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Proteoglycan, Competition and Growth Control

August 27, 2015

Proteoglycan, Competition and Growth Control

Ana Ferreira and Marco Milán show that the loss of tumor suppressor genes induces a non-autonomous reduction of growth and proliferation rates in adjacent cell populations via competition for available growth factors; the proteoglycan Dally helps mediate this effect.

Image credit: 10.1371/journal.pbio.1002239

08/27/2015

Perspective

Sharing Research Data and Intellectual Property Law

This Perspective by Michael Carroll addresses questions and concerns that biologists often have about intellectual property rights in research data and how these interact with the deposition or sharing of data.

Image credit: Flickr user Horia Varlan

Sharing Research Data and Intellectual Property Law

Recently Published Articles

Current Issue

Current Issue August 2015

08/25/2015

Primer

Leaky Vaccination Can Select for Higher Virulence

This Primer from Mike Boots explains how new evidence from studies of Marek’s disease supports evolutionary theory, suggesting that vaccination can select for increased parasite virulence. Read the Research Article

Image credit: Flickr user Garrett Heath

Leaky Vaccination Can Select for Higher Virulence

08/21/2015

Perspective

The Question of Data Integrity in Article-Level Metrics

Article-level metric (ALM) data need to be secure and reliable if they are to be trusted and used by all. This Perspective by Gregg Gordon, Jennifer Lin, Richard Cave and Ralph Dandrea explores the different approaches taken by two organizations to establish ALM data integrity.

Image credit: Flickr user Duncan Hull

The Question of Data Integrity in Article-Level Metrics

08/18/2015

Research Article

After the Crash: Genomic Marks of the Bird Super-Radiation

A study of ancient genetic variation by Alexander Suh, Linnea Smeds and Hans Ellegren reveals genomic evidence for near-simultaneous speciation at the base of Neoaves, which temporally coincides with the mass extinction of nonavian dinosaurs and archaic birds. Read the Synopsis

After the Crash: Genomic Marks of the Bird Super-Radiation

Image credit: Alexander Suh and Jon Fjeldså

08/13/2015

Research Article and synopsis

Detecting (and Clamping) Homologous DNA Strands

Marcel Ander, Erik Schäffer and colleagues reveal how, during the annealing of single-stranded DNA molecules, homologous regions are first bound by monomers and subsequently secured by dimerization of single-strand annealing proteins, thereby triggering the growth of the nucleoprotein filament. Read the Synopsis.

Detecting (and Clamping) Homologous DNA Strands

Image credit: Marcel Ander

08/14/2015

research article

How Brains Identify Unchanging Scenery

Prior activity in the visual cortex induces a long-delayed depolarization that aids the extraction of invariant features from the changing visual world.

How Brains Identify Unchanging Scenery

Image credit: Brockhaus & Efron Encyclopedic Dictionary

08/12/2015

research article

Spatiotemporal Spike Coding of Behavioral Adaptation

Spike timing is relevant for cognitive information transmission and behavioral prediction, suggesting that downstream areas are unlikely to act as mere neural integrators.

Spatiotemporal Spike Coding of Behavioral Adaptation

Image credit: Flickr user Marieke IJsendoorn-Kuijpers

08/07/2015

Research Article

Interspecies Mating and Whole-Genome Duplication

A study presents evidence for an interspecies hybridization event before the famous ancient whole-genome duplication in the baker's yeast lineage. Read the Primer.

Interspecies Mating and Whole-Genome Duplication

Image credit: Iris Joval Granollers