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April 2016

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Genetic roles of six7 in photoreceptor development.

Issue Image

Vision is highly dependent on the number and types of retinal photoreceptors and their arrangement. This image shows the asymmetric distribution of rod photoreceptors (yellow) in the cone-dominated larval zebrafish retina. The density of rods is highest in the ventral retina but rapidly declines in the central and dorsal retina. Exploiting photoreceptor patterning in zebrafish, Sotolongo-Lopez and colleagues reveal two independent functions of six7 in photoreceptor development. Their study shows that the asymmetric distribution of rods is regulated in a dosage dependent manner by the transcription factor six7, and that six7 is essential for survival of green-wavelength sensitive cone precursors. See Sotolongo-Lopez et al.

Image Credit: James M. Fadool and Karen Alvarez-Delfin

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