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08/16/2018

pearls

cGAS and STING: At the intersection of DNA and RNA virus sensing networks

In this PLOS Pathogens Pearls article, Damania and colleagues address the innate immune sensing of RNA and DNA viruses. They touch on the canonical role of the cGAS–STING pathway in sensing DNA virus infection, as well as the noncanonical role of the cGAS–STING pathway in restricting RNA virus infection. They discuss the evasion of the cGAS–STING pathway by DNA and RNA viruses, and comment on future directions.

Image credit: Ni G, Ma Z, Damania B (2018)

cGAS and STING: At the intersection of DNA and RNA virus sensing networks

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