The small dorsal root ganglion (DRG) neurons of the bladder carry information related to pain from the bladder to the spinal cord. The level of electrical activity of these neurons is generally low but rises in abnormal conditions such as bladder inflammation or spinal cord injury. To investigate the reasons for this hyperactivity, Mandge et al. construct a model of the bladder small DRG neuron soma including its membrane ion channels and intracellular Ca2+ dynamics.
Image credit: Mandge et al.