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Genome analysis

A bioinformatic single-cell and structure-informed framework identifies a baicalin–CA2–keratinocyte state axis in atopic dermatitis

Boyan Yang, Guilin Zhou, Jun Dai

From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease

Wenbin Xu, Aocheng Ji, [ ... ], Chunyan Zeng

‘PePApipe’: A complete bioinformatics analysis pipeline for African Swine Fever Virus genome

Vicente Lopez-Chavarrias, Irene Aldea, Jovita Fernández-Pinero

External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts

Reuben S. Maghembe

Codon bias variation in Staphylococcus aureus

Kathleen O’Connor, Benjamin D. Mallinger, Nicholas A. Bedard, Robin Patel

High AUROC can mask decision failure in sepsis transcriptomic classifiers: Preprocessing stability outweighs post hoc calibration across cohorts

Hongwei Zheng, Wenbiao Chen

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Na Li, Qian Ma, [ ... ], Xinyi Li

An interpretable Hallmark pathway activity classifier for distinguishing CIN3/HSIL from invasive cervical squamous carcinoma: Development, external validation, and feature stability assessment

Mingyu Jia, Youyi Song, [ ... ], Mingzhu Ye

Highly contiguous reference genome assembly of the endangered Orcés’ blue whiptail Holcosus orcesi

Gabriela Pozo, Diego F. Cisneros-Heredia, [ ... ], Maria de Lourdes Torres

Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

Wei-Jia Kong, Jing-Xian Xue, [ ... ], Jiang-Tao Deng

Structural insights into the mosaic and modular organization of fourteen co-occurring resistance genes in multidrug resistant Enterobacteriaceae

Connor A. J. Rossel, Lieke B. van Alphen, Edou R. Heddema, Paul H. M. Savelkoul

Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome

Bin Sun, Yiqiao Lu, Wei Liu, Chengze Wang

Revisiting differential expression analysis: An updated six-dimensional comparative study

Jianxiong Wu, Shaoke Lu, Hui Yao, Zhaoyuan Fang

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