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Spermidine Protects the Aging Memory

September 29, 2016

Spermidine Protects the Aging Memory

Varun Gupta, Stephan Sigrist and co-authors find that feeding spermidine to Drosophila protects them from age-dependent memory impairment by suppressing structural and functional alterations in presynaptic performance.

Image credit: pbio.1002563

Open Highlights: Highlighting Open Access research from PLOS and beyond

Open Highlights

09/29/2016

 Research Article

Autism: Disruption of Recently Evolved Synaptic Gene Expression

A comparative transcriptome study by Xiling Liu, Dingding Han, Mehmet Somel, Svante Pääbo, Schahram Akbarian, Philipp Khaitovich and colleagues draws a connection between the gene expression alterations in autism and molecular features of cortical development that are unique to humans.

Image credit: pbio.1002558

Autism: Disruption of Recently Evolved Synaptic Gene Expression

Recently Published Articles

Current Issue

Current Issue September 2016

09/29/2016

Essay

Breast Cancer Patients Have Greatly Benefited from Research

Progress in treatment has led to increased survival of breast cancer patients, allowing them many productive high-quality years. In this Research Matters, Bernd Groner and Nancy Hynes explore what led to this progress and ask whether we can expect even more advances in the future.

Image credit: Flickr user Ed Uthman

Breast Cancer Patients Have Greatly Benefited from Research

09/30/2016

Open Highlights

In Search of Autism’s Roots

This Open Highlight by Liza Gross describes recent research aimed at establishing the neurodevelopmental origins of autism spectrum disorder and the efforts to help those with associated health problems.

Image credit: pbio.2000958

In Search of Autism’s Roots

09/21/2016

Research Article

Longitudinal Axon Guidance by Ternary Complex

During the development of the insect central nervous system, Maryam Alavi, Thomas Kidd and co-workers find that cleavage of the secreted signaling protein Slit allows the formation of a complex with the receptors Dscam1 and Robo1 that is required for longitudinal axon growth across body segment boundaries.

Longitudinal Axon Guidance by Ternary Complex

Image credit: Ryan Allen

09/21/2016

Research Article

Def-CAPN3 Pathway: Nucleolar Checkpoint for Proliferation

Yihong Guan, Delai Huang, Jun Chen, Jinrong Peng and co-authors find that during organogenesis, cell proliferation is controlled not only by many known regulatory networks but also by the newly identified Def-CAPN3 nucleolar protein degradation pathway.

Def-CAPN3 Pathway: Nucleolar Checkpoint for Proliferation

Image credit: pbio.1002555

09/16/2016

 Research Article

Sam68 and DNA Damage Repair

Xin Sun, Kai Fu, Fengyi Wan and co-workers reveal that the RNA-binding protein Sam68 has unexpected function in the early signaling of DNA damage, and is critical for the activation and regulation of poly(ADP-ribose) polymerase 1 in response to DNA damage.

Sam68 and DNA Damage Repair

Image credit: pbio.1002543

09/21/2016

Research Article

EDA-Fibronectin in Fibrosis and Cancer

Osteoblasts produce an isoform of fibronectin (EDA-fibronectin) that acts on myeloid cells to protect against fibrosis but can also enhance cancer growth.

EDA-Fibronectin in Fibrosis and Cancer

Image credit: pbio.1002562

09/21/2016

 Research Article

Molecular Pathogenesis of Inherited Erythromelalgia

Mutations in the Nav1.7 sodium channel cause idiopathic erythromelalgia via modification of gating behavior rather than via competing pore block by the Navβ4 peptide.

Molecular Pathogenesis of Inherited Erythromelalgia

Image credit: pbio.1002561

09/15/2016

Research Article

Sensitizing Bacteria to Antibiotics

Reducing expression of the AcrAB-TolC efflux system of Escherichia coli by antisense-mediated translation inhibition increases the susceptibility of bacteria to a wide range of antibiotics.

Sensitizing Bacteria to Antibiotics

Image credit: Flickr user: NIAID

09/30/2016

PLOs biologue

A Fungus Among Us

To mark UK Fungus Day on October 9th, Lauren Richardson looks at recent open access research on this diverse kingdom, ranging from virulent pathogens to essential symbiotic partners.

A Fungus Among Us

Image credit: US Department of Agriculture