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Evolution of Cooperative Breeding

June 21, 2017

Evolution of Cooperative Breeding

How did cooperative breeding arise in birds? A comparative analysis of more than 3,000 bird species by Michael Griesser, Szymon Drobniak, Shinichi Nakagawa and Carlos Botero shows that family living evolved first in variable environments and helping at the nest evolved subsequently in less productive environments.

Image credit: Beatrice Murch

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PLOS Research News

06/20/2017

research article

Screening for Synergistic Drug Pairs

Morgan Wambaugh, Viplendra Shakya, Jessica Brown and co-workers use a novel high-throughput screen to identify small molecules that synergize with the antibiotic trimethoprim, elucidating the molecular mechanism underlying the interactions, and exploiting the new mechanism to design improved treatments for Escherichia coli infections.

Image credit: Morgan Wambaugh

Screening for Synergistic Drug Pairs

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Current Issue May 2017

06/21/2017

research article

Getting Myelin Thickness Right

Monica Ghidinelli, Hwan Tae Park, Maria Laura Feltri and colleagues reveal that laminin 211 can inhibit peripheral myelination by suppressing the axonal regulator neuregulin 1 type III, helping to explain why certain neuropathies are characterized by hypermyelination.

Image credit: pbio.2001408

Getting Myelin Thickness Right

06/20/2017

research article

Aging, Mortality and Trade-Offs in Fission Yeast

Hidenori Nakaoka and Yuichi Wakamoto use microfluidics to reveal an absence of aging in old-pole cell lineages of the fission yeast Schizosaccharomyces pombe, with elevated mortality under fast growing conditions.

Image credit: pbio.2001109

Aging, Mortality and Trade-Offs in Fission Yeast

06/20/2017

research article

Superantigens Trigger Toxic Shock-Like Response in MAIT Cells

Christopher Shaler, Mansour Haeryfar and co-workers show that mucosa-associated invariant T cells (MAIT cells) mount an excessive inflammatory response to bacterial superantigens, which results in their exhaustion and failure to participate in antimicrobial host defense.

Superantigens Trigger Toxic Shock-Like Response in MAIT Cells

Image credit: Flickr user: NIAID

06/12/2017

research article

Viral Genetics in HIV Pathogenesis

In individuals infected by HIV-1, the viral load in asymptomatic infection is highly variable. In this study by François Blanquart, Christophe Fraser, the BEEHIVE collaboration and other colleagues, phylogenetic methods applied to data from a large European collaboration reveal that one third of this variation is explained by viral genetic factors.

Viral Genetics in HIV Pathogenesis

Image credit: C. Goldsmith Content Providers: CDC/ C. Goldsmith, P. Feorino, E. L. Palmer, W. R. McManus

06/15/2017

research article

Where Did that Sound Come from?

Stephen Town, Owen Brimijoin and Jennifer Bizley use neural recording in freely moving ferrets to reveal that auditory cortex represents sound location in both head-centered (egocentric) and world-centered (allocentric) coordinate frames.

Where Did that Sound Come from?

Image credit: Flickr user Max Moreau

06/06/2017

research article

How Do We Decide What Takes More Effort?

A decision-making study characterizes how humans assess physical effort when choosing between arm movements; common cost factors influence both action selection and action control.

How Do We Decide What Takes More Effort?

Image credit: Flickr user photocatcher

06/08/2017

research article

Five Stressors; Five Mutational Spectra

This study of Escherichia coli reveals that genetic variation is markedly dependent on the nature of the environmental stresses that the bacterium experiences. Read the accompanying Primer.

Five Stressors; Five Mutational Spectra

Image credit: Flickr user NIAID

06/08/2017

community page

Wide-Open: Liberation of Overdue Datasets

Wide-Open is a text-mining system that automates the detection of datasets overdue for public access; it triggered the release of hundreds of gene expression datasets from GEO within weeks.

Wide-Open: Liberation of Overdue Datasets

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