Figures
Game of Clones (Resistance is Coming)
Craig et al. introduce the concept of "Cooperative adaptation to therapy" (CAT), in which cancer cells work together immediately upon 'seeing' a drug to build resistance even in the absence of new, acquired mutations. This novel paradigm may help explain why aggressive cancers, such as non-small cell lung cancer, are able to rapidly overcome the pressures of anticancer therapy even when 'druggable' mutations exist.
The image depicts clones of cancer cells converging in a unified, cooperative fashion on an iron throne of 'medicine'. The use of game theory mathematical modeling is represented by the 'foundation', which supports the overtaking of the 'throne'!
Image Credit: Artist: Illustration by Jesse Morris, 2019 Jesse Morris Art, www.jessemorrisart, provided under CC BY 4.0.
Citation: (2019) PLoS Computational Biology Issue Image | Vol. 15(8) August 2019. PLoS Comput Biol 15(8): ev15.i08. https://doi.org/10.1371/image.pcbi.v15.i08
Published: August 30, 2019
Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Craig et al. introduce the concept of "Cooperative adaptation to therapy" (CAT), in which cancer cells work together immediately upon 'seeing' a drug to build resistance even in the absence of new, acquired mutations. This novel paradigm may help explain why aggressive cancers, such as non-small cell lung cancer, are able to rapidly overcome the pressures of anticancer therapy even when 'druggable' mutations exist.
The image depicts clones of cancer cells converging in a unified, cooperative fashion on an iron throne of 'medicine'. The use of game theory mathematical modeling is represented by the 'foundation', which supports the overtaking of the 'throne'!
Image Credit: Artist: Illustration by Jesse Morris, 2019 Jesse Morris Art, www.jessemorrisart, provided under CC BY 4.0.