LYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles and is relevant to multiple human diseases. Lyst-mutant mice exhibit a variety of defects, including a unique pattern of concentric transillumination defects in the iris. In this issue of PLoS Genetics, Trantow et al. utilized iris phenotypes in a search for modifier genes that influence Lyst pathways. A priori, the expectation would have been that modifiers of Lyst would logically be related to organelle biogenesis. Instead, the authors show that at the level of the whole-animal, oxidative damage to membranes is a highly relevant event.
Image Credit: Michael Anderson
Interview
Question and Answer: An Anniversary Interview with Jane Gitschier
PLOS Genetics: published July 22, 2010 | https://doi.org/10.1371/journal.pgen.1001018
Perspective
Chromatin Remodeling in Development and Disease: Focus on CHD7
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Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo
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