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Short Survey

06/18/2018

Research Article

Stochastic shielding and edge importance for Markov chains with timescale separation

Schmidt et al. explore the range of validity of stochastic shielding for processes with nonuniform stationary probabilities and multiple timescales, including ion channels with “bursty” dynamics. We show that stochastic shielding is robust to the introduction of timescale separation, for a class of simple networks, but it can break down for more complex systems with three distinct timescales.

Image credit: Schmidt et al.

Stochastic shielding and edge importance for Markov chains with timescale separation

Recently Published Articles

Current Issue

Current Issue May 2018

06/18/2018

Research Article

Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response

This work proposes a “reverse perturbation” approach for identifying allosteric sites as a result of a perturbation applied to the functional ones. Tee, Guarnera et al. show that considering non-overlapping regulatory and functional sites is a critical prerequisite for the successful detection of allosteric sites.

Image credit: Tee, Guarnera et al.

Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response

06/18/2018

Research Article

Modeling the functions of condensin in chromosome shaping and segregation

Sakai et al. construct a coarse-grained physical model of chromosomal DNA and condensins. They assume that condensins have two molecular activities: consecutive loop formation in DNA and inter-condensin attractions. Their simulation demonstrates that both of these activities and their balancing acts are essential for the efficient shaping and segregation of mitotic chromosomes.

Modeling the functions of condensin in chromosome shaping and segregation

Image credit: Sakai et al.

06/11/2018

Research Article

Mechanical positioning of multiple nuclei in muscle cells

Manhart et al. use a combination of rough interacting particle and detailed agent-based modeling to examine computationally the hypothesis that a force balance generated by microtubules positions the muscle nuclei. Their work suggests that microtubules growing from nuclear envelopes push on the neighboring nuclei and the cell boundaries.

Mechanical positioning of multiple nuclei in muscle cells

Image credit: Manhart et al.

06/15/2018

Research article

Classification of red blood cell shapes in flow using outlier tolerant machine learning

The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating RBCs in microcapillary Poiseuille flow, Kihm et al. overcome this drawback by introducing a convolutional neural regression network for an automatic, outlier tolerant shape classification.

Classification of red blood cell shapes in flow using outlier tolerant machine learning

Image credit: Kihm et al.

04/25/2008

Featured Issue Image

A leaf's venation pattern


Image of a Miconia sp. leaf, from Ilha Grande, Brazil. Some features shared by all angiosperm leaves can be observed.

A leaf's venation pattern

Image credit: Image by M.F. Laguna.

06/08/2018

featured collection

PLOS Ebola Channel


A centralised hub for the latest research and updates on the 2018 Ebola virus outbreak in DRC.

PLOS Ebola Channel

Image credit: CDC

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