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Two Gradients Better than One

March 31, 2015

Two Gradients Better than One

Tyler Sloan, Frédéric Charron and co-authors use microfluidic devices to show that shallow gradients of the axon guidance cues Shh and Netrin synergize to guide growth cones, where one cue alone would be insufficiently steep.

Image credit: Jimmy Peng and Tyler Sloan.

04/01/2015

research article

Amacrine Feedback Refines Fly Vision

A systematic study of the Drosophila visual system by Wen Hu, Junhai Han and colleagues clarifies the mechanisms and effects of the feedback regulation of photoreceptors by amacrine cells, essential for maintaining light sensitivity.

Image credit: 10.1371/journal.pbio.1002115.g003

Amacrine Feedback Refines Fly Vision

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Current Issue

Current Issue March 2015

03/23/2015

research article

Relatedness, Conflict, and the Evolution of Eusociality

Mathematical modelling, conducted by Xiaoyun Liao, Stephen Rong, and David Queller, shows that the evolution of sterile castes requires genetic relatedness but also involves conflicts between kin; these results contradict recent claims but agree with inclusive fitness theory.

Image credit: Flickr user Thinboyfatter

Relatedness, Conflict, and the Evolution of Eusociality

03/20/2015

community page

Why Buy When You Can 3-D Print Your Own Lab Equipment?

Tom Baden, Thomas Euler and colleagues explore free-and-open online designs for self-built, sophisticated lab equipment that provide access to teaching and research tools for an increasingly broad user base worldwide.

Image credit: 10.1371/journal.pbio.1002086.g001

Why Buy When You Can 3-D Print Your Own Lab Equipment?

03/25/2015

research article

Scribble Regulates CNS Myelination

Research from Andrew Jarjour, Charles ffrench-Constant and co-authors shows that the polarity protein Scribble regulates the formation and properties of myelin sheaths in the central nervous system, both during development and after demyelinating injury.

Scribble Regulates CNS Myelination

Image credit: 10.1371/journal.pbio.1002107.g002

03/26/2015

research article

Voltage-Gated Calcium Channel Regulates Lysosomal Fusion

Xuejun Tian, Upasana Gala, Chao Tong and colleagues discover that a voltage-gated calcium channel required for neurotransmitter release also regulates the fusion of neuronal lysosomes with endosomes and autophagosomes, thereby helping to maintain cellular homeostasis.

Voltage-Gated Calcium Channel Regulates Lysosomal Fusion

Image credit: 10.1371/journal.pbio.1002103

03/25/2015

education

A Biotic Game Design Project

Nate Cira, Alice Chung, Ingmar Riedel-Kruse and co-authors describe a "biotic game design" project to motivate student learning at the interface of life sciences and device engineering.

A Biotic Game Design Project

Image credit: 10.1371/journal.pbio.1002110

03/18/2015

research article

Cell Cycle–Dependent Differentiation in the Pancreas

Asymmetric or symmetric differentiation of progenitor cells results from priming of mitotic progenitors at different stages of the cell cycle.

Cell Cycle–Dependent Differentiation in the Pancreas

Image credit: 10.1371/journal.pbio.1002111 S1 Fig.

03/13/2015

perspective

Usage and Abusage of the P-Value

Publication bias resulting from "p-hacking" is pervasive throughout the life sciences, but its effects appear to be weak.

Usage and Abusage of the P-Value