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02/17/2017

research article

Sequencing the Extrachromosomal Circular Mobilome Reveals Retrotransposon Activity in Plants

Sophie Lanciano and colleagues apply a methodology based on the high throughput sequencing of extrachromosomal circular DNA forms of active retrotransposons to characterize the repertoire of mobile retrotransposons in plants. This method successfully identified known active retrotransposons in both Arabidopsis and rice material where the epigenome is destabilized.

Image credit: Sophie Lanciano and colleagues

Sequencing the Extrachromosomal Circular Mobilome Reveals Retrotransposon Activity in Plants

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Current Issue January 2017

02/21/2017

research article

Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase

Kara R. Barber and colleagues show that overexpression of Par-1/MARK kinase leads to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. They also find that Par-1 acts independently of Tau— one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau.

Image credit: Kara R. Barber and colleagues

Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase

02/23/2017

research article

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

Kaisa Thorell, Koji Yahara and colleagues find evidence for admixture between H. pylori of European and African origin throughout the Americas, without substantial input from pre-Columbian bacteria. In the US, strains of African and European origin have remained genetically distinct, while in Colombia and Nicaragua, bottlenecks and rampant genetic exchange amongst isolates have led to the formation of national gene pools.

Image credit: Kaisa Thorell, Koji Yahara and colleagues

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

02/14/2017

research article

Genetic prediction of male pattern baldness

Saskia P. Hagenaars, W. David Hill and colleagues present the largest genome-wide study of baldness to date, exploring the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40–69 years. They also split their dataset in two to build and apply a genetic predictor of baldness. Of those with a polygenic score below the median, 14% had severe hair loss and 39% no hair loss.

 

 

Genetic prediction of male pattern baldness

Image credit: Douglas Robertson, University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology

02/16/2017

RESEARCH ARTICLE

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways

Caspase 9 in mammals and its Drosophila ortholog Dronc carry a protein-protein interaction domain (CARD) in their prodomain which interacts with scaffolding proteins to form the apoptosome. Hatem Elif Kamber Kaya and colleagues show that Dronc is mono-ubiquitylated at Lysine 78 in its CARD domain. 

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways

Image credit: Hatem Elif Kamber Kaya and colleagues

02/16/2017

RESEARCH ARTICLE

JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity

Using C. elegans as model system, Pier Giorgio Amendola and colleagues show that loss of jmjd-5, resulting in increased levels of H3K36me2, impairs the resolution of recombination intermediates and the release of RAD-51, with consequences in the DNA repair process after ionizing radiation and in meiotic recombination. 

JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity

Image credit: Pier Giorgio Amendola and Demetrio Romeo

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