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Muscle's Circadian Metabolic Rhythm

August 10, 2018

Muscle's Circadian Metabolic Rhythm

Kenneth Dyar, Henriette Uhlenhaut and colleagues compare in vivo genomic binding patterns of transcription factors BMAL1 and REV-ERB with 24-hour transcriptional and metabolic changes upon their loss to reveal how the circadian clock directs the diurnal rhythms of muscle metabolism.

Image credit: Kenneth Allen Dyar

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

08/10/2018

research article

Growing a Shapely Eye

Marija Matejčić, Guillaume Salbreux and Caren Norden show that during vertebrate retinal development, a non-cell autonomous redistribution of actin is prerequisite for a timely change of cell shape, which in turn enables isotropic growth of the tissue.

Image credit: pbio.2006018

Growing a Shapely Eye

Recently Published Articles

Current Issue

Current Issue July 2018

08/15/2018

research article

Keeping Working Memory Balls in the Air

Analysis of human intracranial electrocorticography data, by Ali Bahramisharif, Ole Jensen, Joshua Jacobs and John Lisman demonstrates that items in working memory are activated sequentially and that the activation is coordinated by coupled theta/alpha and gamma oscillations.

Image credit: pbio.2003805

Keeping Working Memory Balls in the Air

08/15/2018

Essay

Human and Non-Human Language

A key feature of human language is our ability to combine words into larger meaningful structures. This Essay by Simon Townsend, Balthasar Bickel and co-authors argues that comparison with call combinations in non-human animals sheds light on the evolutionary origins of this ability. Also see this Formal Comment in which Toshitaka Suzuki, David Wheatcroft and Michael Griesser refute recent criticism by Johan Bolhuis and co-authors.

Image credit: pbio.2006425

Human and Non-Human Language

08/10/2018

research article

Antibody Memory of Viruses & Vaccines.

How long do individuals maintain protective levels of antibodies after vaccination or infection? Alice Antia, Rustom Antia, Mark Slifka and colleagues show that some individuals make longer-lasting responses to vaccines than others and quantifies how variation between individuals affects the decay of immunity at the population level.

Antibody Memory of Viruses & Vaccines.

Image credit: Flickr user: PATH global health

08/13/2018

research article

Deep Roots of Gamete Fusion

Structure-function dissection of the conserved transmembrane protein HAP2, by Juliette Fedry, Jennifer Forcina, Mark Johnson, Felix Rey, Thomas Krey and co-workers, defines a mechanism for target membrane insertion during gamete fusion, and provides insights into how this process evolved to accommodate the diversity of sexual reproductive systems.

Deep Roots of Gamete Fusion

Image credit: pbio.2006357

08/13/2018

perspective

Keep MTAs Simple!

While risk aversion can dominate in negotiations for Material Transfer Agreements, Jane Nielsen, Dianne Nicol and co-authors maintain that examples of good practice provide us with strategies to improve the process for this important method of tracking provenance.

Keep MTAs Simple!

Image credit: Flickr user Joseph Elsbernd

08/16/2018

research article

Leaky Resistance and the Bacteriophage

A high rate of either phenotypic or genetic transition from resistance to susceptibility allows phages to persist in populations dominated by bacteria within which the phages cannot replicate.

Leaky Resistance and the Bacteriophage

Image credit: Pixabay

08/06/2018

research article

Epigenetic Repression of Immune Responses

Silencing of the immune response by some pathogens and cancer cells is mediated by the KDM5 histone demethylases; their inhibition may prove therapeutically useful.

Epigenetic Repression of Immune Responses

Image credit: pbio.2006134

08/07/2018

research article

Prioritizing Problematic Cargo

This study reveals prioritized trafficking of problematic soluble cargo proteins out of the endoplasmic reticulum via the affinity of the Surf4/Erv29p receptor for different N-terminal tripeptides.

Prioritizing Problematic Cargo

Image credit: pbio.2005140

08/10/2018

PlOS Biologue

The XV Collection: Perverse Outcomes of Novel Therapies

Andrew Read celebrates our 15th Anniversary by highlighting this Essay by Pedro Vale, Andy Fenton and Sam Brown exploring adverse consequences of an "evolution-proof" solution to infectious diseases. View the XV Collection here.

The XV Collection: Perverse Outcomes of Novel Therapies

Image credit: Flickr use: NIAID

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