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02/22/2018

pearls

Pneumocystis and interactions with host immune receptors

The majority of deaths from fungal infections occur in Africa. Pneumocystis is an unusual host-specific fungus that takes advantage of a weakened immune system and causes pneumonia in AIDS patients. In this PLOS Pathogens Pearls article, Dr. Jennifer Claire Hoving briefly summarizes key mechanisms of host recognition of Pneumocystis spp. and how these systems fail in an immunocompromised host. She highlights Dectin-1, CLR Mincle, other CLRs, and TLRs.

Image credit: Hoving JC (2018)

Pneumocystis and interactions with host immune receptors

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Current Issue January 2018

02/22/2018

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HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

Zaph and colleagues show that the atRA-dependent transcription factor Hypermethylated in cancer 1 is required for ILC homeostasis and function in the steady state as well as following infection with the bacterial pathogen Citrobacter rodentium. Thus, HIC1 links RA signalling to intestinal immune responses. 

Image credit: Burrows K, et al. (2018)

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

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