Table of Contents: December 2008

Prions are transmissible, nonconventional agents that cause fatal neurodegenerative disorders in several mammalian species. Intraspecies, inter-individual transmission is mainly responsible for prion diseases spreading in animals. The capacity of prions to transmit between species remains largely unknown and the control of the human and animal dietary exposure to these agents are considered to be important for preventing such transmission. In this context, prion shedding in milk raises new concerns (see Lacroux et al., doi:10.1371/journal.ppat.1000238).

Image Credit: Caroline Lacroux and Olivier Andréoletti, UMR INRA ENVT

Research Articles

Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment

Robert T. Wheeler, Diana Kombe, Sudeep D. Agarwala, Gerald R. Fink

Identification of Tuberculosis Susceptibility Genes with Human Macrophage Gene Expression Profiles

Nguyen Thuy Thuong Thuong, Sarah J. Dunstan, Tran Thi Hong Chau, Vesteinn Thorsson, Cameron P. Simmons, Nguyen Than Ha Quyen, Guy E. Thwaites, Nguyen Thi Ngoc Lan, Martin Hibberd, Yik Y. Teo, Mark Seielstad, Alan Aderem, Jeremy J. Farrar, Thomas R. Hawn

APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts

Kate N. Bishop, Mohit Verma, Eun-Young Kim, Steven M. Wolinsky, Michael H. Malim

Detection of Prion Infectivity in Fat Tissues of Scrapie-Infected Mice

Brent Race, Kimberly Meade-White, Michael B. A. Oldstone, Richard Race, Bruce Chesebro

FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling

Ali A. Ashkar, Karen L. Mossman, Brian K. Coombes, Carlton L. Gyles, Randy Mackenzie

Structure of Reovirus σ1 in Complex with Its Receptor Junctional Adhesion Molecule-A

Eva Kirchner, Kristen M. Guglielmi, Holger M. Strauss, Terence S. Dermody, Thilo Stehle

Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection

Karen A. Chachu, Anna D. LoBue, David W. Strong, Ralph S. Baric, Herbert W. Virgin

The Chromatin Remodeler SPLAYED Regulates Specific Stress Signaling Pathways

Justin W. Walley, Heather C. Rowe, Yanmei Xiao, E. Wassim Chehab, Daniel J. Kliebenstein, Doris Wagner, Katayoon Dehesh

Prions in Milk from Ewes Incubating Natural Scrapie

Caroline Lacroux, Stéphanie Simon, Sylvie L. Benestad, Séverine Maillet, Jacinthe Mathey, Séverine Lugan, Fabien Corbière, Hervé Cassard, Pierrette Costes, Dominique Bergonier, Jean-Louis Weisbecker, Torffin Moldal, Hugh Simmons, Frederic Lantier, Cécile Feraudet-Tarisse, Nathalie Morel, François Schelcher, Jacques Grassi, Olivier Andréoletti

Innate Invariant NKT Cells Recognize Mycobacterium tuberculosis–Infected Macrophages, Produce Interferon-γ, and Kill Intracellular Bacteria

Isabel Sada-Ovalle, Asako Chiba, Adaena Gonzales, Michael B. Brenner, Samuel M. Behar

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

Timothy Sheahan, Thomas E. Morrison, William Funkhouser, Satoshi Uematsu, Shizou Akira, Ralph S. Baric, Mark T. Heise

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

Kimberly M. Davis, Henry T. Akinbi, Alistair J. Standish, Jeffrey N. Weiser

Frequent Toggling between Alternative Amino Acids Is Driven by Selection in HIV-1

Wayne Delport, Konrad Scheffler, Cathal Seoighe

Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis

Ondřej Šmíd, Anna Matušková, Simon R. Harris, Tomáš Kučera, Marián Novotný, Lenka Horváthová, Ivan Hrdý, Eva Kutějová, Robert P. Hirt, T. Martin Embley, Jiří Janata, Jan Tachezy

Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

Hilde M. van der Schaar, Michael J. Rust, Chen Chen, Heidi van der Ende-Metselaar, Jan Wilschut, Xiaowei Zhuang, Jolanda M. Smit

Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease

Audrey Fischer, Darren J. Mushrush, D. Borden Lacy, Mauricio Montal

Regulated Nuclear Trafficking of rpL10A Mediated by NIK1 Represents a Defense Strategy of Plant Cells against Virus

Claudine M. Carvalho, Anésia A. Santos, Silvana R. Pires, Carolina S. Rocha, Daniela I. Saraiva, João Paulo B. Machado, Eliciane C. Mattos, Luciano G. Fietto, Elizabeth P. B. Fontes

Independent Regulation of Reovirus Membrane Penetration and Apoptosis by the μ1 φ Domain

Pranav Danthi, Caroline M. Coffey, John S. L. Parker, Ty W. Abel, Terence S. Dermody

Surviving Mousepox Infection Requires the Complement System

Elizabeth A. Moulton, John P. Atkinson, R. Mark L Buller

The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b

Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F. Zipfel

Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association

Stephen C. Graham, René Assenberg, Olivier Delmas, Anil Verma, Alireza Gholami, Chiraz Talbi, Raymond J. Owens, David I. Stuart, Jonathan M. Grimes, Hervé Bourhy