Advertisement

Table of Contents: January 2018

False colored SEM image of an Arabidopsis mutant fruit showing ovules transformed into flower organ-like structure (green) or finger-like protrusion (purple). A wild-type developing ovule appears in orange. Ovule identity is conferred by homeotic D-class genes SHATTERPROOF1 (SHP1), SHP2 and SEEDSTICK (STK), related to the MADS-domain gene AGAMOUS (AG). AG pre-mRNA maturation is regulated by RNA-binding protein-encoding genes collectively termed the HUA-PEP activity. SHP1, SHP2 and STK activity is dramatically reduced in severe hua-pep backgrounds. Prematurely terminated transcripts accumulate at the expense of functional transcripts, pointing to pre-mRNA processing misregulation as the origin of the ovule developmental defects. See Rodríguez-Cazorla et al.

Download January's cover page.

Image Credit: E. Rodríguez-Cazorla, A. Martínez-Laborda, A. Vera

Reviews

Taking cohesin and condensin in context

Kobe C. Yuen, Jennifer L. Gerton

Research Articles

Inferring sex-specific demographic history from SNP data

Florian Clemente, Mathieu Gautier, Renaud Vitalis

Coordination of olfactory receptor choice with guidance receptor expression and function in olfactory sensory neurons

Puneet Dang, Stephen A. Fisher, Derek J. Stefanik, Junhyong Kim, Jonathan A. Raper

Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism

Patricia Molina-Ortiz, Tanguy Orban, Maud Martin, Audrey Habets, Franck Dequiedt, Stéphane Schurmans

MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6

Bastian Stielow, Florian Finkernagel, Thorsten Stiewe, Andrea Nist, Guntram Suske

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

Matt Ravenhall, Susana Campino, Nuno Sepúlveda, Alphaxard Manjurano, Behzad Nadjm, George Mtove, Hannah Wangai, Caroline Maxwell, Raimos Olomi, Hugh Reyburn, Christopher J. Drakeley, Eleanor M. Riley, Taane G. Clark, in collaboration with MalariaGEN

The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization

Sandra Korge, Bert Maier, Franziska Brüning, Lea Ehrhardt, Thomas Korte, Matthias Mann, Andreas Herrmann, Maria S. Robles, Achim Kramer

Rewired RNAi-mediated genome surveillance in house dust mites

Mosharrof Mondal, Pavel Klimov, Alex Sutton Flynt

Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies

Lori L. O’Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M. Hasso, Young-Jin Lee, Alan Fang, Albert D. Kim, Jinjin Guo, Trudy M. Hong, Kevin A. Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D. Smith, Anton Valouev, Andrew P. McMahon

WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN polarity

Tomáš Prát, Jakub Hajný, Wim Grunewald, Mina Vasileva, Gergely Molnár, Ricardo Tejos, Markus Schmid, Michael Sauer, Jiří Friml

Kinesin Khc-73/KIF13B modulates retrograde BMP signaling by influencing endosomal dynamics at the Drosophila neuromuscular junction

Edward H. Liao, Lindsay Gray, Kazuya Tsurudome, Wassim El-Mounzer, Fatima Elazzouzi, Christopher Baim, Sarah Farzin, Mario R. Calderon, Grant Kauwe, A. Pejmun Haghighi

CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory

Tianyu Song, Shenghui Liang, Jiye Liu, Tingyue Zhang, Yifei Yin, Chenlu Geng, Shaobing Gao, Yan Feng, Hao Xu, Dongqing Guo, Amanda Roberts, Yuchun Gu, Yong Cang

A switch in the mode of Wnt signaling orchestrates the formation of germline stem cell differentiation niche in Drosophila

Maitreyi Upadhyay, Michael Kuna, Sara Tudor, Yesenia Martino Cortez, Prashanth Rangan

Insular Celtic population structure and genomic footprints of migration

Ross P. Byrne, Rui Martiniano, Lara M. Cassidy, Matthew Carrigan, Garrett Hellenthal, Orla Hardiman, Daniel G. Bradley, Russell L. McLaughlin

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

Rebecca King, Felix L. Struebing, Ying Li, Jiaxing Wang, Allison Ashley Koch, Jessica N. Cooke Bailey, Puya Gharahkhani, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium, Stuart MacGregor, R. Rand Allingham, Michael A. Hauser, Janey L. Wiggs, Eldon E. Geisert

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Alix Warburton, Catherine J. Redmond, Katharine E. Dooley, Haiqing Fu, Maura L. Gillison, Keiko Akagi, David E. Symer, Mirit I. Aladjem, Alison A. McBride

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions

Zuchra Zakirova, Tomas Fanutza, Justine Bonet, Ben Readhead, Weijia Zhang, Zhengzi Yi, Genevieve Beauvais, Thomas P. Zwaka, Laurie J. Ozelius, Robert D. Blitzer, Pedro Gonzalez-Alegre, Michelle E. Ehrlich

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

Xiao P. Peng, Shelly Lim, Shibai Li, Lisette Marjavaara, Andrei Chabes, Xiaolan Zhao

Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

Jorge V. Beira, Joana Torres, Renato Paro

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay

Olivier Duverger, Jenna C. Carlson, Chelsea M. Karacz, Mary E. Schwartz, Michael A. Cross, Mary L. Marazita, John R. Shaffer, Maria I. Morasso

Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide

Julienne C. Kaiser, Alyssa N. King, Jason C. Grigg, Jessica R. Sheldon, David R. Edgell, Michael E. P. Murphy, Shaun R. Brinsmade, David E. Heinrichs

The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth

Valentin Hammoudi, Like Fokkens, Bas Beerens, Georgios Vlachakis, Sayantani Chatterjee, Manuel Arroyo-Mateos, Paul F. K. Wackers, Martijs J. Jonker, Harrold A. van den Burg

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings

Jacoba J. Louw, Ricardo Nunes Bastos, Xiaowen Chen, Céline Verdood, Anniek Corveleyn, Yaojuan Jia, Jeroen Breckpot, Marc Gewillig, Hilde Peeters, Massimo M. Santoro, Francis Barr, Koenraad Devriendt

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa

Xiaoying Zhou, Bin Wang, Jillian M. Emerson, Carol S. Ringelberg, Scott A. Gerber, Jennifer J. Loros, Jay C. Dunlap

Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks

Sneha Palliyil, Jinjin Zhu, Luke R. Baker, Sarah D. Neuman, Arash Bashirullah, Justin P. Kumar

DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli

Sarah S. Henrikus, Elizabeth A. Wood, John P. McDonald, Michael M. Cox, Roger Woodgate, Myron F. Goodman, Antoine M. van Oijen, Andrew Robinson

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers

Daniel P. Hollern, Matthew R. Swiatnicki, Eran R. Andrechek

Ovule identity mediated by pre-mRNA processing in Arabidopsis

Encarnación Rodríguez-Cazorla, Samanta Ortuño-Miquel, Héctor Candela, Lindsay J. Bailey-Steinitz, Martin F. Yanofsky, Antonio Martínez-Laborda, Juan-José Ripoll, Antonio Vera

MORC2B is essential for meiotic progression and fertility

Baolu Shi, Jiangyang Xue, Jian Zhou, Seth D. Kasowitz, Yuanwei Zhang, Guanxiang Liang, Yongjuan Guan, Qinghua Shi, Mingxi Liu, Jiahao Sha, Xiaoyan Huang, P. Jeremy Wang

Identification of an elaborate NK-specific system regulating HLA-C expression

Hongchuan Li, Martin A. Ivarsson, Victoria E. Walker-Sperling, Jeff Subleski, Jenna K. Johnson, Paul W. Wright, Mary Carrington, Niklas K. Björkström, Daniel W. McVicar, Stephen K. Anderson

Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye

Carolyn A. Morrison, Hao Chen, Tiffany Cook, Stuart Brown, Jessica E. Treisman

Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

Morgan N. Price, Grant M. Zane, Jennifer V. Kuehl, Ryan A. Melnyk, Judy D. Wall, Adam M. Deutschbauer, Adam P. Arkin

Brassinosteroids regulate root growth by controlling reactive oxygen species homeostasis and dual effect on ethylene synthesis in Arabidopsis

Bingsheng Lv, Huiyu Tian, Feng Zhang, Jiajia Liu, Songchong Lu, Mingyi Bai, Chuanyou Li, Zhaojun Ding

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure

Janek Salatzki, Anna Foryst-Ludwig, Kajetan Bentele, Annelie Blumrich, Elia Smeir, Zsofia Ban, Sarah Brix, Jana Grune, Niklas Beyhoff, Robert Klopfleisch, Sebastian Dunst, Michal A. Surma, Christian Klose, Michael Rothe, Frank R. Heinzel, Alexander Krannich, Erin E. Kershaw, Dieter Beule, P. Christian Schulze, Nikolaus Marx, Ulrich Kintscher

Cdc73 suppresses genome instability by mediating telomere homeostasis

Rahul V. Nene, Christopher D. Putnam, Bin-Zhong Li, Katarina G. Nguyen, Anjana Srivatsan, Christopher S. Campbell, Arshad Desai, Richard D. Kolodner

Genome wide comparison of Ethiopian Leishmania donovani strains reveals differences potentially related to parasite survival

Arie Zackay, James A. Cotton, Mandy Sanders, Asrat Hailu, Abedelmajeed Nasereddin, Alon Warburg, Charles L. Jaffe

AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster

Neeta Bala Tannan, Giovanna Collu, Ashley C. Humphries, Ekatherina Serysheva, Ursula Weber, Marek Mlodzik

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

Jeffrey B. Rosa, Mark M. Metzstein, Amin S. Ghabrial

Regulation of circadian clock transcriptional output by CLOCK:BMAL1

Alexandra J. Trott, Jerome S. Menet

A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects

Julia E. Draper, Patrycja Sroczynska, Muhammad Z. H. Fadlullah, Rahima Patel, Gillian Newton, Wolfgang Breitwieser, Valerie Kouskoff, Georges Lacaud