Figures
Genetic interactions between novel susceptibility loci in canine dermatomyositis.
A 4-month-old Shetland sheepdog, Lorelei, displays facial skin lesions from dermatomyositis, a chronic inflammatory myopathy and vasculopathy affecting both people and dogs. Evans et al. identified three loci that contribute to pathogenesis in dogs and 9 allelic combinations that confer high or moderate probability of disease. Lorelei's genotype (AABbCC) is high-risk; 92% of dogs having this genotypic combination showed clinical signs of dermatomyositis. See Evans et al.
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Image Credit: Lex Gatineau
Citation: (2017) PLoS Genetics Issue Image | Vol. 13(2) February 2017. PLoS Genet 13(2): ev13.i02. https://doi.org/10.1371/image.pgen.v13.i02
Published: February 28, 2017
Copyright: © 2017 Lex Gatineau. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A 4-month-old Shetland sheepdog, Lorelei, displays facial skin lesions from dermatomyositis, a chronic inflammatory myopathy and vasculopathy affecting both people and dogs. Evans et al. identified three loci that contribute to pathogenesis in dogs and 9 allelic combinations that confer high or moderate probability of disease. Lorelei's genotype (AABbCC) is high-risk; 92% of dogs having this genotypic combination showed clinical signs of dermatomyositis. See Evans et al.
Download February's cover page here.
Image Credit: Lex Gatineau