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Mitochondrial Dynamics and Wolfram Syndrome

July 19, 2016

Mitochondrial Dynamics and Wolfram Syndrome

Michal Cagalinec, Mailis Liiv, Allen Kaasik and colleagues reveal that deficiency of the protein Wolframin in Wolfram syndrome triggers a stress cascade in the endoplasmic reticulum; this leads to altered calcium homeostasis, which in turn impairs mitochondrial dynamics and consequently inhibits neuronal development.

Image credit: pbio.1002511

Open Highlights: Highlighting Open Access research from PLOS and beyond

Biologue

07/18/2016

Research article

Mitochondria and Presynaptic Ca2+ Clearance

Seok-Kyu Kwon, Franck Polleux and colleagues show that the capture of mitochondria at individual presynaptic boutons plays a synapse-specific role in regulating neurotransmission through the ability to regulate presynaptic calcium levels.

Image credit: pbio.1002516

Mitochondria and Presynaptic Ca2+ Clearance

Recently Published Articles

Current Issue

Current Issue June 2016

07/18/2016

research matters

How Cells Process Information and Make Decisions

In PLOS Biology's first ever Research Matters, Michael Laub explains the importance of understanding the transmission and interpretation of complex biological signals by our own cells and by the bacterial cells that live in or on us.

Image credit: pbio.1002519

How Cells Process Information and Make Decisions

07/18/2016

editorial

Introducing PLOS Biology's "Research Matters"

PLOS Biology's “Research Matters” is a new article series in which active scientists engage with the public about why basic research in their field matters. Research Matters will bridge the gap between researchers and the public by explaining how basic research positively impacts public health, society, life, and the environment.

Image credit: pbio.1002518

Introducing PLOS Biology's "Research Matters"

07/21/2016

research article

Architectural Invariants in the Cerebral Cortex

Szabolcs Horvát, Răzvan Gămănuț, Mária Ercsey-Ravasz, Zoltán Toroczkai, Henry Kennedy and co-authors find that the cortical network obeys common architectural principals in mouse and macaque. Differences include a relative decrease in long-range connections in the large brain of the macaque compared to the mouse.

Architectural Invariants in the Cerebral Cortex

Image credit: pbio.1002512

07/14/2016

research article

Network Organization of Lymph Node Scaffold

Topological complex network analysis by Mario Novkovic, Lucas Onder, Jovana Cupovic, Burkhard Ludewig and co-workers reveals an underlying robust "small-world" organization of fibroblastic reticular cells and its critical role in the maintenance of lymph node functionality.

Network Organization of Lymph Node Scaffold

Image credit: pbio.1002515

07/12/2016

research article

Genes vs Chromosome in Battle for Control of Germline Expression

Expression of sex-linked genes in the Drosophila male germline reflects a balance between an X chromosome-wide transcriptional suppression and long-term, gene-wise evolutionary recruitment of strong, compensatory promoter elements.

Genes vs Chromosome in Battle for Control of Germline Expression

Image credit: Steve Dorus and Shelley Kummer

07/11/2016

Open highlights

Understanding Disease Tolerance and Resilience

Recent research into the complex relationship between host and pathogen during the course of an infection, and the factors that determine its eventual outcome.

Understanding Disease Tolerance and Resilience

Image credit: 10.1371/journal.pbio.1002436.g003.

07/11/2016

Editorial

Introducing Open Highlights

PLOS Biology announces a new article type, Open Highlights, which uses a recent paper to link up to ten related research articles from PLOS journals and other Open Access sources.

Introducing Open Highlights

Image credit: Flickr user, Puliarfanita

07/12/2016

research article

Structural Basis of Notch Pathway Repression

The structure of the complex between the Notch transcription factor Su(H) and its antagonist, Hairless, reveals a novel binding mode and unanticipated structural plasticity.

Structural Basis of Notch Pathway Repression

Image credit: 10.1371/journal.pbio.1002509