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IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ

July 29, 2015

IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ

Meiqing Shi and colleagues 

Image credit: Liu G, Xu J, Wu H, Sun D, Zhang X, Zhu X, et al. (2015)

Publishing Initiatives at PLOS: A Look Back and a Look Ahead

A status update on current PLOS projects and upcoming initiatives planned for 2015-2016.

Blog

07/30/2015

research matters

Basic prion science "spreads" insight

In the latest Research Matters PLOS Pathogens Editor David Westaway reflects on his serendipitous launch into the sciences. Dr. Westaway notes the contrast between funding "Research and Development" versus basic research. He exemplifies the need for basic research using his work in prions; showing that prions share many commonalities with neurodegenerative diseases like Alzheimer's and Parkinson's and have provided insight into studying these diseases.

Image credit: David Westaway

Basic prion science "spreads" insight

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Current Issue

Current Issue July 2015

07/30/2015

pearls

Periodontal Diseases: Bug Induced, Host Promoted

Periodontal disease is one of the most ubiquitous diseases of mankind, considered to be the second most common dental disease worldwide, after dental decay. Mary Ann Jabra-Rizk and colleagues discuss a range of topics related to periodontal disease, from the risk factors and diagnosis, etiology, the contributions of the host that exacerbate disease, therapies, and systemic effects.

Image credit: Khan SA, Kong EF, Meiller TF, Jabra-Rizk MA (2015)

Periodontal Diseases: Bug Induced, Host Promoted