Scanning electron microscopy image of a Cryptococcus neoformans giant cell isolated from the lung of an infected mouse. The image illustrates one of the most characteristic phenotypic features of giant cells, which is the high density of polysaccharide fibers present in the capsule. This structure presents as a highly cross-linked net, which is accumulated as a very compact layer around the cell body (see Zaragoza et al., doi:10.1371/journal.ppat.1000945).
Image Credit: Oscar Zaragoza, Instituto de Salud Carlos III, Spain, and Albert Einstein College of Medicine, United States of America
Opinions
DNA Watermarking of Infectious Agents: Progress and Prospects
PLOS Pathogens: published June 17, 2010 | https://doi.org/10.1371/journal.ppat.1000950
Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs
PLOS Pathogens: published June 10, 2010 | https://doi.org/10.1371/journal.ppat.1000803
Pearls
Entry and Fusion of Emerging Paramyxoviruses
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000881
Paramyxovirus Entry and Targeted Vectors for Cancer Therapy
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000973
Reviews
Research Articles
EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000957
Protein Expression Redirects Vesicular Stomatitis Virus RNA Synthesis to Cytoplasmic Inclusions
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000958
Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000959
NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000960
The Enteropathogenic E. coli Effector EspF Targets and Disrupts the Nucleolus by a Process Regulated by Mitochondrial Dysfunction
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000961
Formation of Complexes at Plasmodesmata for Potyvirus Intercellular Movement Is Mediated by the Viral Protein P3N-PIPO
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000962
Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000963
Staphylococcus aureus Host Cell Invasion and Virulence in Sepsis Is Facilitated by the Multiple Repeats within FnBPA
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000964
Human Cytomegalovirus UL29/28 Protein Interacts with Components of the NuRD Complex Which Promote Accumulation of Immediate-Early RNA
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000965
Role of PKR and Type I IFNs in Viral Control during Primary and Secondary Infection
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000966
A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs
PLOS Pathogens: published June 24, 2010 | https://doi.org/10.1371/journal.ppat.1000967
Fungal Cell Gigantism during Mammalian Infection
PLOS Pathogens: published June 17, 2010 | https://doi.org/10.1371/journal.ppat.1000945
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Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity
PLOS Pathogens: published June 17, 2010 | https://doi.org/10.1371/journal.ppat.1000953
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Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step
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A Crucial Role for Infected-Cell/Antibody Immune Complexes in the Enhancement of Endogenous Antiviral Immunity by Short Passive Immunotherapy
PLOS Pathogens: published June 10, 2010 | https://doi.org/10.1371/journal.ppat.1000948
Epigenetic Repression of p16INK4A by Latent Epstein-Barr Virus Requires the Interaction of EBNA3A and EBNA3C with CtBP
PLOS Pathogens: published June 10, 2010 | https://doi.org/10.1371/journal.ppat.1000951
Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin
PLOS Pathogens: published June 10, 2010 | https://doi.org/10.1371/journal.ppat.1000952
The SOCS-Box of HIV-1 Vif Interacts with ElonginBC by Induced-Folding to Recruit Its Cul5-Containing Ubiquitin Ligase Complex
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Trypanosoma brucei Modifies the Tsetse Salivary Composition, Altering the Fly Feeding Behavior That Favors Parasite Transmission
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000926
A Staphylococcus aureus Small RNA Is Required for Bacterial Virulence and Regulates the Expression of an Immune-Evasion Molecule
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000927
Serum-Dependent Selective Expression of EhTMKB1-9, a Member of Entamoeba histolytica B1 Family of Transmembrane Kinases
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Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression
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Rotavirus Structural Proteins and dsRNA Are Required for the Human Primary Plasmacytoid Dendritic Cell IFNα Response
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000931
Suppressing Glucose Transporter Gene Expression in Schistosomes Impairs Parasite Feeding and Decreases Survival in the Mammalian Host
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000932
Epithelial p38α Controls Immune Cell Recruitment in the Colonic Mucosa
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The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes
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An RNA Element at the 5′-End of the Poliovirus Genome Functions as a General Promoter for RNA Synthesis
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000936
Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
PLOS Pathogens: published June 3, 2010 | https://doi.org/10.1371/journal.ppat.1000939