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ENS Constrains Intestinal Microbiota

February 16, 2017

ENS Constrains Intestinal Microbiota

Annah Rolig, Judith Eisen, Karen Guillemin and colleagues study zebrafish lacking an enteric nervous system, revealing a striking role for these neurons in maintaining a balanced intestinal microbial community and preventing intestinal inflammation.

Image credit: pbio.2000689

PLOS Research News: stay up-to-date with research published in PLOS

PLOS Research News

02/16/2017

Research article

Narciclasine Reduces Diet-Induced Obesity

Sofi Julien, Sun-Yee Kim, Feng Xu and colleagues show that the natural compound narciclasine attenuates diet-induced obesity in mice by promoting energy expenditure; it also induces a number of beneficial metabolic effects and activates AMPK signaling in skeletal muscle.

Image credit: pbio.1002597

Narciclasine Reduces Diet-Induced Obesity

Recently Published Articles

Current Issue

Current Issue January 2017

02/15/2017

essay

Ecological Networks Can Inform Transposon Transfers

This Essay by Samuel Venner, Dominique Pontier and co-authors proposes network theory as a robust conceptual framework to delineate how complex interactions between diverse organisms may synergize to promote horizontal transfer of transposable elements.

Image credit: pbio.2001536

Ecological Networks Can Inform Transposon Transfers

02/16/2017

research article

Serotonin in Reward and Effort Learning

A neuroimaging study by Jacqueline Scholl, Catherine Harmer and colleagues uses a commonly prescribed antidepressant to reveal that raised serotonin levels can increase neural and behavioral measures of learning about rewards and effort in healthy humans.

Image credit: pbio.2000756

Serotonin in Reward and Effort Learning

02/15/2017

perspective

Harnessing the Creativity of the Scientific Crowd

A Perspective article by Adrian Carter, Amy Donner, Wen Hwa Lee and Chas Bountra argues that the potential of open innovation to improve drug discovery can only be realized if scientists and policy makers establish reliable frameworks for converting the output of the crowd into actionable plans.

Harnessing the Creativity of the Scientific Crowd

Image credit: pbio.2001387

02/09/2017

research article

Treating Infections and Cancer: All-Out War or Containment?

A general mathematical analysis by Elsa Hansen, Robert Woods and Andrew Read shows that there is no “one-size-fits-all” solution; containment can improve some situations, but it can also make things worse. The study identifies when containment is the best choice – and when aggressive treatment is better.

Treating Infections and Cancer: All-Out War or Containment?

Image credit: National Cancer Institute via Wikimedia Commons

02/09/2017

research article

Martinotti Cells Sync the Cortex

Specific identification of Martinotti cells in layer 5 of the cortex by Markus Hilscher, Katarina Leão, Klas Kullander and colleagues allows the demonstration of spike-train synchronization in a reciprocally connected pyramidal-interneuronal network via brief bursts of inhibition.

Martinotti Cells Sync the Cortex

Image credit: Markus M. Hilscher

02/10/2017

research article

Second-Guessing the Beat

Rhythmic streams produce resonance that entails behavioral costs, but phase concentration and alignment during the stream are not unique neural signatures of rhythm entrainment.

Second-Guessing the Beat

Image credit: Flickr user slgc

01/31/2017

Research Article

Communications from a Completely Locked-In State

"Locked in" patients suffering from advanced ALS, with no reliable means of communication, can learn to answer questions requiring a “yes” or “no” thought using fNIRS.

Communications from a Completely Locked-In State

Image credit: Wyss Center

12/22/2016

PLOS Biologue

Celldance Videos at ASCB 2016

PLOS sponsored the production of the Celldance videos at ASCB 2016. Ines Alvarez-Garcia discusses these visually astounding works and discovers the motivation behind them


Celldance Videos at ASCB 2016

Image credit: Renaud Chabrier

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