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Current Issue June 2018

07/09/2018

Research Article

Differential roles of sleep spindles and sleep slow oscillations in memory consolidation

Sleep plays an important role in the consolidation of recent memories. However, the cellular and synaptic mechanisms of consolidation during sleep remain poorly understood. In this study, using a realistic computational model of the thalamocortical network, Wei, Krishnan et al. tested the role of Non-Rapid Eye Movement (NREM) sleep in memory consolidation.

Image credit: Wei, Krishnan et al.

Differential roles of sleep spindles and sleep slow oscillations in memory consolidation

07/12/2018

Research Article

Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection

Treatment of hepatitis C virus (HCV) infection is seeing a paradigm shift with powerful drugs called direct-acting antiviral agents (DAAs) replacing earlier treatments involving interferon (IFN). Venugopal et al. hypothesize here that responsiveness to DAAs and IFN are causally linked. Using a new multiscale mathematical model, they found strong evidence supporting this hypothesis.

Image credit: Venugopal et al.

Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection

04/28/2011

Featured Issue Image

A model of the morphology of the rat vibrissal array.


The rat vibrissal system provides an ideal model to examine how the physical embodiment of a sensory array shapes the sensing process.


A model of the morphology of the rat vibrissal array.

Image credit: Brian Quist, Northwestern University.

12/27/2012

Featured Collection

Translational Bioinformatics


'Translational Bioinformatics' is a collection of articles which reads as a "book" to be used as a reference or tutorial for a graduate level introductory course on the science of translational bioinformatics.

Translational Bioinformatics

Image credit: PLOS.

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