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In Vivo Structure of Biological Membranes

May 23, 2017

In Vivo Structure of Biological Membranes

A novel strategy employing isotopic labeling and neutron scattering, by Jonathan Nickels, Sneha Chatterjee, Robert Standaert, James Elkins and John Katsaras reveals the structure of the membrane in a living cell and provides evidence for the existence of nanoscopic lipid domains, consistent with hypothesized lipid rafts.

Image credit: X Cheng & MA Matheson

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PLOS Research News

05/23/2017

research article

To Understand Evolution, First Learn Genetics

A large trial of UK secondary school pupils by Rebecca Mead, Momna Hejmadi, Laurence Hurst shows that the teaching of genetics before the teaching of evolution improves the understanding of evolution at no cost to the understanding of genetics.

Image credit: Unknown, Maull & Fox; via Wikipedia

To Understand Evolution, First Learn Genetics

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Current Issue April 2017

05/26/2017

research article

Oligodendroglial Myelination Needs Astrocyte Lipids

Nutabi Camargo, Andrea Goudriaan, Mark Verheijen and co-workers show that the formation of myelin membrane by oligodendrocytes in the brain is dependent on extracellular lipids derived from astrocytes and diet.

Image credit: pbio.1002605

Oligodendroglial Myelination Needs Astrocyte Lipids

05/24/2017

research article

Complex Microcircuitry of the Amygdala

Neuroanatomical and electrophysiological techniques combined with optogenetics, by Tibor Andrási, Judit Veres, Laura Rovira-Esteban, Norbert Hájos and co-authors, reveal organizing principles of wiring between principal cells and inhibitory interneurons in the basal amygdala that may be a general feature of cortical networks.

Image credit: pbio.2001421

Complex Microcircuitry of the Amygdala

05/16/2017

research article

Whole-Genome Duplication: Caught in the Act

Raúl Ortiz-Merino, Kenneth Wolfe and colleagues find that a young hybrid yeast species, Zygosaccharomyces parabailii, retraces the evolutionary steps hypothesized to have caused whole-genome duplication in an ancestor of Saccharomyces cerevisiae.

Whole-Genome Duplication: Caught in the Act

Image credit: pbio.2002128

05/16/2017

research article

Not-So-Silent Cystic Fibrosis Variants?

Sebastian Kirchner, David Sheppard, Zoya Ignatova and colleagues show that a synonymous single-nucleotide polymorphism alters the structure and function of the cystic fibrosis transmembrane conductance regulator (CFTR) by changing the local speed of translation in a tissue- and tRNA-dependent fashion.

Not-So-Silent Cystic Fibrosis Variants?

Image credit: pbio.2000779

05/16/2017

community page

1,200,000 Kids and Counting – Mobile Science Laboratories

A survey of the Mobile Laboratory Coalition by Amanda Jones and Mary Stapleton revealed that collectively these programs have provided hands-on science activities to over 1,200,000 students and 16,000 teachers across the US.

1,200,000 Kids and Counting – Mobile Science Laboratories

Image credit: pbio.2001692

05/19/2017

research article

How Campylobacter Colonizes

A comprehensive view of the metabolic requirements for intestinal colonization by Campylobacter jejuni, a leading cause of food-borne gastroenteritis in industrialized countries.

How Campylobacter Colonizes

Image credit: NIAID

05/15/2017

primer

Manipulating Fate

This Primer reflects on a study that used pharmacogenomics to control the differentiation of subventricular stem cells, paving the way for using endogenous stem cells for brain repair. Read the related Research Article.

Manipulating Fate

Image credit: pbio.2000698

05/10/2017

research article

Diverse Responses to DNA Damage

After X-ray irradiation, adult neural progenitor cells and progenitor cells in neonatal mice undergo distinct responses with respect to apoptosis and activation of quiescent cells.

Diverse Responses to DNA Damage

Image credit: pbio.2001264

05/09/2017

research article

Phenotypic Heterogeneity Promotes Evolution

Phenotypic heterogeneity shapes evolutionary trajectories and facilitates evolutionary rescue from a deteriorating environmental stress by enlarging the beneficial effects of mutations.

Phenotypic Heterogeneity Promotes Evolution

Image credit: Zoltán Bódi and Zoltán Farkas

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