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12th July: PLOS Science Wednesday AMA

In this week's AMA, Ronnie Sebro discusses how mating patterns in a European-American population                                     changed over time, as well as the implication of these findings for current genetic studies.

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07/17/2017

research article

Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

During skeletal morphogenesis diverse mechanisms are used to support bone formation, for example some bones require a cartilage template. In zebrafish, the cartilage template persists, and the bone mineralizes around the cartilage scaffold. In this study, Adrian Santos-Ledo and colleagues identify a conserved role for the Kinesin-1 heavy chain, kif5B, in maintaining muscle integrity and a novel role in cartilage development during craniofacial morphogenesis.

Image credit: Adrian Santos-Ledo and colleagues

Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

Recently Published Articles

Current Issue

Current Issue June 2017

07/20/2017

RESEARCH ARTICLE

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

Gene drive systems provide a wide array of potential applications, including new strategies for the control of vector-borne diseases. In this study, Jackson Champer and colleagues developed two CRISPR/Cas9 gene drive constructs using different promoters and target sites in the model organism Drosophila melanogaster.

Image credit: Jackson Champer and colleagues

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

07/17/2017

research article

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid

In the present study, Maha El Shahawy and colleagues demonstrate that Sonic hedgehog (SHH) inhibits taste placode and lingual gland formation by antagonizing RA inputs. The authors also show that loss of SHH signaling elicits Merkel cell formation in the lingual epithelium, a tissue normally bereft of Merkel cells.

Image credit: Maha El Shahawy and colleagues

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid

07/13/2017

review

Genetic compensation: A phenomenon in search of mechanisms

Mohamed A. El-Brolosy and Didier Y. R. Stainier revisit genetic compensation studies in higher eukaryotes, and outline possible molecular mechanisms of genetic compensation.

Genetic compensation: A phenomenon in search of mechanisms

Image credit: Emma A. Hall, PLOS Genetics, pgen.1003928

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