in gene expression and increases survival under oxidative stress. 

Image credit: Ana Catalán and colleagues

PLOS Genetics Editors elected to the American Academy of Arts and Sciences

Congratulations to Michael Lichten and Andrew Clark for their prestigious elections to the Academy!

Read more here.

04/21/2016

research article

Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm

Using sea urchin embryos, Junko Yaguchi and colleagues describe how the combination of orthogonally functioning signaling pathways regulates their targeting transcription factors expressing at the anterior neuroectoderm to restrict and pattern the default neurogenic region. 

Image credit: Junko Yaguchi and colleagues

Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm

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Current Issue

Current Issue March 2016

04/14/2016

REVIEW

What Is the Tree of Life?

W. Ford Doolittle and Tyler Brunet discuss the Tree of Life (TOL) hypothesis and the challenges posed to a simple interpretation of a universal TOL by microbiology.

What Is the Tree of Life?

Image credit: Marc Dalmulder, Flickr, CC BY

04/07/2016

REVIEW

The Increasing Importance of Gene-Based Analyses

Elizabeth Cirulli investigates 150 exome sequencing studies, and their methods, that claim to have discovered that a disease can be caused by different rare variants in the same gene.

The Increasing Importance of Gene-Based Analyses

Image credit: John Goode, Flickr, CC BY

03/31/2016

REVIEW

What Is Speciation?

B. Jesse Shapiro and colleagues review how microbial population genomics has enabled us to catch speciation “in the act” and how the results have challenged and enriched our concepts of species, with implications for all domains of life.

What Is Speciation?

Image credit: isis325, Flickr, CC BY