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Deep Reads: How I learnt to love population genetics

Jonathan Flint delves into “Basic Concepts in Population, Quantitative and Evolutionary Genetics” 

Deep Reads

01/12/2018

research article

Ovule identity mediated by pre-mRNA processing in Arabidopsis

Homeotic transformations of ovules into flower organ-like structures occur in plants in which the HUA-PEP function is compromised. In such backgrounds, prematurely terminated transcripts of SHP1, SHP2 and STK accumulate at the expense of their respective functional transcripts. The data presented here by Rodríguez-Cazorla et al provide compelling evidence for considering the HUA-PEP proteins as part of the co-transcriptional regulatory machinery involved in coordinating transcription and pre-mRNA processing.

Image credit: Encarnación Rodríguez-Cazorla and colleagues

Ovule identity mediated by pre-mRNA processing in Arabidopsis

Recently Published Articles

Current Issue

Current Issue December 2017

01/19/2018

research article

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa

Circadian clocks are ubiquitous in eukaryotic organisms where they are used to anticipate regularly occurring diurnal and seasonal environmental changes. Nevertheless, little is known regarding pathways connecting the core clock to its output pathways. In this study, Xiaoying Zhou and colleagues report that the HAD family phosphatase CSP-6 is required for overt circadian clock output but not for the core oscillation. 

Image credit: Xiaoying Zhou and colleagues

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa

01/18/2018

research article

Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

In C. elegans, Offenburger et al search for genes that protect dopaminergic neurons against oxidative stress, and show that apoptosis proteins, the calcium chaperone CRT-1, and the neuroligin-like GLIT-1 protect against neurodegeneration after oxidative stress exposure.

Image credit: Sarah-Lena Offenburger and colleagues

Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

01/11/2018

Research article

Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye

Morrison et al use Drosophila to show that Glass acts not only in photoreceptors, but also in the non-neuronal support cells of the eye. To determine whether Glass activity is limited to neuronal lineages, the effects of misexpressing it in neuroblasts of the larval brain and in epithelial cells of the wing disc was compared. This study suggests that the role of Glass is to give each cell type its identity as a component of the eye. 

Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye

Image credit: Carolyn A. Morrison and colleagues

01/08/2018

research article

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

Here, Rosa et al use a forward genetic approach in the Drosophila tracheal system to characterize a mutant called ichor. Ichor compromises the integrity and shape of seamless tubes, but was found to promote these by transcriptionally activating genes required to assemble an extracellular matrix lining the lumens of terminal cells.

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

Image credit: Jeffrey B. Rosa and colleagues

11/28/2017

review

The evolution and adaptation of A-to-I RNA editing

Yablonovitch and colleagues discuss results related to the evolution of RNA editing, with a focus on comparative genomics approaches and its use as a mechanism to adapt to varying environmental conditions.

The evolution and adaptation of A-to-I RNA editing

Image credit: Arielle L. Yablonovitch and colleagues

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