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Table of Contents: May 2017

Vero cells expressing canine SLAM were co-cultured with white blood cells of ferrets. The animals had been inoculated via different routes with recombinant canine distemper viruses expressing the fluorescent proteins Venus, dTom or TagBFP. Systemic virus dissemination in vivo resulted in circulation of single, double- and triple-infected lymphocytes. Morbillivirus isolation in vitro induced formation of multinucleated syncytia of which the cytoplasm was flooded with different combinations of fluorescent reporter proteins. This virus competition model will facilitate identification of factors associated with viral fitness and transmission. Image taken by confocal laser scanning microscopy. de Swart et al.

Image Credit: Rory de Vries, Paul Duprex and Rik de Swart

Pearls

Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay

Larissa F. Paranaiba, Lucélia J. Pinheiro, Ana C. Torrecilhas, Diego H. Macedo, Armando Menezes-Neto, Wagner L. Tafuri, Rodrigo P. Soares

Targeting pathogen sterols: Defence and counterdefence?

Kemal Kazan, Donald M. Gardiner

Hijacked: Co-option of host behavior by entomophthoralean fungi

Andrii P. Gryganskyi, Bradley A. Mullens, Michael T. Gajdeczka, Stephen A. Rehner, Rytas Vilgalys, Ann E. Hajek

Research Articles

Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica

Britta Peters, Johanna Stein, Stefan Klingl, Nathalie Sander, Achim Sandmann, Nicola Taccardi, Heinrich Sticht, Roman G. Gerlach, Yves A. Muller, Michael Hensel

Hepatitis E virus persists in the presence of a type III interferon response

Xin Yin, Xinlei Li, Charuta Ambardekar, Zhimin Hu, Sébastien Lhomme, Zongdi Feng

MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection

Sanjaya Kumar Sahu, Manish Kumar, Sohini Chakraborty, Srijon Kaushik Banerjee, Ranjeet Kumar, Pushpa Gupta, Kuladip Jana, Umesh D. Gupta, Zhumur Ghosh, Manikuntala Kundu, Joyoti Basu

A unique profilin-actin interface is important for malaria parasite motility

Catherine A. Moreau, Saligram P. Bhargav, Hirdesh Kumar, Katharina A. Quadt, Henni Piirainen, Léanne Strauss, Jessica Kehrer, Martin Streichfuss, Joachim P. Spatz, Rebecca C. Wade, Inari Kursula, Friedrich Frischknecht

A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

Matthew Brecher, Zhong Li, Binbin Liu, Jing Zhang, Cheri A. Koetzner, Adham Alifarag, Susan A. Jones, Qishan Lin, Laura D. Kramer, Hongmin Li

Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus

Julia Uebele, Christoph Stein, Minh-Thu Nguyen, Anja Schneider, Franziska Kleinert, Olga Tichá, Gabriele Bierbaum, Friedrich Götz, Isabelle Bekeredjian-Ding

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription

Baca Chan, Vladimir Gonçalves Magalhães, Niels A. W. Lemmermann, Vanda Juranić Lisnić, Markus Stempel, Kendra A. Bussey, Elisa Reimer, Jürgen Podlech, Stefan Lienenklaus, Matthias J. Reddehase, Stipan Jonjić, Melanie M. Brinkmann

Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques

Sydney M. Nguyen, Kathleen M. Antony, Dawn M. Dudley, Sarah Kohn, Heather A. Simmons, Bryce Wolfe, M. Shahriar Salamat, Leandro B. C. Teixeira, Gregory J. Wiepz, Troy H. Thoong, Matthew T. Aliota, Andrea M. Weiler, Gabrielle L. Barry, Kim L. Weisgrau, Logan J. Vosler, Mariel S. Mohns, Meghan E. Breitbach, Laurel M. Stewart, Mustafa N. Rasheed, Christina M. Newman, Michael E. Graham, Oliver E. Wieben, Patrick A. Turski, Kevin M. Johnson, Jennifer Post, Jennifer M. Hayes, Nancy Schultz-Darken, Michele L. Schotzko, Josh A. Eudailey, Sallie R. Permar, Eva G. Rakasz, Emma L. Mohr, Saverio Capuano III, Alice F. Tarantal, Jorge E. Osorio, Shelby L. O’Connor, Thomas C. Friedrich, David H. O’Connor, Thaddeus G. Golos

A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

Alison F. Feder, Christopher Kline, Patricia Polacino, Mackenzie Cottrell, Angela D. M. Kashuba, Brandon F. Keele, Shiu-Lok Hu, Dmitri A. Petrov, Pleuni S. Pennings, Zandrea Ambrose

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration

Víctor González-Motos, Carina Jürgens, Birgit Ritter, Kai A. Kropp, Verónica Durán, Olav Larsen, Anne Binz, Werner J. D. Ouwendijk, Tihana Lenac Rovis, Stipan Jonjic, Georges M. G. M. Verjans, Beate Sodeik, Thomas Krey, Rudolf Bauerfeind, Thomas F. Schulz, Benedikt B. Kaufer, Ulrich Kalinke, Amanda E. I. Proudfoot, Mette M. Rosenkilde, Abel Viejo-Borbolla

Elevated catalase expression in a fungal pathogen is a double-edged sword of iron

Arnab Pradhan, Carmen Herrero-de-Dios, Rodrigo Belmonte, Susan Budge, Angela Lopez Garcia, Aljona Kolmogorova, Keunsook K. Lee, Brennan D. Martin, Antonio Ribeiro, Attila Bebes, Raif Yuecel, Neil A. R. Gow, Carol A. Munro, Donna M. MacCallum, Janet Quinn, Alistair J. P. Brown

Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition

Sarah L. Sherrington, Eleanor Sorsby, Nabeel Mahtey, Pizga Kumwenda, Megan D. Lenardon, Ian Brown, Elizabeth R. Ballou, Donna M. MacCallum, Rebecca A. Hall

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R. Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

Jae-Hoon Kim, Min-Eun Park, Chamilani Nikapitiya, Tae-Hwan Kim, Md Bashir Uddin, Hyun-Cheol Lee, Eunhee Kim, Jin Yeul Ma, Jae U. Jung, Chul-Joong Kim, Jong-Soo Lee

Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection

Mathieu Iampietro, Patrick Younan, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Rodrigo I. Santos, Richard A. Koup, Michael G. Katze, Alexander Bukreyev

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection

Bridgette M. Cumming, Md. Aejazur Rahman, Dirk A. Lamprecht, Kyle H. Rohde, Vikram Saini, John H. Adamson, David G. Russell, Adrie J. C. Steyn

Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection

Emily M. Eshleman, Christine Delgado, Staci J. Kearney, Rachel S. Friedman, Laurel L. Lenz

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

Som Gowda Nanjappa, Andrew J. McDermott, J. Scott Fites, Kevin Galles, Marcel Wüthrich, George S. Deepe Jr., Bruce S. Klein

Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants

Andrea Introini, Stéphanie Boström, Frideborg Bradley, Anna Gibbs, Axel Glaessgen, Annelie Tjernlund, Kristina Broliden

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

Monique Ramos de Oliveira Trugilho, Eugenio Damaceno Hottz, Giselle Villa Flor Brunoro, André Teixeira-Ferreira, Paulo Costa Carvalho, Gustavo Adolfo Salazar, Guy A. Zimmerman, Fernando A. Bozza, Patrícia T. Bozza, Jonas Perales

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D

An Li, Guangwen Lu, Jianxun Qi, Lili Wu, Kegong Tian, Tingrong Luo, Yi Shi, Jinghua Yan, George F. Gao

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

Wei Zhang, Ben A. Bailey-Elkin, Robert C. M. Knaap, Baldeep Khare, Tim J. Dalebout, Garrett G. Johnson, Puck B. van Kasteren, Nigel J. McLeish, Jun Gu, Wenguang He, Marjolein Kikkert, Brian L. Mark, Sachdev S. Sidhu

Promiscuous signaling by a regulatory system unique to the pandemic PMEN1 pneumococcal lineage

Anagha Kadam, Rory A. Eutsey, Jason Rosch, Xinyu Miao, Mark Longwell, Wenjie Xu, Carol A. Woolford, Todd Hillman, Anfal Shakir Motib, Hasan Yesilkaya, Aaron P. Mitchell, N. Luisa Hiller

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, María-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen M. O’Hare

Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes

Faye H. Rodgers, Mathilde Gendrin, Claudia A. S. Wyer, George K. Christophides

UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication

Peng-Nien Huang, Jia-Rong Jheng, Jamie J. Arnold, Jen-Ren Wang, Craig E. Cameron, Shin-Ru Shih

Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni

Xiao-Jun Wu, Nathalie Dinguirard, Grzegorz Sabat, Hong-di Lui, Laura Gonzalez, Michael Gehring, Utibe Bickham-Wright, Timothy P. Yoshino

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium

Christin Friedrich, Panagiota Mamareli, Sophie Thiemann, Friederike Kruse, Zuobai Wang, Bernhard Holzmann, Till Strowig, Tim Sparwasser, Matthias Lochner

Structural insights into reptarenavirus cap-snatching machinery

Maria Rosenthal, Nadja Gogrefe, Dominik Vogel, Juan Reguera, Bianka Rauschenberger, Stephen Cusack, Stephan Günther, Sophia Reindl

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

Benjamin Krämer, Felix Goeser, Philipp Lutz, Andreas Glässner, Christoph Boesecke, Carolynne Schwarze-Zander, Dominik Kaczmarek, Hans Dieter Nischalke, Vittorio Branchi, Steffen Manekeller, Robert Hüneburg, Tobias van Bremen, Tobias Weismüller, Christian P. Strassburg, Jürgen K. Rockstroh, Ulrich Spengler, Jacob Nattermann

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence

Amy K. Barczak, Roi Avraham, Shantanu Singh, Samantha S. Luo, Wei Ran Zhang, Mark-Anthony Bray, Amelia E. Hinman, Matthew Thompson, Raymond M. Nietupski, Aaron Golas, Paul Montgomery, Michael Fitzgerald, Roger S. Smith, Dylan W. White, Anna D. Tischler, Anne E. Carpenter, Deborah T. Hung

Structure of Ca2+-binding protein-6 from Entamoeba histolytica and its involvement in trophozoite proliferation regulation

Deepshikha Verma, Aruna Murmu, Samudrala Gourinath, Alok Bhattacharya, Kandala V. R. Chary

Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques

Yongjun Sui, Blake Frey, Yichuan Wang, Rolf Billeskov, Shweta Kulkarni, Katherine McKinnon, Tracy Rourke, Linda Fritts, Christopher J. Miller, Jay A. Berzofsky

Characterization of miR-122-independent propagation of HCV

Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa

Jianfang Li, Matteo M. E. Metruccio, David J. Evans, Suzanne M. J. Fleiszig

Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host

Tejas Bouklas, Luz Alonso-Crisóstomo, Tamás Székely Jr., Elizabeth Diago-Navarro, Erika P. Orner, Kalie Smith, Mansa A. Munshi, Maurizio Del Poeta, Gábor Balázsi, Bettina C. Fries

Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets

Rory D. de Vries, Martin Ludlow, Alwin de Jong, Linda J. Rennick, R. Joyce Verburgh, Geert van Amerongen, Debby van Riel, Peter R. W. A. van Run, Sander Herfst, Thijs Kuiken, Ron A. M. Fouchier, Albert D. M. E. Osterhaus, Rik L. de Swart, W. Paul Duprex

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection

Yao Bian, Shaobin Shang, Sarah Siddiqui, Jie Zhao, Simone A. Joosten, Tom H. M. Ottenhoff, Harvey Cantor, Chyung-Ru Wang

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii

Shaojun Long, Kevin M. Brown, Lisa L. Drewry, Bryan Anthony, Isabelle Q. H. Phan, L. David Sibley

Protein-protein interactions in the RPS4/RRS1 immune receptor complex

Sung Un Huh, Volkan Cevik, Pingtao Ding, Zane Duxbury, Yan Ma, Laurence Tomlinson, Panagiotis F. Sarris, Jonathan D. G. Jones

HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

Yusuke Nakano, Naoko Misawa, Guillermo Juarez-Fernandez, Miyu Moriwaki, Shinji Nakaoka, Takaaki Funo, Eri Yamada, Andrew Soper, Rokusuke Yoshikawa, Diako Ebrahimi, Yuuya Tachiki, Shingo Iwami, Reuben S. Harris, Yoshio Koyanagi, Kei Sato

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

Christine M. Fennessey, Mykola Pinkevych, Taina T. Immonen, Arnold Reynaldi, Vanessa Venturi, Priyanka Nadella, Carolyn Reid, Laura Newman, Leslie Lipkey, Kelli Oswald, William J. Bosche, Matthew T. Trivett, Claes Ohlen, David E. Ott, Jacob D. Estes, Gregory Q. Del Prete, Jeffrey D. Lifson, Miles P. Davenport, Brandon F. Keele

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters

Oliver F. Brandenberg, Carsten Magnus, Peter Rusert, Huldrych F. Günthard, Roland R. Regoes, Alexandra Trkola

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry

Inci Aydin, Ruth Villalonga-Planells, Lilo Greune, Matthew P. Bronnimann, Christine M. Calton, Miriam Becker, Kun-Yi Lai, Samuel K. Campos, M. Alexander Schmidt, Mario Schelhaas

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