Table of Contents: December 2009

Since its discovery in 1945, enteropathogenic Escherichia coli (EPEC) has been considered an extracellular pathogen, which triggers formation of actin-rich pedestal-like structures at the bacterial attachment site. Richard Bulgin et al. discovered a novel category of invasive EPEC. EPEC (blue) invasion via membrane ruffles (red) is dependent on the type III secretion system effector EspT and activation of Rac1 and Wave2. Invasive bacteria reside within an EPEC-containing vacuole (ECV) and trigger formation of intracellular actin pedestals that are essential for intracellular survival/multiplication (see Bulgin et al., doi:10.1371/journal.ppat.1000683).

Image Credit: Richard Bulgin, Centre for Molecular Microbiology and Infection, Imperial College London


Expanding the Paradigms of Plant Pathogen Life History and Evolution of Parasitic Fitness beyond Agricultural Boundaries

Cindy E. Morris, Marc Bardin, Linda L. Kinkel, Benoit Moury, Philippe C. Nicot, David C. Sands


The Inflammasomes

Mohamed Lamkanfi, Vishva M. Dixit


Research Articles

RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis

Kelly E. Coller, Kristi L. Berger, Nicholas S. Heaton, Jacob D. Cooper, Rosa Yoon, Glenn Randall

Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice

Lin Lin, Ashraf S. Ibrahim, Xin Xu, Joshua M. Farber, Valentina Avanesian, Beverlie Baquir, Yue Fu, Samuel W. French, John E. Edwards Jr., Brad Spellberg

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

Christopher T. Price, Souhaila Al-Khodor, Tasneem Al-Quadan, Marina Santic, Fabien Habyarimana, Awdhesh Kalia, Yousef Abu Kwaik

A Unique Role for the Host ESCRT Proteins in Replication of Tomato bushy stunt virus

Daniel Barajas, Yi Jiang, Peter D. Nagy

Three Dimensional Structure of the MqsR:MqsA Complex: A Novel TA Pair Comprised of a Toxin Homologous to RelE and an Antitoxin with Unique Properties

Breann L. Brown, Simina Grigoriu, Younghoon Kim, Jennifer M. Arruda, Andrew Davenport, Thomas K. Wood, Wolfgang Peti, Rebecca Page

Analysis of FOXP3+ Regulatory T Cells That Display Apparent Viral Antigen Specificity during Chronic Hepatitis C Virus Infection

Shuo Li, Stefan Floess, Alf Hamann, Silvana Gaudieri, Andrew Lucas, Margaret Hellard, Stuart Roberts, Geza Paukovic, Magdalena Plebanski, Bruce E. Loveland, Campbell Aitken, Simon Barry, Louis Schofield, Eric J. Gowans

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