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Current Issue September 2017

10/17/2017

RESEARCH ARTICLE

Mycobacterium tuberculosis infection modulates adipose tissue biology

Beigier-Bompadre and colleagues demonstrate that Mtb can infect and persist within adipocytes where it upregulates stress-related genes. In vivo, relative proportions of leukocyte subsets infiltrating adipose tissue vary under different conditions of infection. Their study shows that adipose tissue is not only a potential reservoir for Mtb, but that it also undergoes significant alteration during TB infection.

Image credit: Beigier-Bompadre M, et al. (2017)

Mycobacterium tuberculosis infection modulates adipose tissue biology

10/17/2017

research article

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

Pornillos et al. determine that the SPRY domains in the TRIM lattice are organized in pairs and likely to be stably tethered against the hexagonal scaffold. This arrangement maximizes the avidity of capsid binding and allows TRIM5α to act as a “molecular ruler” that matches the spacings and orientations of the capsid subunits.

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

Image credit: Roganowicz MD, et al. (2017)

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