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Viral Transmission: Stochasticity Drives Adaptation

March 17, 2015

Viral Transmission: Stochasticity Drives Adaptation

Models of cell-to-cell viral transmission, carried out by Shuhei Miyashita, Masayuki Ishikawa and colleagues, illustrate how stochastic processes occurring within individual infected cells form a sophisticated adaptation system that optimizes viruses for further infection. Read more in the Synopsis.

Image credit: 10.1371/journal.pbio.1002095

03/18/2015

research article

Cell Cycle–Dependent Differentiation in the Pancreas

Yung Hae Kim, Anne Grapin-Botton and co-authors show that during the development of the pancreas, the asymmetric or symmetric differentiation of progenitor cells into endocrine cells results from stochastic priming of mitotic progenitors at different stages of the cell cycle.

Image credit: 10.1371/journal.pbio.1002111 S1 Fig.

Cell Cycle–Dependent Differentiation in the Pancreas

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Current Issue February 2015

03/13/2015

perspective

P-Hacking: Usage and Abusage of the P-Value

Megan Head, Michael Jennions and co-authors show that publication bias resulting from so-called "p-hacking" is pervasive throughout the life sciences; however, its effects on general conclusions made from the literature appear to be weak.

P-Hacking: Usage and Abusage of the P-Value

03/18/2015

formal comments

Genomic Imprinting: Conflict or Coadaptation?

Francisco Úbeda and Andy Gardner challenge the interpretation of a recent Research Article in which a  gene mediating interactions between mouse mothers and pups was claimed to support coadaptation rather than the kinship theory of genomic imprinting. Authors Jason Wolf, Michael Cowley and Andrew Ward respond.

Image credit: 10.1371/journal.pbio.1001799.g001

Genomic Imprinting: Conflict or Coadaptation?

03/11/2015

research article

Time-Window Separation Helps Find a Mate

Neuronal data, computational modeling, and behavioral experiments, conducted by Jannis Hildebrandt, Jan Benda and colleagues, reveal how the conflict between sensory adaptation and sound localization is resolved in the grasshopper auditory system, allowing processing of both absolute and relative sound levels.

Time-Window Separation Helps Find a Mate

Image credit: Flickr user Kumon

03/12/2015

research article and synopsis

CAP350/Alpha-catenin in Epithelial Morphogenesis

In epithelial cells, the normally centrosomal protein CAP350 binds to α-catenin at adherens junctions and helps to establish the cells' parallel apico-basal microtubule array and columnar shape. Read more in the Synopsis.

CAP350/Alpha-catenin in Epithelial Morphogenesis

Image credit: 10.1371/journal.pbio.1002087.g004

03/12/2015

perspective

Biodiversity Governance: A Tower of Babel of Scales and Cultures

To achieve full biodiversity governance, Jorge Soberón and Townsend Peterson suggest, requires the participation of local actors and their problems and knowledge, therefore the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) must recognize a key role of local institutions.

Biodiversity Governance: A Tower of Babel of Scales and Cultures

Image credit: Pieter Bruegel the Elder

03/12/2015

research article

A Flexible SUMO Ligase Coordinates DNA Repair

Conformational joints in the Mms21-Smc5/6 complex allow integration of its structural and signaling roles during DNA repair.

A Flexible SUMO Ligase Coordinates DNA Repair

Image credit: 10.1371/journal.pbio.1002089.g009

03/12/2015

research article

The Molecular Basis of a Bistable Switch

An experimentally evolved colony-level phenotype switch affects a metabolic bifurcation point where nucleotides can be used for either cell division or capsule polymer synthesis.

The Molecular Basis of a Bistable Switch

Image credit: 10.1371/journal.pbio.1002109.g001

03/05/2015

Perspective

Open Collaborations in Environmental Governance

A willingness to experiment with new forms of participation for environmental management can pay off in ways that can make a difference to people and place.

Open Collaborations in Environmental Governance

Image credit: Flickr user Pam loves pie