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05/16/2018

research article

Condensin I protects meiotic cohesin from WAPL-1 mediated removal

Margarita R. Hernandez and colleagues identify a new role for condensin in the maintenance of sister chromatid cohesion during C. elegans meiosis. Using conventional and stimulated emission depletion (STED) microscopy, the authors show that levels of chromosomally-bound cohesin were significantly reduced in dpy-28 mutants, which lack a subunit of condensin I, and find that condensin I binds to C. elegans WAPL-1 and counteracts WAPL-1-dependent cohesin removal. 

Image credit: Margarita R. Hernandez and colleagues

Condensin I protects meiotic cohesin from WAPL-1 mediated removal

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Current Issue

Current Issue April 2018

05/16/2018

research erticle

A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

Here, Sara Gonçalves, Julie Patat and colleagues report on the pathogenicity of ADD3 mutations in three families with intellectual disability, microcephaly, cataracts and skeletal defects, and show that the renal and cardiac phenotypes in one of the families could be unmasked by a homozygous variant in the lysine acetyltransferase encoding KAT2B gene. 

Image credit: Sara Gonçalves, Julie Patat and colleagues

A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

05/14/2018

research article

Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis

In this study, Wei, Srinivas, Lin, Tang and colleagues report on the functional definition of ICR-Mo from M. osloensis, a chromosomally encoded determinant of colistin resistance, in close relation to current MCR-1/2 family. The authors find that the two domains of ICR-Mo cannot be functionally exchanged with their counterparts in MCR-1/2, validating its standing as a distinct phylogenetic entity.

Image credit: Wenhui Wei, Swaminath Srinivas, Jingxia Lin, Zichen Tang and colleagues

Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis

05/10/2018

Perspective

Moss genetics and the way forward

Neil Ashton comments on work by Xinxin Ding et al, who capitalize on the haploid growth-phase of the moss Physcomitrella patens to identify conditional loss-of-growth (CLoG) mutants with impaired growth at high temperature.

Moss genetics and the way forward

Image credit: Neil Ashton

04/05/2018

Review

A genomic overview of the population structure of Salmonella

Alikhan et al discuss the recent proposal to replace serotyping of Salmonella enterica by so-called eBurst groups (eBGs) - based on the alleles of seven housekeeping genes - and the associated problems.

A genomic overview of the population structure of Salmonella

Image credit: Nabil-Fareed Alikhan and colleagues

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