Advertisement
Drug Sequence Influences Evolution of Resistance

August 8, 2017

Drug Sequence Influences Evolution of Resistance

A study of the human bacterial pathogen Pseudomonas aeruginosa by Phillip Yen and Jason Papin shows that different adaptation histories to antibiotics lead to distinct evolutionary dynamics of multidrug resistance, potentially informing the design of strategies to mitigate resistance and combat bacterial infections.

Image credit: CDC/ James Archer

Stay up-to-date on the latest research publishing by PLOS

PLOS Research News

08/11/2017

research article 

Recombination between Centromeres Drives Mating System Evolution

A comparative study of the pathogenic fungus Cryptococcus by Sheng Sun, Vikas Yadav, Joseph Heitman and colleagues reveals that chromosomal rearrangements involving centromeric regions played important roles in the evolution of fungal genomes, including the transition between different mating systems.

Image credit: Flickr user: Ed Uthman

Recombination between Centromeres Drives Mating System Evolution

Recently Published Articles

Current Issue

Current Issue July 2017

08/01/2017

research article

Dietary Restriction Enhances Learning

Mihir Vohra, George Lemieux, Lin Lin and Kaveh Ashrafi show that the beneficial effects of reduced nutrient intake on enhancement of learning are not just secondary consequences of extended lifespan but are specifically due to depletion of the tryptophan metabolite (and glutamatergic antagonist) kynurenic acid.

Image credit: pbio.2002032

Dietary Restriction Enhances Learning

08/01/2017

research article

lncRNA Turns White Fat Brown

A comprehensive profile of lncRNA transcriptome changes during white fat browning and brown fat activation, by Zhiqiang Bai, Xiao-ran Chai, Sujoy Ghosh, Lei Sun and co-authors, identifies lncBATE10 as a novel regulator of these biological processes.

Image credit: pbio.1001314

lncRNA Turns White Fat Brown

08/01/2017

perspective

The Open Science Prize

It’s rare for international funders to work together but the Open Science Prize brought three funders – The NIH, Wellcome Trust and HHMI – to do just that. Here Elizabeth Kittrie, Philip Bourne and co-authors discuss the successes and challenges that running the Open Science Prize presented.

The Open Science Prize

Image credit: pbio.2002617

08/03/2017

research article

Making a Bacterial Flagellum I

Takuma Fukumura, Keiichi Namba, Katsumi Imada, Tohru Minamino and co-authors use structural and functional analyses of the core structure of the bacterial flagellar type III export gate complex to reveal novel insights into how the gate complex is formed inside the flagellar basal body MS ring. Read the accompanying article.

Making a Bacterial Flagellum I

Image credit: pbio.2002281

08/03/2017

research article

Making a Bacterial Flagellum II

Florian Fabiani, Thibaud Renault, Marc Erhardt and co-authors reveal that an integral-membrane chaperone, FliO, coordinates the self-assembly of the multi-component type III secretion system needed to export the building blocks of the bacterial flagellum. See the accompanying article.

Making a Bacterial Flagellum II

Image credit: pbio.2002267

08/04/2017

research article 

Ciliary Targeting by Nuclear Localization Signal

The karyopherin-β2 nuclear import system regulates the targeting of the Hedgehog signaling pathway transcription factor Gli to the primary cilium, and forms a positive feedback loop.

Ciliary Targeting by Nuclear Localization Signal

Image credit: pbio.2002063

08/03/2017

research article

How EBV Dwells Peacefully within Us

Epstein Barr virus transcription factors help establish viral latency in memory B cells, by epigenetically suppressing the B cell-to-plasma cell differentiation pathway.

How EBV Dwells Peacefully within Us

Image credit: CDC via Wikimedia Commons

08/03/2017

community page

The Genomic Observatories Metadatabase (GeOMe)

GeOMe is an open access repository for the geospatial and environmental metadata directly associated with genetic data, essential to scientific reproducibility and synthesis.

The Genomic Observatories Metadatabase (GeOMe)

Image credit: pbio.2002925

08/31/2017

primer

Does Saving Nature Make ‘Cents’?

This Primer discusses how the economic valuation of ecosystem services can be used to choose sites for either land conservation or development. Read the related Research Article.

Does Saving Nature Make ‘Cents’?

Image credit: Flickr user: Tax Credits

Get new content from PLOS Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again