Craig et al. introduce the concept of "Cooperative adaptation to therapy" (CAT), in which cancer cells work together immediately upon 'seeing' a drug to build resistance even in the absence of new, acquired mutations. This novel paradigm may help explain why aggressive cancers, such as non-small cell lung cancer, are able to rapidly overcome the pressures of anticancer therapy even when 'druggable' mutations exist.
The image depicts clones of cancer cells converging in a unified, cooperative fashion on an iron throne of 'medicine'. The use of game theory mathematical modeling is represented by the 'foundation', which supports the overtaking of the 'throne'!
Image Credit: Artist: Illustration by Jesse Morris, 2019 Jesse Morris Art, www.jessemorrisart, provided under CC BY 4.0.
Education
Twelve quick tips for designing sound dynamical models for bioprocesses
PLOS Computational Biology: published August 22, 2019 | https://doi.org/10.1371/journal.pcbi.1007222
Research Articles
Efficiency of protein synthesis inhibition depends on tRNA and codon compositions
PLOS Computational Biology: published August 1, 2019 | https://doi.org/10.1371/journal.pcbi.1006979
Reappraising the utility of Google Flu Trends
PLOS Computational Biology: published August 2, 2019 | https://doi.org/10.1371/journal.pcbi.1007258
Bayesian hypothesis testing and experimental design for two-photon imaging data
PLOS Computational Biology: published August 2, 2019 | https://doi.org/10.1371/journal.pcbi.1007205
Related Articles
Every which way? On predicting tumor evolution using cancer progression models
PLOS Computational Biology: published August 2, 2019 | https://doi.org/10.1371/journal.pcbi.1007246
Colony entropy—Allocation of goods in ant colonies
PLOS Computational Biology: published August 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006925
Predicting kinase inhibitors using bioactivity matrix derived informer sets
PLOS Computational Biology: published August 5, 2019 | https://doi.org/10.1371/journal.pcbi.1006813
Energy-efficient information transfer at thalamocortical synapses
PLOS Computational Biology: published August 5, 2019 | https://doi.org/10.1371/journal.pcbi.1007226
Motion, fixation probability and the choice of an evolutionary process
PLOS Computational Biology: published August 5, 2019 | https://doi.org/10.1371/journal.pcbi.1007238
Reduced model to predict thrombin and fibrin during thrombosis on collagen/tissue factor under venous flow: Roles of γ’-fibrin and factor XIa
PLOS Computational Biology: published August 5, 2019 | https://doi.org/10.1371/journal.pcbi.1007266
Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma
PLOS Computational Biology: published August 6, 2019 | https://doi.org/10.1371/journal.pcbi.1007090
Bayesian phylodynamics of avian influenza A virus H9N2 in Asia with time-dependent predictors of migration
PLOS Computational Biology: published August 6, 2019 | https://doi.org/10.1371/journal.pcbi.1007189
On the optimal design of metabolic RNA labeling experiments
PLOS Computational Biology: published August 7, 2019 | https://doi.org/10.1371/journal.pcbi.1007252
Directed migration shapes cooperation in spatial ecological public goods games
PLOS Computational Biology: published August 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006948
Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation
PLOS Computational Biology: published August 8, 2019 | https://doi.org/10.1371/journal.pcbi.1007260
Predicting the effects of deep brain stimulation using a reduced coupled oscillator model
PLOS Computational Biology: published August 8, 2019 | https://doi.org/10.1371/journal.pcbi.1006575
A generative learning model for saccade adaptation
PLOS Computational Biology: published August 9, 2019 | https://doi.org/10.1371/journal.pcbi.1006695
Machine learning-based microarray analyses indicate low-expression genes might collectively influence PAH disease
PLOS Computational Biology: published August 12, 2019 | https://doi.org/10.1371/journal.pcbi.1007264
Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels
PLOS Computational Biology: published August 12, 2019 | https://doi.org/10.1371/journal.pcbi.1007223
Pulse transit time estimation of aortic pulse wave velocity and blood pressure using machine learning and simulated training data
PLOS Computational Biology: published August 15, 2019 | https://doi.org/10.1371/journal.pcbi.1007259
Recombination and mutational robustness in neutral fitness landscapes
PLOS Computational Biology: published August 15, 2019 | https://doi.org/10.1371/journal.pcbi.1006884
Size and structure of the sequence space of repeat proteins
PLOS Computational Biology: published August 15, 2019 | https://doi.org/10.1371/journal.pcbi.1007282
FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics
PLOS Computational Biology: published August 16, 2019 | https://doi.org/10.1371/journal.pcbi.1007230
PRAS: Predicting functional targets of RNA binding proteins based on CLIP-seq peaks
PLOS Computational Biology: published August 19, 2019 | https://doi.org/10.1371/journal.pcbi.1007227
TeXP: Deconvolving the effects of pervasive and autonomous transcription of transposable elements
PLOS Computational Biology: published August 19, 2019 | https://doi.org/10.1371/journal.pcbi.1007293
Characterising antibody kinetics from multiple influenza infection and vaccination events in ferrets
PLOS Computational Biology: published August 19, 2019 | https://doi.org/10.1371/journal.pcbi.1007294
Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity
PLOS Computational Biology: published August 19, 2019 | https://doi.org/10.1371/journal.pcbi.1006795
Learning to synchronize: How biological agents can couple neural task modules for dealing with the stability-plasticity dilemma
PLOS Computational Biology: published August 20, 2019 | https://doi.org/10.1371/journal.pcbi.1006604
Uncertainty reduction in biochemical kinetic models: Enforcing desired model properties
PLOS Computational Biology: published August 20, 2019 | https://doi.org/10.1371/journal.pcbi.1007242
Variation in plastic responses to light results from selection in different competitive environments—A game theoretical approach using virtual plants
PLOS Computational Biology: published August 21, 2019 | https://doi.org/10.1371/journal.pcbi.1007253
Identifying nonlinear dynamical systems via generative recurrent neural networks with applications to fMRI
PLOS Computational Biology: published August 21, 2019 | https://doi.org/10.1371/journal.pcbi.1007263
Integrating Hi-C links with assembly graphs for chromosome-scale assembly
PLOS Computational Biology: published August 21, 2019 | https://doi.org/10.1371/journal.pcbi.1007273
Transient crosslinking kinetics optimize gene cluster interactions
PLOS Computational Biology: published August 21, 2019 | https://doi.org/10.1371/journal.pcbi.1007124
Gaussian curvature and the budding kinetics of enveloped viruses
PLOS Computational Biology: published August 21, 2019 | https://doi.org/10.1371/journal.pcbi.1006602
ProtFus: A Comprehensive Method Characterizing Protein-Protein Interactions of Fusion Proteins
PLOS Computational Biology: published August 22, 2019 | https://doi.org/10.1371/journal.pcbi.1007239
A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes
PLOS Computational Biology: published August 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006661
A computational model for gonadotropin releasing cells in the teleost fish medaka
PLOS Computational Biology: published August 22, 2019 | https://doi.org/10.1371/journal.pcbi.1006662
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
PLOS Computational Biology: published August 23, 2019 | https://doi.org/10.1371/journal.pcbi.1007207
Related Articles
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer
PLOS Computational Biology: published August 26, 2019 | https://doi.org/10.1371/journal.pcbi.1007278
CNEr: A toolkit for exploring extreme noncoding conservation
PLOS Computational Biology: published August 26, 2019 | https://doi.org/10.1371/journal.pcbi.1006940
Selective recruitment of cortical neurons by electrical stimulation
PLOS Computational Biology: published August 26, 2019 | https://doi.org/10.1371/journal.pcbi.1007277
A lipophilicity-based energy function for membrane-protein modelling and design
PLOS Computational Biology: published August 28, 2019 | https://doi.org/10.1371/journal.pcbi.1007318
Measuring the impact of gene prediction on gene loss estimates in Eukaryotes by quantifying falsely inferred absences
PLOS Computational Biology: published August 28, 2019 | https://doi.org/10.1371/journal.pcbi.1007301
Tracking Pseudomonas aeruginosa transmissions due to environmental contamination after discharge in ICUs using mathematical models
PLOS Computational Biology: published August 28, 2019 | https://doi.org/10.1371/journal.pcbi.1006697
Non-trophic interactions strengthen the diversity—functioning relationship in an ecological bioenergetic network model
PLOS Computational Biology: published August 29, 2019 | https://doi.org/10.1371/journal.pcbi.1007269
Network analyses to quantify effects of host movement in multilevel disease transmission models using foot and mouth disease in Cameroon as a case study
PLOS Computational Biology: published August 29, 2019 | https://doi.org/10.1371/journal.pcbi.1007184
The formation of preference in risky choice
PLOS Computational Biology: published August 29, 2019 | https://doi.org/10.1371/journal.pcbi.1007201
A benchmark of computational CRISPR-Cas9 guide design methods
PLOS Computational Biology: published August 29, 2019 | https://doi.org/10.1371/journal.pcbi.1007274
Anatomically accurate model of EMG during index finger flexion and abduction derived from diffusion tensor imaging
PLOS Computational Biology: published August 29, 2019 | https://doi.org/10.1371/journal.pcbi.1007267
Fast uncertainty quantification for dynamic flux balance analysis using non-smooth polynomial chaos expansions
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007308
Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1006938
Mechanical properties of tubulin intra- and inter-dimer interfaces and their implications for microtubule dynamic instability
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007327
PanoView: An iterative clustering method for single-cell RNA sequencing data
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007040
Red blood cells stabilize flow in brain microvascular networks
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007231
Dark-matter matters: Discriminating subtle blood cancers using the darkest DNA
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007332
Toxin production spontaneously becomes regulated by local cell density in evolving bacterial populations
PLOS Computational Biology: published August 30, 2019 | https://doi.org/10.1371/journal.pcbi.1007333