Advertisement

06/21/2018

featured research

Prion replication environment defines the fate of prion strain adaptation

Baskakov and colleagues suggest that prion adaptation during cross-species transmission depends, in part, on surrounding RNA levels during replication. While RNA is not incorporated into the structure of prions, it could be that its unique structure and sites of negative electrical charge influence prion replication. This research could help improve understanding of cross-species prion transmission and factors that control prion adaptation.

Image credit: Katorcha E, et al. (2018)

Prion replication environment defines the fate of prion strain adaptation

Recently Published Articles

Current Issue

Current Issue May 2018

06/21/2018

pearls

Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host

Djordjevic and Lev show a cross-species comparison of PHO signalling machinery reveals divergence at the transcriptional level and that the absence of Pho4/Pho2 coregulation in C. neoformans and Candida spp. coincides with expansion of Pho4 gene targets. They conclude that fungal dissemination requires a functional and expanded PHO gene repertoire.

Image credit: Lev S, Djordjevic JT (2018)

Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host

06/21/2018

pearls

Origin of the Poxviral Membrane: A 50-Year-Old Riddle

Dr. Bernard Moss takes a look at a de novo origin of the poxviral envelope. Moss provides an alternate hypothesis for poxviral envelope formation, and creates connections between the endoplasmic reticulum (ER) and viral membranes revealed. He concludes with a model for poxviral membrane biogenesis.

Origin of the Poxviral Membrane: A 50-Year-Old Riddle

Image credit: Moss B (2018)

Get new content from PLOS Pathogens in your inbox

Thank you! You have successfully subscribed to the PLOS Pathogens newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again