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A mechanism for bistability in glycosylation

August 3, 2018

A mechanism for bistability in glycosylation

Image credit: McDonald et al.

08/07/2018

RESEARCH ARTICLE

Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials

Allosteric regulation has traditionally been described by mathematically-complex allosteric rate laws in the form of ratios of polynomials derived from the application of simplifying kinetic assumptions. Alternatively, an approach that explicitly describes all known ligand-binding events requires no simplifying assumptions while allowing for the computation of enzymatic states.

Image credit: Yurkovich et al.

Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials

Recently Published Articles

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Current Issue July 2018

08/03/2018

RESEARCH ARTICLE

Rare-event sampling of epigenetic landscapes and phenotype transitions

Stochastic simulation has been a powerful tool for studying the dynamics of gene regulatory networks, particularly in terms of understanding how cell-phenotype stability and fate-transitions are impacted by noisy gene expression. However, gene networks often have dynamics characterized by multiple attractors.

Rare-event sampling of epigenetic landscapes and phenotype transitions

Image credit: Tse et al.

08/09/2018

RESEARCH ARTICLE

Flexible resonance in prefrontal networks with strong feedback inhibition

Oscillations are ubiquitous features of brain dynamics that undergo task-related changes in synchrony, power, and frequency. In this work, we used a biophysically detailed model of prefrontal cortex (PFC) to explore the effects of varying the spike rate, synchrony, and waveform of strong oscillatory inputs on the behavior of cortical networks driven by them.

Flexible resonance in prefrontal networks with strong feedback inhibition

Image credit: Sherfey et al.

06/29/2018

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2018 EBOLA VIRUS OUTBREAK


A centralised hub for the latest research and updates on the 2018 Ebola virus outbreak in DRC.

2018 EBOLA VIRUS OUTBREAK

Image credit: CDC Global

06/21/2018

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PLOS Computational Biology: Methods

The PLOS Computational Biology Methods Section was launched in 2013 and has given computational method development a dedicated space in the journal.

PLOS Computational Biology: Methods

Image credit: Van Valen et al.

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