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Sky Color and Clock Entrainment

May 21, 2015

Sky Color and Clock Entrainment

This Primer by Hester van Diepen, Russell Foster and Johanna Meijer examines the implications of a recent PLOS Biology paper which revealed that entrainment of the circadian clock combines both environmental irradiance and color information.

Image credit: Flickr user Pai Shih

05/21/2015

research article and synopsis

LPA Controls Synaptic Strength and Plasticity

Victoria García-Morales, Bernardo Moreno-López and co-workers reveal that lysophospholipids derived from membranes are important regulators of neurotransmission, acting as local messengers that couple synaptic strength to recent neuronal activity. Read the Synopsis.

Image credit: 10.1371/journal.pbio.1002153.g009

LPA Controls Synaptic Strength and Plasticity

Recently Published Articles

Current Issue

Current Issue April 2015

05/20/2015

research article

How EGFRvIII Promotes Stemness in Glioma

Jinlong Yin, Gunwoo Park, Jong Bae Park and colleagues find that a permanently activated mutant form of the epidermal growth factor receptor found in glioblastoma promotes self-renewal and tumor progression by inducing autocrine signalling via pigment epithelium-derived factor (PEDF).

Image credit: 10.1371/journal.pbio.1002152.g008

How EGFRvIII Promotes Stemness in Glioma

05/20/2015

community page

Applying the ARRIVE Guidelines to an In Vivo Database

Transparent reporting is key to ensuring reproducibility of animal research. This article by Natasha Karp, Steve Brown and co-authors examines the challenges of applying the ARRIVE guidelines to a large-scale, collaborative, in vivo research initiative—the International Mouse Phenotyping Consortium.

Image credit: Rama, Wikimedia Commons

Applying the ARRIVE Guidelines to an In Vivo Database

05/12/2015

ESSAY

Understanding Brains: Details, Intuition, and Big Data

This personal view from connectomics pioneer Eve Marder asks how we should balance a plethora of biological data with the need to extract general principles that bring insight into brain function.

Understanding Brains: Details, Intuition, and Big Data

Image credit: journal.pcbi.1003557.g006

05/12/2015

research article

The Intricate Workings of a Hippo Pathway Kinase

The structure of an ancient signaling complex in the Hippo pathway (an NDR/LATS family kinase), determined by Gergő Gógl, Kyle Schneider, Attila Reményi, Eric Weiss and co-workers,reveals a distinctive activation switch, and shows how this regulator recognizes short and rapidly evolving protein motifs.

The Intricate Workings of a Hippo Pathway Kinase

Image credit: Jay Ryan, The Bird Machine

05/05/2015

Education

“Molecule of the Month” - Inspiring Biology

David Goodsell, Stephen Burley and colleagues highlight the educational value of the >180 "Molecule of the Month" features that have graced the RCSB PDB website for the last 15 years.

“Molecule of the Month” - Inspiring Biology

Image credit: doi:10.1371/journal.pbio.1002140.g001

05/07/2015

research article

Designer Optogenetics Rescue Blind Mice

Restoration of sight by expressing a protein engineered from melanopsin and a metabotropic glutamate receptor in retinal ON-bipolar cells.

Designer Optogenetics Rescue Blind Mice

Image credit: 10.1371/journal.pbio.1002143 S2 Fig.

05/06/2015

perspective

The Renaissance of Developmental Biology

Daniel St Johnston explores the recent decline and imminent re-emergence of developmental biology as a key area of research.

The Renaissance of Developmental Biology

Image credit: journal.pbio.1002069.g006