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Amphioxus Prompts Re-Think of Vertebrate Brain

April 19, 2017

Amphioxus Prompts Re-Think of Vertebrate Brain

A study of gene expression patterns in the developing nervous system of the basal chordate amphioxus, by Beatriz Albuixech-Crespo, Jordi Garcia-Fernàndez, Luis Puelles, Manuel Irimia, José Luis Ferran and co-workers, highlights its complex molecular regionalization and challenges the classic separation between forebrain and midbrain in vertebrate brains.

Image credit: Beatriz Albuixech-Crespo with Manel Bosch/CCiT-UB.

10 Years of PLOS Neglected Tropical Diseases

PLOS NTDs

04/17/2017

research article

Calcium Channel Helps Balance Synapse Endocytosis

How does the cell balance exocytosis with endocytosis? This study by Chi-Kuang Yao, Ping-Yen Wu and colleagues reveals how a synaptic vesicle-associated Ca2+ channel, transferred to endocytic zones during neurotransmission, promotes one form of endocytosis under mild stimulation and—by triggering Ca2+ influx—another form under intense stimulation.

Image credit: Chi-Kuang Yao

Calcium Channel Helps Balance Synapse Endocytosis

Recently Published Articles

Current Issue

Current Issue March 2017

04/18/2017

research article

Rapid Compensation in Multi-drug Resistant Bacteria

Jorge Moura de Sousa, Roberto Balbontín, Paulo Durão and Isabel Gordo show that compensation in multi-drug resistant bacteria can be driven by further mutations that in turn compensate for the epistatic interactions between the resistance mutations; this favors the stabilization of multiple resistances in bacterial populations.

Image credit: NIAID

Rapid Compensation in Multi-drug Resistant Bacteria

04/17/2017

research article

Circadian Transcriptional Logic of the Liver

Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Bart Deplancke, Felix Naef, the CycliX consortium and other authors used around-the-clock temporally resolved measurements of the mouse liver epigenome to shed light on the underlying circadian gene regulatory network and its transcriptional interconnection with feeding/fasting cycles.

Image credit: Flickr user catmachine

Circadian Transcriptional Logic of the Liver

04/19/2017

research article

A Critical-Like Collective State for Aggregating Amoebae

Giovanna De Palo, Darvin Yi and Robert Endres use a multiscale model and imaging data to show that cells of the slime mold Dictyostelium discoideum maximize their cell–cell communication range during aggregation by a critical-like state known from phase transitions in physical systems.

A Critical-Like Collective State for Aggregating Amoebae

Image credit: pbio.1002602

04/17/2017

perspective

If Authors Authenticate their Cell Lines...?

What can journals do to counteract the persisting problem of cell line cross-contamination in the published literature? This Perspective article by Norbert Fusenig, Peter Lichter and co-authors examines what happened when the International Journal of Cancer took the lead by mandating cell line authentication at the point of submission.

If Authors Authenticate their Cell Lines...?

Image credit: NIH

04/17/2017

research matters

Less Fear, more Diversity

In this Research Matters article, Gregory Quirk discusses how research on learned fear responses can be applied to the treatment of anxiety disorders, and how we can increase ethnic diversity in neuroscience.

Less Fear, more Diversity

Image credit: Edvard Munch

04/13/2017

research article

Genetic Variation Tracks Species Diversity Gradient

Genetic variation within bird species forms a latitudinal diversity gradient that is similar to the pattern of high species diversity in the tropics.

Genetic Variation Tracks Species Diversity Gradient

Image credit: Ben Winger

04/12/2017

research article

Amoebae as Environmental Niche for Bordetella

Bordetella bronchiseptica can evade amoebic predation while exploiting the amoeba Dictyostelium discoideum as a dissemination and expansion vector.

Amoebae as Environmental Niche for Bordetella

Image credit: pbio.2000420

04/11/2017

research article

Reinventing the Solution to Seeing in Dark Waters

Adaptation of stickleback color vision genes to life in blackwater lakes shows that convergent evolution can be based on the same genetic mechanism over very different evolutionary time scales

Reinventing the Solution to Seeing in Dark Waters

Image credit: Emil Walter via Biodiversity Heritage Library via Flickr

04/13/2017

research article

Diffusion fMRI and Cell Swelling

Pharmacological studies of diffusion fMRI using anaesthetic agents reveal that water diffusion quantitatively reflects underlying neural activity and is associated with local cell swelling.

Diffusion fMRI and Cell Swelling

Image credit: pbio.2001494

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