June 2007

Young Finnish monozygotic twins. While genetically identical, environmental and stochastic effects do produce differences between twins even for highly heritable traits like height. However, in the presence of genetic effects, this difference is expected to be smaller on average for monozygotic than for dizygotic twins (see Perola et al.).

Image Credit: Photograph by Elina Ketola, Helsinki, Finland.

Review

Modulating the Expression of Disease Genes with RNA-Based Therapy

Matthew Wood, Haifang Yin, Graham McClorey

PLOS Genetics: published June 29, 2007 | https://doi.org/10.1371/journal.pgen.0030109

Research Articles

Arabidopsis TFL2/LHP1 Specifically Associates with Genes Marked by Trimethylation of Histone H3 Lysine 27

Franziska Turck, François Roudier, Sara Farrona, Marie-Laure Martin-Magniette, Elodie Guillaume, Nicolas Buisine, Séverine Gagnot, Robert A Martienssen, George Coupland, Vincent Colot

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030086

Whole-Genome Cartography of Estrogen Receptor α Binding Sites

Chin-Yo Lin, Vinsensius B Vega, Jane S Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D Miller, Edwin Cheung, Benita S Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T Liu

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030087

Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish

Chao-Tsung Yang, Anna E Hindes, Keith A Hultman, Stephen L Johnson

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030088

Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs

Henriette O'Geen, Sharon L Squazzo, Sushma Iyengar, Kim Blahnik, John L Rinn, Howard Y Chang, Roland Green, Peggy J Farnham

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030089

Localizing Recent Adaptive Evolution in the Human Genome

Scott H Williamson, Melissa J Hubisz, Andrew G Clark, Bret A Payseur, Carlos D Bustamante, Rasmus Nielsen

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030090

A Transcriptional Program Mediating Entry into Cellular Quiescence

Helen Liu, Adam S Adler, Eran Segal, Howard Y Chang

PLOS Genetics: published June 8, 2007 | https://doi.org/10.1371/journal.pgen.0030091

Reverse Genetic Analysis of the Yeast RSC Chromatin Remodeler Reveals a Role for RSC3 and SNF5 Homolog 1 in Ploidy Maintenance

Coen Campsteijn, Anne-Marie J Wijnands-Collin, Colin Logie

PLOS Genetics: published June 1, 2007 | https://doi.org/10.1371/journal.pgen.0030092

Selection for Robustness in Mutagenized RNA Viruses

Rafael Sanjuán, José M Cuevas, Victoria Furió, Edward C Holmes, Andrés Moya

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030093

Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor

Alex Yick-Lun So, Christina Chaivorapol, Eric C Bolton, Hao Li, Keith R Yamamoto

PLOS Genetics: published June 8, 2007 | https://doi.org/10.1371/journal.pgen.0030094

No Influence of Indy on Lifespan in Drosophila after Correction for Genetic and Cytoplasmic Background Effects

Janne M Toivonen, Glenda A Walker, Pedro Martinez-Diaz, Ivana Bjedov, Yasmine Driege, Howard T Jacobs, David Gems, Linda Partridge

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030095

Network-Based Analysis of Affected Biological Processes in Type 2 Diabetes Models

Manway Liu, Arthur Liberzon, Sek Won Kong, Weil R Lai, Peter J Park, Isaac S Kohane, Simon Kasif

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030096

Combined Genome Scans for Body Stature in 6,602 European Twins: Evidence for Common Caucasian Loci

Markus Perola, Sampo Sammalisto, Tero Hiekkalinna, Nick G Martin, Peter M Visscher, Grant W Montgomery, Beben Benyamin, Jennifer R Harris, Dorret Boomsma, Gonneke Willemsen, Jouke-Jan Hottenga, Kaare Christensen, Kirsten Ohm Kyvik, Thorkild I. A Sørensen, Nancy L Pedersen, Patrik K. E Magnusson, Tim D Spector, Elisabeth Widen, Karri Silventoinen, Jaakko Kaprio, Aarno Palotie, Leena Peltonen, GenomEUtwin Project

PLOS Genetics: published June 8, 2007 | https://doi.org/10.1371/journal.pgen.0030097

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease

Timothy G Lesnick, Spiridon Papapetropoulos, Deborah C Mash, Jarlath Ffrench-Mullen, Lina Shehadeh, Mariza de Andrade, John R Henley, Walter A Rocca, J. Eric Ahlskog, Demetrius M Maraganore

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030098

Identification of Common Genetic Variation That Modulates Alternative Splicing

Jeremy Hull, Susana Campino, Kate Rowlands, Man-Suen Chan, Richard R Copley, Martin S Taylor, Kirk Rockett, Gareth Elvidge, Brendan Keating, Julian Knight, Dominic Kwiatkowski

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030099

Cis- and Trans-Acting Elements Regulate the Mouse Psmb9 Meiotic Recombination Hotspot

Frédéric Baudat, Bernard de Massy

PLOS Genetics: published June 22, 2007 | https://doi.org/10.1371/journal.pgen.0030100

Laser Microdissection of Narrow Sheath Mutant Maize Uncovers Novel Gene Expression in the Shoot Apical Meristem

Xiaolan Zhang, Shahinez Madi, Lisa Borsuk, Dan Nettleton, Robert J Elshire, Brent Buckner, Diane Janick-Buckner, Jon Beck, Marja Timmermans, Patrick S Schnable, Michael J Scanlon

PLOS Genetics: published June 15, 2007 | https://doi.org/10.1371/journal.pgen.0030101

COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity

Isao Kurihara, Dong-Kee Lee, Fabrice G Petit, Jaewook Jeong, Kevin Lee, John P Lydon, Francesco J DeMayo, Ming-Jer Tsai, Sophia Y Tsai

PLOS Genetics: published June 22, 2007 | https://doi.org/10.1371/journal.pgen.0030102

Phenotype Frequencies of Autosomal Minor Histocompatibility Antigens Display Significant Differences among Populations

Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy

PLOS Genetics: published June 29, 2007 | https://doi.org/10.1371/journal.pgen.0030103

The Genographic Project Public Participation Mitochondrial DNA Database

Doron M Behar, Saharon Rosset, Jason Blue-Smith, Oleg Balanovsky, Shay Tzur, David Comas, R. John Mitchell, Lluis Quintana-Murci, Chris Tyler-Smith, R. Spencer Wells, The Genographic Consortium

PLOS Genetics: published June 29, 2007 | https://doi.org/10.1371/journal.pgen.0030104

Sensitivity of Yeast Strains with Long G-Tails to Levels of Telomere-Bound Telomerase

Leticia R Vega, Jane A Phillips, Brian R Thornton, Jennifer A Benanti, Mutiat T Onigbanjo, David P Toczyski, Virginia A Zakian

PLOS Genetics: published June 22, 2007 | https://doi.org/10.1371/journal.pgen.0030105

Sex-Specific Crossover Distributions and Variations in Interference Level along Arabidopsis thaliana Chromosome 4

Jan Drouaud, Raphaël Mercier, Liudmila Chelysheva, Aurélie Bérard, Matthieu Falque, Olivier Martin, Vanessa Zanni, Dominique Brunel, Christine Mézard

PLOS Genetics: published June 29, 2007 | https://doi.org/10.1371/journal.pgen.0030106

Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans

Joyce van de Leemput, Jayanth Chandran, Melanie A Knight, Lynne A Holtzclaw, Sonja Scholz, Mark R Cookson, Henry Houlden, Katrina Gwinn-Hardy, Hon-Chung Fung, Xian Lin, Dena Hernandez, Javier Simon-Sanchez, Nick W Wood, Paola Giunti, Ian Rafferty, John Hardy, Elsdon Storey, R. J. McKinlay Gardner, Susan M Forrest, Elizabeth M. C Fisher, James T Russell, Huaibin Cai, Andrew B Singleton

PLOS Genetics: published June 22, 2007 | https://doi.org/10.1371/journal.pgen.0030108

Cover

Young Finnish monozygotic twins