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A New Canal in Nicaragua: Lessons from Panama

July 27, 2015

A New Canal in Nicaragua: Lessons from Panama

Objections have been raised to a new canal in Nicaragua, but this Essay by Richard Condit argues that those dire predictions are exaggerated; rather, the project could help fund environmental protection and modernize employment in this largely rural country.

Image credit: Flickr user Colleen Morgan

07/27/2015

Research Article

Leaky Vaccines Can Favor Emergence of Virulent Strains

A study using Marek's disease virus in poultry, carried out by Andrew Read, Venugopal Nair and colleagues, shows that by reducing natural selection against highly virulent strains, imperfect vaccination enables the spread of viral strains that would otherwise be too lethal to persist.

Image credit: Flickr user Garrett Heath

Leaky Vaccines Can Favor Emergence of Virulent Strains

Recently Published Articles

Current Issue

Current Issue July 2015

07/27/2015

Perspective

Prioritizing Gender Diversity in Data Science

Data science is accelerating innovation, and the best and the brightest from both genders are needed to achieve its potential. This Perspective from Francine Berman and Philip Bourne discusses what you can do to advance the field, including "10 Simple Rules" for increasing gender diversity.

Prioritizing Gender Diversity in Data Science

07/30/2015

Perspective

Genetics and Genomics in 2025

The last few decades have utterly transformed genetics and genomics, but what might the next ten years bring? In this Perspective, eight leading authors, spanning a range of related areas, give us their predictions as to how the discipline will look in 2025.

Image credit: 10.1371journal.pbio.1002216.g001

Genetics and Genomics in 2025

07/29/2015

Research Article

When to Pupate: Integrating Nutritional and Developmental Cues

New research by Xiao-Jun Xie, Jun-Yuan Ji and colleagues shows that during the larval-pupal transition in Drosophila melanogaster, CDK8-CycC helps to link nutrient intake to development by activating ecdysone receptor-dependent transcription and to fat metabolism by inhibiting SREBP-activated gene expression.

When to Pupate: Integrating Nutritional and Developmental Cues

Image credit: 10.1371/journal.pbio.1002207

07/23/2015

Research Article

The Functional Connectome of Speech Control

This study by Stefan Fuertinger, Barry Horwitz and Kristina Simonyan uses graph theory to analyze functional MRI data recorded from speakers as they produce single syllables or whole sentences, revealing the complexity of the brain network machinery that controls speech and language.

The Functional Connectome of Speech Control

Image credit: Stefan Fuertinger, Kristina Simonyan

07/23/2015

Community Page

Biodiversity E-Infrastructures for Megadiverse Countries

This Community Page by Dora Canhos, Mariane Sousa-Baena, Townsend Peterson and colleagues calls for new governance and funding models to ensure the sustainability of national e-infrastructures—important for global systems and crucial for local education, research, and policy

Biodiversity E-Infrastructures for Megadiverse Countries

Image credit: Flickr user Gilad Rom

07/23/2015

essay

Diffusion MRI: What Water Can Tell Us

This Essay looks at the history and future potential of diffusion MRI, an imaging concept that gives non-invasive insights into brain architecture and function—whether normal or diseased.

Diffusion MRI: What Water Can Tell Us

Image credit: 10.1371/journal.pbio.1002203.g002

07/21/2015

Research Article and synopsis

Parasite Uncovers New Modulator of STAT1

A study using Toxoplasma identifies the host orphan nuclear hormone receptor TLX as a key enhancer of STAT1-dependent immunity. Read the Synopsis.

Parasite Uncovers New Modulator of STAT1

Image credit: 10.1371/image.pbio.v10.i12

07/15/2015

Research Article

Photoreceptor Degeneration in Mitochondrial Mutants

Some mitochondrial disorders cause blindness via degeneration of light-activated photoreceptors because of the shortfall in mitochondrial energy production, rather than oxidative stress.

Photoreceptor Degeneration in Mitochondrial Mutants

Image credit: Manish Jaiswal