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08/17/2017

research article

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

Cilia play a central role in sensing and transducing Hedgehog signals in the context of mammalian embryogenesis and in a variety of cancers. In the present study, Snouffer, Brown, Lee and colleagues investigate the functions of Cell Cycle Related Kinase (CCRK), which plays an evolutionarily conserved function in the assembly of cilia and flagella, and show that mouse CCRK positively and negatively regulates ciliary length.

Image credit: Snouffer, Brown, Lee and colleagues

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

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Current Issue July 2017

08/17/2017

research article

Tissue-specific insulin signaling mediates female sexual attractiveness

Animals choose their mates based on specific attractive traits, like song and plumage characteristics in birds, or smell and call features in mammals. In this study, Tatyana Y. Fedina and colleagues show that insulin signaling—a conserved nutrient-sensing pathway that affects female metabolic status—acts specifically in certain tissues to increase fecundity and, at the same time, increases attractiveness of female pheromones in the fruitfly, Drosophila melanogaster.

Image credit: C. Gendron

Tissue-specific insulin signaling mediates female sexual attractiveness

08/07/2017

Research article

SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana

Chunhong Cheng, Zhijuan Wang and colleagues investigate the regulation of SnRK2 turnover, and show that SnRK2s are degraded by 26S proteasome and ABA promotes SnRK2.3 degradation. They also show that an F-box protein, AtPP2-B11, which interacts with ASK1 and ASK2, is a component of a SKP1/Cullin/F-box E3 ubiquitin ligase complex.

SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana

Image credit: Chunhong Cheng, Zhijuan Wang and colleagues

07/13/2017

review

Genetic compensation: A phenomenon in search of mechanisms

Mohamed A. El-Brolosy and Didier Y. R. Stainier revisit genetic compensation studies in higher eukaryotes, and outline possible molecular mechanisms of genetic compensation.

Genetic compensation: A phenomenon in search of mechanisms

Image credit: Emma A. Hall, PLOS Genetics, pgen.1003928

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