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The Sea Cucumber Genome

October 12, 2017

The Sea Cucumber Genome

The high-quality genome sequence of the sea cucumber Apostichopus japonicus by Xiaojun Zhang, Jianhai Xiang and colleagues provides a resource for research on echinoderm and deuterostome biology, comparative genomics and commercial breeding.

Image credit: Qiang Xu

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PLOS Research News

10/04/2017

research article

Female Body Growth Controlled by Sex of Specific Neurons

Annick Sawala and Alex Gould show that female fruit flies grow faster than males during larval development and that this depends upon expression of the sex determination gene Sex-lethal in two specific subsets of neurons in the brain.

Image credit: Annick Sawala & Alex Gould

Female Body Growth Controlled by Sex of Specific Neurons

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Current Issue

Current Issue September 2017

09/29/2017

research article

Intron Retention Regulates Translation during Hypoxia

Transcriptomic analysis of head and neck cancer cells by Lauren Brady, Constantinos Koumenis and co-authors reveals alternative splicing of EIF2B5 as a previously uncharacterized mechanism of translational control under conditions of hypoxia.

Image credit: pbio.2002623

Intron Retention Regulates Translation during Hypoxia

10/02/2017

formal comment

The RCR: a Good Metric, or a Flawed One?

The American NIH has introduced a new metric to evaluate the influence of scientific research articles, the Relative Citation Ratio. This Formal Comment by Cecile Janssens, Marta Gwinn and colleagues raises several concerns about its validity; see also the response by RCR authors Ian Hutchins, George Santangelo and co-workers.

Image credit: pbio.1002541

The RCR: a Good Metric, or a Flawed One?

09/27/2017

research article

Segmentation: from Short-Germ to Long-Germ

A modelling study by Erik Clark finds that kinematic expression waves of the pair-rule gene even-skipped are crucial for segment patterning in Drosophila, suggesting that key aspects of long-germ segmentation are inherited from short-germ ancestors.

Segmentation: from Short-Germ to Long-Germ

Image credit: pbio.2002439

09/22/2017

methods and resources

How Bacteria Colonize Plants

Benjamin Cole, Meghan Feltcher, Jeffery Dangl, Axel Vise and co-workers used a genome-wide barcoded transposon mutagenesis study in a root-colonizing strain of the bacterium Pseudomonas simiae to identify over a hundred genes that significantly impact the ability to competitively colonize roots of the plant Arabidopsis thaliana.

How Bacteria Colonize Plants

Image credit: pbio.2002860

09/22/2017

research article

Complex Regulation of Stomatal Closure

Réka Albert, Sarah Assmann and co-authors used structural, logic-based, and experimental analysis of a plant signal transduction network regulating stomatal closure to predict a previously unrecognized feedback mechanism involving cytosolic calcium ions.

Complex Regulation of Stomatal Closure

Image credit: James Kremer

09/28/2017

community page

The Experimental Design Assistant

The Experimental Design Assistant is a free-to-use web-based tool which helps in vivo researchers plan their experiments and provides feedback to improve the experimental design and analysis plans.

The Experimental Design Assistant

Image credit: pbio.2003779

09/19/2017

essay

The "Central Dogma" — 60 Years On

This essay explores the rich content of Francis Crick’s 1957 ‘central dogma’ lecture and its continuing power to help us think about how genes work.

The "Central Dogma" — 60 Years On

Image credit: Marc Lieberman

09/21/2017

research article

Wiring the Female Sexual Brain

How factors such as sexual experience influence the development of the genital cortex and how genital cortex growth affects female sexual maturation in rats.

Wiring the Female Sexual Brain

Image credit: Flickr user Understanding Animal Research

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