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Membrane Contact Sites Regulate Phospholipids

May 21, 2018

Membrane Contact Sites Regulate Phospholipids

Evan Quon, Yves Sere, Christopher Beh, Anant Menon and co-authors eliminate contact sites between the endoplasmic reticulum and the plasma membrane in yeast, revealing their role in the regulation of phospholipid synthesis and phosphatidylinositol-4-phosphate turn-over.

Image credit: pbio.2003864

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PLOS Biology's XV Collection

05/21/2018

METHODS AND RESOURCES

Targeting Allostery

This structural biology study by Daniel Stöppler, Alex Macpherson, Hartmut Oschkinat, Alastair Lawson and colleagues establishes an innovative approach to characterizing the allosteric effects of ligand binding, here exploring new compounds that bind to the neonatal Fc receptor, a validated drug-target in autoimmune diseases.

Image credit: pbio.2006192

Targeting Allostery

Recently Published Articles

Current Issue

Current Issue April 2018

05/18/2018

RESEARCH ARTICLE

How FtsZ Runs Rings around the Cell

Diego Ramirez-Diaz, Daniela García-Soriano, Ana Raso, Petra Schwille and co-workers show that FtsZ, the primary protein of the bacterial Z ring that guides cell division, when artificially targeted to the membrane in the absence of its normal membrane anchor FtsA, self-assembles to form dynamic chiral rings in manner dependent on surface concentration.

Image credit: pbio.2004845

How FtsZ Runs Rings around the Cell

05/24/2018

unsolved mystery

What Roads Lead to Ferroptosis?

Huizhong Feng and Brent Stockwell explore three unsolved mysteries about the process of lipid peroxidation that drives cell death by ferroptosis, and how these may illuminate new therapeutic strategies and regulatory mechanisms.

Image credit: pbio.2006203

What Roads Lead to Ferroptosis?

05/16/2018

Research Article

Fat1 Cadherin Controls Neuromuscular Morphogenesis

Françoise Helmbacher explores how the cadherin Fat1 tunes the morphogenesis of subsets of muscles and their partner motor neurons by playing distinct complementary activities in motor neurons, muscles and connective tissues.

Fat1 Cadherin Controls Neuromuscular Morphogenesis

Image credit: pbio.2004734

05/16/2018

methods and resources

Haploinsufficiency - Not as Rare as You Think

Shinsuke Ohnuki and Yoshikazu Ohya use high-dimensional single-cell phenotyping to show that more than half of the essential genes in budding yeast exhibit haploinsufficiency, challenging the assumption that this phenomenon is rare.

Haploinsufficiency - Not as Rare as You Think

Image credit: pbio.2005130

05/17/2018

short report

Intermediates of Carbohydrate Metabolism Mediate Axon Growth

Hosni Cherif, François Duhamel, Jean-François Bouchard and colleagues reveal the influence of two intermediates of carbohydrate metabolism (succinate and α-ketoglutarate) and their receptors (GPR91 and GPR99) on the growth of retinal ganglion cell axons during development of the retino-thalamic system.

Intermediates of Carbohydrate Metabolism Mediate Axon Growth

Image credit: pbio.2003619

05/11/2018

research article

Inhibit p38α to Turn White Fat Brown

The MAP kinase p38α plays a vital role in the browning of white fat and in energy homeostasis; mice lacking adipose p38α display a lean phenotype, improved metabolism, and resistance to obesity.

Inhibit p38α to Turn White Fat Brown

Image credit: pbio.2004225

05/11/2018

short report

Pro-Tumoral T Cells' Oxidative Achilles' Heel

During tumor progression, neutrophils inhibit a tumor-supporting subset of T cells. Their sensitivity to neutrophil-induced oxidative stress is due to low levels of the anti-oxidant glutathione.

Pro-Tumoral T Cells' Oxidative Achilles' Heel

Image credit: Ben Mills via Wikimedia Commons

05/16/2018

unsolved Mystery

Do Plants Have a Segregated Germline?

This Essay re-visits an old mystery, the nature of the plant germline, concluding that we know a lot less than we think we do, and proposing a new approach to reveal the nature of the germline in all plants.

Do Plants Have a Segregated Germline?

Image credit: Ella Maru

05/11/2018

research article

Ignore (Bacterial) Death at your Peril

Reported increases in mutation rates under stress are systematically over-estimated because of cell death, and are often compensated by reduced population sizes.

Ignore (Bacterial) Death at your Peril

Image credit: Jbuzbee via Wikimedia Commons

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