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08/07/2017

research article

A stochastic-field description of finite-size spiking neural networks

Over the last two decades, mean-field theory has brought an important added value to the study of emergent properties of neural circuits. Nonetheless, in the mean-field framework, the thermodynamic limit has to be taken to postulate the number of neurons to be infinite. Doing so, small fluctuations are neglected. Dumont et al. address this issue by showing that the dynamics of finite-size networks can be represented by stochastic partial differential equations. 

Image credit: Mike Seyfang/ Flickr

A stochastic-field description of finite-size spiking neural networks

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08/07/2017

research article

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

Cichonska et al. evaluate the predictive power of a well-established machine learning model in filling the gaps in existing profiling studies and prediction of target interactions for a new drug candidate. Specifically, the authors focus on kinase inhibitors, which form the largest class of new drugs approved for cancer treatment.

Image credit: freestocks.org/ unsplash.com

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

08/08/2017

research article

Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection

Neural circuits are wired by chemotactic migration of growth cones guided by extracellular guidance cue gradients. How growth cone chemotaxis builds the macroscopic structure of the neural circuit is a fundamental question in neuroscience. Honda Naoki addresses this issue in the case of the ordered axonal projections called topographic maps in the retinotectal system.

Image credit: Honda Naoki

Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection

08/09/2017

plos science wednesday

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PLOS ONE author Ben Halpern discusses his study which investigates the health of the ocean of 220 coastal countries and territories worldwide.

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