10/27/2015
Research article and synopsis
Pawel Licznerski, Ronald Duman and co-authors find that the activity of the protein kinase SGK1 is reduced in the prefrontal cortex of individuals with post-traumatic stress disorder (PTSD), and SGK1 inhibition can cause PTSD-related behavioral changes in an animal model. Read the accompanying Synopsis.
Image credit: Flickr user Marines
Current Issue October 2015
10/29/2015
research article
Ileana Soto, Gareth Howell, and co-authors show that age-related deterioration of the neurovascular unit and increased neuroinflammation in aging mice is prevented by long-term exercise, but not in the absence of apolipoprotein E.
Image credit: 10.1371/journal.pbio.1002279
10/23/2015
Research article
Christian Njoo, Rohini Kuner and colleagues reveal the actin nucleation complex WAVE1 as a hitherto unknown binding partner of cannabinoid receptor 1 and explore the functional role of this interaction in regulating pain-related structural plasticity.
Image credit: Biodiversity Heritage Library
10/23/2015
PRimer
Lisa Genzel and Edwin Robertson examine the implications of a new study showing that the pattern of neuronal activity during the formation of a memory is replayed during sleep, changing memory circuits and enhancing the memory. Read the Research Article.
Image credit: 10.1371/journal.pbio.1002263
10/22/2015
Community Page
This Community Page from Yiwei Wang, Nicole Kaplan, Greg Newman and Russell Scarpino proposes a platform to support effective metadata documentation with a view to improving the discoverability and reusability of citizen-gathered science data.
Image credit: Flickr user: Mount Rainier National Park
10/16/2015
Unsolved Mystery
It remains unclear why infection leads to adverse cognitive, emotional, and behavioral changes. This article from Keren Shakher and Guy Shakhar introduces the "Eyam hypothesis," suggesting that selection may favor such sickness behaviors because they limit disease transmission to kin.
Image credit: Pixabay
10/15/2015
Research Article and synopsis
Production of insulin by the pancreatic β cells activates the IRE1α branch of the unfolded protein response pathway. Read the Synopsis.
Image credit: Dorothy Sorenson, Donalyn Scheuner
10/16/2015
Research Article
Scaling is a universal property of animal organs; this study identifies a molecular circuit involving TOR and Yorkie that underlies scaling of the Drosophila wing.
Image credit: Joseph Parker
10/13/2015
Perspective
A systematic analysis of in vivo research reveals poor reporting of measures that reduce the risk of bias and an inverse relationship between impact factor and the reporting of randomization.
Image credit: Wikimedia Commons
04/15/2015
PLOS BLOGs
This weekly Ask Me Anything (AMA) series features PLOS authors in live chats on redditscience. This week Oliver Cumming, Pinaki Panigrahi and Yael Velleman talked about the Unicef WASH programs.
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Visit the all-new PLOS Collections platform, currently hosting 15 collections!
This Collection presents research focused on the biology, ecology and conservation of the most captivating creatures in the ocean.
This Collection highlights studies of the components that make up the body's immune system, their emergence during development, their function, and their evolution in different organisms.
This Collection highlights efforts from a range of disciplines focused on mitigating and adapting to the effects of the changing climate.
This Collection highlights how basic research discoveries are being translated into methods to develop and improve important crop traits.
Synaptotagmins contribute to priming of synaptic vesicles, as well as triggering fusion. Read the Synopsis
The functional connectivity of brain regions involved in face recognition: striking similarities between humans and monkeys.
Information regarding the position of whiskers during "whisking" is encoded along the same neuronal pathway as touch.
Neural populations in the human inferior parietal lobule are tuned to specific durations of time.
How temperature can affect neural circuits but neuromodulators can compensate for detrimental effects.
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