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09/15/2017

research article

A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

Genetic and genomic information on sheep can be used to improve production traits such as growth rate and health and fitness traits including disease resilience. In this present study, Clark, Bush and colleagues present a large-scale RNA-Seq dataset representing all the major organ systems from adult sheep and from several juvenile, neonatal and prenatal developmental time points.

Image credit: Emily L. Clark, Stephen J. Bush and colleagues

A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

Recently Published Articles

Current Issue

Current Issue August 2017

09/20/2017

research article

CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB

This present study focuses on the CbtA toxin of E. coli, known to inhibit both bacterial cell division and also bacterial cell elongation. Here, Danielle M. Heller and colleagues genetically separate the effects of CbtA on cell elongation and cell division, showing that CbtA interacts directly and independently with FtsZ and MreB.

Image credit: Danielle M. Heller and colleagues

CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB

09/11/2017

research article

Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms

Cytoplasmic assembly of ciliary dyneins requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated. Here, Yamamoto, Obbineni and colleagues show that the classical Chlamydomonas motility mutant pf23 is defective in the Chlamydomonas homolog of DYX1C1

Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms

Image credit: Ryosuke Yamamoto, Jagan M. Obbineni and colleagues

09/14/2017

research article

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Patients with mutations of the THRA gene exhibit features of hypothyroidism, including erythroid disorders. In Thra1PV/+ mice expressing a dominant negative mutant TRα1PV, Sunmi Park and colleagues find abnormal red blood cell indices similar to patients. This study suggests that therapies aimed at GATA1 could be tested as a potential target in treating erythroid abnormalities in patients.

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Image credit: Sunmi Park and colleagues

09/14/2017

research article

Genomics-enabled analysis of the emergent disease cotton bacterial blight

Cotton bacterial blight (CBB), an important disease of (Gossypium hirsutum) in the early 20th century, had been controlled by resistant germplasm for over half a century. Recently, CBB re-emerged as an agronomic problem in the United States. Anne Z. Phillips and colleagues reveal important insights into the Xcm-G. hirsutum disease complex and strategies for future development of resistant cultivars.

Genomics-enabled analysis of the emergent disease cotton bacterial blight

Image credit: Anne Z. Phillips and colleagues

09/07/2017

perspective

"T-bet"-ing on autoimmunity variants

This perspective discusses Soderquest et al.'s research on how genetic variants alters the binding landscape of T-bet, a critical transcriptional regulator in immune cells, and highlights the need for mechanistic studies in this area.

"T-bet"-ing on autoimmunity variants

Image credit: Michelle L. T. Nguyen, Dimitre R. Simeonov and colleagues

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