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Extracellular Phosphorylation, Synapses and Pain

July 18, 2017

Extracellular Phosphorylation, Synapses and Pain

Kenji Hanamura, Halley Washburn, Matthew Dalva and colleagues show that the receptor tyrosine kinase EphB undergoes ligand-dependent extracellular phosphorylation to regulate NMDA receptor synaptic localization and pathological pain in mice.

Image credit: pbio.2002457

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PLOS Research News

07/19/2017

research article

Seed Size and Angiosperm Diversification

A study of 30,000 species of plant by Javier Igea, Andrew Tanentzap and co-workers reveals that faster changing seed sizes are associated with increased rates of species formation across the angiosperm tree of life.

Image credit: pbio.2002792

Seed Size and Angiosperm Diversification

Recently Published Articles

Current Issue

Current Issue June 2017

07/17/2017

essay

Building the Biomedical Data Science Workforce

Data science in biomedicine is a field where the demand for the workforce far outweighs the supply; this article by Michelle Dunn and Philip Bourne describes how the US National Institutes of Health has set about addressing the situation.

Image credit: pbio.1002209

Building the Biomedical Data Science Workforce

07/18/2017

community page

The €100 Lab for Fish, Fly and Worm Behavior

This Community Page article by Andre Maia Chagas, Tom Baden and colleagues tells you how to build your own fluorescence microscope and behavioral rig for less than €100 using 3-D printed parts and off-the-shelf electronics.

Image credit: pbio.2002702

The €100 Lab for Fish, Fly and Worm Behavior

07/12/2017

research article

Making a Blastocyst: Four Simple Rules Suffice

A new model developed by Silas Boye Nissen, Joshua Brickman, Ala Trusina and colleagues, in which four simple rules can produce a mammalian embryo and explain scaling, ensures developmental robustness while allowing evolution to play with stochasticity.

Making a Blastocyst: Four Simple Rules Suffice

Image credit: pbio.2000737

07/07/2017

research article

Hierarchical Patterning of Hair Follicles

James Glover, Denis Headon and co-workers reveal that hair follicle development involves establishing a hierarchy of patterning systems, whereby a patterning process driven by cell movement is subordinated to a signal-based reaction-diffusion mechanism.

Hierarchical Patterning of Hair Follicles

Image credit: pbio.2002117

07/13/2017

research article

Snake Venom's Deadly Grip on Integrin

Johannes Eble, Matthew McDougall, Jörg Stetefeld and co-authors show that a bifunctional snake venom protein from the Malayan pit viper Calloselasma rhodostoma blocks collagen mediated platelet aggregation, undergoing dramatic conformational changes as it binds α2β1 integrin.

Snake Venom's Deadly Grip on Integrin

Image credit: pbio.2001492

07/12/2017

research matters

From Melittobia to Malaria

In this Research Matters article, Andrew Read recalls how an analysis of incest in wasps revealed a way to improve human well-being.

From Melittobia to Malaria

Image credit: 10.3897/zookeys.181.2752 and NIAID

07/06/2017

research article

Cells Store Tau with tRNA in Liquid Droplets

Tau protein binds tRNA in cells, and reversibly condenses to form complex liquid droplets that may be precursors of the tau fibrils found in neurodegenerative diseases.

Cells Store Tau with tRNA in Liquid Droplets

Image credit: Peter Allen

07/03/2017

methods & resources

Neurochemical Connectome of the Rat Brain

ChemNetDB; a systematic open-access resource for the multi-scale neurochemical connectome of the rat brain, containing data from 34,464 animals.

Neurochemical Connectome of the Rat Brain

Image credit: pbio.2002612

07/06/2017

short reports

Cognitive Effects of General Anesthesia

Anesthetic exposure in early childhood may cause lasting cognitive deficits. This study shows that isoflurane acts on the mTOR pathway to cause dendritic spine loss and learning deficits in mice.

Cognitive Effects of General Anesthesia

Image credit: Army Medicine, Flickr

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