March 3, 2016
Image credit: Eric Kilby/ Flickr
02/29/2016
research article
Transcription factor p53 is a pivotal node of a network that governs critical processes of DNA repair, cell cycle arrest, and apoptosis. Hat et al. construct a mathematical model of intact p53 network to understand the dynamics of non-cancerous cells and then cancerous cells by introducing perturbations to the regulatory system.
Image credit: Iyer, Killingback
Current Issue February 2016
02/29/2016
methods paper
Song et al. describe a framework for gradient descent-based training of excitatory-inhibitory RNNs that can incorporate a variety of biological knowledge. The authors provide an implementation for this framework based on the machine learning library Theano.
Image credit: digitalbob8/ Flickr
02/25/2016
Message from iscb
The 16th annual Bioinformatics Open Source Conference (BOSC 2015) was held in Dublin, Ireland, in July 2015. The conference brought together over 125 bioinformatics researchers, developers, and users of open source software. Co-chair of the conference Nomi Harris and colleagues describe the highlights of BOSC 2015, including a panel on 'Increasing Diversity in the Bioinformatics Open Source Community'.
Image credit: Vignesh GP
03/03/2016
research article
Across the animal kingdom, chemical senses play a central role in guiding social behaviors. Kahan and Ben-Shaul investigate how the mouse vomeronasal system detects behaviorally relevant traits from natural stimuli.
Image credit: Yaron Ben-Shaul
02/29/2016
research article
Pan-cancer proteomic datasets from The Cancer Genome Atlas provide a unique opportunity to study the functions of proteins in human cancers. Şenbabaoğlu et al. utilize a high-throughput proteomic dataset from The Cancer Genome Atlas to systematically test different families of network inference methods.
Image credit: Şenbabaoğlu et al.
02/25/2016
research article
The striatum is a major brain structure that is critical for appropriately timing behavior to receive rewards. Angulo-Garcia et al. show that even a simplified model of the striatal network is capable of producing slowly-changing activity sequences.
Image credit: Angulo-Garcia et al.
Image credit: Twitter
03/02/2016
plos science wednesday
Alexander Suh discusses his PLOS Biology paper which evaluates the evolutionary signature of modern birds.
Image credit: Mariano/ Flickr
03/04/2016
featured collection
A new PLOS Collection has been launched which will collate research on zika, an arbovirus infection transmitted by several different species of Aedes mosquitoes.
Image credit: PLOS
Image credit: Matthew Clay
Highlighting some of the latest advancements in computational treatments of macromolecules.
Addresses the ethical challenges that accompany the use of “big data” in biology and medicine.
A collection that aims to increase the coverage of computational biology topics on Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
"Ten Simple Rules" articles provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
This collection is designed to document the progress of the ISCB Student Council, instruct others on planning activities, and encourage students to build and maintain a thriving student community.
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome
Molecular Integrative Clustering of Asian Gastric Cell Lines Revealed Two Distinct Chemosensitivity Clusters
The Hologenome Concept: Helpful or Hollow?
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