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The use of ambient humidity conditions to improve influenza forecast

November 16, 2017

The use of ambient humidity conditions to improve influenza forecast

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Editors' highlights from the PLOS Computational Biology October 2017 issue

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11/14/2017

research article

A free-boundary model of a motile cell explains turning behavior


To understand shapes and movements of simple motile cells, Nickaeen et al. explore minimal models describing a cell as a two-dimensional actin-myosin gel with a free boundary. The models accounts for actin-myosin contraction balanced by viscous stresses in the actin gel and uniform adhesion. The myosin contraction causes the lamellipodial boundary to retract. 

Image credit: Nickaeen et al.

A free-boundary model of a motile cell explains turning behavior

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Current Issue October 2017

11/13/2017

research article

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

G protein-coupled receptors (GPCRs) are a major target for drug discovery. Coudrat et al. present a novel computational GPCR binding pocket refinement method that can generate predictive GPCR/ligand complexes with improved SBVS performance. This ligand-directed modeling workflow uses parallel processing to search the GPCR/ligand conformational space faster than the widely used protein refinement method molecular dynamics.

Image credit: Coudrat et al.

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

11/16/2017

research article

Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue

The mechanisms leading to ventricular arrhythmias are not fully understood. One hypothesis is that a group of cardiac myocytes spontaneously depolarize at precisely the same moment to excite the surrounding tissue. Walker et al. develop a model spanning the molecular, cellular, and tissue scales that realistically reproduces the mechanisms underlying this hypothesis.

Image credit: Walker et al.

Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue

11/13/2017

research article

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

In the continuous mode of cell culture, a constant flow carrying fresh media replaces cells, nutrients and secreted metabolites. Fernandez-de-Cossio-Diaz et al. present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation. 

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

Image credit: Fernandez-de-Cossio-Diaz et al.

01/27/2006

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