Parasites interfere with the assembly of chromatin remodeling complexes and histone acetylation at STAT1-regulated promoters. Histone deacetylase inhibitors can rescue Toxoplasma-infected macrophages from unresponsiveness to IFN-γ (see Lang et al., doi:10.1371/journal.ppat.1002483). The inhibition of IFN-γ-induced MHC class II expression (green fluorescence) after infection of macrophages with T. gondii (blue fluorescence) is shown by confocal microscopy; total cells were stained with propidium iodide (red stain).
Image Credit: Carsten Lüder, University Medical Center Göttingen
Opinions
How “Humane” Is Your Endpoint?—Refining the Science-Driven Approach for Termination of Animal Studies of Chronic Infection
PLOS Pathogens: published January 19, 2012 | https://doi.org/10.1371/journal.ppat.1002399
Type 1 Interferons and Antiviral CD8 T-Cell Responses
PLOS Pathogens: published January 5, 2012 | https://doi.org/10.1371/journal.ppat.1002352
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Sexual Development in Plasmodium: Lessons from Functional Analyses
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Sequence Divergent RXLR Effectors Share a Structural Fold Conserved across Plant Pathogenic Oomycete Species
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Zebrafish: A See-Through Host and a Fluorescent Toolbox to Probe Host–Pathogen Interaction
PLOS Pathogens: published January 5, 2012 | https://doi.org/10.1371/journal.ppat.1002349
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Systems Biology Approaches Reveal a Specific Interferon-Inducible Signature in HTLV-1 Associated Myelopathy
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The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines
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IL-10R Blockade during Chronic Schistosomiasis Mansoni Results in the Loss of B Cells from the Liver and the Development of Severe Pulmonary Disease
PLOS Pathogens: published January 26, 2012 | https://doi.org/10.1371/journal.ppat.1002490
The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture
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