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Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

February 26, 2015

Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

PLOS Pathogens Editor Jeffery L. Dangl, Peter J Balint-Kurti, and colleagues

Image credit: Jiabing Ji

PLOS Pathogens 2014 Reviewer Thank You

A tremendous thank you to the 2,900 reviewers from around the world helped evaluate over 1,200 articles.  Click to the right to see the full list.

Editorial

Recently Published Articles

Current Issue

Current Issue February 2015

02/24/2015

research article

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

Globular domain ligands (GDL), which refers to single-chain variable fragments directed against the globular domain of PrPC, are neurotoxic. Adriano Aguzzi and colleagues show that GDL and prion infections activate the same pathways, concluding that GDL mimic the interaction of PrPSc with PrPC, triggering downstream events characteristic of prion infection.

Image credit: Herrmann US, Sonati T, Falsig J, Reimann RR, et al. (2015)

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

02/24/2015

research article

Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites

The HIV-1 protein complex ESCRT is recruited by nascent viruses to release themselves from infected cells. Using super-resolution imaging with endogenous ESCRT proteins or ESCRT proteins containing a small tag, Don C. Lamb and colleagues were able to provide insight into how ESCRT leads to budding of HIV-1.

Image credit: Prescher J, Baumgärtel V, Ivanchenko S, et al. (2015)

Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites

02/25/2015

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Vaccine Hesitancy Collection

Multidisciplinary Perspectives on Vaccine Hesitancy and Contemporary Vaccination Coverage

Vaccine Hesitancy Collection

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