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A bulldog.
There are hundreds of breeds of domestic dog, which each have unique characteristics. The huge phenotypic variability of dogs results from strong artificial selection. Vaysse et al. identified footprints of selection in the dog's genome.
Image Credit: User Nokdie at flickr.com
Perspectives
An Adaptive Allelic Series Featuring Complex Gene Rearrangements
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002347
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Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002296
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Research Articles
Insights into Hox Protein Function from a Large Scale Combinatorial Analysis of Protein Domains
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002302
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis Pneumonia
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002328
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002341
Comparative Genomic Analysis of Human Fungal Pathogens Causing Paracoccidioidomycosis
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002345
A Conserved Developmental Patterning Network Produces Quantitatively Different Output in Multiple Species of Drosophila
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002346
Small RNAs Prevent Transcription-Coupled Loss of Histone H3 Lysine 9 Methylation in Arabidopsis thaliana
PLOS Genetics: published October 27, 2011 | https://doi.org/10.1371/journal.pgen.1002350
Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002266
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Global Mapping of Cell Type–Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002311
Identification of Widespread Ultra-Edited Human RNAs
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002317
Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002319
Transforming Growth Factor β Receptor Type 1 Is Essential for Female Reproductive Tract Integrity and Function
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002320
Transcriptome-Wide Binding Sites for Components of the Saccharomyces cerevisiae Non-Poly(A) Termination Pathway: Nrd1, Nab3, and Sen1
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002329
Feed-Forward Microprocessing and Splicing Activities at a MicroRNA–Containing Intron
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002330
Genetic Rearrangements Can Modify Chromatin Features at Epialleles
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002331
A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002332
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002333
HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002336
Successive Increases in the Resistance of Drosophila to Viral Infection through a Transposon Insertion Followed by a Duplication
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002337
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Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002338
Temporal Coordination of Gene Networks by Zelda in the Early Drosophila Embryo
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002339
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Novel Function of Distal-less as a Gap Gene during Spider Segmentation
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002342
Genetic Diversity in Cytokines Associated with Immune Variation and Resistance to Multiple Pathogens in a Natural Rodent Population
PLOS Genetics: published October 20, 2011 | https://doi.org/10.1371/journal.pgen.1002343
Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002276
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A One Base Pair Deletion in the Canine ATP13A2 Gene Causes Exon Skipping and Late-Onset Neuronal Ceroid Lipofuscinosis in the Tibetan Terrier
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002304
Multiple Wnts Redundantly Control Polarity Orientation in Caenorhabditis elegans Epithelial Stem Cells
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002308
Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002312
Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002315
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002316
The Thermoanaerobacter Glycobiome Reveals Mechanisms of Pentose and Hexose Co-Utilization in Bacteria
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002318
Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002321
A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002322
The Bicoid Stability Factor Controls Polyadenylation and Expression of Specific Mitochondrial mRNAs in Drosophila melanogaster
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002324
Whole-Exome Sequencing Identifies Homozygous AFG3L2 Mutations in a Spastic Ataxia-Neuropathy Syndrome Linked to Mitochondrial m-AAA Proteases
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002325
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Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002326
MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002327
Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans
PLOS Genetics: published October 13, 2011 | https://doi.org/10.1371/journal.pgen.1002335
Dynamic Replacement of Histone H3 Variants Reprograms Epigenetic Marks in Early Mouse Embryos
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002279
Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002282
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A Barcode Screen for Epigenetic Regulators Reveals a Role for the NuB4/HAT-B Histone Acetyltransferase Complex in Histone Turnover
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002284
Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002298
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CtIP Mutations Cause Seckel and Jawad Syndromes
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002310
Genetic Determinants of Serum Testosterone Concentrations in Men
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002313
Developmental Stability: A Major Role for Cyclin G in Drosophila melanogaster
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002314
Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion
PLOS Genetics: published October 6, 2011 | https://doi.org/10.1371/journal.pgen.1002323