September 2014

Immunostaining of Salmonella Typhimurium (red) in small intestinal tissue 4 days after infection of 1-day-old neonate mice. Counterstaining with E-cadherin (white) and Dapi (blue). Magnification x 200. Hornef et al.

Image Credit: Kaiyi Zhang and Mathias Hornef

Viewpoints

Virus Control Goes Epigenetic

Jing-hsiung James Ou

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004370

Opinion

Wolbachia Can Enhance Plasmodium Infection in Mosquitoes: Implications for Malaria Control?

Grant L. Hughes, Ana Rivero, Jason L. Rasgon

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004182

Pearls

Teaching Fido New ModiFICation Tricks

Jonathan W. Cruz, Nancy A. Woychik

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004349

The Role of Iron in Prion Disease and Other Neurodegenerative Diseases

Neena Singh

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004335

The Ins and Outs of Rust Haustoria

Diana P. Garnica, Adnane Nemri, Narayana M. Upadhyaya, John P. Rathjen, Peter N. Dodds

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004329

Prion Strains and Amyloid Polymorphism Influence Phenotypic Variation

Kevin C. Stein, Heather L. True

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004328

Review

Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum

Daniel Bargieri, Vanessa Lagal, Nicole Andenmatten, Isabelle Tardieux, Markus Meissner, Robert Ménard

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004273

Research Articles

Out-of-Sequence Signal 3 as a Mechanism for Virus-Induced Immune Suppression of CD8 T Cell Responses

Stina L. Urban, Raymond M. Welsh

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004357

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

Yue Qin, Mao-Tian Zhou, Ming-Ming Hu, Yun-Hong Hu, Jing Zhang, Lin Guo, Bo Zhong, Hong-Bing Shu

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004358

Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis

Miriam H. P. van Lieshout, Adam A. Anas, Sandrine Florquin, Baidong Hou, Cornelis van't Veer, Alex F. de Vos, Tom van der Poll

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004368

Reorganization of the Endosomal System in Salmonella-Infected Cells: The Ultrastructure of Salmonella-Induced Tubular Compartments

Viktoria Krieger, David Liebl, Yuying Zhang, Roopa Rajashekar, Petr Chlanda, Katrin Giesker, Deepak Chikkaballi, Michael Hensel

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004374

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

Kelly M. Shepardson, Anupam Jhingran, Alayna Caffrey, Joshua J. Obar, Benjamin T. Suratt, Brent L. Berwin, Tobias M. Hohl, Robert A. Cramer

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004378

CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression

Selena Viganò, Riddhima Banga, Florence Bellanger, Céline Pellaton, Alex Farina, Denis Comte, Alexandre Harari, Matthieu Perreau

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004380

Identification and Characterisation of a Hyper-Variable Apoplastic Effector Gene Family of the Potato Cyst Nematodes

Sebastian Eves-van den Akker, Catherine J. Lilley, John T. Jones, Peter E. Urwin

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004391

Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells

Ohad Yogev, Dimitris Lagos, Tariq Enver, Chris Boshoff

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004400

Identification and Functional Expression of a Glutamate- and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish

Isabel Cornejo, Olga Andrini, María Isabel Niemeyer, Vanessa Marabolí, F. Danilo González-Nilo, Jacques Teulon, Francisco V. Sepúlveda, L. Pablo Cid

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004402

Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

Kathryn A. K. Finton, Della Friend, James Jaffe, Mesfin Gewe, Margaret A. Holmes, H. Benjamin Larman, Andrew Stuart, Kevin Larimore, Philip D. Greenberg, Stephen J. Elledge, Leonidas Stamatatos, Roland K. Strong

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004403

Persistence of Virus Reservoirs in ART-Treated SHIV-Infected Rhesus Macaques after Autologous Hematopoietic Stem Cell Transplant

Maud Mavigner, Benjamin Watkins, Benton Lawson, S. Thera Lee, Ann Chahroudi, Leslie Kean, Guido Silvestri

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004406

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

Christopher R. Lupfer, Paras K. Anand, Zhiping Liu, Kate L. Stokes, Peter Vogel, Mohamed Lamkanfi, Thirumala-Devi Kanneganti

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004410

Exploitation of the Complement System by Oncogenic Kaposi's Sarcoma-Associated Herpesvirus for Cell Survival and Persistent Infection

Myung-Shin Lee, Tiffany Jones, Dae-Yong Song, Jae-Hyuk Jang, Jae U. Jung, Shou-Jiang Gao

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004412

MIF Contributes to Trypanosoma brucei Associated Immunopathogenicity Development

Benoît Stijlemans, Lin Leng, Lea Brys, Amanda Sparkes, Liese Vansintjan, Guy Caljon, Geert Raes, Jan Van Den Abbeele, Jo A. Van Ginderachter, Alain Beschin, Richard Bucala, Patrick De Baetselier

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004414

Multivalent Adhesion Molecule 7 Clusters Act as Signaling Platform for Host Cellular GTPase Activation and Facilitate Epithelial Barrier Dysfunction

Jenson Lim, Daniel H. Stones, Catherine Alice Hawley, Charlie Anne Watson, Anne Marie Krachler

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004421

Transgenic Analysis of the Leishmania MAP Kinase MPK10 Reveals an Auto-inhibitory Mechanism Crucial for Stage-Regulated Activity and Parasite Viability

Mathieu Cayla, Najma Rachidi, Olivier Leclercq, Dirk Schmidt-Arras, Heidi Rosenqvist, Martin Wiese, Gerald F. Späth

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004347

The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo

Chris Coward, Olivier Restif, Richard Dybowski, Andrew J. Grant, Duncan J. Maskell, Pietro Mastroeni

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004359

Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans

Linda M. Holland, Markus S. Schröder, Siobhán A. Turner, Heather Taff, David Andes, Zsuzsanna Grózer, Attila Gácser, Lauren Ames, Ken Haynes, Desmond G. Higgins, Geraldine Butler

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004365

Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Wolbachia Strains

Julien Martinez, Ben Longdon, Simone Bauer, Yuk-Sang Chan, Wolfgang J. Miller, Kostas Bourtzis, Luis Teixeira, Francis M. Jiggins

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004369

Functional Fluorescent Protein Insertions in Herpes Simplex Virus gB Report on gB Conformation before and after Execution of Membrane Fusion

John R. Gallagher, Doina Atanasiu, Wan Ting Saw, Matthew J. Paradisgarten, J. Charles Whitbeck, Roselyn J. Eisenberg, Gary H. Cohen

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004373

LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis

Rajiv L. Gaur, Kangning Ren, Antje Blumenthal, Suresh Bhamidi, Sara Gibbs, Mary Jackson, Richard N. Zare, Sabine Ehrt, Joel D. Ernst, Niaz Banaei

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004376

Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function

Armand O. Brown, Beth Mann, Geli Gao, Jane S. Hankins, Jessica Humann, Jonathan Giardina, Paola Faverio, Marcos I. Restrepo, Ganesh V. Halade, Eric M. Mortensen, Merry L. Lindsey, Martha Hanes, Kyle I. Happel, Steve Nelson, Gregory J. Bagby, Jose A. Lorent, Pablo Cardinal, Rosario Granados, Andres Esteban, Claude J. LeSaux, Elaine I. Tuomanen, Carlos J. Orihuela

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004383

Molecular Insights Into the Evolutionary Pathway of Vibrio cholerae O1 Atypical El Tor Variants

Eun Jin Kim, Dokyung Lee, Se Hoon Moon, Chan Hee Lee, Sang Jun Kim, Jae Hyun Lee, Jae Ouk Kim, Manki Song, Bhabatosh Das, John D. Clemens, Jean William Pape, G. Balakrish Nair, Dong Wook Kim

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004384

Crimean-Congo Hemorrhagic Fever Virus Entry into Host Cells Occurs through the Multivesicular Body and Requires ESCRT Regulators

Olena Shtanko, Raisa A. Nikitina, Cengiz Z. Altuntas, Alexander A. Chepurnov, Robert A. Davey

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004390

The CD14⁺CD16⁺ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria

Lis R. V. Antonelli, Fabiana M. S. Leoratti, Pedro A. C. Costa, Bruno C. Rocha, Suelen Q. Diniz, Mauro S. Tada, Dhelio B. Pereira, Andrea Teixeira-Carvalho, Douglas T. Golenbock, Ricardo Gonçalves, Ricardo T. Gazzinelli

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004393

Exploitation of Mycobacterium tuberculosis Reporter Strains to Probe the Impact of Vaccination at Sites of Infection

Neelima Sukumar, Shumin Tan, Bree B. Aldridge, David G. Russell

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004394

MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major

Zhirong Mou, Dong Liu, Ifeoma Okwor, Ping Jia, Kanami Orihara, Jude Ezeh Uzonna

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004396

Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli

Andrea A. Berry, Yi Yang, Natalia Pakharukova, James A. Garnett, Wei-chao Lee, Ernesto Cota, Jan Marchant, Saumendra Roy, Minna Tuittila, Bing Liu, Keith G. Inman, Fernando Ruiz-Perez, Inacio Mandomando, James P. Nataro, Anton V. Zavialov, Steve Matthews

PLOS Pathogens: published September 18, 2014 | https://doi.org/10.1371/journal.ppat.1004404

Evolution of Plastic Transmission Strategies in Avian Malaria

Stéphane Cornet, Antoine Nicot, Ana Rivero, Sylvain Gandon

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004308

Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis

Michael Waisberg, Alvaro Molina-Cruz, Daniella M. Mizurini, Nidhi Gera, Beatriz C. Sousa, Dongying Ma, Ana C. Leal, Tainá Gomes, Michalis Kotsyfakis, José M. C. Ribeiro, Jan Lukszo, Karine Reiter, Stephen F. Porcella, Carlo J. Oliveira, Robson Q. Monteiro, Carolina Barillas-Mury, Susan K. Pierce, Ivo M. B. Francischetti

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004338

The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1

Aurélie Ducroux, Shirine Benhenda, Lise Rivière, O. John Semmes, Monsef Benkirane, Christine Neuveut

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004343

Structural Correlates of Rotavirus Cell Entry

Aliaa H. Abdelhakim, Eric N. Salgado, Xiaofeng Fu, Mithun Pasham, Daniela Nicastro, Tomas Kirchhausen, Stephen C. Harrison

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004355

EhCoactosin Stabilizes Actin Filaments in the Protist Parasite Entamoeba histolytica

Nitesh Kumar, Somlata, Mohit Mazumder, Priyanka Dutta, Sankar Maiti, Samudrala Gourinath

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004362

Strong Epistatic Selection on the RNA Secondary Structure of HIV

Raquel Assis

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004363

Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus pneumoniae β-galactosidase, BgaA

Anirudh K. Singh, Benjamin Pluvinage, Melanie A. Higgins, Ankur B. Dalia, Shireen A. Woodiga, Matthew Flynn, Audrey R. Lloyd, Jeffrey N. Weiser, Keith A. Stubbs, Alisdair B. Boraston, Samantha J. King

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004364

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP^Sc Glycoform and Prion Infectivity

Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra d′Azzo, Ilia V. Baskakov

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004366

Incomplete Deletion of IL-4Rα by LysM^Cre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Kevin M. Vannella, Luke Barron, Lee A. Borthwick, Kristen N. Kindrachuk, Prakash Babu Narasimhan, Kevin M. Hart, Robert W. Thompson, Sandra White, Allen W. Cheever, Thirumalai R. Ramalingam, Thomas A. Wynn

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004372

Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4⁺ and CD8⁺ T Cell Responses in a Process Dependent on IL-10

Parakkal Jovvian George, Rajamanickam Anuradha, Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V. Banurekha, Thomas B. Nutman, Subash Babu

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004375

A New Human 3D-Liver Model Unravels the Role of Galectins in Liver Infection by the Parasite Entamoeba histolytica

Debora B. Petropolis, Daniela M. Faust, Gagan Deep Jhingan, Nancy Guillen

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004381

Functional Characterisation of Germinant Receptors in Clostridium botulinum and Clostridium sporogenes Presents Novel Insights into Spore Germination Systems

Jason Brunt, June Plowman, Duncan J. H. Gaskin, Manoa Itchner, Andrew T. Carter, Michael W. Peck

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004382

Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

Kaiyi Zhang, Aline Dupont, Natalia Torow, Fredrik Gohde, Sara Leschner, Stefan Lienenklaus, Siegfried Weiss, Melanie M. Brinkmann, Mark Kühnel, Michael Hensel, Marcus Fulde, Mathias W. Hornef

PLOS Pathogens: published September 11, 2014 | https://doi.org/10.1371/journal.ppat.1004385

Distinct Dictation of Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality via Triggering TLR3 and TLR4 Signal Pathways

Young Woo Han, Jin Young Choi, Erdenebelig Uyangaa, Seong Bum Kim, Jin Hyoung Kim, Bum Seok Kim, Koanhoi Kim, Seong Kug Eo

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004319

Bacillus Calmette-Guerin Infection in NADPH Oxidase Deficiency: Defective Mycobacterial Sequestration and Granuloma Formation

Christine Deffert, Michela G. Schäppi, Jean-Claude Pache, Julien Cachat, Dominique Vesin, Ruth Bisig, Xiaojuan Ma Mulone, Tiina Kelkka, Rikard Holmdahl, Irene Garcia, Maria L. Olleros, Karl-Heinz Krause

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004325

Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin

Kristin R. Wade, Eileen M. Hotze, David E. Briles, Rodney K. Tweten

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004353

Evidence for a Transketolase-Mediated Metabolic Checkpoint Governing Biotrophic Growth in Rice Cells by the Blast Fungus Magnaporthe oryzae

Jessie Fernandez, Margarita Marroquin-Guzman, Richard A. Wilson

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004354

Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition

Victoria R. Tenge, Anshu P. Gounder, Mayim E. Wiens, Wuyuan Lu, Jason G. Smith

PLOS Pathogens: published September 4, 2014 | https://doi.org/10.1371/journal.ppat.1004360

Corrections

Correction: Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

The PLOS Pathogens Staff

PLOS Pathogens: published September 25, 2014 | https://doi.org/10.1371/journal.ppat.1004476

Correction: Narrow Bottlenecks Affect Pea Seedborne Mosaic Virus Populations during Vertical Seed Transmission but not during Leaf Colonization

The PLOS Pathogens Staff

PLOS Pathogens: published September 23, 2014 | https://doi.org/10.1371/journal.ppat.1004468

Correction: A Molecularly Cloned, Live-Attenuated Japanese Encephalitis Vaccine SA₁₄-14-2 Virus: A Conserved Single Amino Acid in the ij Hairpin of the Viral E Glycoprotein Determines Neurovirulence in Mice

The PLOS Pathogens Staff

PLOS Pathogens: published September 22, 2014 | https://doi.org/10.1371/journal.ppat.1004465

Correction: Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency

The PLOS Pathogens Staff

PLOS Pathogens: published September 5, 2014 | https://doi.org/10.1371/journal.ppat.1004392

Correction: The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses

The PLOS Pathogens Staff

PLOS Pathogens: published September 2, 2014 | https://doi.org/10.1371/journal.ppat.1004408

Cover

Enterocyte invasion and microcolony formation by Salmonella after oral infection of neonate mice.

Viewpoints

Related Articles

Opinion

Pearls

Review

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Corrections

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

**Enterocyte invasion and microcolony formation by Salmonella after oral infection of neonate mice.**