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Cell signaling

An efficient ranking deep neural network algorithm for the prediction of Ca²⁺ binding sites of the protein

Pritee Parwekar, Samudrala Gourinath, Jaishree Jain, Shilpa Gundagatti, Jabir Ali, Punit Gupta, Asmir Butkovic

published 13 Aug 2026

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Integrating dynamic modeling of signaling pathways with subject-specific transcriptomic data to assess breast cancer risk

Piyanut Ratphibun Yamashita, Anuwat Tangthanawatsakul, Teerasit Termsaithong, Yaowaluck Maprang Roshorm, Teeraphan Laomettachit

published 13 Aug 2026

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Molecular regulatory mechanism of TRPV4-mediated calcium-dependent 5-HT secretion from enterochromaffin cells and its involvement in ulcerative colitis

Shuo Tong, Yujuan Wang, Jianxin Wang, Chengxin Qu, Shude Pang, Wenwen Zhao, Hui Dong

published 13 Aug 2026

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Ortholog transfer stress test: Regulatory edge conservation across species, tissues, and evolutionary distance

Ihor Kendiukhov

published 12 Aug 2026

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Mechanistic insights into daidzin from Glycine max against breast cancer via network pharmacology and multi-level molecular modeling

Lan Thi Vu, Luong Trong Vu, Lien Thi Kim Vu, Hang Thi Thuy Pho, Quan Huu Nguyen, Lan Thi Ngoc Nguyen, Yen Thi Hai Nguyen, Hung Duc Nguyen, Mau Hoang Chu

published 11 Aug 2026

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Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications

Qin Qin, Cenyuan Dong, Ziyi Zhou, Yangyuanzhi Liu, Mengpan Liu, Chunyu Cao, Lin Teng

published 11 Aug 2026

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Reproductive-state dependent changes in inner ear gene expression in female plainfin midshipman fish

Coty Jasper, Sumaya Hassan, Robin Gibson, Tot Nguyen, Olivia Molano, Leila Farbod, Joseph A. Sisneros, Jennifer S. Stone, Allison B. Coffin

published 04 Aug 2026

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Functional CCR7A-mediated cellular responses are negatively modulated by the splice variant CCR7B

Minyeong Cho, Hee-Kyung Park, Lan Phuong Nguyen, Thai Uy Nguyen, Duc Trung Nguyen, Soyeon In, Sunghoon Hurh, Beom Jin Park, Jae Young Seong, Jong-Ik Hwang

published 04 Aug 2026

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FAERS-based pharmacovigilance and network toxicology analysis of esomeprazole-associated osteoporosis

Yan Wang, Xiaolong Xu, Guanjun Huang, Hongyan Zhu, Xuan Li, Jue Lin

published 04 Aug 2026

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Integrative network pharmacology, transcriptomics, and molecular docking identify candidate Centella asiatica constituents and targets in neurodegenerative diseases

Yuxi Xie, Chong-Teik Lim, Xin-Jieh Lam, Pike-See Cheah, King-Hwa Ling, Tan Huang

published 31 Jul 2026

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Concordant RNA-protein evidence and human tissue metabolomics prioritize UPP1-associated nucleotide remodeling in prostate cancer

Xuancai Chen, Wei Su, Qun Zhou, Yucheng Qi, Juanjuan Xie, Yachun Tang, Xin Tang, Hao Fu

published 31 Jul 2026

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Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro

Ghalia Khoder, Rose Ghemrawi, Nour Sammani, Rania Harati, Mohamad Hamad, Jibran Sualeh Muhammad, Walaa Mousa, Mostafa Khair

published 30 Jul 2026

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Overexpression of CD97 in intestinal epithelial cells attenuates LPS-induced pro-inflammatory cytokine induction via stabilization of β-catenin early in life

Niklas Dressler, Steffi Mayer, Thomas Wiemers, Florentine Weise, Xiaoyan Feng, Gabriela Aust, Nicole Peukert, Martin Lacher, Jan Riedel

published 30 Jul 2026

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