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The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

May 22, 2015

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

A plasmid-based cell culture assay detects new retrotransposition events that cause expression of a neomycin resistance reporter gene contained within an active LINE1.  John Goodier and colleagues increase understanding of how ZAP, an important restriction factor against positive- and negative-strand RNA and some DNA viruses, also interacts with human retrotransposons to prevent genome mutation.

Image credit: John Goodier and colleagues

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Current Issue May 2015

05/15/2015

research article

Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids

Using the nematode C. elegans, Zhiyu Liu and colleagues devised a highly specific and sensitive genetic screen to identify new modulators in the BMP pathway. Through this screen, they identified three conserved tetraspanin molecules as novel factors that function to promote BMP signaling in a living organism.

Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids

Image credit: Zhiyu Liu and colleagues

05/07/2015

interview

The Philosophical Approach: An Interview with Ford Doolittle

Doolittle has cogitated on a variety of intriguing evolutionary questions, including the origin of introns, lateral gene transfer, and the meaning of “function". He is always worth listening to.

The Philosophical Approach: An Interview with Ford Doolittle

Image credit: Jane Gitschier