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Table of Contents: July 2005

Unlike many animals, cats are indifferent to the sweet taste of sugar. Research reported by Li et al. suggests that the sweet receptor gene has become pseudogenized in the cat, rendering them "sweet-blind." The cover image is representational only, as the lynx depicted here, while a felid, was not a subject of the Li et al. study. The superimposed image shows part of the gene structure of the two genes that code for the sweet taste receptor dimer in the domestic cat, one of which contains a premature stop codon, rendering it nonfunctional.

Image Credit: Photograph by Erwin and Peggy Bauer, USFWS; line graphic by Felice Macera.

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Wayne N Frankel

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Research Articles

A Human-Curated Annotation of the Candida albicans Genome

Burkhard R Braun, Marco van het Hoog, Christophe d'Enfert, Mikhail Martchenko, Jan Dungan, Alan Kuo, Diane O Inglis, M. Andrew Uhl, Hervé Hogues, Matthew Berriman, Michael Lorenz, Anastasia Levitin, Ursula Oberholzer, Catherine Bachewich, Doreen Harcus, Anne Marcil, Daniel Dignard, Tatiana Iouk, Rosa Zito, Lionel Frangeul, Fredj Tekaia, Kim Rutherford, Edwin Wang, Carol A Munro, Steve Bates, Neil A Gow, Lois L Hoyer, Gerwald Köhler, Joachim Morschhäuser, George Newport, Sadri Znaidi, Martine Raymond, Bernard Turcotte, Gavin Sherlock, Maria Costanzo, Jan Ihmels, Judith Berman, Dominique Sanglard, Nina Agabian, Aaron P Mitchell, Alexander D Johnson, Malcolm Whiteway, André Nantel

Pseudogenization of a Sweet-Receptor Gene Accounts for Cats' Indifference toward Sugar

Xia Li, Weihua Li, Hong Wang, Jie Cao, Kenji Maehashi, Liquan Huang, Alexander A Bachmanov, Danielle R Reed, Véronique Legrand-Defretin, Gary K Beauchamp, Joseph G Brand

Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage

Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W.M John

Diversity of Flowering Responses in Wild Arabidopsis thaliana Strains

Janne Lempe, Sureshkumar Balasubramanian, Sridevi Sureshkumar, Anandita Singh, Markus Schmid, Detlef Weigel

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Patricia L. M Dahia, Ken N Ross, Matthew E Wright, César Y Hayashida, Sandro Santagata, Marta Barontini, Andrew L Kung, Gabriela Sanso, James F Powers, Arthur S Tischler, Richard Hodin, Shannon Heitritter, Francis Moore Jr., Robert Dluhy, Julie Ann Sosa, I. Tolgay Ocal, Diana E Benn, Deborah J Marsh, Bruce G Robinson, Katherine Schneider, Judy Garber, Seth M Arum, Márta Korbonits, Ashley Grossman, Pascal Pigny, Sérgio P. A Toledo, Vania Nosé, Cheng Li, Charles D Stiles

Fog2 Is Required for Normal Diaphragm and Lung Development in Mice and Humans

Kate G Ackerman, Bruce J Herron, Sara O Vargas, Hailu Huang, Sergei G Tevosian, Lazaros Kochilas, Cherie Rao, Barbara R Pober, Randal P Babiuk, Jonathan A Epstein, John J Greer, David R Beier