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Genomics

High AUROC can mask decision failure in sepsis transcriptomic classifiers: Preprocessing stability outweighs post hoc calibration across cohorts

Hongwei Zheng, Wenbiao Chen

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Na Li, Qian Ma, [ ... ], Xinyi Li

Whole-genome sequencing reveals divergent and shared selection signatures of heat stress adaptation in indigenous Ethiopian zebu cattle from dry-hot and humid-hot environments

Endashaw Terefe, Gurja Belay, [ ... ], Olivier Hanotte

Assessment of genomic prediction and genetic gain in multi‑population half-sib families in the perennial grass crop intermediate wheatgrass

Prabin Bajgain, Jacob M. Jungers, James A. Anderson

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting

Kady D. Waggle, Marissa Pacey Griffith, [ ... ], Lora Lee Pless

Isolation, antibiogram and whole genome sequence analysis of Pasteurella multocida type A from layer birds

Md Ahosanul Haque Shahid, Ajran Kabir, [ ... ], K. H. M. Nazmul Hussain Nazir

An interpretable Hallmark pathway activity classifier for distinguishing CIN3/HSIL from invasive cervical squamous carcinoma: Development, external validation, and feature stability assessment

Mingyu Jia, Youyi Song, [ ... ], Mingzhu Ye

Machine Learning approaches for the detection of disease-causing variants in whole-genome data need to address the expression of functional genes

Camilla Mapstone, Julia Handl, David Talavera

Breastmilk microbiota and its association with infant iron deficiency anaemia: A 16S rRNA metagenomic study in Peruvian mothers cohort

Arturo Octavio Gonzales-Rodriguez, Luis Edgardo Gonzales-Huerta, [ ... ], Francesca Antonia Reale

Highly contiguous reference genome assembly of the endangered Orcés’ blue whiptail Holcosus orcesi

Gabriela Pozo, Diego F. Cisneros-Heredia, [ ... ], Maria de Lourdes Torres

Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

Wei-Jia Kong, Jing-Xian Xue, [ ... ], Jiang-Tao Deng

Structural insights into the mosaic and modular organization of fourteen co-occurring resistance genes in multidrug resistant Enterobacteriaceae

Connor A. J. Rossel, Lieke B. van Alphen, Edou R. Heddema, Paul H. M. Savelkoul

Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome

Bin Sun, Yiqiao Lu, Wei Liu, Chengze Wang

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