May 2008

Pseudo-colored scanning electron micrograph of the eye of a transgenic Drosophila expressing CagA. The normal crystalline array of facets in the eye is disrupted (see Botham et al., doi:10.1371/journal.ppat.1000064).

Image Credit: Image generated by Crystal M. Botham.

Review

Viral Control of Mitochondrial Apoptosis

Lorenzo Galluzzi, Catherine Brenner, Eugenia Morselli, Zahia Touat, Guido Kroemer

PLOS Pathogens: published May 30, 2008 | https://doi.org/10.1371/journal.ppat.1000018

Research Articles

SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro

Martijn J. van Hemert, Sjoerd H. E. van den Worm, Kèvin Knoops, A. Mieke Mommaas, Alexander E. Gorbalenya, Eric J. Snijder

PLOS Pathogens: published May 2, 2008 | https://doi.org/10.1371/journal.ppat.1000054

Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood

Robert De Rose, Caroline S. Fernandez, Miranda Z. Smith, C. Jane Batten, Sheilajen Alcântara, Vivienne Peut, Erik Rollman, Liyen Loh, Rosemarie D. Mason, Kim Wilson, Matthew G. Law, Amanda J. Handley, Stephen J. Kent

PLOS Pathogens: published May 2, 2008 | https://doi.org/10.1371/journal.ppat.1000055

A Novel Small Acid Soluble Protein Variant Is Important for Spore Resistance of Most Clostridium perfringens Food Poisoning Isolates

Jihong Li, Bruce A. McClane

PLOS Pathogens: published May 2, 2008 | https://doi.org/10.1371/journal.ppat.1000056

Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction

Natalia Sharova, Yuanfei Wu, Xiaonan Zhu, Ruzena Stranska, Rajnish Kaushik, Mark Sharkey, Mario Stevenson

PLOS Pathogens: published May 2, 2008 | https://doi.org/10.1371/journal.ppat.1000057

Changing Selective Pressure during Antigenic Changes in Human Influenza H3

Benjamin P. Blackburne, Alan J. Hay, Richard A. Goldstein

PLOS Pathogens: published May 2, 2008 | https://doi.org/10.1371/journal.ppat.1000058

Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

Smita Srivastava, Selene K. Swanson, Nicolas Manel, Laurence Florens, Michael P. Washburn, Jacek Skowronski

PLOS Pathogens: published May 9, 2008 | https://doi.org/10.1371/journal.ppat.1000059

Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization

Steevenson Nelson, Christiane A. Jost, Qinq Xu, Jessica Ess, Julie E. Martin, Theodore Oliphant, Stephen S. Whitehead, Anna P. Durbin, Barney S. Graham, Michael S. Diamond, Theodore C. Pierson

PLOS Pathogens: published May 9, 2008 | https://doi.org/10.1371/journal.ppat.1000060

Suppression of Plant Resistance Gene-Based Immunity by a Fungal Effector

Petra M. Houterman, Ben J. C. Cornelissen, Martijn Rep

PLOS Pathogens: published May 9, 2008 | https://doi.org/10.1371/journal.ppat.1000061

A Cysteine Protease Is Critical for Babesia spp. Transmission in Haemaphysalis Ticks

Naotoshi Tsuji, Takeharu Miyoshi, Badger Battsetseg, Tomohide Matsuo, Xuenan Xuan, Kozo Fujisaki

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000062

HtrA2/Omi Terminates Cytomegalovirus Infection and Is Controlled by the Viral Mitochondrial Inhibitor of Apoptosis (vMIA)

A. Louise McCormick, Linda Roback, Edward S. Mocarski

PLOS Pathogens: published May 9, 2008 | https://doi.org/10.1371/journal.ppat.1000063

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

Crystal M. Botham, Anica M. Wandler, Karen Guillemin

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000064

Targeting of Pseudorabies Virus Structural Proteins to Axons Requires Association of the Viral Us9 Protein with Lipid Rafts

Mathew G. Lyman, Dusica Curanovic, Lynn W. Enquist

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000065

The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis

Marie Benoit, Eric Ghigo, Christian Capo, Didier Raoult, Jean-Louis Mege

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000066

Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence

Igor E. Brodsky, Ruslan Medzhitov

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000067

Parasite Burden and CD36-Mediated Sequestration Are Determinants of Acute Lung Injury in an Experimental Malaria Model

Fiona E. Lovegrove, Sina A. Gharib, Lourdes Peña-Castillo, Samir N. Patel, John T. Ruzinski, Timothy R. Hughes, W. Conrad Liles, Kevin C. Kain

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000068

Conserved Mosquito/Parasite Interactions Affect Development of Plasmodium falciparum in Africa

Antonio M. Mendes, Timm Schlegelmilch, Anna Cohuet, Parfait Awono-Ambene, Maria De Iorio, Didier Fontenille, Isabelle Morlais, George K. Christophides, Fotis C. Kafatos, Dina Vlachou

PLOS Pathogens: published May 16, 2008 | https://doi.org/10.1371/journal.ppat.1000069

Transmission Blocking Immunity in the Malaria Non-Vector Mosquito Anopheles quadriannulatus Species A

Tibebu Habtewold, Michael Povelones, Andrew M. Blagborough, George K. Christophides

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000070

Role for A-Type Lamins in Herpesviral DNA Targeting and Heterochromatin Modulation

Lindsey Silva, Anna Cliffe, Lynne Chang, David M. Knipe

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000071

Genetic Compatibility and Virulence of Reassortants Derived from Contemporary Avian H5N1 and Human H3N2 Influenza A Viruses

Li-Mei Chen, C. Todd Davis, Hong Zhou, Nancy J. Cox, Ruben O. Donis

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000072

Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA

Vijay R. Gupta, Hetal K. Patel, Sean S. Kostolansky, Roberto A. Ballivian, Joseph Eichberg, Steven R. Blanke

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000073

Proteasomal Degradation of TRIM5α during Retrovirus Restriction

Christopher James Rold, Christopher Aiken

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000074

Intraspecies Transmission of BASE Induces Clinical Dullness and Amyotrophic Changes

Guerino Lombardi, Cristina Casalone, Antonio D' Angelo, Daniela Gelmetti, Gloria Torcoli, Ilaria Barbieri, Cristiano Corona, Elisa Fasoli, Alessia Farinazzo, Michele Fiorini, Matteo Gelati, Barbara Iulini, Fabrizio Tagliavini, Sergio Ferrari, Maria Caramelli, Salvatore Monaco, Lorenzo Capucci, Gianluigi Zanusso

PLOS Pathogens: published May 23, 2008 | https://doi.org/10.1371/journal.ppat.1000075

The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds

Vivien G. Dugan, Rubing Chen, David J. Spiro, Naomi Sengamalay, Jennifer Zaborsky, Elodie Ghedin, Jacqueline Nolting, David E. Swayne, Jonathan A. Runstadler, George M. Happ, Dennis A. Senne, Ruixue Wang, Richard D. Slemons, Edward C. Holmes, Jeffery K. Taubenberger

PLOS Pathogens: published May 30, 2008 | https://doi.org/10.1371/journal.ppat.1000076

Human Metapneumovirus Glycoprotein G Inhibits Innate Immune Responses

Xiaoyong Bao, Tianshuang Liu, Yichu Shan, Kui Li, Roberto P. Garofalo, Antonella Casola

PLOS Pathogens: published May 30, 2008 | https://doi.org/10.1371/journal.ppat.1000077

Trypanosomiasis-Induced B Cell Apoptosis Results in Loss of Protective Anti-Parasite Antibody Responses and Abolishment of Vaccine-Induced Memory Responses

Magdalena Radwanska, Patrick Guirnalda, Carl De Trez, Bernard Ryffel, Samuel Black, Stefan Magez

PLOS Pathogens: published May 30, 2008 | https://doi.org/10.1371/journal.ppat.1000078

Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP

Danijela Koppers-Lalic, Marieke C. Verweij, Andrea D. Lipińska, Ying Wang, Edwin Quinten, Eric A. Reits, Joachim Koch, Sandra Loch, Marisa Marcondes Rezende, Franz Daus, Krystyna Bieńkowska-Szewczyk, Nikolaus Osterrieder, Thomas C. Mettenleiter, Mirjam H. M. Heemskerk, Robert Tampé, Jacques J. Neefjes, Shafiqul I. Chowdhury, Maaike E. Ressing, Frans A. M. Rijsewijk, Emmanuel J. H. J. Wiertz

PLOS Pathogens: published May 30, 2008 | https://doi.org/10.1371/journal.ppat.1000080

Cover

**Expression of the Helicobacter pylori CagA Protein Disrupts Drosophila Eye Development.**