Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes
Dok7 is a peripheral membrane protein that is associated with the MuSK receptor tyrosine kinase. The mechanism of the Dok7 association with the membrane remains largely unknown. Using multi-scale molecular dynamics simulations, Buyan et al. explore the formation of the Dok7 PH/membrane complex.
Image credit: Buyan et al.