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Table of Contents: August 2017

The pattern of isolation-by-distance is observed often in nature, but we rarely have means to directly understand how dispersal creates these patterns. Aguillon et al. capitalize on long-term monitoring of a population of Florida Scrub-Jays to demonstrate how extremely short dispersal distances result in genealogical relatives living close together geographically. Detailed dispersal, pedigree, and genomic data available for this population allowed an unusually detailed understanding of how dispersal shapes patterns of isolation-by-distance. This image shows an adult Florida Scrub-Jay from the study population, including its uniquely identifying, colored leg bands. See Aguillon et al.

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Image Credit: Reed Bowman, Archbold Biological Station, Venus, Florida, United States of America

Viewpoints

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Kinrin Yamanaka, Nimrat Chatterjee, Michael T. Hemann, Graham C. Walker

Research Articles

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development

Hua He, Meina Huang, Shenfei Sun, Yihui Wu, Xinhua Lin

MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus

Patricia Blanchet, Martina Bebin, Shaam Bruet, Gregory M. Cooper, Michelle L. Thompson, Benedicte Duban-Bedu, Benedicte Gerard, Amelie Piton, Sylvie Suckno, Charu Deshpande, Virginia Clowes, Julie Vogt, Peter Turnpenny, Michael P. Williamson, Yves Alembik, Clinical Sequencing Exploratory Research Study Consortium, Deciphering Developmental Disorders Consortium, Eric Glasgow, Alisdair McNeill

Plant microRNAs in larval food regulate honeybee caste development

Kegan Zhu, Minghui Liu, Zheng Fu, Zhen Zhou, Yan Kong, Hongwei Liang, Zheguang Lin, Jun Luo, Huoqing Zheng, Ping Wan, Junfeng Zhang, Ke Zen, Jiong Chen, Fuliang Hu, Chen-Yu Zhang, Jie Ren, Xi Chen

Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma

Edward Britton, Connor Rogerson, Shaveta Mehta, Yaoyong Li, Xiaodun Li, the OCCAMS consortium, Rebecca C. Fitzgerald, Yeng S. Ang, Andrew D. Sharrocks

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline

Devanshi Jain, Cem Meydan, Julian Lange, Corentin Claeys Bouuaert, Nathalie Lailler, Christopher E. Mason, Kathryn V. Anderson, Scott Keeney

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression

Ayako Fukunaka, Toshiyuki Fukada, Jinhyuk Bhin, Luka Suzuki, Takamasa Tsuzuki, Yuri Takamine, Bum-Ho Bin, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Hisashi Naito, Takeshi Miyatsuka, Shinzaburo Takamiya, Tsutomu Sasaki, Takeshi Inagaki, Tadahiro Kitamura, Shingo Kajimura, Hirotaka Watada, Yoshio Fujitani

β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice

Dany Gaillard, Spencer G. Bowles, Ernesto Salcedo, Mingang Xu, Sarah E. Millar, Linda A. Barlow

Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity

Suzana Ulian-Benitez, Simon Bishop, Istvan Foldi, Jill Wentzell, Chinenye Okenwa, Manuel G. Forero, Bangfu Zhu, Marta Moreira, Mark Phizacklea, Graham McIlroy, Guiyi Li, Nicholas J. Gay, Alicia Hidalgo

Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion

Laurits Skov, The Danish Pan Genome Consortium, Mikkel Heide Schierup

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart

Melisa Gomez-Velazquez, Claudio Badia-Careaga, Ana Victoria Lechuga-Vieco, Rocio Nieto-Arellano, Juan J. Tena, Isabel Rollan, Alba Alvarez, Carlos Torroja, Eva F. Caceres, Anna R. Roy, Niels Galjart, Paul Delgado-Olguin, Fatima Sanchez-Cabo, Jose Antonio Enriquez, Jose Luis Gomez-Skarmeta, Miguel Manzanares

Functional significance of rare neuroligin 1 variants found in autism

Moe Nakanishi, Jun Nomura, Xiao Ji, Kota Tamada, Takashi Arai, Eiki Takahashi, Maja Bućan, Toru Takumi

Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells

Uri Weissbein, Omer Plotnik, Dan Vershkov, Nissim Benvenisty

Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations

Nina Hollfelder, Carina M. Schlebusch, Torsten Günther, Hiba Babiker, Hisham Y. Hassan, Mattias Jakobsson

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)

Jinsung Yang, Min Ju Kim, Woongchang Yoon, Eun Young Kim, Hyunjin Kim, Yoonjeong Lee, Boram Min, Kyung Shin Kang, Jin H. Son, Hwan Tae Park, Jongkyeong Chung, Hyongjong Koh

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity

Wern-Chir Liao, Liang-Yi Juo, Yen-Ling Shih, Yen-Hui Chen, Yu-Ting Yan

Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate

Irnov Irnov, Zhe Wang, Nicholas D. Jannetty, Julian A. Bustamante, Kyu Y. Rhee, Christine Jacobs-Wagner

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Greicy H. Goto, Hiroo Ogi, Himadri Biswas, Avik Ghosh, Seiji Tanaka, Katsunori Sugimoto

Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries

Radha Raman Pandey, David Homolka, Kuan-Ming Chen, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S. Pillai

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans

Rachele Sangaletti, Massimo D’Amico, Jeff Grant, David Della-Morte, Laura Bianchi

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

Ashley Snouffer, Desmond Brown, Hankyu Lee, Jonathon Walsh, Floria Lupu, Ryan Norman, Karl Lechtreck, Hyuk Wan Ko, Jonathan Eggenschwiler

Tissue-specific insulin signaling mediates female sexual attractiveness

Tatyana Y. Fedina, Devin Arbuthnott, Howard D. Rundle, Daniel E. L. Promislow, Scott D. Pletcher

Fruit weight is controlled by Cell Size Regulator encoding a novel protein that is expressed in maturing tomato fruits

Qi Mu, Zejun Huang, Manohar Chakrabarti, Eudald Illa-Berenguer, Xiaoxi Liu, Yanping Wang, Alexis Ramos, Esther van der Knaap

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways

Michael Crompton, Tom Purnell, Hayley E. Tyrer, Andrew Parker, Greg Ball, Rachel E. Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H. Dean, Michelle M. Simon, Ann-Marie Mallon, Sara Wells, Mahmood F. Bhutta, Martin J. Burton, Hilda Tateossian, Steve D. M. Brown

Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study

Paul J. Leo, Margaret M. Madeleine, Sophia Wang, Stephen M. Schwartz, Felicity Newell, Ulrika Pettersson-Kymmer, Kari Hemminki, Goran Hallmans, Sven Tiews, Winfried Steinberg, Janet S. Rader, Felipe Castro, Mahboobeh Safaeian, Eduardo L. Franco, François Coutlée, Claes Ohlsson, Adrian Cortes, Mhairi Marshall, Pamela Mukhopadhyay, Katie Cremin, Lisa G. Johnson, Suzanne Garland, Sepehr N. Tabrizi, Nicolas Wentzensen, Freddy Sitas, Julian Little, Maggie Cruickshank, Ian H. Frazer, Allan Hildesheim, Matthew A. Brown

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich

A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Claire J. Cairney, Lauren S. Godwin, Alan E. Bilsland, Sharon Burns, Katrina H. Stevenson, Lynn McGarry, John Revie, Jon D. Moore, Ceri M. Wiggins, Rebecca S. Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C. Bennett, Masashi Narita, Christopher J. Torrance, W. Nicol Keith

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development

Tobias Bohnenpoll, Anna B. Wittern, Tamrat M. Mamo, Anna-Carina Weiss, Carsten Rudat, Marc-Jens Kleppa, Karin Schuster-Gossler, Irina Wojahn, Timo H.-W. Lüdtke, Mark-Oliver Trowe, Andreas Kispert

Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency

Virginia E. Glazier, Thomas Murante, Daniel Murante, Kristy Koselny, Yuan Liu, Dongyeop Kim, Hyun Koo, Damian J. Krysan

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

Jérémy Manry, Yohann Nédélec, Vinicius M. Fava, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Vu Hong Thai, Guillaume Laval, Luis B. Barreiro, Erwin Schurr

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

Eric W. Lin, Tatiana A. Karakasheva, Dong-Jin Lee, Ju-Seog Lee, Qi Long, Adam J. Bass, Kwok K. Wong, Anil K. Rustgi

Rare coding variants pinpoint genes that control human hematological traits

Abdou Mousas, Georgios Ntritsos, Ming-Huei Chen, Ci Song, Jennifer E. Huffman, Ioanna Tzoulaki, Paul Elliott, Bruce M. Psaty, Blood-Cell Consortium, Paul L. Auer, Andrew D. Johnson, Evangelos Evangelou, Guillaume Lettre, Alexander P. Reiner

SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana

Chunhong Cheng, Zhijuan Wang, Ziyin Ren, Liya Zhi, Bin Yao, Chao Su, Liu Liu, Xia Li

MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut

Bo Zhao, Keira J. Lucas, Tusar T. Saha, Jisu Ha, Lin Ling, Vladimir A. Kokoza, Sourav Roy, Alexander S. Raikhel

Deconstructing isolation-by-distance: The genomic consequences of limited dispersal

Stepfanie M. Aguillon, John W. Fitzpatrick, Reed Bowman, Stephan J. Schoech, Andrew G. Clark, Graham Coop, Nancy Chen

Variation of the meiotic recombination landscape and properties over a broad evolutionary distance in yeasts

Christian Brion, Sylvain Legrand, Jackson Peter, Claudia Caradec, David Pflieger, Jing Hou, Anne Friedrich, Bertrand Llorente, Joseph Schacherer