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Current Issue May 2016

06/23/2016

perspective

The Context-Dependence of Mutations: A Linkage of Formalisms


The quantitative definitions of epistasis vary among fields, and its analysis beyond just pairwise effects remains problematic. Poelwijk et al. bring together a number of previous results that show that different definitions of epistasis are versions of a single mathematical formalism— the weighted Walsh-Hadamard transform. 

Image credit: Poelwijk et al.

The Context-Dependence of Mutations: A Linkage of Formalisms

06/22/2016

plos science wednesday

Reddit AMA


Professor Damien Keating discusses his PLOS Genetics paper which shows that gene RCAN1 is linked to blood sugar problems in both Type 2 Diabetes and Down Syndrome.

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Image credit: PLOS