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Current Issue July 2018

08/13/2018

RESEARCH ARTICLE

Scaling up data curation using deep learning: An application to literature triage in genomic variation resources

Manually curating biomedical knowledge from publications is necessary to build a knowledge based service that provides highly precise and organized information to users. The process of retrieving relevant publications for curation, which is also known as document triage, is usually carried out by querying and reading articles in PubMed. 

Image credit: Lee et al.

Scaling up data curation using deep learning: An application to literature triage in genomic variation resources

08/13/2018

RESEARCH ARTICLE

Regulation of Pom cluster dynamics in Myxococcus xanthus


Precise positioning of the cell division site is essential for the correct segregation of the genetic material into the two daughter cells. In the bacterium Myxococcus xanthus, the proteins PomX and PomY form a cluster on the chromosome that performs a biased random walk to midcell and positively regulates cell division there. PomZ, an ATPase, is necessary for tethering of the cluster to the nucleoid and regulates its movement towards midcell.

Image credit: Frey et al.

Regulation of Pom cluster dynamics in Myxococcus xanthus

08/14/2018

RESEARCH ARTICLE

Interplay of multiple pathways and activity-dependent rules in STDP

Hebbian plasticity describes a basic mechanism for synaptic plasticity whereby synaptic weights evolve depending on the relative timing of paired activity of the pre- and postsynaptic neurons. Spike-timing-dependent plasticity (STDP) constitutes a central experimental and theoretical synaptic Hebbian learning rule.

Interplay of multiple pathways and activity-dependent rules in STDP

Image credit: Vignoud et al.

08/09/2018

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