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Making a Blastocyst: Four Simple Rules Suffice

July 12, 2017

Making a Blastocyst: Four Simple Rules Suffice

A new model developed by Silas Boye Nissen, Joshua Brickman, Ala Trusina and colleagues, in which four simple rules can produce a mammalian embryo and explain scaling, ensures developmental robustness while allowing evolution to play with stochasticity.

Image credit: pbio.2000737

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PLOS Research News

07/07/2017

research article

Hierarchical Patterning of Hair Follicles

James Glover, Denis Headon and co-workers reveal that hair follicle development involves establishing a hierarchy of patterning systems, whereby a patterning process driven by cell movement is subordinated to a signal-based reaction-diffusion mechanism.

Image credit: pbio.2002117

Hierarchical Patterning of Hair Follicles

Recently Published Articles

Current Issue

Current Issue June 2017

07/13/2017

research article

Snake Venom's Deadly Grip on Integrin

Johannes Eble, Matthew McDougall, Jörg Stetefeld and co-authors show that a bifunctional snake venom protein from the Malayan pit viper Calloselasma rhodostoma blocks collagen mediated platelet aggregation, undergoing dramatic conformational changes as it binds α2β1 integrin.

Image credit: pbio.2001492

Snake Venom's Deadly Grip on Integrin

07/12/2017

research matters

From Melittobia to Malaria

In this Research Matters article, Andrew Read recalls how an analysis of incest in wasps revealed a way to improve human well-being.

Image credit: 10.3897/zookeys.181.2752 and NIAID

From Melittobia to Malaria

07/06/2017

research article

Cells Store Tau with tRNA in Liquid Droplets

Xuemei Zhang, Kenneth Kosik, Songi Han and co-workers show that tau protein binds tRNA in living cells, and under physiological conditions reversibly condenses to form complex liquid droplets that may be precursors for the formation of tau fibrils found in neurodegenerative diseases.

Cells Store Tau with tRNA in Liquid Droplets

Image credit: Peter Allen

07/03/2017

methods & resources article

Neurochemical Connectome of the Rat Brain

Hamid Noori, Rainer Spanagel and colleagues describe ChemNetDB; a systematic, terminologically consistent open-access resource for the multi-scale neurochemical connectome of the rat brain, containing data from 34,464 animals.

Neurochemical Connectome of the Rat Brain

Image credit: pbio.2002612

07/06/2017

short reports

Cognitive Effects of General Anesthesia

Anesthetic exposure in early childhood may cause lasting cognitive deficits. Eunchai Kang, Danye Jiang, Yun Kyoung Ryu, David Mintz and colleagues show that isoflurane acts on the mTOR pathway to cause dendritic spine loss and learning deficits in mice.

Cognitive Effects of General Anesthesia

Image credit: Army Medicine, Flickr

06/27/2017

research article

Training: from Attentional Gain to Noise Reduction

Quantitative modeling of data recorded from human subjects over one month reveals that attentional mechanisms shift from gain to noise reduction as a function of training duration.

Training: from Attentional Gain to Noise Reduction

Image credit: Geralt, Pixabay

06/27/2017

research article

Stimulated Copy Number Variation in Yeast

Yeast can stimulate changes in copy number at environmentally relevant genetic loci, resulting in novel adaptive alleles that enhance growth under challenging conditions.

Stimulated Copy Number Variation in Yeast

Image credit: Flickr user Conor Lawless

06/28/2017

research article

Rhythmic Sampling of the Visual Environment

Attention rhythmically samples multiple visual objects, and the sampling profile changes adaptively according to context.

Rhythmic Sampling of the Visual Environment

Image credit: Flickr user Demietrich Baker

06/27/2017

research article

Cyclophilin 40 Unravels Neurotoxic Amyloids

The chaperone Cyclophilin 40 can disintegrate neurotoxic aggregates of tau protein, a hallmark of Alzheimer’s and other diseases, by interacting with proline-rich sites.

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Cyclophilin 40 Unravels Neurotoxic Amyloids

Image credit: pbio.2001336

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