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Table of Contents: April 2008

A composite photo showing two distinct traditional lifestyles in different geographic contexts experienced by Moroccan Amazighs: desert nomadic (upper) and mountain agrarian (lower). Regional population differences, including lifestyle, geography, and biotic factors, can play at least as great a role as genetic divergence in modulating gene expression variation in humans (see Idaghdour et al., 10.1371/journal.pgen.1000052).

Image Credit: Photographs by Youssef Idaghdour

Special Reports

SNPs Meet CNVs in Genome-Wide Association Studies: HGV2007 Meeting Report

Xavier Estivill, Nancy J. Cox, Stephen J. Chanock, Pui-Yan Kwok, Stephen W. Scherer, Anthony J. Brookes

Reviews

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

Michelle M. A. Fernando, Christine R. Stevens, Emily C. Walsh, Philip L. De Jager, Philippe Goyette, Robert M. Plenge, Timothy J. Vyse, John D. Rioux

Research Articles

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

Ying Liu, Cynthia Helms, Wilson Liao, Lisa C. Zaba, Shenghui Duan, Jennifer Gardner, Carol Wise, Andrew Miner, M. J. Malloy, Clive R. Pullinger, John P. Kane, Scott Saccone, Jane Worthington, Ian Bruce, Pui–Yan Kwok, Alan Menter, James Krueger, Anne Barton, Nancy L. Saccone, Anne M. Bowcock

Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus

Natalie D. Fedorova, Nora Khaldi, Vinita S. Joardar, Rama Maiti, Paolo Amedeo, Michael J. Anderson, Jonathan Crabtree, Joana C. Silva, Jonathan H. Badger, Ahmed Albarraq, Sam Angiuoli, Howard Bussey, Paul Bowyer, Peter J. Cotty, Paul S. Dyer, Amy Egan, Kevin Galens, Claire M. Fraser-Liggett, Brian J. Haas, Jason M. Inman, Richard Kent, Sebastien Lemieux, Iran Malavazi, Joshua Orvis, Terry Roemer, Catherine M. Ronning, Jaideep P. Sundaram, Granger Sutton, Geoff Turner, J. Craig Venter, Owen R. White, Brett R. Whitty, Phil Youngman, Kenneth H. Wolfe, Gustavo H. Goldman, Jennifer R. Wortman, Bo Jiang, David W. Denning, William C. Nierman

An Increase in Mitochondrial DNA Promotes Nuclear DNA Replication in Yeast

Heidi M. Blank, Chonghua Li, John E. Mueller, Lydia M. Bogomolnaya, Mary Bryk, Michael Polymenis

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A Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs

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