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Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

December 29, 2015

Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

Congratulations to Santiago Naranjo, Justin Smith and colleagues, winners of the PLOS Genetics Research Prize 2016! The winning research identifies four genes contributing to the evolution of resistance to citrinin, a naturally occurring toxin in yeast, providing a detailed view of a complex evolutionary adaptation. 

Image credit: Yuan et al (2015)

PLOS Genetics Research Prize 2016 Winner Announced

Read the full announcement here

Recently Published Articles

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Current Issue August 2016

09/22/2016

RESEARCH ARTICLE

Sex-Specific Selection and Sex-Biased Gene Expression in Humans and Flies

Mark Kirkpatrick and Changde Cheng use genomic data from humans and flies to quantify the relation between ongoing selection pressures and gene expression. A distinctive pattern in both species reveals that many genes are experiencing selection that is currently acting differentially on males and females.

Image credit: balapagos, Flickr, CC BY

Sex-Specific Selection and Sex-Biased Gene Expression in Humans and Flies

09/22/2016

RESEARCH ARTICLE 

The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer

Ngoc-Han Ha and colleagues show that a commonly used model of metastatic breast cancer is capable of identifying genes that play a role in the metastatic progression of ER- breast cancers. They also identify the circadian rhythm gene, Arntl2, as a gene associated with inherited susceptibility for the development of metastatic lesions.

Image credit: Darryl Leja, NHGRI, Flickr, CC BY

The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer

09/15/2016

RESEARCH ARTICLE

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

M. Kasim Diril and colleagues show that the Cdk1->Greatwall kinase/Mastl->PP2A pathway plays a central role in regulating the spindle assembly checkpoint (SAC) by preventing premature SAC silencing. They also show that Mastl is required for multi-site phosphorylation of the essential SAC protein MPS1 as well as robust MPS1 kinase activity in mitosis.

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

Image credit: M. Kasim Diril and colleagues