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SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs

February 12, 2018

SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs

Image credit: Daniel W. Hagey and colleagues

PLOS Research News: stay up to date with research from across PLOS

PLOS Research News

02/15/2018

research article

Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study

In this study, Kevin H. Eng et al. argue that an ovarian cancer susceptibility gene on the X-chromosome acting independently of BRCA1 and BRCA2, exists. Using germline X-chromosome exome sequencing, the authors provide results consistent with an X-linked dominant model and also isolate a candidate gene, MAGEC3, that may be associated with earlier onset of ovarian cancer.

Image credit: Kevin H. Eng and colleagues

Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study

Recently Published Articles

Current Issue

Current Issue January 2018

02/12/2018

research article

Comprehensive analysis of central carbon metabolism illuminates connections between nutrient availability, growth rate, and cell morphology in Escherichia coli

Here, Corey S. Westfall and Petra Anne Levin use Escherichia coli to screen the entirety of non-essential carbon metabolic genes for their contribution to growth rate and cell shape, and find the presence of multiple regulatory circuits coordinating different metabolic pathways in cell growth and morphology.

Image credit: Corey S. Westfall and Petra Anne Levin

Comprehensive analysis of central carbon metabolism illuminates connections between nutrient availability, growth rate, and cell morphology in Escherichia coli

02/08/2018

research article

Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

In this study, Kyra Campbell et al. find the Drosophila EMT-inducers, Snail and Serpent, are both capable of driving over-proliferation in primary tumours. The authors further show that both Snail and Serpent trigger activation of the Yorki pathway and in addition, Serpent also triggers activation of the Ras pathway, providing insight into how EMT-inducing genes promote growth.

Image credit: Kyra Campbell and colleagues

Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

02/06/2018

research article

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

In this study, Ofelia Tacchelly-Benites and colleagues use Drosophila to show a major role for APC (Adenomatous polyposis coli) in the direct regulation of the scaffold protein Axin, in both Wnt-on and Wnt-off conditions. Results indicate that APC promotes Axin phosphorylation, which is required not only to inhibit signalling in the unstimulated state, but also to activate signalling following Wnt stimulation. 

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

Image credit: Ofelia Tacchelly-Benites and colleagues

01/30/2018

research article

Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism

Using a combination of loss of function studies in mouse and zebrafish and in vitro cell biology approaches, Patricia Molina-Ortiz, Tanguy Orban and colleagues, show that Rasa3, a GTPase activating protein of the GAP1 family, controls Rap1 activation, endothelial cell adhesion and migration as well as formation of vascular lumens.

Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism

Image credit: Patricia Molina-Ortiz and colleagues

01/25/2018

Review

Taking cohesin and condensin in context

Yuen & Gerton review adaptor proteins for structural maintenance of chromosome (SMC) complexes and how these may capture SMC complexes to provide a framework for chromosome organization.

Taking cohesin and condensin in context

Image credit: Kobe C. Yuen and Jennifer L. Gerton

11/28/2017

review

The evolution and adaptation of A-to-I RNA editing

Yablonovitch and colleagues discuss results related to the evolution of RNA editing, with a focus on comparative genomics approaches and its use as a mechanism to adapt to varying environmental conditions.

The evolution and adaptation of A-to-I RNA editing

Image credit: Arielle L. Yablonovitch and colleagues

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