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Longitudinal Axon Guidance by Ternary Complex

September 21, 2016

Longitudinal Axon Guidance by Ternary Complex

During the development of the insect central nervous system, Maryam Alavi, Thomas Kidd and co-workers find that cleavage of the secreted signaling protein Slit allows the formation of a complex with the receptors Dscam1 and Robo1 that is required for longitudinal axon growth across body segment boundaries.

Image credit: Ryan Allen

Open Highlights: Highlighting Open Access research from PLOS and beyond

Open Highlights

09/21/2016

Research Article

Def-CAPN3 Pathway: Nucleolar Checkpoint for Proliferation

Yihong Guan, Delai Huang, Jun Chen, Jinrong Peng and co-authors find that during organogenesis, cell proliferation is controlled not only by many known regulatory networks but also by the newly identified Def-CAPN3 nucleolar protein degradation pathway.

Image credit: pbio.1002555

Def-CAPN3 Pathway: Nucleolar Checkpoint for Proliferation

Recently Published Articles

Current Issue

Current Issue August 2016

09/16/2016

 Research Article

Sam68 and DNA Damage Repair

Xin Sun, Kai Fu, Fengyi Wan and co-workers reveal that the RNA-binding protein Sam68 has unexpected function in the early signaling of DNA damage, and is critical for the activation and regulation of poly(ADP-ribose) polymerase 1 in response to DNA damage.

Image credit: pbio.1002543

Sam68 and DNA Damage Repair

09/21/2016

Research Article

EDA-Fibronectin in Fibrosis and Cancer

Stephanie Rossnagl, Inaam Nakchbandi and co-workers find that osteoblasts produce an isoform of fibronectin (EDA-fibronectin) that acts on myeloid cells to increase arginase-1 expression and protect against fibrosis. However, it can also enhance cancer growth; interfering with the interaction between EDA-fibronectin and its receptor diminishes this effect.

Image credit: pbio.1002562

EDA-Fibronectin in Fibrosis and Cancer

09/21/2016

 Research Article

Molecular Pathogenesis of Inherited Erythromelalgia

Mutations in the Nav1.7 sodium channel cause idiopathic erythromelalgia. Chiung-Wei Huang, Ming-Jen Lee, Chung-Chin Kuo and colleagues show that the pathogenic resurgent sodium currents arise via modification of gating behavior rather than via competing pore block by the Navβ4 peptide.

Molecular Pathogenesis of Inherited Erythromelalgia

Image credit: pbio.1002561

09/15/2016

Research Article

Sensitizing Bacteria to Antibiotics

Dilay Ayhan, Yusuf Tamer, David Greenberg, Erdal Toprak and co-workers demonstrate that reducing expression of the AcrAB-TolC efflux system of Escherichia coli by antisense-mediated translation inhibition increases the susceptibility of bacteria to a wide range of antibiotics.

Sensitizing Bacteria to Antibiotics

Image credit: Flickr user: NIAID

09/12/2016

research article

MAPK Cascade Regulates Shoot Development

Weiyan Jia, Jiayang Li, Yonghong Wang and colleagues show that the MKK7-MPK6 cascade plays a specific role in regulating auxin-related developmental events and phosphorylates PIN1, affecting its polarization and determining shoot branching in Arabidopsis.

MAPK Cascade Regulates Shoot Development

Image credit: pbio.1002550

09/15/2016

Research Article

Essential RNA Modification of the Mitoribosome

Two solutions were selected during evolution to allow proper function of the vertebrate mitochondrial 16S ribosomal RNA—either RNA methylation or ancient mutation.

Essential RNA Modification of the Mitoribosome

Image credit: pbio.1002557

09/14/2016

research article

Watching Emotions in an Idle Mind

What happens to our emotions in the absence of external stimuli? fMRI reveals that the brain dynamically fluctuates between multiple emotional states during rest.

Watching Emotions in an Idle Mind

Image credit: pbio.2000106

09/15/2016

Research Matters

Chasing Ecological Interactions

Ecologist Pedro Jordano assesses how basic research is helping us to address the current fast-paced extinction of species due to human activities.

Chasing Ecological Interactions

Image credit: pbio.1002559

09/07/2016

PLOS Biologue

Double Bill on Citation Metrics

Lauren Richardson and Hashi Wijayatilake discuss two recent papers about the complexities of measuring the influence of scientific research.

Double Bill on Citation Metrics

Image credit: pbio.1002541