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Adenosine Secures Energy for Immune Activity

April 27, 2015

Adenosine Secures Energy for Immune Activity

A study of the fruit fly's response to parasitoid wasp eggs by Adam Bajgar, Tomas Dolezal and co-workers reveals that immune cells selfishly release adenosine as a signal to trigger a systemic metabolic switch, thereby suppressing non-immune processes and securing energy and nutrients for immune activity. Read the Primer by Brian Lazzaro.

Image credit: Tomas Dolezal

Recently Published Articles

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Current Issue March 2015

04/20/2015

research article

Cooperating Bacteria Mimic van Gogh to Migrate

Jordi van Gestel, Hera Vlamakis and Roberto Kolter show that in the bacterium Bacillus subtilis, cooperation between surfactin-producing and matrix-producing cells drives migration over solid surfaces by the formation of filamentous looped "van Gogh bundles" at the edge of the colony.

Image credit: Jordi van Gestel

Cooperating Bacteria Mimic van Gogh to Migrate

04/17/2015

research article

Color Entrains the Circadian Clock

Environmental measurements and physiological recordings, by Lauren Walmsley, Robert Lucas, Timothy Brown and co-authors, reveal that mice not only use changes in the intensity of sunlight to entrain their circadian clock, but also employ blue–yellow color discrimination to detect spectral changes associated with dawn and dusk.

Image credit: Flickr user 白士 李

Color Entrains the Circadian Clock

04/22/2015

research article

Stress Overcomes Drug Resistance in Malaria Parasites

Resistance to artemisinin antimalarial drugs is jeopardizing malaria control. Con Dogovski, Stanley Xie, Nectarios Klonis, Leann Tilley and colleagues find that proteasome-mediated stress responses can be targeted to overcome artemisinin resistance and suggest alternate therapeutic regimens and monitoring strategies.

Stress Overcomes Drug Resistance in Malaria Parasites

Image credit: Dr Eric Hanssen, Bio21 Institute, University of Melbourne.

04/22/2015

perspective

Time to Kill off Bar Graphs?

A systematic review of research articles by Tracey Weissgerber, Vesna Garovic and co-authors reveals that poor practice in the presentation of continuous data is widespread in the literature. The authors recommend training for scientific investigators and supply templates for easy use.

Time to Kill off Bar Graphs?

Image credit: modified from 10.1371/journal.pbio.1002128.g001

04/17/2015

research article

Cellular Self-Fusion during Vasculature Pruning

In vivo live imaging of zebrafish embryos, conducted by Anna Lenard, Markus Affolter and colleagues, reveals the diverse cellular activities involved in the pruning of unwanted blood vessels, including the self-fusion of endothelial cells.

Cellular Self-Fusion during Vasculature Pruning

Image credit: journal.pbio.1002126.g002

04/17/2015

Research Article

Flow Directs Cell Migration and Polarity in Vessel Pruning

Differential blood flow patterns direct the orientation and migration of endothelial cells as a mechanism for stabilizing or pruning individual blood vessel segments.

Flow Directs Cell Migration and Polarity in Vessel Pruning

Image credit: doi:10.1371/journal.pbio.1002125.g001