Table of Contents: August 2011

Measles virus infects primary human airway epithelial cells and cell lines derived from lung, breast, and colon adenocarcinomas. Microarray analysis of genes expressed in cells susceptible and non-susceptible to measles virus revealed that PVRL4 (Nectin 4) was a viral receptor. This confocal micrograph shows that PVRL4 is localized to adherens junctions as well as the apical surfaces of susceptible MCF7 breast cancer cells. PVRL4 was labeled with anti-PVRL4 antibodies and detected with fluorescent mouse anti-goat antibodies. Nuclei were revealed with TO-PRO-3. Non-susceptible cells failed to express PVRL4. Measles virus may have oncolytic properties against tumors that over-express PVRL4 (see Noyce et al., doi:10.1371/journal.ppat.1002240).

Image Credit: Ryan S. Noyce and Christopher D. Richardson, Department of Microbiology & Immunology, Dalhousie University


Phenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery

Jose F. Garcia-Bustos, Francisco-Javier Gamo


Research Articles

The Plant Pathogen Pseudomonas syringae pv. tomato Is Genetically Monomorphic and under Strong Selection to Evade Tomato Immunity

Rongman Cai, James Lewis, Shuangchun Yan, Haijie Liu, Christopher R. Clarke, Francesco Campanile, Nalvo F. Almeida, David J. Studholme, Magdalen Lindeberg, David Schneider, Massimo Zaccardelli, Joao C. Setubal, Nadia P. Morales-Lizcano, Adriana Bernal, Gitta Coaker, Christy Baker, Carol L. Bender, Scotland Leman, Boris A. Vinatzer

Disruption of PML Nuclear Bodies Is Mediated by ORF61 SUMO-Interacting Motifs and Required for Varicella-Zoster Virus Pathogenesis in Skin

Li Wang, Stefan L. Oliver, Marvin Sommer, Jaya Rajamani, Mike Reichelt, Ann M. Arvin

Viral Infection Induces Expression of Novel Phased MicroRNAs from Conserved Cellular MicroRNA Precursors

Peng Du, Jianguo Wu, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei, Yi Li

Histo-Blood Group Antigens Act as Attachment Factors of Rabbit Hemorrhagic Disease Virus Infection in a Virus Strain-Dependent Manner

Kristina Nyström, Ghislaine Le Gall-Reculé, Paola Grassi, Joana Abrantes, Nathalie Ruvoën-Clouet, Beatrice Le Moullac-Vaidye, Ana M. Lopes, Pedro J. Esteves, Tanja Strive, Stéphane Marchandeau, Anne Dell, Stuart M. Haslam, Jacques Le Pendu

A Novel Persistence Associated EBV miRNA Expression Profile Is Disrupted in Neoplasia

Jin Qiu, Katherine Cosmopoulos, Michiel Pegtel, Erik Hopmans, Paul Murray, Jaap Middeldorp, Michael Shapiro, David A. Thorley-Lawson

Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration

Lihong Zhou, Elena Sokolskaja, Clare Jolly, William James, Sally A. Cowley, Ariberto Fassati

Modulation of NKp30- and NKp46-Mediated Natural Killer Cell Responses by Poxviral Hemagglutinin

Mostafa Jarahian, Manuela Fiedler, André Cohnen, Dominik Djandji, Günter J. Hämmerling, Cornelius Gati, Adelheid Cerwenka, Peter C. Turner, Richard W. Moyer, Carsten Watzl, Hartmut Hengel, Frank Momburg

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein

Ronan Le Goffic, Olivier Leymarie, Christophe Chevalier, Emmanuelle Rebours, Bruno Da Costa, Jasmina Vidic, Delphyne Descamps, Jean-Michel Sallenave, Michel Rauch, Michel Samson, Bernard Delmas

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

Jonathan J. Wilksch, Ji Yang, Abigail Clements, Jacinta L. Gabbe, Kirsty R. Short, Hanwei Cao, Rosalia Cavaliere, Catherine E. James, Cynthia B. Whitchurch, Mark A. Schembri, Mary L. C. Chuah, Zhao-Xun Liang, Odilia L. Wijburg, Adam W. Jenney, Trevor Lithgow, Richard A. Strugnell

Pseudomonas Evades Immune Recognition of Flagellin in Both Mammals and Plants

Bart W. Bardoel, Sjoerd van der Ent, Michiel J. C. Pel, Jan Tommassen, Corné M. J. Pieterse, Kok P. M. van Kessel, Jos A. G. van Strijp

A Communal Bacterial Adhesin Anchors Biofilm and Bystander Cells to Surfaces

Cedric Absalon, Katrina Van Dellen, Paula I. Watnick

Beta-HPV 5 and 8 E6 Promote p300 Degradation by Blocking AKT/p300 Association

Heather L. Howie, Jennifer I. Koop, Joleen Weese, Kristin Robinson, Greg Wipf, Leslie Kim, Denise A. Galloway

Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells

Senta M. Walton, Sanja Mandaric, Nicole Torti, Albert Zimmermann, Hartmut Hengel, Annette Oxenius

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

Ryan S. Noyce, Daniel G. Bondre, Michael N. Ha, Liang-Tzung Lin, Gary Sisson, Ming-Sound Tsao, Christopher D. Richardson

Coordination of KSHV Latent and Lytic Gene Control by CTCF-Cohesin Mediated Chromosome Conformation

Hyojeung Kang, Andreas Wiedmer, Yan Yuan, Erle Robertson, Paul M. Lieberman

Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)

Naoki Sakane, Hye-Sook Kwon, Sara Pagans, Katrin Kaehlcke, Yasuhiro Mizusawa, Masafumi Kamada, Kara G. Lassen, Jonathan Chan, Warner C. Greene, Martina Schnoelzer, Melanie Ott

Anti-Apoptotic Machinery Protects the Necrotrophic Fungus Botrytis cinerea from Host-Induced Apoptotic-Like Cell Death during Plant Infection

Neta Shlezinger, Anna Minz, Yonatan Gur, Ido Hatam, Yasin F. Dagdas, Nicholas J. Talbot, Amir Sharon

Salmonella bongori Provides Insights into the Evolution of the Salmonellae

Maria Fookes, Gunnar N. Schroeder, Gemma C. Langridge, Carlos J. Blondel, Caterina Mammina, Thomas R. Connor, Helena Seth-Smith, Georgios S. Vernikos, Keith S. Robinson, Mandy Sanders, Nicola K. Petty, Robert A. Kingsley, Andreas J. Bäumler, Sean-Paul Nuccio, Inés Contreras, Carlos A. Santiviago, Duncan Maskell, Paul Barrow, Tom Humphrey, Antonino Nastasi, Mark Roberts, Gad Frankel, Julian Parkhill, Gordon Dougan, Nicholas R. Thomson

B Cell Repertoire Analysis Identifies New Antigenic Domains on Glycoprotein B of Human Cytomegalovirus which Are Target of Neutralizing Antibodies

Sonja Pötzsch, Nadja Spindler, Anna-Katharina Wiegers, Tanja Fisch, Pia Rücker, Heinrich Sticht, Nina Grieb, Tina Baroti, Florian Weisel, Thomas Stamminger, Luis Martin-Parras, Michael Mach, Thomas H. Winkler

Association of Human TLR1 and TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants

April Kaur Randhawa, Muki S. Shey, Alana Keyser, Blas Peixoto, Richard D. Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A. Hanekom, Thomas R. Hawn

Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization

Qibo Zhang, Samuel C. Leong, Paul S. McNamara, Ayman Mubarak, Richard Malley, Adam Finn

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

Mirco Schmolke, Balaji Manicassamy, Lindomar Pena, Troy Sutton, Rong Hai, Zsuzsanna T. Varga, Benjamin G. Hale, John Steel, Daniel R. Pérez, Adolfo García-Sastre

Crystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated Oligosaccharides

Dirk M. Reiter, Johnna M. Frierson, Elizabeth E. Halvorson, Takeshi Kobayashi, Terence S. Dermody, Thilo Stehle

Giardia Flagellar Motility Is Not Directly Required to Maintain Attachment to Surfaces

Susan A. House, David J. Richter, Jonathan K. Pham, Scott C. Dawson

Recruitment of the Major Vault Protein by InlK: A Listeria monocytogenes Strategy to Avoid Autophagy

Laurent Dortet, Serge Mostowy, Ascel Samba Louaka, Edith Gouin, Marie-Anne Nahori, Erik A.C. Wiemer, Olivier Dussurget, Pascale Cossart

Related Articles

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Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion

Ivona Pandrea, Thaidra Gaufin, Rajeev Gautam, Jan Kristoff, Daniel Mandell, David Montefiori, Brandon F. Keele, Ruy M. Ribeiro, Ronald S. Veazey, Cristian Apetrei

IL-10 Blocks the Development of Resistance to Re-Infection with Schistosoma mansoni

Mark S. Wilson, Allen W. Cheever, Sandra D. White, Robert W. Thompson, Thomas A. Wynn

Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus

Jie Sun, Amber Cardani, Ashish K. Sharma, Victor E. Laubach, Robert S. Jack, Werner Müller, Thomas J. Braciale

A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes

Meenu Kesarwani, Ronen Hazan, Jianxin He, YokAi Que, Yiorgos Apidianakis, Biliana Lesic, Gaoping Xiao, Valérie Dekimpe, Sylvain Milot, Eric Deziel, François Lépine, Laurence G. Rahme

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