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05/15/2017

research article

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

In this present study, Corentin Claeys Bouuaert and Scott Keeney examine a complex of proteins called MutLγ, important for the formation of meiotic crossovers, and uncover intriguing features of the interaction of Saccharomyces cerevisiae MutLy with DNA.

Image credit: Corentin Claeys Bouuaert and Scott Keeney

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

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Current Issue April 2017

05/15/2017

research article

The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure

The INT6 gene has been identified as the insertion site of the mouse mammary tumor virus, and shown to be involved in human tumorigenesis. In this study, Fioranna Renda and colleagues show that depletion of the Drosophila orthologue of INT6 results in short spindles, delayed progression though metaphase and abnormally shaped centromeres/kinetochores.

Image credit: Fioranna Renda and colleagues

The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure

05/05/2017

research article

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless

Praxenthaler, Nagel and colleagues introduced three mutations that affect interactions with the repressor Hairless, but not the activator NICD, into the native Suppressor of Hairless locus by genome engineering, to analyse the effects these mutants have on normal fly development.

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless

Image credit: Heiko Praxenthaler, Anja C. Nagel and colleagues

05/11/2017

research article

Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor

Insect hormones such as ecdysteroids and juvenoids play a key role in accessory gland development and protein synthesis, but little is known about underlying molecular players. In the present study, Vandana Sharma and colleagues examine the roles of hormone-dependent transcription factors in accessory gland development, function and male fertility of Drosophila melanogaster.

Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor

Image credit: Vandana Sharma and colleagues

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