June 2016

False-color electron micrograph depicting bacteria (blue) and the DNA-based trap (yellow). Tran et al.

Image Credit: Tran et al.

Opinion

The Janus-Face of Bacteriophages across Human Body Habitats

Adam Wahida, Klaus Ritter, Hans-Peter Horz

PLOS Pathogens: published June 23, 2016 | https://doi.org/10.1371/journal.ppat.1005634

Pearls

IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses

Emmanuel Stephen-Victor, Helmut Fickenscher, Jagadeesh Bayry

PLOS Pathogens: published June 23, 2016 | https://doi.org/10.1371/journal.ppat.1005624

Impact of the DNA Damage Response on Human Papillomavirus Chromatin

Dipendra Gautam, Cary A. Moody

PLOS Pathogens: published June 16, 2016 | https://doi.org/10.1371/journal.ppat.1005613

Immune Sensing of Lipopolysaccharide in Plants and Animals: Same but Different

Stefanie Ranf

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005596

Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections

Bryan R. Coad, Hans J. Griesser, Anton Y. Peleg, Ana Traven

PLOS Pathogens: published June 2, 2016 | https://doi.org/10.1371/journal.ppat.1005598

Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy

Kelly K. Lee, Long Gui

PLOS Pathogens: published June 30, 2016 | https://doi.org/10.1371/journal.ppat.1005625

Lessons from Nature: Understanding Immunity to HCV to Guide Vaccine Design

Zachary T. Freeman, Andrea L. Cox

PLOS Pathogens: published June 30, 2016 | https://doi.org/10.1371/journal.ppat.1005632

Research Matters

Lessons from Reverse Translation

Adam S. Lauring

PLOS Pathogens: published June 16, 2016 | https://doi.org/10.1371/journal.ppat.1005516

The Importance of Role Models in Research

James B. Bliska

PLOS Pathogens: published June 2, 2016 | https://doi.org/10.1371/journal.ppat.1005426

Research Articles

TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response

Raquel Espín-Palazón, Alicia Martínez-López, Francisco J. Roca, Azucena López-Muñoz, Sylwia D. Tyrkalska, Sergio Candel, Diana García-Moreno, Alberto Falco, José Meseguer, Amparo Estepa, Victoriano Mulero

PLOS Pathogens: published June 28, 2016 | https://doi.org/10.1371/journal.ppat.1005699

Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody

Ning Chai, Lee R. Swem, Mike Reichelt, Haiyin Chen-Harris, Elizabeth Luis, Summer Park, Ashley Fouts, Patrick Lupardus, Thomas D. Wu, Olga Li, Jacqueline McBride, Michael Lawrence, Min Xu, Man-Wah Tan

PLOS Pathogens: published June 28, 2016 | https://doi.org/10.1371/journal.ppat.1005702

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

Francesca R. Cianfanelli, Juliana Alcoforado Diniz, Manman Guo, Virginia De Cesare, Matthias Trost, Sarah J. Coulthurst

PLOS Pathogens: published June 28, 2016 | https://doi.org/10.1371/journal.ppat.1005735

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

Mohsin Khan, Gulam Hussain Syed, Seong-Jun Kim, Aleem Siddiqui

PLOS Pathogens: published June 27, 2016 | https://doi.org/10.1371/journal.ppat.1005693

An Epstein-Barr Virus-Encoded Protein Complex Requires an Origin of Lytic Replication In Cis to Mediate Late Gene Transcription

Reza Djavadian, Ya-Fang Chiu, Eric Johannsen

PLOS Pathogens: published June 27, 2016 | https://doi.org/10.1371/journal.ppat.1005718

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α₄β₇ and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

Géraldine Arrode-Brusés, Diana Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, Elena Martinelli

PLOS Pathogens: published June 27, 2016 | https://doi.org/10.1371/journal.ppat.1005720

Lytic Promoters Express Protein during Herpes Simplex Virus Latency

Tiffany A. Russell, David C. Tscharke

PLOS Pathogens: published June 27, 2016 | https://doi.org/10.1371/journal.ppat.1005729

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

Anna A. Müller, Tamas Dolowschiak, Mikael E. Sellin, Boas Felmy, Carolin Verbree, Sandra Gadient, Alexander J. Westermann, Jörg Vogel, Salome LeibundGut-Landmann, Wolf-Dietrich Hardt

PLOS Pathogens: published June 24, 2016 | https://doi.org/10.1371/journal.ppat.1005723

Escaping Underground Nets: Extracellular DNases Degrade Plant Extracellular Traps and Contribute to Virulence of the Plant Pathogenic Bacterium Ralstonia solanacearum

Tuan Minh Tran, April MacIntyre, Martha Hawes, Caitilyn Allen

PLOS Pathogens: published June 23, 2016 | https://doi.org/10.1371/journal.ppat.1005686

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

Veronika I. Zarnitsyna, Jennie Lavine, Ali Ellebedy, Rafi Ahmed, Rustom Antia

PLOS Pathogens: published June 23, 2016 | https://doi.org/10.1371/journal.ppat.1005692

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

Rupkatha Mukhopadhyay, Sujayita Roy, Rajkumar Venkatadri, Yu-Pin Su, Wenjuan Ye, Elena Barnaeva, Lesley Mathews Griner, Noel Southall, Xin Hu, Amy Q. Wang, Xin Xu, Andrés E. Dulcey, Juan J. Marugan, Marc Ferrer, Ravit Arav-Boger

PLOS Pathogens: published June 23, 2016 | https://doi.org/10.1371/journal.ppat.1005717

The WOPR Protein Ros1 Is a Master Regulator of Sporogenesis and Late Effector Gene Expression in the Maize Pathogen Ustilago maydis

Marie Tollot, Daniela Assmann, Christian Becker, Janine Altmüller, Julien Y. Dutheil, Carl-Eric Wegner, Regine Kahmann

PLOS Pathogens: published June 22, 2016 | https://doi.org/10.1371/journal.ppat.1005697

A Human Trypanosome Suppresses CD8⁺ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4⁺ Foxp3⁺ T Cells

Jonatan Ersching, Alexandre Salgado Basso, Vera Lucia Garcia Kalich, Karina Ramalho Bortoluci, Maurício M. Rodrigues

PLOS Pathogens: published June 22, 2016 | https://doi.org/10.1371/journal.ppat.1005698

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

Timothy J. Nice, Lisa C. Osborne, Vesselin T. Tomov, David Artis, E. John Wherry, Herbert W. Virgin

PLOS Pathogens: published June 21, 2016 | https://doi.org/10.1371/journal.ppat.1005684

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection

Adarsh Dharan, Sarah Talley, Abhishek Tripathi, João I. Mamede, Matthias Majetschak, Thomas J. Hope, Edward M. Campbell

PLOS Pathogens: published June 21, 2016 | https://doi.org/10.1371/journal.ppat.1005700

Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals

Agustina Taglialegna, Susanna Navarro, Salvador Ventura, James A. Garnett, Steve Matthews, José R. Penades, Iñigo Lasa, Jaione Valle

PLOS Pathogens: published June 21, 2016 | https://doi.org/10.1371/journal.ppat.1005711

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair

Jennifer Quantius, Carole Schmoldt, Ana I. Vazquez-Armendariz, Christin Becker, Elie El Agha, Jochen Wilhelm, Rory E. Morty, István Vadász, Konstantin Mayer, Stefan Gattenloehner, Ludger Fink, Mikhail Matrosovich, Xiaokun Li, Werner Seeger, Juergen Lohmeyer, Saverio Bellusci, Susanne Herold

PLOS Pathogens: published June 20, 2016 | https://doi.org/10.1371/journal.ppat.1005544

Superparasitism Drives Heritable Symbiont Epidemiology and Host Sex Ratio in a Wasp

Steven R. Parratt, Crystal L. Frost, Martijn A. Schenkel, Annabel Rice, Gregory D. D. Hurst, Kayla C. King

PLOS Pathogens: published June 20, 2016 | https://doi.org/10.1371/journal.ppat.1005629

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

Ashwanth C. Francis, Mariana Marin, Jiong Shi, Christopher Aiken, Gregory B. Melikyan

PLOS Pathogens: published June 20, 2016 | https://doi.org/10.1371/journal.ppat.1005709

CLCuMuB βC1 Subverts Ubiquitination by Interacting with NbSKP1s to Enhance Geminivirus Infection in Nicotiana benthamiana

Qi Jia, Na Liu, Ke Xie, Yanwan Dai, Shaojie Han, Xijuan Zhao, Lichao Qian, Yunjing Wang, Jinping Zhao, Rena Gorovits, Daoxin Xie, Yiguo Hong, Yule Liu

PLOS Pathogens: published June 17, 2016 | https://doi.org/10.1371/journal.ppat.1005668

Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis

Ivey A. Geoghegan, Sarah J. Gurr

PLOS Pathogens: published June 17, 2016 | https://doi.org/10.1371/journal.ppat.1005703

Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement

Michael A. Schmid, Dustin R. Glasner, Sanjana Shah, Daniela Michlmayr, Laura D. Kramer, Eva Harris

PLOS Pathogens: published June 16, 2016 | https://doi.org/10.1371/journal.ppat.1005676

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases

Juan Reguera, Piotr Gerlach, Maria Rosenthal, Stephanie Gaudon, Francesca Coscia, Stephan Günther, Stephen Cusack

PLOS Pathogens: published June 15, 2016 | https://doi.org/10.1371/journal.ppat.1005636

Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence

Yanyu Wang, Sarah A. Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A. Wetsel, Yi Xu

PLOS Pathogens: published June 15, 2016 | https://doi.org/10.1371/journal.ppat.1005678

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

Simone A. Joosten, Krista E. van Meijgaarden, Franca del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H. Smits, Fabrizio Palmieri, Delia Goletti, Tom H. M. Ottenhoff

PLOS Pathogens: published June 15, 2016 | https://doi.org/10.1371/journal.ppat.1005687

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

Yaiza Fernández-García, Juan Reguera, Carola Busch, Gregor Witte, Oliberto Sánchez-Ramos, Christian Betzel, Stephen Cusack, Stephan Günther, Sophia Reindl

PLOS Pathogens: published June 14, 2016 | https://doi.org/10.1371/journal.ppat.1005635

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

Laura Berneking, Marie Schnapp, Andreas Rumm, Claudia Trasak, Klaus Ruckdeschel, Malik Alawi, Adam Grundhoff, Alexey G. Kikhney, Friedrich Koch-Nolte, Friedrich Buck, Markus Perbandt, Christian Betzel, Dmitri I. Svergun, Moritz Hentschke, Martin Aepfelbacher

PLOS Pathogens: published June 14, 2016 | https://doi.org/10.1371/journal.ppat.1005660

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Andrew S. Brown, Chao Yang, Ka Yee Fung, Annabell Bachem, Dorothée Bourges, Sammy Bedoui, Elizabeth L. Hartland, Ian R. van Driel

PLOS Pathogens: published June 14, 2016 | https://doi.org/10.1371/journal.ppat.1005691

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

Katja Koeppen, Thomas H. Hampton, Michael Jarek, Maren Scharfe, Scott A. Gerber, Daniel W. Mielcarz, Elora G. Demers, Emily L. Dolben, John H. Hammond, Deborah A. Hogan, Bruce A. Stanton

PLOS Pathogens: published June 13, 2016 | https://doi.org/10.1371/journal.ppat.1005672

Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection

Sarah E. Clark, Holly C. Filak, Brandon S. Guthrie, Rebecca L. Schmidt, Amanda Jamieson, Patricia Merkel, Vijaya Knight, Caroline M. Cole, David H. Raulet, Laurel L. Lenz

PLOS Pathogens: published June 13, 2016 | https://doi.org/10.1371/journal.ppat.1005708

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

Ruben R. Bender, Anke Muth, Irene C. Schneider, Thorsten Friedel, Jessica Hartmann, Andreas Plückthun, Andrea Maisner, Christian J. Buchholz

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005641

GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii

Clément N. David, Elma S. Frias, Jenny I. Szu, Philip A. Vieira, Jacqueline A. Hubbard, Jonathan Lovelace, Marena Michael, Danielle Worth, Kathryn E. McGovern, Iryna M. Ethell, B. Glenn Stanley, Edward Korzus, Todd A. Fiacco, Devin K. Binder, Emma H. Wilson

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005643

The Race against Protease Activation Defines the Role of ESCRTs in HIV Budding

Mourad Bendjennat, Saveez Saffarian

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005657

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut

Tingting Wang, Deng Pan, Zhicheng Zhou, Yun You, Changying Jiang, Xueqiang Zhao, Xin Lin

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005662

Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

Fengliang Liu, Xiuzhen Fan, Sarah Auclair, Monique Ferguson, Jiaren Sun, Lynn Soong, Wei Hou, Robert R. Redfield, Deborah L. Birx, Silvia Ratto-Kim, Merlin L. Robb, Jerome H. Kim, Nelson L. Michael, Haitao Hu

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005663

Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation

Kendi Okuda, Mei Tong, Brian Dempsey, Kathryn J. Moore, Ricardo T. Gazzinelli, Neal Silverman

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005669

Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63

Christine Matte, Pierre-André Casgrain, Olivier Séguin, Neda Moradin, Wan Jin Hong, Albert Descoteaux

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005690

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10

Louis S. Ates, Aniek D. van der Woude, Jovanka Bestebroer, Gunny van Stempvoort, René J. P. Musters, Juan J. Garcia-Vallejo, Daisy I. Picavet, Robert van de Weerd, Massimiliano Maletta, Coenraad P. Kuijl, Nicole N. van der Wel, Wilbert Bitter

PLOS Pathogens: published June 9, 2016 | https://doi.org/10.1371/journal.ppat.1005696

Nonclassical MHC Ib-restricted CD8⁺ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection

Shaobin Shang, Sarah Siddiqui, Yao Bian, Jie Zhao, Chyung-Ru Wang

PLOS Pathogens: published June 7, 2016 | https://doi.org/10.1371/journal.ppat.1005688

Small RNA-Based Antiviral Defense in the Phytopathogenic Fungus Colletotrichum higginsianum

Sonia Campo, Kerrigan B. Gilbert, James C. Carrington

PLOS Pathogens: published June 2, 2016 | https://doi.org/10.1371/journal.ppat.1005640

A σ^E-Mediated Temperature Gauge Controls a Switch from LuxR-Mediated Virulence Gene Expression to Thermal Stress Adaptation in Vibrio alginolyticus

Dan Gu, Min Guo, Minjun Yang, Yuanxing Zhang, Xiaohui Zhou, Qiyao Wang

PLOS Pathogens: published June 2, 2016 | https://doi.org/10.1371/journal.ppat.1005645

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M. Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L. Samuels, Rebecca Hoh, Jonah B. Sacha, Philip J. Norris, Toshiro Niki, Cecilia M. Shikuma, Mitsuomi Hirashima, Steven G. Deeks, Lishomwa C. Ndhlovu, Satish K. Pillai

PLOS Pathogens: published June 2, 2016 | https://doi.org/10.1371/journal.ppat.1005677

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

Kan Lin, Kathryn M. O'Brien, Carolina Trujillo, Ruojun Wang, Joshua B. Wallach, Dirk Schnappinger, Sabine Ehrt

PLOS Pathogens: published June 1, 2016 | https://doi.org/10.1371/journal.ppat.1005675

S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages

Susan Realegeno, Kindra M. Kelly-Scumpia, Angeline Tilly Dang, Jing Lu, Rosane Teles, Philip T. Liu, Mirjam Schenk, Ernest Y. Lee, Nathan W. Schmidt, Gerard C. L. Wong, Euzenir N. Sarno, Thomas H. Rea, Maria T. Ochoa, Matteo Pellegrini, Robert L. Modlin

PLOS Pathogens: published June 29, 2016 | https://doi.org/10.1371/journal.ppat.1005705

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding

Gopal Sapparapu, Rita Czakó, Gabriela Alvarado, Sreejesh Shanker, B. V. Venkataram Prasad, Robert L. Atmar, Mary K. Estes, James E. Crowe Jr.

PLOS Pathogens: published June 29, 2016 | https://doi.org/10.1371/journal.ppat.1005719

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

Ferdy R. van Diemen, Elisabeth M. Kruse, Marjolein J. G. Hooykaas, Carlijn E. Bruggeling, Anita C. Schürch, Petra M. van Ham, Saskia M. Imhof, Monique Nijhuis, Emmanuel J. H. J. Wiertz, Robert Jan Lebbink

PLOS Pathogens: published June 30, 2016 | https://doi.org/10.1371/journal.ppat.1005701

Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans

Robert J. Luallen, Aaron W. Reinke, Linda Tong, Michael R. Botts, Marie-Anne Félix, Emily R. Troemel

PLOS Pathogens: published June 30, 2016 | https://doi.org/10.1371/journal.ppat.1005724

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