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Unconventional Terminal Selector of Nociceptive Neurons

April 19, 2018

Unconventional Terminal Selector of Nociceptive Neurons

A study of the development of the nervous system of the nematode Caenorhabditis elegans by Neda Masoudi, Oliver Hobert and colleagues reveals a novel function for a member of the basic helix-loop-helix family of transcription factors in controlling terminal neuron differentiation (rather than initial commitment to a neural fate).

Image credit: Hang Ung

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PLOS Biology's XV Collection

04/19/2018

meta-research article

Scientific Gender Gap will Last for Generations

Text mining of more than 10 million academic papers by Luke Holman, Devi Stuart-Fox and Cindy Hauser identifies those fields of science that will retain a highly imbalanced gender ratio for many years to come.

Image credit: Pixabay

Scientific Gender Gap will Last for Generations

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Current Issue March 2018

04/19/2018

perspective

When Youthful Enthusiasm Clouds Scientific Judgement

In the early 1980s two young scientists working in the newly born field of electron cryo-microscopy made an apparently significant discovery that others failed to replicate. More than thirty years later, Nobel laureate Jacques Dubochet and his co-worker Erwin Knapek reunite to discuss what went wrong.

Image credit: pbio.2005550

When Youthful Enthusiasm Clouds Scientific Judgement

04/18/2018

research article

Non-Canonical Early Role for Dynamin-1 in Endocytosis

Saipraveen Srinivasan, Christoph Burckhardt, Sandra Schmid and co-workers use live cell imaging reveals a non-canonical and isoform-specific role for dynamin-1, the fission GTPase, in regulating the assembly and maturation of clathrin-coated pits, and functioning as a nexus between signaling and endocytosis.

Image credit: pbio.2005377

Non-Canonical Early Role for Dynamin-1 in Endocytosis

04/16/2018

meta-research article

Happier Lab Mice Won't Compromise Data.

A large-scale study of two strains of lab mouse by Viola André, Martin Hrabé de Angelis and co-authors shows that the inclusion of nesting material and shelters as environmental enrichment does not impair the scientific assessment of a battery of 164 physiological parameters in mice.

Happier Lab Mice Won't Compromise Data.

Image credit: pbio.2005019

04/13/2018

research article

Regulation of Non-REM Sleep

Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Zhi-Li Huang and colleagues show that the tail of the ventral tegmental area of the midbrain, which is primarily composed of GABAergic neurons, regulates non-rapid eye movement sleep by modulating dopaminergic systems.

Regulation of Non-REM Sleep

Image credit: Pixabay

04/13/2018

research article

The Immune Ecology of Wild Mice

A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of wild house mice – the same species as the lab mouse –  shows that their immune state is promoted by individuals’ body condition and constrained by their age.

The Immune Ecology of Wild Mice

Image credit: Flickr user: Paul Dunleavy

04/18/2018

research articlr

Dectins are Receptors for Schistosome Antigens

The parasitic helminth Schistosoma mansoni primes Th2 responses via an interaction between helminth egg antigens and the host receptors Dectin-1 and -2.

Dectins are Receptors for Schistosome Antigens

Image credit: David Williams

04/17/2018

perspective

Should Alien Species Count as Biodiversity?

Biodiversity indicators focus on native species; this Perspective article proposes that non-native species should also be included to better reflect both what is observed in the field and the interests of non-biologists.

Should Alien Species Count as Biodiversity?

Image credit: pbio.2005568

04/16/2018

research article

Thiamine Deficiency Promotes Metabolic Syndrome

Mice lacking the organic cation transporter OCT1 provide molecular insights into how levels of thiamine (vitamin B1) and OCT1 influence metabolic traits observed in humans and mice.

Thiamine Deficiency Promotes Metabolic Syndrome

Image credit: pbio.2002907

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