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Dawn and Dusk Colors Entrain the Circadian Clock

April 17, 2015

Dawn and Dusk Colors Entrain the Circadian Clock

Lauren Walmsley, Robert Lucas, Timothy Brown and co-authors reveal that mice not only use changes in the intensity of sunlight to entrain their circadian clock, but also employ blue–yellow color discrimination to detect spectral changes associated with dawn and dusk.

Image credit: Flickr user Don McCullough

04/17/2015

research article

Cellular Self-Fusion during Vasculature Pruning

In vivo live imaging of zebrafish embryos, conducted by Anna Lenard, Markus Affolter and colleagues, reveals the diverse cellular activities involved in the pruning of unwanted blood vessels, including the self-fusion of endothelial cells.

Image credit: journal.pbio.1002126.g002

Cellular Self-Fusion during Vasculature Pruning

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Current Issue

Current Issue March 2015

04/17/2015

Research Article

Flow Directs Cell Migration and Polarity in Vessel Pruning

A study of mouse retina and zebrafish vasculature, from Claudio Franco, Holger Gerhardt and co-workers, shows how differential blood flow patterns direct the orientation and migration of endothelial cells as a mechanism for stabilizing or pruning individual blood vessel segments.

Image credit: doi:10.1371/journal.pbio.1002125.g001

Flow Directs Cell Migration and Polarity in Vessel Pruning

04/10/2015

research article and synopsis

Selection Constrains Genetic Diversity across Species

Russell Corbett-Detig, Daniel Hartl and Timothy Sackton use whole-genome genetic variation data from 40 species to explain why levels of neutral diversity do not scale with population size. Read the accompanying Synopsis.

Image credit: Flickr user Liz West

Selection Constrains Genetic Diversity across Species

04/16/2015

research article and primer

Fly Sex Chromosomes Are Highly Dynamic

Analysis of the genomes of 37 fly species from 22 families, conducted by Beatriz Vicoso and Doris Bachtrog, shows that superficially similar karyotypes conceal the true extent of sex chromosome variation and that sex chromosome transitions are in fact frequent in flies. Read the Primer by Kevin Wei and Daniel Barbash.

Fly Sex Chromosomes Are Highly Dynamic

Image credit: Flickr user Marcelo César Augusto Romeo

04/15/2015

Essay

Stopping Marine Invaders

Classifying the impact of non-indigenous species presents special problems in marine environments. This Essay by Henn Ojaveer and co-authors presents a framework that focuses on values and emphasizes precaution in managing the data limitations and uncertainties that are found in the marine context.

Stopping Marine Invaders

Image credit: public domain

04/14/2015

research article and synopsis

How Salmonella Survives Acid Attack

Smarajit Chakraborty, Hideaki Mizusaki and Linda Kenney find that, rather than using the cadaverine operon to combat the acid conditions of the macrophage vacuole, Salmonella allows its cytoplasm to become acidified, which in turn drives secretion of effectors into the host cell. Read the Synopsis.

How Salmonella Survives Acid Attack

Image credit: doi:10.1371/journal.pbio.1002116.g009

04/13/2015

research article

Bundling Microtubules during Cytokinesis

Centralspindlin non-motor subunit CYK4 reconfigures the motor domains of the kinesin subunit MKLP1 to help it bundle microtubules.

Bundling Microtubules during Cytokinesis

Image credit: doi:10.1371/journal.pbio.1002121.g008

04/10/2015

research article

Reassembling the Primary Cilium

The asymmetric assembly of a new primary cilium in one of two daughter cells after mitosis is regulated by a cascade involving GSK3β, Dzip1, and Rab8.

Reassembling the Primary Cilium

Image credit: doi:10.1371/journal.pbio.1002129.g001

04/09/2015

education

The Virtual Cell Animation Collection

Freely available multimedia materials designed to help molecular and cellular biology students conceptualize the dynamic nature of cells.

The Virtual Cell Animation Collection

Image credit: doi:10.1371/journal.pbio.1002118.g001