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Fat1 Cadherin Controls Neuromuscular Morphogenesis

May 16, 2018

Fat1 Cadherin Controls Neuromuscular Morphogenesis

Françoise Helmbacher explores how the cadherin Fat1 tunes the morphogenesis of subsets of muscles and their partner motor neurons by playing distinct complementary activities in motor neurons, muscles and connective tissues.

Image credit: pbio.2004734

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

05/16/2018

methods and resources

Haploinsufficiency - Not as Rare as You Think

Shinsuke Ohnuki and Yoshikazu Ohya use high-dimensional single-cell phenotyping to show that more than half of the essential genes in budding yeast exhibit haploinsufficiency, challenging the assumption that this phenomenon is rare.

Image credit: pbio.2005130

Haploinsufficiency - Not as Rare as You Think

Recently Published Articles

Current Issue

Current Issue April 2018

05/17/2018

short report

Intermediates of Carbohydrate Metabolism Mediate Axon Growth

Hosni Cherif, François Duhamel, Jean-François Bouchard and colleagues reveal the influence of two intermediates of carbohydrate metabolism (succinate and α-ketoglutarate) and their receptors (GPR91 and GPR99) on the growth of retinal ganglion cell axons during development of the retino-thalamic system.

Image credit: pbio.2003619

Intermediates of Carbohydrate Metabolism Mediate Axon Growth

05/11/2018

research article

Inhibit p38α to Turn White Fat Brown

Shengjie Zhang, Hao Ying and co-workers reveal a vital role for the MAP kinase p38α in the browning of white fat and in energy homeostasis; mice lacking p38α in adipose tissues display a lean phenotype, improved metabolism, and resistance to diet-induced obesity.

Image credit: pbio.2004225

Inhibit p38α to Turn White Fat Brown

05/11/2018

research article

How the 'Killer Fragment' Kills to Control Neuroblastoma

In the absence of its ligand neurotrophin-3, the cell surface receptor TrkC acts as a tumor suppressor in neuroblastoma by triggering apoptosis; Marie Ménard, Patrick Mehlen, Servane Tauszig-Delamasure and colleagues show that its caspase-cleaved 'killer fragment' is translocated to the nucleus, interacts with Hey1, and stabilizes p53.

How the 'Killer Fragment' Kills to Control Neuroblastoma

Image credit: pbio.2002912

05/11/2018

short report

Pro-Tumoral T Cells' Oxidative Achilles' Heel

During tumor progression, neutrophils inhibit a tumor-supporting subset of T cells – the interleukin-17-producing γδ T cells. Sofia Mensurado, Karine Serre, Bruno Silva-Santos and co-authors show that their particular sensitivity to neutrophil-induced oxidative stress is due to their low levels of the anti-oxidant glutathione.

Pro-Tumoral T Cells' Oxidative Achilles' Heel

Image credit: Ben Mills via Wikimedia Commons

05/16/2018

unsolved Mystery

Do Plants Have a Segregated Germline?

This Essay by Robert Lanfear re-visits an old mystery – the nature of the plant germline – concluding that we know a lot less than we think we do, and proposing a new approach to reveal the nature of the germline in all plants.

Do Plants Have a Segregated Germline?

Image credit: Ella Maru

05/11/2018

research article

Ignore (Bacterial) Death at your Peril

Reported increases in mutation rates under stress are systematically over-estimated because of cell death, and are often compensated by reduced population sizes.

Ignore (Bacterial) Death at your Peril

Image credit: Jbuzbee via Wikimedia Commons

05/17/2018

plos biologue

Science of Effective Conservation Requires

How can scientific evidence help direct conservation efforts? PLOS Biology board member Georgina Mace discusses two studies. Check out our 15th Anniversary Collection.

Science of Effective Conservation Requires

Image credit: Mark Priest

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