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PrPSc formation and clearance as determinants of prion tropism

March 29, 2017

PrPSc formation and clearance as determinants of prion tropism

Jason C. Bartz and colleagues 

Image credit: Shikiya RA, et al. (2017)

For our 2016 Reviewer and Editorial Board

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03/30/2017

Pearls

Location, location, location: Use of CRISPR-Cas9 for genome editing in human pathogenic fungi

Aaron P. Mitchell discusses Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas9 systems. Mitchell looks at CRSIPR-Cas9 systems' programming abilities, revolutionary effect on the genetic manipulation of model organisms, and adaptive use in a variety of fungi. Some questions regarding the field of genome editing include how off-target effects can be assessed and minimized. 

Image credit: Mitchell AP (2017)

Location, location, location: Use of CRISPR-Cas9 for genome editing in human pathogenic fungi

03/27/2017

Research Article

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

Jesse D. Bloom and colleagues look at how all single amino-acid mutations to the nucleoprotein affect mxA sensitivity in the context of replication-competent virus. Their use of an unbiased deep mutational scanning approach leads to a new strategy for identifying regions of viral proteins that affect inhibition by host factors.

Image credit: Ashenberg O, et al. (2017)

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

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