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06/14/2018

research matters

Reflections on an inflection: From virology to parasitology guided by POLARIS

The lives of individuals are marked by inflection points, events that seem prosaic at the time of their occurrence but have profound consequences as life unfolds. For Dr. Akhil B. Vaidya, such an inflection point happened in 1980 while he was working on mouse mammary tumor virus. Dr. Vaidya reflects on the subsequent study that altered the course of his scientific career (and led him to cancel his subscription to Journal of Virology). 

Image credit: Vaidya AB (2018)

Reflections on an inflection: From virology to parasitology guided by POLARIS

Recently Published Articles

Current Issue

Current Issue May 2018

06/14/2018

pearls

CRISPR-Cas antimicrobials: Challenges and future prospects

In this PLOS Pathogens Pearls article, van Houte and colleagues assess using CRISPR-Cas to target AMR in bacteria. The authors discuss the challenges ahead. These challenges include complex microbial communities, CRISPR-Cas delivery vehicles and architecture, resistance evolution against CRISPR-Cas, and legislation and responsible governance of CRISPR-Cas–based antimicrobials. Finally, they provide context on how we can best overcome these challenges.

Image credit: Pursey E, et al. (2018)

CRISPR-Cas antimicrobials: Challenges and future prospects

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