Advertisement

04/19/2018

featured research

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy

Over the past decade, multiple strategies have been investigated for HIV Cure, such as those inspired by the cure of the Berlin Patient. The goal of Kiem and colleagues is to apply a safer version of this curative approach to more patients, using gene editing to create a similar CCR5 mutation in a patient’s own cells.

Image credit: Peterson CW, et al. (2018)

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy

Recently Published Articles

Current Issue

Current Issue March 2018

04/19/2018

review

ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart

Paiva and colleagues consider shifting the old paradigm as well as evidences in favor of ROS as a promoter of T. cruzi infection. They also identify mechanisms underlying T. cruzi growth in oxidative environment, and make the case for peroxynitrite as a main trypanocidal species in activated macrophages. They provide counter evidence for oxidative stress as a promoter of T. cruzi infection, and identify heart parasite burden under different redox status.

Image credit: Paiva CN, et al. (2018)

ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart

04/19/2018

pearls

Antibiotic interceptors: Creating safe spaces for bacteria

Edwards and colleagues discuss how bacteria can resist antibiotics by sequestering them. They also assess membrane lipid decoys, as well as antimicrobial interception by proteins and antimicrobial interception by polysaccharides. Additionally they discuss antimicrobial sequestration by DNA, and more.

Antibiotic interceptors: Creating safe spaces for bacteria

Image credit: Sabnis A, et al. (2018)

04/13/2018

research article

Tissue maintenance of CMV-specific inflationary memory T cells by IL-15

Oxenius and colleagues show that inflationary CD8 T cells are long-lived T cells and have a markedly prolonged half-life compared to effector CD8 T cells. In peripheral organs such as lung, IL-15 cytokine is pivotal in promoting maintenance of inflationary cells by inducing expression of the anti-apoptotic molecule Bcl-2. 

Tissue maintenance of CMV-specific inflationary memory T cells by IL-15

Image credit: Baumann NS, et al. (2018)

Get new content from PLOS Pathogens in your inbox

Thank you! You have successfully subscribed to the PLOS Pathogens newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again