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04/19/2018

software paper

EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos

State-of-the-art light-sheet and confocal microscopes allow recording of entire embryos in 3D and over time (3D+t) for many hours. Here Schott et al. present EmbryoMiner, a new interactive open-source framework suitable for in-depth analyses and comparisons of entire embryos, including an extensive set of trajectory features.

Image credit: Schott et al.

EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos

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Current Issue March 2018

04/16/2018

research article

Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases

In this study, Kaiser et al. present an exhaustive structural analysis of ATP binding motifs. The authors unveil an oppositional implementation of enzyme substrate binding in each aaRS Class. While Class I binds via interactions mediated by backbone hydrogen bonds, Class II uses a pair of arginine residues to establish salt bridges to its ATP ligand. 

Image credit: Kaiser et al.

Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases

04/13/2018

software paper

Biobeam—Multiplexed wave-optical simulations of light-sheet microscopy


Modern microscopes allow us to acquire high quality images of large fields of view. However, this high image quality can only be obtained at the very surface of biological specimens. Here Weigert et al. present a software that allows one to simulate how microscopes record images deep inside scattering biological samples.

Image credit: Weigert et al.

Biobeam—Multiplexed wave-optical simulations of light-sheet microscopy

04/19/2018

research article

Decision making improves sperm chemotaxis in the presence of noise

Chemotaxis is used by sperm cells to find the egg. To measure and compare concentrations, cells count stochastic binding events of signalling molecules that diffuse to cellular receptors. In this paper, Kromer et al. reveal a fundamental relationship between the speed of chemotactic steering and the strength of directional fluctuations that result from the amplification of noise.

Decision making improves sperm chemotaxis in the presence of noise

Image credit: Kromer et al.

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