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Current Issue June 2018

07/12/2018

featured research

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

Arenaviruses have been recently incorporated by the World Health Organization in a list of critical emerging diseases for which additional research and identification of clinical targets is urgently required. Zuniga and colleagues demonstrate that the ATP-dependent RNA helicase DDX3 interacts with the arenavirus nucleoprotein, which displays fundamental functions in different steps of the viral-cycle. 

Image credit: Sheli Radoshitzky, USAMRIID

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

07/12/2018

pearls

Illuminating pathogen–host intimacy through optogenetics

The evolution of optogenetics has resulted in an unprecedented advancement in our understanding of the brain, however, the tool remains still largely relegated to neuroscience. In this PLOS Pathogens Pearls article, Gupta and colleagues introduce selected aspects of optogenetics with potential applications in infection biology that will not only answer long-standing questions about intracellular pathogens but also broaden the dimension of current research in entwined models. 

Image credit: Arroyo-Olarte RD, et al. (2018)

Illuminating pathogen–host intimacy through optogenetics

07/09/2018

research article

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

Mesri and colleagues show that KSHV lytic replication as well as the KSHV-oncogene vGPCR activates PDGFRA signaling through upregulation of its ligands PDGFA/B, and that blocking of PDGFRA signaling is anti-tumorigenic. Thus, approaches that fully and stably inhibit PDGFR-signaling could lead to successful treatments for KS, validating this as a therapeutic target.

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

Image credit: Cavallin LE, et al. (2018)

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