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09/14/2017

pearls

Genetic and epigenetic engines of diversity in pathogenic microbes

In this PLOS Pathogens Pearls article, Heitman and Billmyre highlight some of the myriad mechanisms by which microorganisms as diverse as fungi, oomycetes, bacteria, and parasites generate phenotypic diversity to better exploit their environments and survive extreme stresses. They touch on RNA interference (RNAi) loss and cytoplasmic elements, epimutations, biological noise, dispensable B chromosomes, and variation in ploidy states.

Image credit: Billmyre RB, Heitman J (2017)

Genetic and epigenetic engines of diversity in pathogenic microbes

09/14/2017

pearls

Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii

Bzik and colleagues assess in this PLOS Pathogens Pearls article whether cancer, inflammation, and microbial infection are interrelated and whether nonreplicating Toxoplasma can be used as a safe vaccine for cancer therapy. They question if NRTUAs trigger effective antitumor immunity, and finally ask what's in Toxoplasma that triggers immunity to cancer?

Image credit: Fox BA, Butler KL, Guevara RB, Bzik DJ (2017)

Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii

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