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Current Issue May 2018

06/11/2018

Research Article

Mechanical positioning of multiple nuclei in muscle cells

Manhart et al. use a combination of rough interacting particle and detailed agent-based modeling to examine computationally the hypothesis that a force balance generated by microtubules positions the muscle nuclei. Their work suggests that microtubules growing from nuclear envelopes push on the neighboring nuclei and the cell boundaries, which is sufficient to establish the nearly-uniform nuclear spreading observed in muscle fibers.

Image credit: Manhart et al.

Mechanical positioning of multiple nuclei in muscle cells

06/11/2018

Research Article

The effect of cell geometry on polarization in budding yeast

The localization (or polarization) of proteins on the membrane during the mating of budding yeast (Saccharomyces cerevisiae) is an important model system for understanding simple pattern formation within cells. Trogdon et al. set out to elucidate the effect that the geometry of the cell can have on the dynamics of certain models of polarization. They show here that there is a complex interplay between the dynamics of polarization and the shape of the cell.


Image credit: Trogdon et al.

The effect of cell geometry on polarization in budding yeast

06/06/2018

research article

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

The human dopamine transporter efficiently removes the neurotransmitter dopamine from the synaptic cleft. Alteration of dopamine transporter function is associated with several neurological diseases. Here Jayaraman et al. perform a large scale comprehensive computational study on transporter oligomerization to reveal dimer geometries and the residues involved in the interfaces.

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

Image credit: Jayaraman et al.

07/26/2012

Featured Issue Image

Visualization of an ant trail pattern.


This pattern was produced by a colony of Argentine ants after one hour of exploration of an empty area.

Visualization of an ant trail pattern.

Image credit: Andrea Perna, Department of Mathematics, Uppsala University.

06/08/2018

featured collection

PLOS Ebola Channel


A centralised hub for the latest research and updates on the 2018 Ebola virus outbreak in DRC.

PLOS Ebola Channel

Image credit: CDC

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