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A Peculiar Centrosome for a Peculiar Cell Cycle

March 3, 2015

A Peculiar Centrosome for a Peculiar Cell Cycle

Elena Suvorova, Michael White and colleagues show that the apicomplexan parasite Toxoplasma gondii has a unique centrosome with two specialized compartments, potentially explaining the remarkable flexibility in life cycle that these organisms can show in diverse host cells.

Image credit: PLoS Biol 10(12): ev10.i12.doi:10.1371/image.pbio.v10.i12

03/03/2015

research article

Learning about Influenza from the Mark it Leaves behind

A combination of cross-sectional serological data from Southern China and mathematical modeling, conducted by Adam Kucharski, Steven Riley and colleagues, reveals key aspects of the human immune system's response to seasonal influenza infection.

Image credit: Flickr user NIAID

Learning about Influenza from the Mark it Leaves behind

Recently Published Articles

Current Issue

Current Issue February 2015

02/27/2015

research article

Cofilin1 Remodels Dendritic Spines to Control Plasticity

Tadashi Tsubota, Yasushi Miyashita and colleagues use in vivo measurement of the electrophysiology and shape of neurons to reveal that cofilin1 is needed for remodeling dendritic spines in circuits that connect mouse whisker barrels, so aiding experience-dependent plasticity in the neocortex.

Image credit: 10.1371/journal.pbio.1002070.g006

Cofilin1 Remodels Dendritic Spines to Control Plasticity

02/24/2015

perspective

8 Billion Visits to Protected Areas Each Year

A new global analysis by Andrew Balmford, Andrea Manica and colleagues estimates that the world’s protected areas receive about 8 billion visits each year, with an annual economic value of hundreds of billions of dollars.

Image credit: Flickr user Yoni Lerner

8 Billion Visits to Protected Areas Each Year

02/24/2015

research article and Synopsis

Making Starch: Targeting Enzymes

David Seung, Samuel Zeeman and co-workers show that the biosynthesis of starch in chloroplasts depends on a novel protein that targets starch synthase to the growing starch granules; this represents a potential target for the biotechnological modification of starch. Read the Synopsis.

Making Starch: Targeting Enzymes

Image credit: 10.1371/journal.pbio.1002080

02/16/2015

research article

Activation and Alliance of Regulatory Pathways in an Infecting Microbe

A study of the invasive infection of a mammalian host by the pathogenic fungus Candida albicans, conducted by Aaron Mitchell and colleagues, reveals characteristic gene regulation patterns in response to the host environment, distinct from those seen when growing in vitro.

Activation and Alliance of Regulatory Pathways in an Infecting Microbe

Image credit: 10.1371/journal.pbio.1000133.g002

02/24/2015

research article

Ribosome Biogenesis: Releasing the Helpers

U3 snoRNA binds to pre-rRNA, helping to orchestrate key steps in ribosome assembly. This study by Richa Sardana, Xin Liu, Arlen Johnson and colleagues identifies Dhr1 as the essential RNA helicase that releases U3 snoRNA and allows ribosome maturation to continue.

Ribosome Biogenesis: Releasing the Helpers

Image credit: 10.1371/journal.pbio.1002083.g003

02/17/2015

research article

Mammary Gland Development: Making the Duct Lumen

Stem cells in the embryonic mammary gland that are progressively restricted to the lumen of the mammary duct.

Mammary Gland Development: Making the Duct Lumen

Image credit: doi:10.1371/journal.pbio.1002069.g007

02/24/2015

research article and primer

We're All Bayesians Now

The human brain uses Bayesian causal inference to integrate and segregate information. Read the Primer.

We're All Bayesians Now

Image credit: 10.1371/journal.pbio.1002073.g003

02/27/2015

Editorial

Thanks to our Reviewers!

PLOS Biology sends heartfelt thanks to all those who helped open access scientific publication by reviewing manuscripts for us during 2014.

Thanks to our Reviewers!

Image credit: Flickr user Sebastien Wiertz

03/02/2015

PLOS Biologue

It's not just about Research

Stavroula Kousta discusses the impactful articles that PLOS Biology publishes in its magazine section.

It's not just about Research

Image credit: Flickr user Micky Aldridge