Prions are transmissible, nonconventional agents that cause fatal neurodegenerative disorders in several mammalian species. Intraspecies, inter-individual transmission is mainly responsible for prion diseases spreading in animals. The capacity of prions to transmit between species remains largely unknown and the control of the human and animal dietary exposure to these agents are considered to be important for preventing such transmission. In this context, prion shedding in milk raises new concerns (see Lacroux et al., doi:10.1371/journal.ppat.1000238).
Image Credit: Caroline Lacroux and Olivier Andréoletti, UMR INRA ENVT
Review
HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000215
Research Articles
Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000227
Identification of Tuberculosis Susceptibility Genes with Human Macrophage Gene Expression Profiles
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000229
Heterologous Replacement of the Supposed Host Determining Region of Avihepadnaviruses: High In Vivo Infectivity Despite Low Infectivity for Hepatocytes
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000230
APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000231
Detection of Prion Infectivity in Fat Tissues of Scrapie-Infected Mice
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000232
FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling
PLOS Pathogens: published December 5, 2008 | https://doi.org/10.1371/journal.ppat.1000233
Structure of Reovirus σ1 in Complex with Its Receptor Junctional Adhesion Molecule-A
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000235
Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000236
The Chromatin Remodeler SPLAYED Regulates Specific Stress Signaling Pathways
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000237
Prions in Milk from Ewes Incubating Natural Scrapie
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000238
Innate Invariant NKT Cells Recognize Mycobacterium tuberculosis–Infected Macrophages, Produce Interferon-γ, and Kill Intracellular Bacteria
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000239
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000240
Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae
PLOS Pathogens: published December 12, 2008 | https://doi.org/10.1371/journal.ppat.1000241
Frequent Toggling between Alternative Amino Acids Is Driven by Selection in HIV-1
PLOS Pathogens: published December 19, 2008 | https://doi.org/10.1371/journal.ppat.1000242
Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis
PLOS Pathogens: published December 19, 2008 | https://doi.org/10.1371/journal.ppat.1000243
Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells
PLOS Pathogens: published December 19, 2008 | https://doi.org/10.1371/journal.ppat.1000244
Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease
PLOS Pathogens: published December 19, 2008 | https://doi.org/10.1371/journal.ppat.1000245
Regulated Nuclear Trafficking of rpL10A Mediated by NIK1 Represents a Defense Strategy of Plant Cells against Virus
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000247
Independent Regulation of Reovirus Membrane Penetration and Apoptosis by the μ1 φ Domain
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000248
Surviving Mousepox Infection Requires the Complement System
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000249
The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000250
Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association
PLOS Pathogens: published December 26, 2008 | https://doi.org/10.1371/journal.ppat.1000251