Bodies are often made of repeated units, or serial homologs, that develop using the same core gene regulatory network. Local inputs and modifications to this network allow serial homologs to evolve different morphologies, but currently we do not understand which modifications allow these repeated traits to evolve different levels of phenotypic plasticity. In this article, the authors describe variation in phenotypic plasticity across serial homologous eyespots of the butterfly Bicyclus anynana, hypothesized to be under selection for similar or different functions in the wet and dry seasonal forms. See Monteiro et al.
Image Credit: Monteiro et al.
Perspectives
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PLOS Genetics: published September 10, 2015 | https://doi.org/10.1371/journal.pgen.1005489
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Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles
PLOS Genetics: published September 29, 2015 | https://doi.org/10.1371/journal.pgen.1005532
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism
PLOS Genetics: published September 25, 2015 | https://doi.org/10.1371/journal.pgen.1005498
Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs
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Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception
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Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci
PLOS Genetics: published September 25, 2015 | https://doi.org/10.1371/journal.pgen.1005535
Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests
PLOS Genetics: published September 24, 2015 | https://doi.org/10.1371/journal.pgen.1005502
Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood
PLOS Genetics: published September 24, 2015 | https://doi.org/10.1371/journal.pgen.1005510
Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response
PLOS Genetics: published September 24, 2015 | https://doi.org/10.1371/journal.pgen.1005511
Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling
PLOS Genetics: published September 24, 2015 | https://doi.org/10.1371/journal.pgen.1005513
Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians
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A Genome-Wide Association Analysis Reveals Epistatic Cancellation of Additive Genetic Variance for Root Length in Arabidopsis thaliana
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The Arabidopsis RCC1 Family Protein TCF1 Regulates Freezing Tolerance and Cold Acclimation through Modulating Lignin Biosynthesis
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RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization
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PLOS Genetics: published September 22, 2015 | https://doi.org/10.1371/journal.pgen.1005533
Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes
PLOS Genetics: published September 22, 2015 | https://doi.org/10.1371/journal.pgen.1005539
KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
PLOS Genetics: published September 21, 2015 | https://doi.org/10.1371/journal.pgen.1005389
HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis
PLOS Genetics: published September 21, 2015 | https://doi.org/10.1371/journal.pgen.1005479
An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster
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Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses
PLOS Genetics: published September 17, 2015 | https://doi.org/10.1371/journal.pgen.1005470
Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae
PLOS Genetics: published September 17, 2015 | https://doi.org/10.1371/journal.pgen.1005518
A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary
PLOS Genetics: published September 17, 2015 | https://doi.org/10.1371/journal.pgen.1005531
ARID1A Is Essential for Endometrial Function during Early Pregnancy
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XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease
PLOS Genetics: published September 15, 2015 | https://doi.org/10.1371/journal.pgen.1005505
Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens
PLOS Genetics: published September 14, 2015 | https://doi.org/10.1371/journal.pgen.1005472
Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots
PLOS Genetics: published September 14, 2015 | https://doi.org/10.1371/journal.pgen.1005512
Photoreceptor Specificity in the Light-Induced and COP1-Mediated Rapid Degradation of the Repressor of Photomorphogenesis SPA2 in Arabidopsis
PLOS Genetics: published September 14, 2015 | https://doi.org/10.1371/journal.pgen.1005516
Critical Function of γH2A in S-Phase
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Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum
PLOS Genetics: published September 11, 2015 | https://doi.org/10.1371/journal.pgen.1005509
Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID
PLOS Genetics: published September 10, 2015 | https://doi.org/10.1371/journal.pgen.1005411
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Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins
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A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis
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The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis
PLOS Genetics: published September 8, 2015 | https://doi.org/10.1371/journal.pgen.1005396
Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation
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A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures
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FUS Interacts with HSP60 to Promote Mitochondrial Damage
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Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion
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Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast
PLOS Genetics: published September 2, 2015 | https://doi.org/10.1371/journal.pgen.1005468
The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity
PLOS Genetics: published September 2, 2015 | https://doi.org/10.1371/journal.pgen.1005492
A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease
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Retraction
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PLOS Genetics: published September 3, 2015 | https://doi.org/10.1371/journal.pgen.1005519
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Expression of Concern
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PLOS Genetics: published September 14, 2015 | https://doi.org/10.1371/journal.pgen.1005499