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Table of Contents: November 2016

Skeletons contain hundreds of joints that are crucial for movement of different bones in the body. Regulatory studies of a key developmental and arthritis risk factor gene (Gdf5) have now identified a battery of distinct non-coding enhancers that control expression in particular joints, including specific joints in the head, shoulders, elbows, hips, and knees (left transgenic reporter mouse embryo), versus fingers and toes in the forelimb and hindlimb (right transgenic embryo carrying a different construct). Changes in individual joint control sequences may underlie localized evolutionary changes in vertebrate limbs, or susceptibility to arthritis in certain parts of the skeleton. See Chen, Capellini et al.

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Image Credit: Chen, Capellini et al.

Research Articles

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality

Alexander M. Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V. Ukraintseva, Deqing Wu, Anatoliy I. Yashin

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