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Genetic interactions between novel susceptibility loci in canine dermatomyositis.

A 4-month-old Shetland sheepdog, Lorelei, displays facial skin lesions from dermatomyositis, a chronic inflammatory myopathy and vasculopathy affecting both people and dogs. Evans et al. identified three loci that contribute to pathogenesis in dogs and 9 allelic combinations that confer high or moderate probability of disease. Lorelei's genotype (AABbCC) is high-risk; 92% of dogs having this genotypic combination showed clinical signs of dermatomyositis. See Evans et al.

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Image Credit: Lex Gatineau