October 2013

The Integrator Complex Subunit 6 (Ints6) Confines the Dorsal Organizer in Vertebrate Embryogenesis

Lee D. Kapp, Elliott W. Abrams, Florence L. Marlow, Mary C. Mullins

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003822

Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish

Cecilia L. Winata, Igor Kondrychyn, Vibhor Kumar, Kandhadayar G. Srinivasan, Yuriy Orlov, Ashwini Ravishankar, Shyam Prabhakar, Lawrence W. Stanton, Vladimir Korzh, Sinnakaruppan Mathavan

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003852

Xbp1 Directs Global Repression of Budding Yeast Transcription during the Transition to Quiescence and Is Important for the Longevity and Reversibility of the Quiescent State

Shawna Miles, Lihong Li, Jerry Davison, Linda L. Breeden

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003854

Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

Céline Duc, Alexander Sherstnev, Christian Cole, Geoffrey J. Barton, Gordon G. Simpson

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003867

Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway

Catherine E. Smith, Marc L. Mendillo, Nikki Bowen, Hans Hombauer, Christopher S. Campbell, Arshad Desai, Christopher D. Putnam, Richard D. Kolodner

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003869

Condensin II Subunit dCAP-D3 Restricts Retrotransposon Mobilization in Drosophila Somatic Cells

Andrew T. Schuster, Kavitha Sarvepalli, Eain A. Murphy, Michelle S. Longworth

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003879

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic

Fang Han, Juliette Faraco, Xiao Song Dong, Hanna M. Ollila, Ling Lin, Jing Li, Pei An, Shan Wang, Ke Wei Jiang, Zhan Cheng Gao, Long Zhao, Han Yan, Ya Nan Liu, Qing Hua Li, Xiao Zhe Zhang, Yan Hu, Jing Yu Wang, Yun Hui Lu, Chang Jun Lu, Wei Zhou, Joachim Hallmayer, Yu Shu Huang, Kingman P. Strohl, Thomas Pollmächer, Emmanuel Mignot

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003880

The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading

Miki Fujioka, Guizhi Sun, James B. Jaynes

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003883

Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail

Bo Yan, Nadin Memar, Julia Gallinger, Barbara Conradt

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003884

PNUTS/PP1 Regulates RNAPII-Mediated Gene Expression and Is Necessary for Developmental Growth

Anita Ciurciu, Louise Duncalf, Vincent Jonchere, Nick Lansdale, Olga Vasieva, Peter Glenday, Andreii Rudenko, Emese Vissi, Neville Cobbe, Luke Alphey, Daimark Bennett

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003885

Tracking Proliferative History in Lymphocyte Development with Cre-Mediated Sister Chromatid Recombination

Baojun Zhang, Meifang Dai, Qi-Jing Li, Yuan Zhuang

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003887

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

Mariana Igoillo-Esteve, Anne Genin, Nelle Lambert, Julie Désir, Isabelle Pirson, Baroj Abdulkarim, Nicolas Simonis, Anais Drielsma, Lorella Marselli, Piero Marchetti, Pierre Vanderhaeghen, Décio L. Eizirik, Wim Wuyts, Cécile Julier, Ali J. Chakera, Sian Ellard, Andrew T. Hattersley, Marc Abramowicz, Miriam Cnop

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003888

Nuclear Fragile X Mental Retardation Protein Is localized to Cajal Bodies

Alain Y. Dury, Rachid El Fatimy, Sandra Tremblay, Timothy M. Rose, Jocelyn Côté, Paul De Koninck, Edouard W. Khandjian

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003890

Mobility of the Native Bacillus subtilis Conjugative Plasmid pLS20 Is Regulated by Intercellular Signaling

Praveen K. Singh, Gayetri Ramachandran, Ricardo Ramos-Ruiz, Ramón Peiró-Pastor, David Abia, Ling J. Wu, Wilfried J. J. Meijer

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003892

Genome-Wide High-Resolution Mapping of UV-Induced Mitotic Recombination Events in Saccharomyces cerevisiae

Yi Yin, Thomas D. Petes

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003894

ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation

Yueqin Zhou, Songyan Liu, Guodong Liu, Arzu Öztürk, Geoffrey G. Hicks

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003895

The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

Julia Hornig, Franziska Fröb, Michael R. Vogl, Irm Hermans-Borgmeyer, Ernst R. Tamm, Michael Wegner

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003907

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

Ivana Murfuni, Giorgia Basile, Shyamal Subramanyam, Eva Malacaria, Margherita Bignami, Maria Spies, Annapaola Franchitto, Pietro Pichierri

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003910

Human Intellectual Disability Genes Form Conserved Functional Modules in Drosophila

Merel A. W. Oortveld, Shivakumar Keerthikumar, Martin Oti, Bonnie Nijhof, Ana Clara Fernandes, Korinna Kochinke, Anna Castells-Nobau, Eva van Engelen, Thijs Ellenkamp, Lilian Eshuis, Anne Galy, Hans van Bokhoven, Bianca Habermann, Han G. Brunner, Christiane Zweier, Patrik Verstreken, Martijn A. Huynen, Annette Schenck

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003911

FliZ Is a Global Regulatory Protein Affecting the Expression of Flagellar and Virulence Genes in Individual Xenorhabdus nematophila Bacterial Cells

Grégory Jubelin, Anne Lanois, Dany Severac, Stéphanie Rialle, Cyrille Longin, Sophie Gaudriault, Alain Givaudan

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003915

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Lanelle R. Connolly, Kristina M. Smith, Michael Freitag

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003916

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

David M. Evans, Marie Jo A. Brion, Lavinia Paternoster, John P. Kemp, George McMahon, Marcus Munafò, John B. Whitfield, Sarah E. Medland, Grant W. Montgomery, The GIANT consortium, The CRP consortium, The TAG Consortium, Nicholas J. Timpson, Beate St. Pourcain, Debbie A. Lawlor, Nicholas G. Martin, Abbas Dehghan, Joel Hirschhorn, George Davey Smith

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003919

Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast

Nina V. Romanova, Gray F. Crouse

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003920

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St. Claire, Gagan B. Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis, Jolene R. Guide, Paula E. Cohen, Guo-Min Li, Christopher E. Pearson, Mark J. Daly, Vanessa C. Wheeler

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003930

High Throughput Sequencing Reveals Alterations in the Recombination Signatures with Diminishing Spo11 Activity

Beth Rockmill, Philippe Lefrançois, Karen Voelkel-Meiman, Ashwini Oke, G. Shirleen Roeder, Jennifer C. Fung

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003932

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

Monica Courtney, Elisabet Gjernes, Noémie Druelle, Christophe Ravaud, Andhira Vieira, Nouha Ben-Othman, Anja Pfeifer, Fabio Avolio, Gunter Leuckx, Sandra Lacas-Gervais, Fanny Burel-Vandenbos, Damien Ambrosetti, Jacob Hecksher-Sorensen, Philippe Ravassard, Harry Heimberg, Ahmed Mansouri, Patrick Collombat

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003934

The Deacetylase Sir2 from the Yeast Clavispora lusitaniae Lacks the Evolutionarily Conserved Capacity to Generate Subtelomeric Heterochromatin

Cara A. Froyd, Shivali Kapoor, Fred Dietrich, Laura N. Rusche

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003935

Co-evolution of Human Leukocyte Antigen (HLA) Class I Ligands with Killer-Cell Immunoglobulin-Like Receptors (KIR) in a Genetically Diverse Population of Sub-Saharan Africans

Paul J. Norman, Jill A. Hollenbach, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Hugo G. Hilton, Marcelo J. Pando, Kwadwo A. Koram, Eleanor M. Riley, Laurent Abi-Rached, Peter Parham

PLOS Genetics: published October 31, 2013 | https://doi.org/10.1371/journal.pgen.1003938

Two Portable Recombination Enhancers Direct Donor Choice in Fission Yeast Heterochromatin

Tadas Jakočiūnas, Lærke Rebekka Holm, Janne Verhein-Hansen, Ala Trusina, Geneviève Thon

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003762

Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice

Yu S. Zhou, Sheila Webb, Laura Lettice, Steve Tardif, Fiona Kilanowski, Christine Tyrrell, Heather MacPherson, Fiona Semple, Peter Tennant, Tina Baker, Alan Hart, Paul Devenney, Paul Perry, Tracey Davey, Perdita Barran, Chris L. Barratt, Julia R. Dorin

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003826

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

Lesly De Arras, Scott Alper

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003855

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Lea K. Davis, Dongmei Yu, Clare L. Keenan, Eric R. Gamazon, Anuar I. Konkashbaev, Eske M. Derks, Benjamin M. Neale, Jian Yang, S. Hong Lee, Patrick Evans, Cathy L. Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrio, Oscar J. Bienvenu, Michael H. Bloch, Rianne M. Blom, Ruth D. Bruun, Cathy L. Budman, Beatriz Camarena, Desmond Campbell, Carolina Cappi, Julio C. Cardona Silgado, Danielle C. Cath, Maria C. Cavallini, Denise A. Chavira, Sylvain Chouinard, David V. Conti, Edwin H. Cook, Vladimir Coric, Bernadette A. Cullen, Dieter Deforce, Richard Delorme, Yves Dion, Christopher K. Edlund, Karin Egberts, Peter Falkai, Thomas V. Fernandez, Patience J. Gallagher, Helena Garrido, Daniel Geller, Simon L. Girard, Hans J. Grabe, Marco A. Grados, Benjamin D. Greenberg, Varda Gross-Tsur, Stephen Haddad, Gary A. Heiman, Sian M. J. Hemmings, Ana G. Hounie, Cornelia Illmann, Joseph Jankovic, Michael A. Jenike, James L. Kennedy, Robert A. King, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F. Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L. Lowe, Fabio Macciardi, James T. McCracken, Lauren M. McGrath, Sandra C. Mesa Restrepo, Rainald Moessner, Jubel Morgan, Heike Muller, Dennis L. Murphy, Allan L. Naarden, William Cornejo Ochoa, Roel A. Ophoff, Lisa Osiecki, Andrew J. Pakstis, Michele T. Pato, Carlos N. Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L. Rauch, Tobias J. Renner, Victor I. Reus, Margaret A. Richter, Mark A. Riddle, Mary M. Robertson, Roxana Romero, Maria C. Rosàrio, David Rosenberg, Guy A. Rouleau, Stephan Ruhrmann, Andres Ruiz-Linares, Aline S. Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey S. Singer, Jan H. Smit, Dan J. Stein, E. Strengman, Jay A. Tischfield, Ana V. Valencia Duarte, Homero Vallada, Filip Van Nieuwerburgh, Jeremy Veenstra-VanderWeele, Susanne Walitza, Ying Wang, Jens R. Wendland, Herman G. M. Westenberg, Yin Yao Shugart, Euripedes C. Miguel, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L. Hanna, Peter Heutink, Damiaan Denys, Paul D. Arnold, Ben A. Oostra, Gerald Nestadt, Nelson B. Freimer, David L. Pauls, Naomi R. Wray, S. Evelyn Stewart, Carol A. Mathews, James A. Knowles, Nancy J. Cox, Jeremiah M. Scharf

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003864

Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins

Liat Rockah-Shmuel, Ágnes Tóth-Petróczy, Asaf Sela, Omri Wurtzel, Rotem Sorek, Dan S. Tawfik

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003882

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

Lyudmila Y. Kadyrova, Tony M. Mertz, Yu Zhang, Matthew R. Northam, Ziwei Sheng, Kirill S. Lobachev, Polina V. Shcherbakova, Farid A. Kadyrov

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003899

Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization

Ramakrishna Kommagani, Maria M. Szwarc, Ertug Kovanci, William E. Gibbons, Nagireddy Putluri, Suman Maity, Chad J. Creighton, Arun Sreekumar, Francesco J. DeMayo, John P. Lydon, Bert W. O'Malley

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003900

Robust Demographic Inference from Genomic and SNP Data

Laurent Excoffier, Isabelle Dupanloup, Emilia Huerta-Sánchez, Vitor C. Sousa, Matthieu Foll

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003905

Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function

Alexander A. Soukas, Christopher E. Carr, Gary Ruvkun

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003908

Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

Gustavo Stadthagen, Disa Tehler, Nina Molin Høyland-Kroghsbo, Jiayu Wen, Anders Krogh, Klaus T. Jensen, Eric Santoni-Rugiu, Lars H. Engelholm, Anders H. Lund

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003913

Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas

Hongzhi Tang, Lijuan Wang, Weiwei Wang, Hao Yu, Kunzhi Zhang, Yuxiang Yao, Ping Xu

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003923

Evolutionary Tuning of Protein Expression Levels of a Positively Autoregulated Two-Component System

Rong Gao, Ann M. Stock

PLOS Genetics: published October 24, 2013 | https://doi.org/10.1371/journal.pgen.1003927

Specific Tandem Repeats Are Sufficient for Paramutation-Induced Trans-Generational Silencing

Christiane L. Belele, Lyudmila Sidorenko, Maike Stam, Rechien Bader, Mario A. Arteaga-Vazquez, Vicki L. Chandler

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003773

The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally

Dan M. Park, Md. Sohail Akhtar, Aseem Z. Ansari, Robert Landick, Patricia J. Kiley

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003839

Genome-Wide and Cell-Specific Epigenetic Analysis Challenges the Role of Polycomb in Drosophila Spermatogenesis

Sherif El-Sharnouby, Juliet Redhouse, Robert A. H. White

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003842

A Novel Intra-U1 snRNP Cross-Regulation Mechanism: Alternative Splicing Switch Links U1C and U1-70K Expression

Tanja Dorothe Rösel-Hillgärtner, Lee-Hsueh Hung, Ekaterina Khrameeva, Patrick Le Querrec, Mikhail S. Gelfand, Albrecht Bindereif

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003856

The Transacting Factor CBF-A/Hnrnpab Binds to the A2RE/RTS Element of Protamine 2 mRNA and Contributes to Its Translational Regulation during Mouse Spermatogenesis

Nanaho Fukuda, Tomoyuki Fukuda, John Sinnamon, Abrahan Hernandez-Hernandez, Manizheh Izadi, Chandrasekhar S. Raju, Kevin Czaplinski, Piergiorgio Percipalle

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003858

De Novo ORFs in Drosophila Are Important to Organismal Fitness and Evolved Rapidly from Previously Non-coding Sequences

Josephine A. Reinhardt, Betty M. Wanjiru, Alicia T. Brant, Perot Saelao, David J. Begun, Corbin D. Jones

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003860

A Minimal Nitrogen Fixation Gene Cluster from Paenibacillus sp. WLY78 Enables Expression of Active Nitrogenase in Escherichia coli

Liying Wang, Lihong Zhang, Zhangzhi Liu, Dehua Zhao, Xiaomeng Liu, Bo Zhang, Jianbo Xie, Yuanyuan Hong, Pengfei Li, Sanfeng Chen, Ray Dixon, Jilun Li

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003865

Yeast Tdh3 (Glyceraldehyde 3-Phosphate Dehydrogenase) Is a Sir2-Interacting Factor That Regulates Transcriptional Silencing and rDNA Recombination

Alison E. Ringel, Rebecca Ryznar, Hannah Picariello, Kuan-lin Huang, Asmitha G. Lazarus, Scott G. Holmes

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003871

A KH-Domain RNA-Binding Protein Interacts with FIERY2/CTD Phosphatase-Like 1 and Splicing Factors and Is Important for Pre-mRNA Splicing in Arabidopsis

Tao Chen, Peng Cui, Hao Chen, Shahjahan Ali, Shoudong Zhang, Liming Xiong

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003875

Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer

Alexandra E. Gylfe, Riku Katainen, Johanna Kondelin, Tomas Tanskanen, Tatiana Cajuso, Ulrika Hänninen, Jussi Taipale, Minna Taipale, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Pia Vahteristo, Sari Tuupanen, Auli Karhu, Lauri A. Aaltonen

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003876

Hsp70-Hsp40 Chaperone Complex Functions in Controlling Polarized Growth by Repressing Hsf1-Driven Heat Stress-Associated Transcription

Aleksandar Vjestica, Dan Zhang, Jianhua Liu, Snezhana Oliferenko

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003886

The Human Nuclear Poly(A)-Binding Protein Promotes RNA Hyperadenylation and Decay

Stefan M. Bresson, Nicholas K. Conrad

PLOS Genetics: published October 17, 2013 | https://doi.org/10.1371/journal.pgen.1003893

Cooperation between RUNX1-ETO9a and Novel Transcriptional Partner KLF6 in Upregulation of Alox5 in Acute Myeloid Leukemia

Russell C. DeKelver, Benjamin Lewin, Kentson Lam, Yukiko Komeno, Ming Yan, Chandler Rundle, Miao-Chia Lo, Dong-Er Zhang

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003765

Natural Genetic Variation of Integrin Alpha L (Itgal) Modulates Ischemic Brain Injury in Stroke

Sehoon Keum, Han Kyu Lee, Pei-Lun Chu, Matthew J. Kan, Min-Nung Huang, Carol J. Gallione, Michael D. Gunn, Donald C. Lo, Douglas A. Marchuk

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003807

Rad52 Sumoylation Prevents the Toxicity of Unproductive Rad51 Filaments Independently of the Anti-Recombinase Srs2

Aline Esta, Emilie Ma, Pauline Dupaigne, Laurent Maloisel, Raphaël Guerois, Eric Le Cam, Xavier Veaute, Eric Coïc

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003833

Reverse PCA, a Systematic Approach for Identifying Genes Important for the Physical Interaction between Protein Pairs

Ifat Lev, Marina Volpe, Liron Goor, Nelly Levinton, Liach Emuna, Shay Ben-Aroya

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003838

A Novel Role for Ecdysone in Drosophila Conditioned Behavior: Linking GPCR-Mediated Non-canonical Steroid Action to cAMP Signaling in the Adult Brain

Hiroshi Ishimoto, Zhe Wang, Yi Rao, Chun-Fang Wu, Toshihiro Kitamoto

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003843

Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

Mauricio Valerio-Santiago, Ana Isabel de los Santos-Velázquez, Fernando Monje-Casas

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003859

Multiple bHLH Proteins form Heterodimers to Mediate CRY2-Dependent Regulation of Flowering-Time in Arabidopsis

Yawen Liu, Xu Li, Kunwu Li, Hongtao Liu, Chentao Lin

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003861

Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection

Nicholas J. Croucher, Andrea M. Mitchell, Katherine A. Gould, Donald Inverarity, Lars Barquist, Theresa Feltwell, Maria C. Fookes, Simon R. Harris, Janina Dordel, Susannah J. Salter, Sarah Browall, Helena Zemlickova, Julian Parkhill, Staffan Normark, Birgitta Henriques-Normark, Jason Hinds, Tim J. Mitchell, Stephen D. Bentley

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003868

Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression

Daisuke Sakurai, Jian Zhao, Yun Deng, Jennifer A. Kelly, Elizabeth E. Brown, John B. Harley, Sang-Cheol Bae, Marta E. Alarcόn-Riquelme, on behalf of the BIOLUPUS and GENLES networks, Jeffrey C. Edberg, Robert P. Kimberly, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vilá, Graciela S. Alarcón, Kenneth M. Kaufman, Timothy J. Vyse, Chaim O. Jacob, Patrick M. Gaffney, Kathy Moser Sivils, Judith A. James, Diane L. Kamen, Gary S. Gilkeson, Timothy B. Niewold, Joan T. Merrill, R. Hal Scofield, Lindsey A. Criswell, Anne M. Stevens, Susan A. Boackle, Jae-Hoon Kim, Jiyoung Choi, Bernardo A. Pons-Estel, on behalf of the Argentine Collaborative Group, Barry I. Freedman, Juan-Manuel Anaya, Javier Martin, C. Yung Yu, Deh-Ming Chang, Yeong Wook Song, Carl D. Langefeld, Weiling Chen, Jennifer M. Grossman, Rita M. Cantor, Bevra H. Hahn, Betty P. Tsao

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003870

Function and Evolution of DNA Methylation in Nasonia vitripennis

Xu Wang, David Wheeler, Amanda Avery, Alfredo Rago, Jeong-Hyeon Choi, John K. Colbourne, Andrew G. Clark, John H. Werren

PLOS Genetics: published October 10, 2013 | https://doi.org/10.1371/journal.pgen.1003872

Conserved Translatome Remodeling in Nematode Species Executing a Shared Developmental Transition

Michael Stadler, Andrew Fire

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003739

A Novel Actin mRNA Splice Variant Regulates ACTG1 Expression

Meghan C. Drummond, Karen H. Friderici

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003743

Genome-Wide Analysis of Cell Type-Specific Gene Transcription during Spore Formation in Clostridium difficile

Laure Saujet, Fátima C. Pereira, Monica Serrano, Olga Soutourina, Marc Monot, Pavel V. Shelyakin, Mikhail S. Gelfand, Bruno Dupuy, Adriano O. Henriques, Isabelle Martin-Verstraete

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003756

Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease

Peter Carbonetto, Matthew Stephens

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003770

The Spore Differentiation Pathway in the Enteric Pathogen Clostridium difficile

Fátima C. Pereira, Laure Saujet, Ana R. Tomé, Mónica Serrano, Marc Monot, Evelyne Couture-Tosi, Isabelle Martin-Verstraete, Bruno Dupuy, Adriano O. Henriques

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003782

Identification of 526 Conserved Metazoan Genetic Innovations Exposes a New Role for Cofactor E-like in Neuronal Microtubule Homeostasis

Melissa Y. Frédéric, Victor F. Lundin, Matthew D. Whiteside, Juan G. Cueva, Domena K. Tu, S. Y. Catherine Kang, Hansmeet Singh, David L. Baillie, Harald Hutter, Miriam B. Goodman, Fiona S. L. Brinkman, Michel R. Leroux

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003804

Distinct Regulatory Mechanisms Act to Establish and Maintain Pax3 Expression in the Developing Neural Tube

Steven Moore, Vanessa Ribes, Javier Terriente, David Wilkinson, Frédéric Relaix, James Briscoe

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003811

Multiple Signaling Pathways Coordinate to Induce a Threshold Response in a Chordate Embryo

Naoyuki Ohta, Yutaka Satou

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003818

Both Rare and De Novo Copy Number Variants Are Prevalent in Agenesis of the Corpus Callosum but Not in Cerebellar Hypoplasia or Polymicrogyria

Samin A. Sajan, Liliana Fernandez, Sahar Esmaeeli Nieh, Eric Rider, Polina Bukshpun, Mari Wakahiro, Susan L. Christian, Jean-Baptiste Rivière, Christopher T. Sullivan, Jyotsna Sudi, Michael J. Herriges, Alexander R. Paciorkowski, A. James Barkovich, Joseph T. Glessner, Kathleen J. Millen, Hakon Hakonarson, William B. Dobyns, Elliott H. Sherr

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003823

Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation

Katherine L. Furniss, Hung-Ji Tsai, Jo Ann W. Byl, Andrew B. Lane, Amit C. Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J. Clarke

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003832

The Serum Resistome of a Globally Disseminated Multidrug Resistant Uropathogenic Escherichia coli Clone

Minh-Duy Phan, Kate M. Peters, Sohinee Sarkar, Samuel W. Lukowski, Luke P. Allsopp, Danilo Gomes Moriel, Maud E. S. Achard, Makrina Totsika, Vikki M. Marshall, Mathew Upton, Scott A. Beatson, Mark A. Schembri

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003834

Chimeric Protein Complexes in Hybrid Species Generate Novel Phenotypes

Elzbieta M. Piatkowska, Samina Naseeb, David Knight, Daniela Delneri

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003836

SUMO Localizes to the Central Element of Synaptonemal Complex and Is Required for the Full Synapsis of Meiotic Chromosomes in Budding Yeast

Karen Voelkel-Meiman, Louis F. Taylor, Pritam Mukherjee, Neil Humphryes, Hideo Tsubouchi, Amy J. MacQueen

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003837

Incorporating Motif Analysis into Gene Co-expression Networks Reveals Novel Modular Expression Pattern and New Signaling Pathways

Shisong Ma, Smit Shah, Hans J. Bohnert, Michael Snyder, Savithramma P. Dinesh-Kumar

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003840

Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

Keiichi Inoue, Joanne Rispoli, Lichuan Yang, David MacLeod, M. Flint Beal, Eric Klann, Asa Abeliovich

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003845

A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2

Elisa Degenkolbe, Jana König, Julia Zimmer, Maria Walther, Carsten Reißner, Joachim Nickel, Frank Plöger, Jelena Raspopovic, James Sharpe, Katarina Dathe, Jacqueline T. Hecht, Stefan Mundlos, Sandra C. Doelken, Petra Seemann

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003846

A Mutation in the SUV39H2 Gene in Labrador Retrievers with Hereditary Nasal Parakeratosis (HNPK) Provides Insights into the Epigenetics of Keratinocyte Differentiation

Vidhya Jagannathan, Jeanette Bannoehr, Philippe Plattet, Regula Hauswirth, Cord Drögemüller, Michaela Drögemüller, Dominique J. Wiener, Marcus Doherr, Marta Owczarek-Lipska, Arnaud Galichet, Monika M. Welle, Katarina Tengvall, Kerstin Bergvall, Hannes Lohi, Silvia Rüfenacht, Monika Linek, Manon Paradis, Eliane J. Müller, Petra Roosje, Tosso Leeb

PLOS Genetics: published October 3, 2013 | https://doi.org/10.1371/journal.pgen.1003848

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A female jewel wasp stings and lays her eggs in a host blowfly pupa

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