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How Cardiomyocytes Release Microparticles

August 14, 2017

How Cardiomyocytes Release Microparticles

Bing Xu, Ying Fu, TingTing Hong and colleagues find that cardiomyocyte t-tubule microfolds containing the membrane deformation protein cBIN1 recruit an ESCRT-III component to snip off and release microparticles; the released cBIN1 can be measured in blood as a marker of myocardial health.

Image credit: Pixabay

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PLOS Research News

08/18/2017

research article

Actin, Rictor and B Cell Receptor Signaling

Lu Huang, Yongjie Zhang, Xiaodong Zhao , Chaohong Liu and co-workers show that during B cell receptor activation, the mTORC component Rictor regulates the phosphorylation of ezrin; loss of Rictor leads to the uncontrolled reorganization of the actin network, resulting in impaired B cell receptor signaling and antibody response.

Image credit: pbio.2001750

Actin, Rictor and B Cell Receptor Signaling

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Current Issue

Current Issue July 2017

08/18/2017

research matters

Unite Taxonomy and Technology!

The modern scientific era offers the perfect opportunity to merge traditional (morphological) taxonomy with cutting-edge “Omics” approaches, says Holly Bik. Incorporating (rather than discarding) such historical knowledge could transform the way biological studies are conducted in the future.

Image credit: Tiago Jose Pereira

Unite Taxonomy and Technology!

08/18/2017

Primer

Perceiving Effort

This Primer by Ignasi Cos examines recent research that identifies utility as a useful notion to formalize how effort is subjectively perceived in the context of cost-benefit analyses for movement control and for decisions between movements. Read the related Research Article.

Image credit: Flickr user photocatcher

Perceiving Effort

08/08/2017

research article

Drug Sequence Influences Evolution of Resistance

A study of the human bacterial pathogen Pseudomonas aeruginosa by Phillip Yen and Jason Papin shows that different adaptation histories to antibiotics lead to distinct evolutionary dynamics of multidrug resistance, potentially informing the design of strategies to mitigate resistance and combat bacterial infections.

Drug Sequence Influences Evolution of Resistance

Image credit: CDC/ James Archer

08/11/2017

research article 

Recombination between Centromeres Drives Mating System Evolution

A comparative study of the pathogenic fungus Cryptococcus by Sheng Sun, Vikas Yadav, Joseph Heitman and colleagues reveals that chromosomal rearrangements involving centromeric regions played important roles in the evolution of fungal genomes, including the transition between different mating systems.

Recombination between Centromeres Drives Mating System Evolution

Image credit: Flickr user: Ed Uthman

08/01/2017

research article

Dietary Restriction Enhances Learning

Mihir Vohra, George Lemieux, Lin Lin and Kaveh Ashrafi show that the beneficial effects of reduced nutrient intake on enhancement of learning are not just secondary consequences of extended lifespan but are specifically due to depletion of the tryptophan metabolite (and glutamatergic antagonist) kynurenic acid.

Dietary Restriction Enhances Learning

Image credit: pbio.2002032

08/04/2017

research article 

Ciliary Targeting by Nuclear Localization Signal

The karyopherin-β2 nuclear import system regulates the targeting of the Hedgehog signaling pathway transcription factor Gli to the primary cilium, and forms a positive feedback loop.

Ciliary Targeting by Nuclear Localization Signal

Image credit: pbio.2002063

08/03/2017

research article

Making a Bacterial Flagellum I

Analysis of the core structure of the bacterial flagellar type III export gate complex reveals novel insights into how the gate complex is formed inside the flagellar basal body MS ring.

Making a Bacterial Flagellum I

Image credit: pbio.2002281

08/03/2017

research article

Making a Bacterial Flagellum II

Aan integral-membrane chaperone, FliO, coordinates the self-assembly of the multi-component type III secretion system needed to export the building blocks of the bacterial flagellum.

Making a Bacterial Flagellum II

Image credit: pbio.2002267

08/01/2017

research article

lncRNA Turns White Fat Brown

A profile of lncRNA transcriptome changes during white fat browning and brown fat activation identifies lncBATE10 as a novel regulator of these biological processes.

lncRNA Turns White Fat Brown

Image credit: pbio.1001314

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