Table of Contents: April 2012

As with DNA double-strand breaks, uncapped telomere ends lead to the formation of dicentric chromosomes. These chromosome configurations may initiate genomic instability by firing BFB-cycles after chromatin bridges break during mitosis. However, some of these may remain unbroken (blue, DNA) during furrow ingression (yellow, cortical actin) up to later stages of cytokinesis. A study by Pampalona et al. in human mammary epithelial cells exhibiting progressive telomere dysfunction reports that persistent chromatin bridges in the cleavage plane engender binucleated polyploid cells by failing to complete cytoplasmatic cell division.

Image Credit: Judit Pampalona (Universitat Autònoma de Barcelona).


Defective Membrane Remodeling in Neuromuscular Diseases: Insights from Animal Models

Belinda S. Cowling, Anne Toussaint, Jean Muller, Jocelyn Laporte

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Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies

Joseph P. Jarvis, Laura B. Scheinfeldt, Sameer Soi, Charla Lambert, Larsson Omberg, Bart Ferwerda, Alain Froment, Jean-Marie Bodo, William Beggs, Gabriel Hoffman, Jason Mezey, Sarah A. Tishkoff

Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng, Marnie Gelbart, Michael Y. Tolstorukov, Annette Plachetka, Peter V. Kharchenko, Youngsook L. Jung, Andrey A. Gorchakov, Erica Larschan, Tingting Gu, Aki Minoda, Nicole C. Riddle, Yuri B. Schwartz, Sarah C. R. Elgin, Gary H. Karpen, Vincenzo Pirrotta, Mitzi I. Kuroda, Peter J. Park

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