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Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye

January 11, 2018

Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye

Image credit: Carolyn A. Morrison and colleagues

Deep Reads: How I learnt to love population genetics

Jonathan Flint delves into “Basic Concepts in Population, Quantitative and Evolutionary Genetics” 

Deep Reads

01/08/2018

research article

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

The factors regulating the formation and maintenance of unicellular lumens devoid of cell junctions remains poorly understood. Here, Rosa et al use a forward genetic approach in the Drosophila tracheal system to characterize a mutant called ichor. Ichor compromises the integrity and shape of seamless tubes, but was found to promote these by transcriptionally activating genes required to assemble an extracellular matrix lining the lumens of terminal cells.

Image credit: Jeffrey B. Rosa and colleagues

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

Recently Published Articles

Current Issue

Current Issue December 2017

01/10/2018

Research article

Cdc73 suppresses genome instability by mediating telomere homeostasis

Genome instability has been linked to multiple human diseases, with defects in Cdc73 shown to give rise to increased genome instability. In this study, Nene, Putnam et al find that Cdc73 defects give rise to partial defects in telomere maintenance, resulting in defects. The data suggests that the mutations in CDC73 and CTR9 found in patients with hyperparathyroidism-jaw tumor syndrome and Wilms tumors, respectively, may contribute to cancer progression by contributing to genome instability.

Image credit: Rahul V. Nene, Christopher D. Putnam and colleagues

Cdc73 suppresses genome instability by mediating telomere homeostasis

01/10/2018

Research Article

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure

Here, Salatzki, Foryst-Ludwig et al show that perturbation of adipose tissue lipolysis by tissue-specific deletion of the lypolytic enzyme ATGL (adipose trigylceride lipase) protects against heart failure development. By using MS-based lipidomics, they show the lack of ATGL in adipose tissue protects the heart against deleterious cardiac lipidome changes.


Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure

Image credit: Janek Salatzki, Anna Foryst-Ludwig and colleagues

01/11/2018

research article

Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

For many bacteria with sequenced genomes, we do not understand how they synthesize some amino acids. Here, Price et al study 10 bacteria with predicted gaps in amino acid biosynthesis that can grow in minimal media. Using genome-wide mutant fitness data, the authors identify novel enzymes and explain the biosynthesis of amino acids by bacteria from six genera.

Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

Image credit: Morgan N. Price and colleagues

11/28/2017

review

The evolution and adaptation of A-to-I RNA editing

Yablonovitch and colleagues discuss results related to the evolution of RNA editing, with a focus on comparative genomics approaches and its use as a mechanism to adapt to varying environmental conditions.

The evolution and adaptation of A-to-I RNA editing

Image credit: Arielle L. Yablonovitch and colleagues

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