Advertisement

06/22/2017

perspective

Good enough practices in scientific computing


Computers are now essential in all branches of science, but most researchers are never taught the equivalent of basic lab skills for research computing. As a result, data can get lost, and researchers are limited in how effectively they can work with software and data. Wilson et al. presents a set of good computing practices that every researcher can adopt, regardless of their current level of computational skill. 

Image credit: PLOS

Good enough practices in scientific computing

06/22/2017

research article

Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease

Wang et al. propose the use of the diffusion process towards understanding perturbations of brain connectivity. We find that while the dynamics of this process are strongly conserved in healthy subjects, they display significant, interpretable deviations in agenesis of the corpus callosum, one of the most common brain malformations. 

Image credit: Wang et al.

Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease

06/22/2017

research article

Transmembrane helical interactions in the CFTR channel pore

Das et al. employ an integrated computational-experimental approach to construct open and closed state structural models of the cystic fibrosis transmembrane conductance regulator (CFTR), the membrane protein responsible for the genetic disorder Cystic Fibrosis.

Transmembrane helical interactions in the CFTR channel pore

Image credit: Das et al.

06/16/2017

research article

Sensory noise predicts divisive reshaping of receptive fields

Perception involves using incoming sensory signals to infer which objects or features are present in the surroundings. To do this, sensory systems must perform two basic operations: (i) combination of noisy sensory cues, and (ii) competition between different percepts. Chalk et al. show that the optimal form of competition depends on how sensory signals are corrupted by noise.

Sensory noise predicts divisive reshaping of receptive fields

Image credit: Chalk et al.

06/21/2017

plos science wednesday

Reddit AMA


PLOS Medicine author Sarka Lisonkova discusses her recent study showing that mothers over 40 years have increasingly higher rates of adverse health outcomes.

Reddit AMA

Image credit: PLOS

Get new content from PLOS Computational Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Computational Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again