The majority of deaths from fungal infections occur in Africa. Pneumocystis is an unusual host-specific fungus that takes advantage of a weakened immune system and causes pneumonia in AIDS patients. In this PLOS Pathogens Pearls article, Dr. Jennifer Claire Hoving briefly summarizes key mechanisms of host recognition of Pneumocystis spp. and how these systems fail in an immunocompromised host. She highlights Dectin-1, CLR Mincle, other CLRs, and TLRs.
Image credit: Hoving JC (2018)