Image credit: Flickr user Thinboyfatter
Image credit: Flickr user Thinboyfatter
Current Issue March 2015
Jordi van Gestel, Hera Vlamakis and Roberto Kolter show that in the bacterium Bacillus subtilis, cooperation between surfactin-producing and matrix-producing cells drives migration over solid surfaces by the formation of filamentous looped "van Gogh bundles" at the edge of the colony.
Image credit: Jordi van Gestel
Environmental measurements and physiological recordings, by Lauren Walmsley, Robert Lucas, Timothy Brown and co-authors, reveal that mice not only use changes in the intensity of sunlight to entrain their circadian clock, but also employ blue–yellow color discrimination to detect spectral changes associated with dawn and dusk.
Image credit: Flickr user 白士 李
Resistance to artemisinin antimalarial drugs is jeopardizing malaria control. Con Dogovski, Stanley Xie, Nectarios Klonis, Leann Tilley and colleagues find that proteasome-mediated stress responses can be targeted to overcome artemisinin resistance and suggest alternate therapeutic regimens and monitoring strategies.
Image credit: Dr Eric Hanssen, Bio21 Institute, University of Melbourne.
A systematic review of research articles by Tracey Weissgerber, Vesna Garovic and co-authors reveals that poor practice in the presentation of continuous data is widespread in the literature. The authors recommend training for scientific investigators and supply templates for easy use.
Image credit: modified from 10.1371/journal.pbio.1002128.g001
In vivo live imaging of zebrafish embryos, conducted by Anna Lenard, Markus Affolter and colleagues, reveals the diverse cellular activities involved in the pruning of unwanted blood vessels, including the self-fusion of endothelial cells.
Image credit: journal.pbio.1002126.g002
Differential blood flow patterns direct the orientation and migration of endothelial cells as a mechanism for stabilizing or pruning individual blood vessel segments.
Image credit: doi:10.1371/journal.pbio.1002125.g001
research article and synopsis
Whole-genome genetic variation data from 40 species explain why levels of neutral diversity do not scale with population size. Read the accompanying Synopsis.
Image credit: Flickr user Mark Jordahl
Lauren Richardson discusses a new Research Article that exploits cellular stress to identify two routes to overcoming artemisinin resistance.
Image credit: CDC
This collection addresses the pressing need for plant research to contribute solutions to improving food security in a sustainable and safe way.
The biosynthesis of starch in plant chloroplasts depends on a novel protein that targets starch synthase to the growing starch granules; this represents a potential target for the biotechnological modification of starch. Read the Synopsis.
The novel protein FAX1 mediates the export of free fatty acids across the inner membrane of chloroplasts so that they can be processed in other plant cell organelles to generate oils, waxes, and other lipids. Also read the Synopsis.
A genome-wide association study identifies the enzyme in plants that transforms arsenate into arsenite, allowing its extrusion into the soil and thereby controlling accumulation of the toxin. See the Synopsis.
During flooding, the plant transcription factor HRA1 counterbalances the hypoxia response triggered by a stabilized plant ethylene responsive factor.
Cross-sectional serological data and mathematical modeling reveal key aspects of the human immune system's response to seasonal influenza infection.
A mathematical model of the 2014 Liberian Ebola outbreak informs how better to contain the epidemic. Read the Primer.
How the protein complex at one special vertex of a membrane-containing icosahedral dsDNA virus packages the viral genome.
Bill Sugden examines the evidence that links this ubiquitous human pathogen to cancer and multiple sclerosis.
Contrasting degrees of viral diversity can be explained by properties of both host and virus.