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Whole-Genome Duplication: Caught in the Act

May 16, 2017

Whole-Genome Duplication: Caught in the Act

Raúl Ortiz-Merino, Kenneth Wolfe and colleagues find that a young hybrid yeast species, Zygosaccharomyces parabailii, retraces the evolutionary steps hypothesized to have caused whole-genome duplication in an ancestor of Saccharomyces cerevisiae.

Image credit: pbio.2002128

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PLOS Research News

05/16/2017

research article

Not-So-Silent Cystic Fibrosis Variants?

Sebastian Kirchner, David Sheppard, Zoya Ignatova and colleagues show that a synonymous single-nucleotide polymorphism alters the structure and function of the cystic fibrosis transmembrane conductance regulator (CFTR) by changing the local speed of translation in a tissue- and tRNA-dependent fashion.

Image credit: pbio.2000779

Not-So-Silent Cystic Fibrosis Variants?

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Current Issue April 2017

05/16/2017

community page

1,200,000 Kids and Counting – Mobile Science Laboratories

A survey of the Mobile Laboratory Coalition by Amanda Jones and Mary Stapleton revealed that collectively these programs have provided hands-on science activities to over 1,200,000 students and 16,000 teachers across the US.

Image credit: pbio.2001692

1,200,000 Kids and Counting – Mobile Science Laboratories

05/19/2017

research article

How Campylobacter Colonizes

A multidisciplinary study by Beile Gao, Hanne Vorwerk, Jorge Galán and Dirk Hofreuter provides a comprehensive view of the metabolic requirements for intestinal colonization by Campylobacter jejuni, a leading cause of food-borne gastroenteritis in industrialized countries.

Image credit: pbio.2001390

How Campylobacter Colonizes

05/15/2017

primer

Manipulating Fate

Pharmacogenomics is emerging as a new tool for directing endogenous neural stem cells toward specific fate. This Primer by Mirjana Maletic-Savatic reflects on a study that used pharmacogenomics to direct subventricular stem cells to oligodendrocytic and glutamatergic lineages in both healthy and hypoxic states, paving the way for using endogenous stem cells for brain repair. Read the related Research Article.

Manipulating Fate

Image credit: pbio.2000698

05/10/2017

research article

Diverse Responses to DNA Damage

Lara Barazzuol, Limei Ju and Penny Jeggo find that after X-ray irradiation, adult neural progenitor cells undergo apoptosis, arrest proliferation and differentiate, activating quiescent stem cells. By contrast, progenitor cells in neonatal mice largely maintain proliferation without quiescent stem cell activation.

Diverse Responses to DNA Damage

Image credit: pbio.2001264

05/09/2017

research article

Phenotypic Heterogeneity Promotes Evolution

A study in the yeast Saccharomyces cerevisiae by Zoltán Bódi, Zoltán Farkas, Csaba Pál and co-authors shows that phenotypic heterogeneity shapes evolutionary trajectories and facilitates evolutionary rescue from a deteriorating environmental stress by enlarging the beneficial effects of mutations.

Phenotypic Heterogeneity Promotes Evolution

Image credit: Zoltán Bódi and Zoltán Farkas

05/03/2017

research article

The Epigenetics of Building a Cortex

Crosstalk between genetic and epigenetic components (including Smek and Mbd3) plays a crucial role in determining cell fate of neural stem cells during cortical neurogenesis in the developing brain.

The Epigenetics of Building a Cortex

Image credit: pbio.2001220

05/04/2017

research article

Auditory Motion Detectors

A neuroimaging study in awake macaques provides the first demonstration that auditory motion is not simply deduced from changes in spatial location but relies on motion-specific mechanisms.

Auditory Motion Detectors

Image credit: pbio.2001379

05/01/2017

research article

Stochasticity & Division of Labor in Bacteria

Stochastic processes in toxin production dynamics influence bacterial competition by shaping the initial conditions and by determining the fraction of toxin producers.

Stochasticity & Division of Labor in Bacteria

Image credit: pbio.2001457

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