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Climate Change and Extinction

December 9, 2016

Climate Change and Extinction

Climate change may threaten many species, but predicting its impacts is difficult. A survey of 976 plant and animal species by John Wiens shows that climate-related extinctions have already occurred in hundreds of species (47%).

Image credit: Flickr user: james j8246

PLOS Research News: stay up-to-date with research published in PLOS

PLOS Research News

12/09/2016

Research Article

Drug-Induced Aggregation of HIV Integrase

A new crystal structure of the HIV integrase enzyme in complex with the allosteric inhibitor GSK1264, by Kushol Gupta, Vesa Turkki, Gregory Van Duyne, Frederic Bushman and co-workers explains how the drug induces aggregation of the viral protein.

Image credit: pbio.1002584

Drug-Induced Aggregation of HIV Integrase

Recently Published Articles

Current Issue

Current Issue November 2016

12/05/2016

 Research Article

Gene Duplication and Mosquito Insecticide Resistance

Analysis of genotype-phenotype relationships by Benoît Assogba, Pascal Milesi, Mylène Weill and colleagues reveals the versatility of fitness trade-offs that result from adaptation to insecticide through gene duplication at the ace-1 locus in the malaria mosquito Anopheles gambiae.

Image credit: Flickr user: Yasser

Gene Duplication and Mosquito Insecticide Resistance

12/06/2016

research article

MAP12 and Stomatal CO2 Signaling

This study by Liina Jakobson, Lauri Vaahtera, Kadri Tõldsepp, Hannes Kollist, Mikael Brosché and co-authors uses natural variation and mutant analysis in the model plant Arabidopsis thaliana to reveal that MAP kinase 12 regulates carbon dioxide signalling in guard cells.

Image credit: pbio.1001792

MAP12 and Stomatal CO2 Signaling

12/06/2016

 Research Article

Striatum Suppresses Movement during Cortical Avalanches

Why don’t neuronal “avalanches” in resting-state cortex cause involuntary movements? This study by Andreas Klaus and Dietmar Plenz shows that a low-correlation striatal resting state suppresses such movements and explores mechanisms that disrupt this inhibition.

Striatum Suppresses Movement during Cortical Avalanches

Image credit: pbio.1002582

12/07/2016

community page

Open Science: The Neuro Experiment

This Community Page article by Richard Gold describes the Montreal Neurological Institute’s launch of an institutional Open Science experiment – open data, open materials and no patenting – to attract new private partners and innovators to its community.

Open Science: The Neuro Experiment

Image credit: Owen Egan and the Montreal Neurological Institute

11/28/2016

research article

Excess Retinoids Hit Hearts Twice

By studying the hearts of zebrafish embryos unable to degrade retinoic acid, Ariel Rydeen and Joshua Waxman reveal that failure to add second heart field progenitors results in outflow tract defects, and disruption of the extracellular environment causes loss of ventricular integrity.

Excess Retinoids Hit Hearts Twice

Image credit: pbio.2000504

11/28/2016

Research Article

Kaposi's Sarcoma Virus and the microRNA Turf War

Kaposi's sarcoma-associated herpesvirus can counteract the human antiviral protein MCPIP1 that would otherwise degrade viral microRNAs.

Kaposi's Sarcoma Virus and the microRNA Turf War

Image credit: Wikipedia: Poulos~commonswiki

12/02/2016

meta-research article

Scientific Rigor of Animal Experiments

An analysis of animal license applications and their associated publications suggests that risk of bias is partly predicted by study protocols.

Scientific Rigor of Animal Experiments

Image credit: Flickr user Understanding Animal Research

11/30/2016

research article

Active State Mechanics of Eukaryotic Protein Kinases

Eukaryotic protein kinase active state mechanics are harmoniously governed by intramolecular hydrophobic and electrostatic interactions from different regions of the catalytic core.

Active State Mechanics of Eukaryotic Protein Kinases

Image credit: pbio.2000127

12/02/2016

plos biologue

ASCB 2016, San Francisco

PLOS Biology editor Ines Alvarez-Garcia looks forward to five days of fantastic cell biology at the ASCB conference in San Francisco and presents some of the recent papers we've published.

ASCB 2016, San Francisco

Image credit: 10.1371/journal.pbio.1002537