Table of Contents: April 2012

The spores of Colletotrichum higginsianum germinate on plant surfaces to produce highly specialized cells called appressoria with thick, darkly melanized cell walls. Long-recognized as organs of attachment and penetration, appressoria also function in the focal delivery of secreted effector proteins (see Kleemann et al., doi: 10.1371/journal.ppat.1002643). Transmission electron microscopy reveals a needle-like penetration hypha emerging from a nanoscale pore (200 nm diameter) in the base of the appressorium to puncture the plant cuticle and cell wall.

Image Credit: Richard O'Connell, Max Planck Institute for Plant Breeding Research, Cologne


The Problem of Auto-Correlation in Parasitology

Laura C. Pollitt, Sarah E. Reece, Nicole Mideo, Daniel H. Nussey, Nick Colegrave


The Accessory Genome as a Cradle for Adaptive Evolution in Pathogens

Daniel Croll, Bruce A. McDonald

The Role of Mast Cells in the Defence against Pathogens

Mirjam Urb, Donald C. Sheppard

Fungal Biofilms

Saranna Fanning, Aaron P. Mitchell


Ross, Macdonald, and a Theory for the Dynamics and Control of Mosquito-Transmitted Pathogens

David L. Smith, Katherine E. Battle, Simon I. Hay, Christopher M. Barker, Thomas W. Scott, F. Ellis McKenzie

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Macrophage Activation Associated with Chronic Murine Cytomegalovirus Infection Results in More Severe Experimental Choroidal Neovascularization

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Loss of Anti-Viral Immunity by Infection with a Virus Encoding a Cross-Reactive Pathogenic Epitope

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Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites

Ashfaq Ghumra, Jean-Philippe Semblat, Ricardo Ataide, Carolyne Kifude, Yvonne Adams, Antoine Claessens, Damian N. Anong, Peter C. Bull, Clare Fennell, Monica Arman, Alfred Amambua-Ngwa, Michael Walther, David J. Conway, Lalla Kassambara, Ogobara K. Doumbo, Ahmed Raza, J. Alexandra Rowe

Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein

Mo Li, Isolde Le Trong, Mike A. Carl, Eric T. Larson, Seemay Chou, Justin A. De Leon, Simon L. Dove, Ronald E. Stenkamp, Joseph D. Mougous

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Lia Vassena, Huiyi Miao, Raffaello Cimbro, Mauro S. Malnati, Giulia Cassina, Michael A. Proschan, Vanessa M. Hirsch, Bernard A. Lafont, Michel Morre, Anthony S. Fauci, Paolo Lusso

Interaction of the Trans-Frame Potyvirus Protein P3N-PIPO with Host Protein PCaP1 Facilitates Potyvirus Movement

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TLR4 and NKT Cell Synergy in Immunotherapy against Visceral Leishmaniasis

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Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature

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Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP Levels in Human Monocytes Promoting Acceleration of HIV Co-Infection

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Structural Basis of Cytotoxicity Mediated by the Type III Secretion Toxin ExoU from Pseudomonas aeruginosa

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Airborne Signals from a Wounded Leaf Facilitate Viral Spreading and Induce Antibacterial Resistance in Neighboring Plants

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Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

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