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Investigating the case of human nose shape and climate adaptation

March 16, 2017

Investigating the case of human nose shape and climate adaptation

Image credit: Arslan A. Zaidi and colleagues

Understanding Images: How genetic makeup of a ‘roommate’ can influence health 

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03/16/2017

research article

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

Lisa Krug and colleagues provide evidence that activation of DNA damage-mediated programmed cell death underlies both neuronal and glial hTDP-43 toxicity, consistent with RTE-mediated effects in both cell types. Their findings suggest a novel mechanism in which RTE activity contributes to neurodegeneration in TDP-43-mediated diseases such as ALS and FTLD.

Image credit: Lisa Krug and colleagues

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

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Current Issue

Current Issue February 2017

03/10/2017

research article

Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans

Kimberly F. McManus and colleagues revisit the evolutionary history of a gene associated with resistance to the most common malaria-causing parasite, Plasmodium vivax. They also show that it is one of the regions of the human genome that has been under strongest selective pressure in our evolutionary history.

Image credit: Kimberly F. McManus and colleagues

Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans

03/16/2017

perspective

The social genome: Current findings and implications for the study of human genetics

Benjamin W. Domingue and Daniel W. Belsky discuss work from Amelie Baud et al on "Social genetic effects", and the impact of social environment on health and disease. Social genetic effects arise when an organism’s phenotype is influenced by the genetic makeup of that organism’s social environment. The article by Baud et al in the January 2017 issue suggests one provocative path forward: measure the genomes of proximate individuals.

Image credit: Spencer Phillips, EMBL-EBI.

The social genome: Current findings and implications for the study of human genetics

03/08/2017

plos science wednesday

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Seth Weinberg and colleagues discuss their recent PLOS Genetics paper concerning the identification of genetic variants that influence human facial features. 

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Image credit: Schaffer, Orlova, Lee et al

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