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Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

April 14, 2015

Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

Roberto Chiesa and colleagues

Image credit: Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, et al. (2015)

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Current Issue March 2015

04/16/2015

Review

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

Herpesviruses often exist as latent infections in their hosts, and the diverse types of herpesviruses display rare evolutionary host specificity. Emmanuel Wiertz and colleagues review current knowledge on how the virus inhibits TAP, a transporter that aids in fighting the virus. 

Image credit: Verweij MC, Horst D, Griffin BD, Luteijn RD, et al. (2015)

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

04/14/2015

research article

Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

One of the most intriguing features of prion diseases is their vast phenotypic heterogeneity. Witold K. Surewicz and colleagues isolate sCJD prions from patients with two distant phenotypes of the disease, comparing their structural organization using recently developed biophysical techniques, and investigate their replication in vitro.

Image credit: Safar JG, Xiao X, Kabir ME, Chen S, Kim C, et al. (2015)

Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions