Papillomaviruses Use Recombination-Dependent Replication to Vegetatively Amplify Their Genomes in Differentiated Cells

Nozomi Sakakibara, Dan Chen, Alison A. McBride

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003321

Signalling C-Type Lectins in Antimicrobial Immunity

Rebecca A. Drummond, Gordon D. Brown

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003417

Pertussis: Challenges Today and for the Future

James D. Cherry

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003418

It's No Fluke: The Planarian as a Model for Understanding Schistosomes

James J. Collins III, Phillip A. Newmark

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003396

Babesia: An Emerging Infectious Threat in Transfusion Medicine

Cheryl A. Lobo, Jeny R. Cursino-Santos, Andy Alhassan, Marilis Rodrigues

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003387

Stress Relief during Host Infection: The Phage Shock Protein Response Supports Bacterial Virulence in Various Ways

Andrew J. Darwin

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003388

Emerging Infectious Diseases: Threats to Human Health and Global Stability

David M. Morens, Anthony S. Fauci

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003467

Tripping on Acid: Trans-Kingdom Perspectives on Biological Acids in Immunity and Pathogenesis

Michael F. Criscitiello, Martin B. Dickman, James E. Samuel, Paul de Figueiredo

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003402

A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity

Jan Balzarini, Graciela Andrei, Emanuela Balestra, Dana Huskens, Christophe Vanpouille, Andrea Introini, Sonia Zicari, Sandra Liekens, Robert Snoeck, Antonín Holý, Carlo-Federico Perno, Leonid Margolis, Dominique Schols

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003456

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex

Felicia M. Wagner, Ilija Brizic, Adrian Prager, Tihana Trsan, Maja Arapovic, Niels A. W. Lemmermann, Jürgen Podlech, Matthias J. Reddehase, Frederic Lemnitzer, Jens Bernhard Bosse, Martina Gimpfl, Lisa Marcinowski, Margaret MacDonald, Heiko Adler, Ulrich H. Koszinowski, Barbara Adler

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003493

Genomic Analysis of the Kiwifruit Pathogen Pseudomonas syringae pv. actinidiae Provides Insight into the Origins of an Emergent Plant Disease

Honour C. McCann, Erik H. A. Rikkerink, Frederic Bertels, Mark Fiers, Ashley Lu, Jonathan Rees-George, Mark T. Andersen, Andrew P. Gleave, Bernhard Haubold, Mark W. Wohlers, David S. Guttman, Pauline W. Wang, Christina Straub, Joel Vanneste, Paul B. Rainey, Matthew D. Templeton

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003503

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A Product of Heme Catabolism Modulates Bacterial Function and Survival

Christopher L. Nobles, Sabrina I. Green, Anthony W. Maresso

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003507

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

Aravindan Ilangovan, Matthew Fletcher, Giordano Rampioni, Christian Pustelny, Kendra Rumbaugh, Stephan Heeb, Miguel Cámara, Alex Truman, Siri Ram Chhabra, Jonas Emsley, Paul Williams

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003508

In Vivo Adaptation and Persistence of Neisseria meningitidis within the Nasopharyngeal Mucosa

Kay O. Johswich, Shannon E. McCaw, Epshita Islam, Anna Sintsova, Angel Gu, John E. Shively, Scott D. Gray-Owen

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003509

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

Yorihiro Nishimura, Hyunwook Lee, Susan Hafenstein, Chikako Kataoka, Takaji Wakita, Jeffrey M. Bergelson, Hiroyuki Shimizu

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003511

Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls

Paul J. McLaren, Cédric Coulonges, Stephan Ripke, Leonard van den Berg, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Judith Dalmau, Steven G. Deeks, Olivier Delaneau, Andrea De Luca, James J. Goedert, David Haas, Joshua T. Herbeck, Sekar Kathiresan, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M. Miro, James I. Mullins, Niels Obel, Stephen J. O'Brien, Florencia Pereyra, Francis A. Plummer, Guido Poli, Ying Qi, Pierre Rucart, Manj S. Sandhu, Patrick R. Shea, Hanneke Schuitemaker, Ioannis Theodorou, Fredrik Vannberg, Jan Veldink, Bruce D. Walker, Amy Weintrob, Cheryl A. Winkler, Steven Wolinsky, Amalio Telenti, David B. Goldstein, Paul I. W. de Bakker, Jean-François Zagury, Jacques Fellay

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003515

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity

Amit P. Bhavsar, Nat F. Brown, Jan Stoepel, Marcel Wiermer, Dale D. O. Martin, Karolynn J. Hsu, Koshi Imami, Colin J. Ross, Michael R. Hayden, Leonard J. Foster, Xin Li, Phil Hieter, B. Brett Finlay

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003518

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Muhamuda Kader, Amanda P. Smith, Cristiana Guiducci, Elizabeth R. Wonderlich, Daniel Normolle, Simon C. Watkins, Franck J. Barrat, Simon M. Barratt-Boyes

PLOS Pathogens: published July 25, 2013 | https://doi.org/10.1371/journal.ppat.1003530

HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

Elizabeth A. Berger, Sharon A. McClellan, Kerry S. Vistisen, Linda D. Hazlett

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003457

Endothelial Cell Permeability during Hantavirus Infection Involves Factor XII-Dependent Increased Activation of the Kallikrein-Kinin System

Shannon L. Taylor, Victoria Wahl-Jensen, Anna Maria Copeland, Peter B. Jahrling, Connie S. Schmaljohn

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003470

Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8⁺ T-Cell Exhaustion

Myeong Sup Lee, Chan Hee Park, Yun Hee Jeong, Young-Joon Kim, Sang-Jun Ha

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003478

Mechanism of HIV-1 Virion Entrapment by Tetherin

Siddarth Venkatesh, Paul D. Bieniasz

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003483

Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies

Pauline E. Chugh, Sang-Hoon Sin, Sezgin Ozgur, David H. Henry, Prema Menezes, Jack Griffith, Joseph J. Eron, Blossom Damania, Dirk P. Dittmer

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003484

Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1

Oliver I. Fregoso, Jinwoo Ahn, Chuanping Wang, Jennifer Mehrens, Jacek Skowronski, Michael Emerman

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003496

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity

Jim Sun, Vijender Singh, Alice Lau, Richard W. Stokes, Andrés Obregón-Henao, Ian M. Orme, Dennis Wong, Yossef Av-Gay, Zakaria Hmama

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003499

The Footprint of Genome Architecture in the Largest Genome Expansion in RNA Viruses

Chris Lauber, Jelle J. Goeman, Maria del Carmen Parquet, Phan Thi Nga, Eric J. Snijder, Kouichi Morita, Alexander E. Gorbalenya

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003500

Cytotoxic T Cells Mediate Pathology and Metastasis in Cutaneous Leishmaniasis

Fernanda O. Novais, Lucas P. Carvalho, Joel W. Graff, Daniel P. Beiting, Gordon Ruthel, David S. Roos, Michael R. Betts, Michael H. Goldschmidt, Mary E. Wilson, Camila I. de Oliveira, Phillip Scott

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003504

EphrinA2 Regulates Clathrin Mediated KSHV Endocytosis in Fibroblast Cells by Coordinating Integrin-Associated Signaling and c-Cbl Directed Polyubiquitination

Dipanjan Dutta, Sayan Chakraborty, Chirosree Bandyopadhyay, Mohanan Valiya Veettil, Mairaj Ahmed Ansari, Vivek Vikram Singh, Bala Chandran

PLOS Pathogens: published July 18, 2013 | https://doi.org/10.1371/journal.ppat.1003510

Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum

Sixto M. Leal Jr, Sanhita Roy, Chairut Vareechon, Steven deJesus Carrion, Heather Clark, Manuel S. Lopez-Berges, Antonio diPietro, Marcus Schrettl, Nicola Beckmann, Bernhard Redl, Hubertus Haas, Eric Pearlman

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003436

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Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

Patricia Martin, Ingrid Marcq, Giuseppe Magistro, Marie Penary, Christophe Garcie, Delphine Payros, Michèle Boury, Maïwenn Olier, Jean-Philippe Nougayrède, Marc Audebert, Christian Chalut, Sören Schubert, Eric Oswald

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003437

An Acidic Microenvironment Increases NK Cell Killing of Cryptococcus neoformans and Cryptococcus gattii by Enhancing Perforin Degranulation

Anowara Islam, Shu Shun Li, Paul Oykhman, Martina Timm-McCann, Shaunna M. Huston, Danuta Stack, Richard F. Xiang, Margaret M. Kelly, Christopher H. Mody

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003439

The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes

Maciej T. Nogalski, Gary C. T. Chan, Emily V. Stevenson, Donna K. Collins-McMillen, Andrew D. Yurochko

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003463

Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function

T. Tristan Brandhorst, René Roy, Marcel Wüthrich, Som Nanjappa, Hanna Filutowicz, Kevin Galles, Marco Tonelli, Darrell R. McCaslin, Kenneth Satyshur, Bruce Klein

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003464

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

Lee Kozakiewicz, Yong Chen, Jiayong Xu, Yanhua Wang, Kyri Dunussi-Joannopoulos, Qinglin Ou, Joanne L. Flynn, Steven A. Porcelli, William R. Jacobs Jr, John Chan

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003472

Reprogramming of Murine Macrophages through TLR2 Confers Viral Resistance via TRAF3-Mediated, Enhanced Interferon Production

Darren J. Perkins, Swamy K. Polumuri, Meghan E. Pennini, Wendy Lai, Ping Xie, Stefanie N. Vogel

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003479

Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions

Olivia Twu, Natalia de Miguel, Gila Lustig, Grant C. Stevens, Ajay A. Vashisht, James A. Wohlschlegel, Patricia J. Johnson

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003482

IL-22 and IDO1 Affect Immunity and Tolerance to Murine and Human Vaginal Candidiasis

Antonella De Luca, Agostinho Carvalho, Cristina Cunha, Rossana G. Iannitti, Lucia Pitzurra, Gloria Giovannini, Antonella Mencacci, Lorenzo Bartolommei, Silvia Moretti, Cristina Massi-Benedetti, Dietmar Fuchs, Flavia De Bernardis, Paolo Puccetti, Luigina Romani

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003486

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

Ruth Serra-Moreno, Kerstin Zimmermann, Lawrence J. Stern, David T. Evans

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003487

CD40 Activation Rescues Antiviral CD8⁺ T Cells from PD-1-Mediated Exhaustion

Masanori Isogawa, Josan Chung, Yasuhiro Murata, Kazuhiro Kakimi, Francis V. Chisari

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003490

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Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria

Joanne Berghout, David Langlais, Irena Radovanovic, Mifong Tam, John D. MacMicking, Mary M. Stevenson, Philippe Gros

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003491

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Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

Richeng Mao, Hui Nie, Dawei Cai, Jiming Zhang, Hongyan Liu, Ran Yan, Andrea Cuconati, Timothy M. Block, Ju-Tao Guo, Haitao Guo

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003494

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

Pan Tao, Marthandan Mahalingam, Michelle L. Kirtley, Christina J. van Lier, Jian Sha, Linsey A. Yeager, Ashok K. Chopra, Venigalla B. Rao

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003495

Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation

James P. J. Hall, Huanhuan Wang, J. David Barry

PLOS Pathogens: published July 11, 2013 | https://doi.org/10.1371/journal.ppat.1003502

DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis

Scarlet S. Shell, Erin G. Prestwich, Seung-Hun Baek, Rupal R. Shah, Christopher M. Sassetti, Peter C. Dedon, Sarah M. Fortune

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003419

Rapid Perturbation in Viremia Levels Drives Increases in Functional Avidity of HIV-specific CD8 T Cells

Selena Viganò, Felicitas Bellutti Enders, Isabelle Miconnet, Cristina Cellerai, Anne-Laure Savoye, Virginie Rozot, Matthieu Perreau, Mohamed Faouzi, Khalid Ohmiti, Matthias Cavassini, Pierre-Alexandre Bart, Giuseppe Pantaleo, Alexandre Harari

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003423

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

Benoît de Chassey, Anne Aublin-Gex, Alessia Ruggieri, Laurène Meyniel-Schicklin, Fabrine Pradezynski, Nathalie Davoust, Thibault Chantier, Lionel Tafforeau, Philippe-Emmanuel Mangeot, Claire Ciancia, Laure Perrin-Cocon, Ralf Bartenschlager, Patrice André, Vincent Lotteau

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003440

Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis

Berit Carow, Ann-Kathrin Reuschl, Dolores Gavier-Widén, Brendan J. Jenkins, Matthias Ernst, Akihiko Yoshimura, Benedict J. Chambers, Martin E. Rottenberg

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003442

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

Masmudur M. Rahman, Jia Liu, Winnie M. Chan, Stefan Rothenburg, Grant McFadden

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003465

Ethnic Variation in Inflammatory Profile in Tuberculosis

Anna K. Coussens, Robert J. Wilkinson, Vladyslav Nikolayevskyy, Paul T. Elkington, Yasmeen Hanifa, Kamrul Islam, Peter M. Timms, Graham H. Bothamley, Alleyna P. Claxton, Geoffrey E. Packe, Mathina Darmalingam, Robert N. Davidson, Heather J. Milburn, Lucy V. Baker, Richard D. Barker, Francis A. Drobniewski, Charles A. Mein, Leena Bhaw-Rosun, Rosamond A. Nuamah, Christopher J. Griffiths, Adrian R. Martineau

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003468

A Key Role for the Urokinase Plasminogen Activator (uPA) in Invasive Group A Streptococcal Infection

Martina L. Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A. Ploplis, Mark J. Walker, Francis J. Castellino

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003469

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

Suresh Pallikkuth, Luca Micci, Zachary S. Ende, Robin I. Iriele, Barbara Cervasi, Benton Lawson, Colleen S. McGary, Kenneth A. Rogers, James G. Else, Guido Silvestri, Kirk Easley, Jacob D. Estes, Francois Villinger, Savita Pahwa, Mirko Paiardini

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003471

Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the Epidemic

Mélanie Bouvin-Pley, Marion Morgand, Alain Moreau, Pauline Jestin, Claire Simonnet, Laurent Tran, Cécile Goujard, Laurence Meyer, Francis Barin, Martine Braibant

PLOS Pathogens: published July 4, 2013 | https://doi.org/10.1371/journal.ppat.1003477