2018 PLOS Genetics Research Prize: Bundling, stabilizing, organizing—The orchestration of acentriolar spindle assembly by microtubule motor proteins

Gregory S. Barsh, Needhi Bhalla, Francesca Cole, Gregory P. Copenhaver, Soni Lacefield, Diana E. Libuda

PLOS Genetics: published September 13, 2018 | https://doi.org/10.1371/journal.pgen.1007649

Structure and function of archaeal histones

Bram Henneman, Clara van Emmerik, Hugo van Ingen, Remus T. Dame

PLOS Genetics: published September 13, 2018 | https://doi.org/10.1371/journal.pgen.1007582

Epistatic control of intrinsic resistance by virulence genes in Listeria

Mariela Scortti, Lei Han, Sonsiray Alvarez, Alexandre Leclercq, Alexandra Moura, Marc Lecuit, Jose Vazquez-Boland

PLOS Genetics: published September 4, 2018 | https://doi.org/10.1371/journal.pgen.1007525

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1. Correction: Epistatic control of intrinsic resistance by virulence genes in Listeria

Parallel clinal variation in the mid-day siesta of Drosophila melanogaster implicates continent-specific targets of natural selection

Yong Yang, Isaac Edery

PLOS Genetics: published September 4, 2018 | https://doi.org/10.1371/journal.pgen.1007612

Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

Amanda C. Davis-Roca, Nikita S. Divekar, Rachel K. Ng, Sarah M. Wignall

PLOS Genetics: published September 4, 2018 | https://doi.org/10.1371/journal.pgen.1007626

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

William P. D. Hendricks, Victoria Zismann, Karthigayini Sivaprakasam, Christophe Legendre, Kelsey Poorman, Waibhav Tembe, Nieves Perdigones, Jeffrey Kiefer, Winnie Liang, Valerie DeLuca, Mitchell Stark, Alison Ruhe, Roe Froman, Nicholas S. Duesbery, Megan Washington, Jessica Aldrich, Mark W. Neff, Matthew J. Huentelman, Nicholas Hayward, Kevin Brown, Douglas Thamm, Gerald Post, Chand Khanna, Barbara Davis, Matthew Breen, Alexander Sekulic, Jeffrey M. Trent

PLOS Genetics: published September 6, 2018 | https://doi.org/10.1371/journal.pgen.1007589

The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

Jennifer K. Pleiman, Amy A. Irving, Zhishi Wang, Erik Toraason, Linda Clipson, William F. Dove, Dustin A. Deming, Michael A. Newton

PLOS Genetics: published September 6, 2018 | https://doi.org/10.1371/journal.pgen.1007611

Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Choongwon Jeong, David B. Witonsky, Buddha Basnyat, Maniraj Neupane, Cynthia M. Beall, Geoff Childs, Sienna R. Craig, John Novembre, Anna Di Rienzo

PLOS Genetics: published September 6, 2018 | https://doi.org/10.1371/journal.pgen.1007650

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

Kärt Tomberg, Randal J. Westrick, Emilee N. Kotnik, Audrey C. Cleuren, David R Siemieniak, Guojing Zhu, Thomas L. Saunders, David Ginsburg

PLOS Genetics: published September 6, 2018 | https://doi.org/10.1371/journal.pgen.1007658

FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination

Ankur Garg, Abdul Hannan, Qian Wang, Tamica Collins, Siying Teng, Mukesh Bansal, Jian Zhong, Keli Xu, Xin Zhang

PLOS Genetics: published September 6, 2018 | https://doi.org/10.1371/journal.pgen.1007660

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

Kathrin Schmeisser, J. Alex Parker

PLOS Genetics: published September 7, 2018 | https://doi.org/10.1371/journal.pgen.1007561

In search of the Goldilocks zone for hybrid speciation

Alexandre Blanckaert, Claudia Bank

PLOS Genetics: published September 7, 2018 | https://doi.org/10.1371/journal.pgen.1007613

Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos

Ben J. Vincent, Max V. Staller, Francheska Lopez-Rivera, Meghan D. J. Bragdon, Edward C. G. Pym, Kelly M. Biette, Zeba Wunderlich, Timothy T. Harden, Javier Estrada, Angela H. DePace

PLOS Genetics: published September 7, 2018 | https://doi.org/10.1371/journal.pgen.1007644

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

Arianne C. Richard, James E. Peters, Natalia Savinykh, James C. Lee, Eric T. Hawley, Françoise Meylan, Richard M. Siegel, Paul A. Lyons, Kenneth G. C. Smith

PLOS Genetics: published September 10, 2018 | https://doi.org/10.1371/journal.pgen.1007458

MiR-202 controls female fecundity by regulating medaka oogenesis

Stéphanie Gay, Jérôme Bugeon, Amine Bouchareb, Laure Henry, Clara Delahaye, Fabrice Legeai, Jérôme Montfort, Aurélie Le Cam, Anne Siegel, Julien Bobe, Violette Thermes

PLOS Genetics: published September 10, 2018 | https://doi.org/10.1371/journal.pgen.1007593

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Daan M. Van Den Brink, Aurélie Cubizolle, Gilles Chatelain, Nathalie Davoust, Victor Girard, Simone Johansen, Francesco Napoletano, Pierre Dourlen, Laurent Guillou, Claire Angebault-Prouteau, Nathalie Bernoud-Hubac, Michel Guichardant, Philippe Brabet, Bertrand Mollereau

PLOS Genetics: published September 10, 2018 | https://doi.org/10.1371/journal.pgen.1007627

Transcription factor CBF-1 is critical for circadian gene expression by modulating WHITE COLLAR complex recruitment to the frq locus

Xuemei Cao, Xiao Liu, Hongda Li, Yumeng Fan, Jiabin Duan, Yi Liu, Qun He

PLOS Genetics: published September 12, 2018 | https://doi.org/10.1371/journal.pgen.1007570

Robust activation of microhomology-mediated end joining for precision gene editing applications

Hirotaka Ata, Thomas L. Ekstrom, Gabriel Martínez-Gálvez, Carla M. Mann, Alexey V. Dvornikov, Kyle J. Schaefbauer, Alvin C. Ma, Drena Dobbs, Karl J. Clark, Stephen C. Ekker

PLOS Genetics: published September 12, 2018 | https://doi.org/10.1371/journal.pgen.1007652

Flexibility and constraint: Evolutionary remodeling of the sporulation initiation pathway in Firmicutes

Philip Davidson, Rory Eutsey, Brendan Redler, N. Luisa Hiller, Michael T. Laub, Dannie Durand

PLOS Genetics: published September 13, 2018 | https://doi.org/10.1371/journal.pgen.1007470

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability

Franck Raynaud, Marco Mina, Daniele Tavernari, Giovanni Ciriello

PLOS Genetics: published September 13, 2018 | https://doi.org/10.1371/journal.pgen.1007669

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

Matthew R. Hart, Donovan J. Anderson, Christopher C. Porter, Tobias Neff, Michael Levin, Marshall S. Horwitz

PLOS Genetics: published September 14, 2018 | https://doi.org/10.1371/journal.pgen.1007642

MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo

M. Dolores Molina, Magali Quirin, Emmanuel Haillot, Noémie De Crozé, Ryan Range, Mathieu Rouel, Felipe Jimenez, Radja Amrouche, Aline Chessel, Thierry Lepage

PLOS Genetics: published September 17, 2018 | https://doi.org/10.1371/journal.pgen.1007621

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

Chang-he Shi, Carrie Rubel, Sarah E. Soss, Rebekah Sanchez-Hodge, Shuo Zhang, Sabrina C. Madrigal, Saranya Ravi, Holly McDonough, Richard C. Page, Walter J. Chazin, Cam Patterson, Cheng-yuan Mao, Monte S. Willis, Hai-Yang Luo, Yu-sheng Li, Donte A. Stevens, Mi-bo Tang, Pan Du, Yao-he Wang, Zheng-wei Hu, Yu-ming Xu, Jonathan C. Schisler

PLOS Genetics: published September 17, 2018 | https://doi.org/10.1371/journal.pgen.1007664

Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli

Julien Brochu, Émilie Vlachos-Breton, Sarah Sutherland, Makisha Martel, Marc Drolet

PLOS Genetics: published September 17, 2018 | https://doi.org/10.1371/journal.pgen.1007668

The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates

Annika Dorn, Sarah Röhrig, Kristin Papp, Susan Schröpfer, Frank Hartung, Alexander Knoll, Holger Puchta

PLOS Genetics: published September 17, 2018 | https://doi.org/10.1371/journal.pgen.1007674

Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes

Jessica E. Spiewak, Emily J. Bain, Jin Liu, Kellie Kou, Samantha L. Sturiale, Larissa B. Patterson, Parham Diba, Judith S. Eisen, Ingo Braasch, Julia Ganz, David M. Parichy

PLOS Genetics: published September 18, 2018 | https://doi.org/10.1371/journal.pgen.1007538

Detecting archaic introgression using an unadmixed outgroup

Laurits Skov, Ruoyun Hui, Vladimir Shchur, Asger Hobolth, Aylwyn Scally, Mikkel Heide Schierup, Richard Durbin

PLOS Genetics: published September 18, 2018 | https://doi.org/10.1371/journal.pgen.1007641

Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes in the porcine genome

Martijn F. L. Derks, Marcos S. Lopes, Mirte Bosse, Ole Madsen, Bert Dibbits, Barbara Harlizius, Martien A. M. Groenen, Hendrik-Jan Megens

PLOS Genetics: published September 19, 2018 | https://doi.org/10.1371/journal.pgen.1007661

Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene

Wangsheng Zhu, Maricris Zaidem, Anna-Lena Van de Weyer, Rafal M. Gutaker, Eunyoung Chae, Sang-Tae Kim, Felix Bemm, Lei Li, Marco Todesco, Rebecca Schwab, Frederik Unger, Marcel Janis Beha, Monika Demar, Detlef Weigel

PLOS Genetics: published September 20, 2018 | https://doi.org/10.1371/journal.pgen.1007628

Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans

Sijie Wu, Manfei Zhang, Xinzhou Yang, Fuduan Peng, Juan Zhang, Jingze Tan, Yajun Yang, Lina Wang, Yanan Hu, Qianqian Peng, Jinxi Li, Yu Liu, Yaqun Guan, Chen Chen, Merel A. Hamer, Tamar Nijsten, Changqing Zeng, Kaustubh Adhikari, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando González-José, Hui Li, Jean Krutmann, Fan Liu, Manfred Kayser, Andres Ruiz-Linares, Kun Tang, Shuhua Xu, Liang Zhang, Li Jin, Sijia Wang

PLOS Genetics: published September 24, 2018 | https://doi.org/10.1371/journal.pgen.1007640

Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney

Jianbing Zhang, Ian Chambers, Sijung Yun, John Phillips, Michael Krause, Iqbal Hamza

PLOS Genetics: published September 24, 2018 | https://doi.org/10.1371/journal.pgen.1007665

The genomic basis of environmental adaptation in house mice

Megan Phifer-Rixey, Ke Bi, Kathleen G. Ferris, Michael J. Sheehan, Dana Lin, Katya L. Mack, Sara M. Keeble, Taichi A. Suzuki, Jeffrey M. Good, Michael W. Nachman

PLOS Genetics: published September 24, 2018 | https://doi.org/10.1371/journal.pgen.1007672

A metabolic checkpoint protein GlmR is important for diverting carbon into peptidoglycan biosynthesis in Bacillus subtilis

Vaidehi Patel, Qun Wu, Pete Chandrangsu, John D. Helmann

PLOS Genetics: published September 24, 2018 | https://doi.org/10.1371/journal.pgen.1007689

Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch

Lucía García-Pastor, María Antonia Sánchez-Romero, Gabriel Gutiérrez, Elena Puerta-Fernández, Josep Casadesús

PLOS Genetics: published September 25, 2018 | https://doi.org/10.1371/journal.pgen.1007677

Mechanisms of acquired resistance to rapalogs in metastatic renal cell carcinoma

Lana Hamieh, Toni K. Choueiri, Barbara Ogórek, Damir Khabibullin, Daniel Rosebrock, Dimitri Livitz, Andre Fay, Jean-Christophe Pignon, David F. McDermott, Neeraj Agarwal, Wenhua Gao, Sabina Signoretti, David J. Kwiatkowski

PLOS Genetics: published September 26, 2018 | https://doi.org/10.1371/journal.pgen.1007679

Genetic basis of thermal plasticity variation in Drosophila melanogaster body size

Elvira Lafuente, David Duneau, Patrícia Beldade

PLOS Genetics: published September 26, 2018 | https://doi.org/10.1371/journal.pgen.1007686

Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles

Ruth E. Thomas, Evelyn S. Vincow, Gennifer E. Merrihew, Michael J. MacCoss, Marie Y. Davis, Leo J. Pallanck

PLOS Genetics: published September 26, 2018 | https://doi.org/10.1371/journal.pgen.1007694

Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly

Jianli Dai, Beatriz Estrada, Sofie Jacobs, Besaiz J. Sánchez-Sánchez, Jia Tang, Mengqi Ma, Patricia Magadán-Corpas, José C. Pastor-Pareja, María D. Martín-Bermudo

PLOS Genetics: published September 27, 2018 | https://doi.org/10.1371/journal.pgen.1007483

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

Pradeep Suri, Melody R. Palmer, Yakov A. Tsepilov, Maxim B. Freidin, Cindy G. Boer, Michelle S. Yau, Daniel S. Evans, Andrea Gelemanovic, Traci M. Bartz, Maria Nethander, Liubov Arbeeva, Lennart Karssen, Tuhina Neogi, Archie Campbell, Dan Mellstrom, Claes Ohlsson, Lynn M. Marshall, Eric Orwoll, Andre Uitterlinden, Jerome I. Rotter, Gordan Lauc, Bruce M. Psaty, Magnus K. Karlsson, Nancy E. Lane, Gail P. Jarvik, Ozren Polasek, Marc Hochberg, Joanne M. Jordan, Joyce B. J. Van Meurs, Rebecca Jackson, Carrie M. Nielson, Braxton D. Mitchell, Blair H. Smith, Caroline Hayward, Nicholas L. Smith, Yurii S. Aulchenko, Frances M. K. Williams

PLOS Genetics: published September 27, 2018 | https://doi.org/10.1371/journal.pgen.1007601

Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development

Taichi Hara, Ikuko Maejima, Tomoko Akuzawa, Rika Hirai, Hisae Kobayashi, Satoshi Tsukamoto, Mika Tsunoda, Aguri Ono, Shota Yamakoshi, Satoshi Oikawa, Ken Sato

PLOS Genetics: published September 27, 2018 | https://doi.org/10.1371/journal.pgen.1007647

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death

Pan Ye, Y. Jeffrey Chiang, Zhen Qi, Yehua Li, Shan Wang, Yuan Liu, Xintong Li, Ye-Guang Chen

PLOS Genetics: published September 27, 2018 | https://doi.org/10.1371/journal.pgen.1007697

Mutation load dynamics during environmentally-driven range shifts

Kimberly J. Gilbert, Stephan Peischl, Laurent Excoffier

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007450

Positive and negative regulation of transferred nif genes mediated by indigenous GlnR in Gram-positive Paenibacillus polymyxa

Tianshu Wang, Xiyun Zhao, Haowen Shi, Li Sun, Yongbin Li, Qin Li, Haowei Zhang, Sanfeng Chen, Jilun Li

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007629

Components of Brachypodium distachyon resistance to nonadapted wheat stripe rust pathogens are simply inherited

Brian Gilbert, Jan Bettgenhaeuser, Narayana Upadhyaya, Melanie Soliveres, Davinder Singh, Robert F. Park, Matthew J. Moscou, Michael Ayliffe

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007636

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The genetic architecture of colonization resistance in Brachypodium distachyon to non-adapted stripe rust (Puccinia striiformis) isolates

Jan Bettgenhaeuser, Matthew Gardiner, Rebecca Spanner, Phon Green, Inmaculada Hernández-Pinzón, Amelia Hubbard, Michael Ayliffe, Matthew J. Moscou

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007637

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Distinct CED-10/Rac1 domains confer context-specific functions in development

Steffen Nørgaard, Shuer Deng, Wei Cao, Roger Pocock

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007670

Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection

Abiola O. Olaitan, Alejandro Aballay

PLOS Genetics: published September 28, 2018 | https://doi.org/10.1371/journal.pgen.1007693

Correction: Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Johanna M. Huusko, Minna K. Karjalainen, Britney E. Graham, Ge Zhang, Emily G. Farrow, Neil A. Miller, Bo Jacobsson, Haley R. Eidem, Jeffrey C. Murray, Bruce Bedell, Patrick Breheny, Noah W. Brown, Frans L. Bødker, Nadia K. Litterman, Pan-Pan Jiang, Laura Russell, David A. Hinds, Youna Hu, the 23andMe Research Team, Antonis Rokas, Kari Teramo, Kaare Christensen, Scott M. Williams, Mika Rämet, Stephen F. Kingsmore, Kelli K. Ryckman, Mikko Hallman, Louis J. Muglia

PLOS Genetics: published September 13, 2018 | https://doi.org/10.1371/journal.pgen.1007673

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