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Table of Contents: February 2007

The same characteristics that made grasshoppers exquisite models for classical cytogenetic studies - few, large chromosomes and well-defined meiotic stages at the cytological level - also make them excellent organisms in which to study protein immunolocalization during meiosis. Shown here are male (top) and female (bottom) Eyprepocnemis plorans (see Valdeolmillos et al., e28).

Image Credit: Photograph by Julio S. Rufas.

Editorials

An Age-Old Problem

Nicholas Katsanis, Susan M Rosenberg

Reviews

The Role of Mitochondrial DNA Mutations in Mammalian Aging

Gregory C Kujoth, Patrick C Bradshaw, Suraiya Haroon, Tomas A Prolla

Research Articles

New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts

Aldo Pagano, Manuele Castelnuovo, Federico Tortelli, Roberto Ferrari, Giorgio Dieci, Ranieri Cancedda

Genomic Relationships and Speciation Times of Human, Chimpanzee, and Gorilla Inferred from a Coalescent Hidden Markov Model

Asger Hobolth, Ole F Christensen, Thomas Mailund, Mikkel H Schierup

A Screen for Retrotransposed Imprinted Genes Reveals an Association between X Chromosome Homology and Maternal Germ-Line Methylation

Andrew J Wood, Roland G Roberts, David Monk, Gudrun E Moore, Reiner Schulz, Rebecca J Oakey

Transition-Transversion Bias Is Not Universal: A Counter Example from Grasshopper Pseudogenes

Irene Keller, Douda Bensasson, Richard A Nichols

Meningococcal Genetic Variation Mechanisms Viewed through Comparative Analysis of Serogroup C Strain FAM18

Stephen D Bentley, George S Vernikos, Lori A. S Snyder, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, Ann Cronin, Paul H Davis, Nancy E Holroyd, Kay Jagels, Mark Maddison, Sharon Moule, Ester Rabbinowitsch, Sarah Sharp, Louise Unwin, Sally Whitehead, Michael A Quail, Mark Achtman, Bart Barrell, Nigel J Saunders, Julian Parkhill

An Unmethylated 3′ Promoter-Proximal Region Is Required for Efficient Transcription Initiation

Ruth Appanah, David R Dickerson, Preeti Goyal, Mark Groudine, Matthew C Lorincz

Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers

Ana M Valdeolmillos, Alberto Viera, Jesús Page, Ignacio Prieto, Juan L Santos, María Teresa Parra, Margarete M. S Heck, Carlos Martínez-A, José L Barbero, José A Suja, Julio S Rufas

Large-Scale Evaluation of Candidate Genes Identifies Associations between VEGF Polymorphisms and Bladder Cancer Risk

Montserrat García-Closas, Núria Malats, Francisco X Real, Meredith Yeager, Robert Welch, Debra Silverman, Manolis Kogevinas, Mustafa Dosemeci, Jonine Figueroa, Nilanjan Chatterjee, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Cristiane Murta-Nascimento, Nathaniel Rothman, Stephen J Chanock

Phenotypic Plasticity in Drosophila Pigmentation Caused by Temperature Sensitivity of a Chromatin Regulator Network

Jean-Michel Gibert, Frédérique Peronnet, Christian Schlötterer

Genetic Complexity and Quantitative Trait Loci Mapping of Yeast Morphological Traits

Satoru Nogami, Yoshikazu Ohya, Gaël Yvert

Elevated Rates of Sister Chromatid Exchange at Chromosome Ends

M. Katharine Rudd, Cynthia Friedman, Sean S Parghi, Elena V Linardopoulou, Li Hsu, Barbara J Trask