HIV infection of dendritic cells and other cells of myeloid lineage provides a potent reservoir from which HIV can later seed CD4 T cells. In dissecting the mechanisms of viral transfer from HIV-infected dendritic cells to CD4 T cells, a dynamic structure consisting of newly formed HIV virions being launched by probing filopodia was observed (see Aggarwal et al., doi:10.1371/journal.ppat.1002762). HIV incorporation into the tips of dendritic cell filopodia is observed in the image, with HIV particles in white and filopodial networks in red visualised by F-actin staining. Nuclear staining by DAPI is presented in blue.
Image Credit: Anupriya Aggarwal and Stuart Turville, Kirby Institute, University of New South Wales
Opinion
Protecting against Pneumococcal Disease: Critical Interactions between Probiotics and the Airway Microbiome
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002652
Pearls
How Do Viruses Interact with Stress-Associated RNA Granules?
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002741
Malassezia Fungi Are Specialized to Live on Skin and Associated with Dandruff, Eczema, and Other Skin Diseases
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002701
Review
Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002676
Research Articles
The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002753
Large Scale Genotype Comparison of Human Papillomavirus E2-Host Interaction Networks Provides New Insights for E2 Molecular Functions
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002761
Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002766
Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002767
GogB Is an Anti-Inflammatory Effector that Limits Tissue Damage during Salmonella Infection through Interaction with Human FBXO22 and Skp1
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002773
Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002777
Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002780
The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002784
An Endogenous Foamy-like Viral Element in the Coelacanth Genome
PLOS Pathogens: published June 28, 2012 | https://doi.org/10.1371/journal.ppat.1002790
Structural and Functional Insights into the Malaria Parasite Moving Junction Complex
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002755
Polyfunctional Type-1, -2, and -17 CD8+ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002759
The Link between Morphotype Transition and Virulence in Cryptococcus neoformans
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002765
Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002769
A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002774
Related Articles
Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002776
Related Articles
Highly Efficient Prion Transmission by Blood Transfusion
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002782
Molecular Inferences Suggest Multiple Host Shifts of Rabies Viruses from Bats to Mesocarnivores in Arizona during 2001–2009
PLOS Pathogens: published June 21, 2012 | https://doi.org/10.1371/journal.ppat.1002786
Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002732
Synergistic Parasite-Pathogen Interactions Mediated by Host Immunity Can Drive the Collapse of Honeybee Colonies
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002735
DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002736
HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002739
The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002743
A High-Resolution View of Genome-Wide Pneumococcal Transformation
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002745
Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002751
African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002754
Role of the Group B Antigen of Streptococcus agalactiae: A Peptidoglycan-Anchored Polysaccharide Involved in Cell Wall Biogenesis
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002756
The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002760
Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002763
The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002764
Tomato TFT1 Is Required for PAMP-Triggered Immunity and Mutations that Prevent T3S Effector XopN from Binding to TFT1 Attenuate Xanthomonas Virulence
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002768
Opposing Regulation of PROX1 by Interleukin-3 Receptor and NOTCH Directs Differential Host Cell Fate Reprogramming by Kaposi Sarcoma Herpes Virus
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002770
Related Articles
Evidence for Induction of Integron-Based Antibiotic Resistance by the SOS Response in a Clinical Setting
PLOS Pathogens: published June 14, 2012 | https://doi.org/10.1371/journal.ppat.1002778
Pathogen-Mediated Proteolysis of the Cell Death Regulator RIPK1 and the Host Defense Modulator RIPK2 in Human Aortic Endothelial Cells
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002723
Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002727
Cytomegalovirus Replicon-Based Regulation of Gene Expression In Vitro and In Vivo
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002728
Evolution of Salmonella enterica Virulence via Point Mutations in the Fimbrial Adhesin
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002733
Anopheles Imd Pathway Factors and Effectors in Infection Intensity-Dependent Anti-Plasmodium Action
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002737
3D Reconstruction of VZV Infected Cell Nuclei and PML Nuclear Cages by Serial Section Array Scanning Electron Microscopy and Electron Tomography
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002740
Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002744
Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002746
Human Herpesvirus 8 Interferon Regulatory Factor-Mediated BH3-Only Protein Inhibition via Bid BH3-B Mimicry
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002748
Circulating Microbial Products and Acute Phase Proteins as Markers of Pathogenesis in Lymphatic Filarial Disease
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002749
Molecular and Electrophysiological Characterization of a Novel Cation Channel of Trypanosoma cruzi
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002750
Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002752
Identification of a General O-linked Protein Glycosylation System in Acinetobacter baumannii and Its Role in Virulence and Biofilm Formation
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002758
Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells
PLOS Pathogens: published June 7, 2012 | https://doi.org/10.1371/journal.ppat.1002762